Prematurity has got special challenge for clinicians and also other medical staff, such as microbiologists. Immature host defense mechanisms support early-onset sepsis, which can be very serious with very high mortality. While the past decade has been marked by a significant decline in early-onset group B streptococcal (GBS) sepsis in both term and preterm neonates, the overall incidence of early-onset sepsis has not decreased in many centers, and several studies have found an increase in sepsis due to gram-negative organisms. With increasing survival of these more fastidious preterm infants, late-onset sepsis or specially nosocomial bloodstream infection (BSI) will continue to be a challenging complication that affects other morbidities, length of hospitalization, cost of care, and mortality rates. Especially the very low birthweight (VLBW) infants sensitive to serious systemic infection during their initial hospital stay. Sepsis caused by multiresistant organisms and Candida spp. are also increasing in incidence, has become the most common cause of death among preterm infants. This review focuses on the clinical microbiology of neonatal sepsis, particularly among preterm babies, summarizing the most frequent bacterial and fungal organisms causing perinatally acquired and also nosocomial sepsis.
-
Andersen, B. M., Lindemann, R., Bergh, K. et al.: Spread of methicillin-resistant Staphylococcus. aureus in a neonatal intensive unit associated with understaffing, overcrowding and mixing of patients. J Hosp Infect 50 , 18–24 (2002).
Bergh K. , 'Spread of methicillin-resistant Staphylococcus. aureus in a neonatal intensive unit associated with understaffing, overcrowding and mixing of patients ' (2002 ) 50 J Hosp Infect : 18 -24.
-
Archibald, L. K., Manning, M. L., Bell, L. M. et al.: Patient density, nurse-to-patient ratio and nosocomial infection risk in a pediatric cardiac intensive care unit. Pediatr Infect Dis J 16 , 1045–1048 (1997).
Bell L. M. , 'Patient density, nurse-to-patient ratio and nosocomial infection risk in a pediatric cardiac intensive care unit ' (1997 ) 16 Pediatr Infect Dis J : 1045 -1048.
-
Aziz, K., McMillan, D. D., Andrews, W. et al.: Variations in rates of nosocomial infection among Canadian neonatal intensive care units may be practice-related. BMC Pediatr 5 , 22 (2005).
Andrews W. , 'Variations in rates of nosocomial infection among Canadian neonatal intensive care units may be practice-related ' (2005 ) 5 BMC Pediatr : 22 -.
-
Baltimore, R. S.: Neonatal sepsis. Epidemiology and management. Pediatr Drugs 5 , 723–740 (2003).
Baltimore R. S. , 'Neonatal sepsis. Epidemiology and management ' (2003 ) 5 Pediatr Drugs : 723 -740.
-
Benitz, W. E., Gould, J. B., Druzin, M. L.: Antimicrobial prevention of early-onset group B streptococcal sepsis: estimates of risk reduction based on a critical literature review. Pediatrics 103 , e78 (1999).
Druzin M. L. , 'Antimicrobial prevention of early-onset group B streptococcal sepsis: estimates of risk reduction based on a critical literature review ' (1999 ) 103 Pediatrics : e78 -.
-
Benjamin, D. K. Jr., DeLong, E., Cotton, C. M. et al.: Mortality following blood culture in premature infants: increased with gram-negative bacteremia and candidemia, but not gram-positive bacteremia. J Perinatol 24 , 175–180 (2004).
Cotton C. M. , 'Mortality following blood culture in premature infants: increased with gram-negative bacteremia and candidemia, but not gram-positive bacteremia ' (2004 ) 24 J Perinatol : 175 -180.
-
Benjamin, D. K. Jr., Ross, K., McKinney, R. E. Jr. et al.: When to suspect fungal infection in neonates: a clinical comparison of Candida albicans and Candida parapsilosis fungemia with coagulase-negative staphylococcal bacteremia. Pediatrics 106 , 712–718 (2000).
McKinney R. E. , 'When to suspect fungal infection in neonates: a clinical comparison of Candida albicans and Candida parapsilosis fungemia with coagulase-negative staphylococcal bacteremia ' (2000 ) 106 Pediatrics : 712 -718.
-
Benjamin, D. K. Jr., Miller, W., Garges, H. et al.: Bacteremia, central catheters, and neonates: when to pull the line. Pediatrics 107 , 1272–1276 (2001).
Garges H. , 'Bacteremia, central catheters, and neonates: when to pull the line ' (2001 ) 107 Pediatrics : 1272 -1276.
-
Berger, A., Salzer, H. R., Weninger, M. et al.: Septicaemia in an Austrian neonatal intensive care unit: a 7-year analysis. Acta Paediatr 87 , 1066–1069 (1998).
Weninger M. , 'Septicaemia in an Austrian neonatal intensive care unit: a 7-year analysis ' (1998 ) 87 Acta Paediatr : 1066 -1069.
-
Bindayna, K. M., Jamsheer, A., Farid, E., Botta, G. A.: Neonatal sepsis 1991–2001: Prevalent bacterial agents and antimicrobial susceptibilities in Bahrain. Med Princ Pract 15 , 131–136 (2006).
Botta G. A. , 'Neonatal sepsis 1991–2001: Prevalent bacterial agents and antimicrobial susceptibilities in Bahrain ' (2006 ) 15 Med Princ Pract : 131 -136.
-
Bizzarro, M. J., Raskind, C., Baltimore, R. S. et al.: Seventy-five years of neonatal sepsis at Yale: 1928–2003. Pediatrics 116 , 595–602 (2005).
Baltimore R. S. , 'Seventy-five years of neonatal sepsis at Yale: 1928–2003 ' (2005 ) 116 Pediatrics : 595 -602.
-
Brady, M. T.: Health care-associated infections in the neonatal intensive care unit. Am J Infect Control 33 , 268–275 (2005).
Brady M. T. , 'Health care-associated infections in the neonatal intensive care unit ' (2005 ) 33 Am J Infect Control : 268 -275.
-
Brodie, S. B., Sands, K. E., Gray, J. E. et al.: Occurrence of nosocomial bloodstream infection in six neonatal intensive care units. Pediatr Infect Dis J 9 , 56–65 (2000).
Gray J. E. , 'Occurrence of nosocomial bloodstream infection in six neonatal intensive care units ' (2000 ) 9 Pediatr Infect Dis J : 56 -65.
-
Bromiker, R., Arad, I., Peleg, O., Engelhard, D.: Neonatal bacteremia: patterns of antibiotic resistance. Infect Control Hosp Epidemiol 22 , 767–770 (2001).
Engelhard D. , 'Neonatal bacteremia: patterns of antibiotic resistance ' (2001 ) 22 Infect Control Hosp Epidemiol : 767 -770.
-
Chapman, R. L., Faix, R. G.: Persistent bacteremia and outcome in late onset infection among infants in a neonatal intensive care unit. Pediatr Infect Dis J 22 , 17–21 (2003).
Faix R. G. , 'Persistent bacteremia and outcome in late onset infection among infants in a neonatal intensive care unit ' (2003 ) 22 Pediatr Infect Dis J : 17 -21.
-
Colardyn, F.: Appropriate and timely empirical antimicrobial treatment of ICU infections — a role for carbapenems. Acta Clinica Belgica 60 , 2 (2005).
Colardyn F. , 'Appropriate and timely empirical antimicrobial treatment of ICU infections — a role for carbapenems ' (2005 ) 60 Acta Clinica Belgica : 2 -.
-
Couto, R. C., Carvalho, E. A. A., Pedrosa, T. M. et al.: A 10-year prospective surveillance of nosocomial infections in neonatal intensive care units. Am J Infect Control 35 , 183–189 (2007).
Pedrosa T. M. , 'A 10-year prospective surveillance of nosocomial infections in neonatal intensive care units ' (2007 ) 35 Am J Infect Control : 183 -189.
-
Crivaro, V., Bagattini, M., Salza, M. F. et al.: Risk factors for nosocomial infections in a neonatal intensive-care unit. Infect Control Hosp Epidemiol 27 , 571–575 (2006).
Salza M. F. , 'Risk factors for nosocomial infections in a neonatal intensive-care unit ' (2006 ) 27 Infect Control Hosp Epidemiol : 571 -575.
-
Crump, J. A., Collingnon, P. J.: Risk factors for extended-spectrum B-lactamase-producing Serratia marcescens and Klebsiella pneumoniae acquisition in a neonatal intensive care unit. J Hosp Infect 67 , 135–141 (2007).
Collingnon P. J. , 'Risk factors for extended-spectrum B-lactamase-producing Serratia marcescens and Klebsiella pneumoniae acquisition in a neonatal intensive care unit ' (2007 ) 67 J Hosp Infect : 135 -141.
-
Crump, J. A., Collingnon, P. J.: Intravascular catheter-associated infections. Eur J Clin Microbiol Infect Dis 19 , 1–8 (2000).
Collingnon P. J. , 'Intravascular catheter-associated infections ' (2000 ) 19 Eur J Clin Microbiol Infect Dis : 1 -8.
-
de Man, P., Verhoeven, B. A. N., Verbrugh, H. A. et al.: An antibiotic policy to prevent emergence of resistant bacilli. Lancet 355 , 973–978 (2000).
Verbrugh H. A. , 'An antibiotic policy to prevent emergence of resistant bacilli ' (2000 ) 355 Lancet : 973 -978.
-
Fahey, J. O.: Clinical management of intra-amniotic infection and chorioamnionitis: A review of the literature. J Midwifery Womens Health 53 , 227–235 (2008).
Fahey J. O. , 'Clinical management of intra-amniotic infection and chorioamnionitis: A review of the literature ' (2008 ) 53 J Midwifery Womens Health : 227 -235.
-
Fanos, V., Dall’Agnola, A.: Antibiotics in neonatal infections. Drugs 58 , 405–427 (1999).
Dall’Agnola A. , 'Antibiotics in neonatal infections ' (1999 ) 58 Drugs : 405 -427.
-
Foca, M., Jakob, K., Whittier, S. et al.: Endemic Pseudomonas aeruginosa infection in a neonatal intensive care unit. N Engl J Med 343 , 695–700 (2000).
Whittier S. , 'Endemic Pseudomonas aeruginosa infection in a neonatal intensive care unit ' (2000 ) 343 N Engl J Med : 695 -700.
-
Galanakis, E., Krallis, N., Levidiotou, S. et al.: Neonatal bacteremia: a population based study. Scand J Infect Dis 34 , 598–601 (2002).
Levidiotou S. , 'Neonatal bacteremia: a population based study ' (2002 ) 34 Scand J Infect Dis : 598 -601.
-
Garcia-Prats, J. A., Cooper, T. R., Schneider, V. F. et al.: Rapid detection of microorganisms in blood cultures of newborn infants utilizing an automated blood culture system. Pediatrics 105 , 523–527 (2000).
Schneider V. F. , 'Rapid detection of microorganisms in blood cultures of newborn infants utilizing an automated blood culture system ' (2000 ) 105 Pediatrics : 523 -527.
-
Gastmeier, P., Hentschel, J., De Veer, I. et al.: Device-associated nosocomial infection surveillance in neonatal intensive care using specified criteria for neonates. J Hosp Infect 38 , 51–60 (1998).
Veer I. , 'Device-associated nosocomial infection surveillance in neonatal intensive care using specified criteria for neonates ' (1998 ) 38 J Hosp Infect : 51 -60.
-
Gastmeier, P., Loui, A., Stamm-Balderjahn, S. et al.: Outbreaks in neonatal intensive care units — They are not like others. Am J Infect Control 35 , 172–176 (2007).
Stamm-Balderjahn S. , 'Outbreaks in neonatal intensive care units — They are not like others ' (2007 ) 35 Am J Infect Control : 172 -176.
-
Goldmann, D. A.: The bacterial flora of neonates in intensive care-monitoring and manipulation. J Hosp Infect 11 , 340–351 (1988).
Goldmann D. A. , 'The bacterial flora of neonates in intensive care-monitoring and manipulation ' (1988 ) 11 J Hosp Infect : 340 -351.
-
Gupta, C., Briski, L. E.: Comparison of two culture media and three sampling techniques for sensitive and rapid screening of vaginal colonization by Group B Streptococcus in pregnant women. J Clin Microbiol 42 , 3975–3977 (2004).
Briski L. E. , 'Comparison of two culture media and three sampling techniques for sensitive and rapid screening of vaginal colonization by Group B Streptococcus in pregnant women ' (2004 ) 42 J Clin Microbiol : 3975 -3977.
-
Haque, K. N., Khan, M. A., Kerry, S. et al.: Pattern of culture-proven neonatal sepsis in a district general hospital in the United Kingdom. Infect Control Hosp Epidemiol 25 , 759–764 (2004).
Kerry S. , 'Pattern of culture-proven neonatal sepsis in a district general hospital in the United Kingdom ' (2004 ) 25 Infect Control Hosp Epidemiol : 759 -764.
-
Harbarth, S., Sudre, P., Dharan, S. et al.: Outbreak of Enterobacter cloaceae related to understaffing, overcrowding, and poor hygiene practices. Infect Control Hosp Epidemiol 20 , 598–603 (1999).
Dharan S. , 'Outbreak of Enterobacter cloaceae related to understaffing, overcrowding, and poor hygiene practices ' (1999 ) 20 Infect Control Hosp Epidemiol : 598 -603.
-
Hervass, J. A., Ballesteros, F., Alomar, A. et al.: Increase of Enterobacter in neonatal sepsis: a twenty-two-year study. Pediatr Infect Dis J 19 , 319–324 (2001).
Alomar A. , 'Increase of Enterobacter in neonatal sepsis: a twenty-two-year study ' (2001 ) 19 Pediatr Infect Dis J : 319 -324.
-
Horan, T. C., Gaynes, R. P.: Surveillance of nosocomial infcetions. In: Mayhall, C. G. (ed.): Hospital Epidemiology and Infection Control, 3rd ed. Lippincott Williams&Wilkins, Philadelphia, 2004, pp. 1659–1702.
Gaynes R. P. , '', in Hospital Epidemiology and Infection Control , (2004 ) -.
-
Huang, Y. C., Su, L. H., Wu, T. L., Lin, T. Y.: Genotyping analysis of colonizing candidal isolates from very-low-birthweight infants in a neonatal intensive care unit. J Hosp Infect 58 , 200–203 (2004).
Lin T. Y. , 'Genotyping analysis of colonizing candidal isolates from very-low-birthweight infants in a neonatal intensive care unit ' (2004 ) 58 J Hosp Infect : 200 -203.
-
Jaballah, N. B., Bouziri, A., Mnif, K. et al.: Epidemiology of hospital-acquired bloodstream infections in a Tunisian pediatric intensive care unit: A 2-year prospective study. Am J Infect Control 35 , 613–618 (2007).
Mnif K. , 'Epidemiology of hospital-acquired bloodstream infections in a Tunisian pediatric intensive care unit: A 2-year prospective study ' (2007 ) 35 Am J Infect Control : 613 -618.
-
Jeong, I. S., Jeong, J. S., Choi, E. O.: Nosocomial infection in a newborn intensive care unit (NICU), South Korea. BMC Infect Dis 6 , 103 (2006).
Choi E. O. , 'Nosocomial infection in a newborn intensive care unit (NICU), South Korea ' (2006 ) 6 BMC Infect Dis : 103 -.
-
Jiang, J. H., Chiu, N. C., Huang, F. Y. et al.: Neonatal sepsis in the neonatal intensive care unit: characteristics of early versus late onset. J Microbiol Immunol Infect 37 , 301–306 (2004).
Huang F. Y. , 'Neonatal sepsis in the neonatal intensive care unit: characteristics of early versus late onset ' (2004 ) 37 J Microbiol Immunol Infect : 301 -306.
-
Jolley, A. E.: The value of surveillance cultures on neonatal intensive care units. J Hosp Infect 25 , 153–159 (1993).
Jolley A. E. , 'The value of surveillance cultures on neonatal intensive care units ' (1993 ) 25 J Hosp Infect : 153 -159.
-
Karlowitz, M. G., Buescher, E. S., Surka, A. E.: Fulminant late-onset sepsis in a neonatal intensive care unit, 1988–1997, and the impact of avoiding empiric vancomycin therapy. Pediatrics 106 , 1387–1390 (2000).
Surka A. E. , 'Fulminant late-onset sepsis in a neonatal intensive care unit, 1988–1997, and the impact of avoiding empiric vancomycin therapy ' (2000 ) 106 Pediatrics : 1387 -1390.
-
Kaufman, D., Fairchild, K. D.: Clinical microbiology of bacterial and fungal sepsis in very-low-birth-weight infants. Clin Microbiol Rev 17 , 638–680 (2004).
Fairchild K. D. , 'Clinical microbiology of bacterial and fungal sepsis in very-low-birth-weight infants ' (2004 ) 17 Clin Microbiol Rev : 638 -680.
-
Kawagoe, J. Y., Segre, C. A. M., Pereira, C. R. et al.: Risk factors for nosocomial infections in critically ill newborns: a 5-year prospective cohort study. Am J Infect Control 29 , 109–114 (2001).
Pereira C. R. , 'Risk factors for nosocomial infections in critically ill newborns: a 5-year prospective cohort study ' (2001 ) 29 Am J Infect Control : 109 -114.
-
Keyserling, H. L., Sinkowitz-Cochran, R. L., Harris, J. M. et al.: Vancomycin use in hospitalized pediatric patients. Pediatrics 112 , 104–111 (2003).
Harris J. M. , 'Vancomycin use in hospitalized pediatric patients ' (2003 ) 112 Pediatrics : 104 -111.
-
Kim, S. D., McDonald, L. C., Jarvis, W. R. et al.: Determining the significance of coagulase-negative staphylococci isolated from blood cultures at a community hospital: a role for species and strain identification. Infect Control Hosp Epidemiol 21 , 213–217 (2000).
Jarvis W. R. , 'Determining the significance of coagulase-negative staphylococci isolated from blood cultures at a community hospital: a role for species and strain identification ' (2000 ) 21 Infect Control Hosp Epidemiol : 213 -217.
-
Kollef, M. H.: The prevention of ventilator-associated pneumonia. N Eng J Med 340 , 627–633 (1999).
Kollef M. H. , 'The prevention of ventilator-associated pneumonia ' (1999 ) 340 N Eng J Med : 627 -633.
-
Kollef, M. H.: Appropriate empirical antibacterial therapy for nosocomial infections. Getting it right the first time. Drugs 63 , 2157–2168 (2003).
Kollef M. H. , 'Appropriate empirical antibacterial therapy for nosocomial infections. Getting it right the first time ' (2003 ) 63 Drugs : 2157 -2168.
-
Kristóf, K., Barcs, I., Cziniel, M. et al.: Connatal listeriosis — a case report and the possibilities of microbiological diagnosis. Acta Microbiol Hung 55 , 63–72 (2008).
Cziniel M. , 'Connatal listeriosis — a case report and the possibilities of microbiological diagnosis ' (2008 ) 55 Acta Microbiol Hung : 63 -72.
-
Kristóf, K., Szabo, D., Marsh, J. W. et al.: Extended-spectrum B-lactamase-producing Klebsiella spp. in a neonatal intensive care unit: risk factors for the infection and the dynamics of the molecular epidemiology. Eur J Clin Microbiol Infect Dis 26 , 563–570 (2007).
Marsh J. W. , 'Extended-spectrum B-lactamase-producing Klebsiella spp. in a neonatal intensive care unit: risk factors for the infection and the dynamics of the molecular epidemiology ' (2007 ) 26 Eur J Clin Microbiol Infect Dis : 563 -570.
-
Ladhani, S., Grandsen, W.: Septicaemia due to glucose non-fermenting, Gram-negative bacilli other than Pseudomonas aeruginosa in children. Acta Paediatr 91 , 303–306 (2002).
Grandsen W. , 'Septicaemia due to glucose non-fermenting, Gram-negative bacilli other than Pseudomonas aeruginosa in children ' (2002 ) 91 Acta Paediatr : 303 -306.
-
Larsen, J. W., Sever, J. L.: Group B Streptococcus and pregnancy: a review. Am J Obstet Gynecol 198 , 440–450 (2008).
Sever J. L. , 'Group B Streptococcus and pregnancy: a review ' (2008 ) 198 Am J Obstet Gynecol : 440 -450.
-
Lau, Y. L., Hey, E.: Sensitivity and specificity of daily tracheal aspirate cultures in predicting organisms causing bacteremia in ventilated neonates. Pediatr Infect Dis J 10 , 290–294 (1991).
Hey E. , 'Sensitivity and specificity of daily tracheal aspirate cultures in predicting organisms causing bacteremia in ventilated neonates ' (1991 ) 10 Pediatr Infect Dis J : 290 -294.
-
Mahieu, L. M., Buitenweg, N., Beutels, P., De Dooy, J. J.: Additional hospital stay and charges due to hospital-aquired infections in a neonatal intensive care unit. J Hosp Infect 47 , 223–229 (2001).
Dooy J. J. , 'Additional hospital stay and charges due to hospital-aquired infections in a neonatal intensive care unit ' (2001 ) 47 J Hosp Infect : 223 -229.
-
Prediction of nosocomial sepsis in neonates by means of a computer-weighted bedside scoring system (NOSEP score). Crit Care Med 28 , 2026–2033 (2000).
-
Makhoul, I. R., Sujov, P., Smolkin, T. et al.: Pathogen-specific early mortality in very low birth weight infants with late-onset sepsis: a national survey. CID 40 , 218–224 (2005).
Smolkin T. , 'Pathogen-specific early mortality in very low birth weight infants with late-onset sepsis: a national survey ' (2005 ) 40 CID : 218 -224.
-
Makhoul, I. R., Sujov, P., Smolkin, T. et al.: Epidemiological, clinical and microbiological characteristics of late-onset sepsis among very low birth weight infants in Israel: a national survey. Pediatrics 109 , 34–39 (2002).
Smolkin T. , 'Epidemiological, clinical and microbiological characteristics of late-onset sepsis among very low birth weight infants in Israel: a national survey ' (2002 ) 109 Pediatrics : 34 -39.
-
Manzoni, P., Farina, D., Galletto, P. et al.: Type and number of sites colonized by fungi and risk of progression to invasive fungal infection in preterm neonates in neonatal intensive care unit. J Perinat Med 35 , 220–226 (2007).
Galletto P. , 'Type and number of sites colonized by fungi and risk of progression to invasive fungal infection in preterm neonates in neonatal intensive care unit ' (2007 ) 35 J Perinat Med : 220 -226.
-
Mireya, U. A., Marti, P. O., Xavier, K. V. et al.: Nosocomial infections in paediatric and neonatal intensive care units. J Infect 54 , 212–220 (2007).
Xavier K. V. , 'Nosocomial infections in paediatric and neonatal intensive care units ' (2007 ) 54 J Infect : 212 -220.
-
Nagata, E., Brito, A., Matsuo, T.: Nosocomial infections in a neonatal intensive care unit: incidence and risk factors. Am J Infect Control 30 , 26–31 (2002).
Matsuo T. , 'Nosocomial infections in a neonatal intensive care unit: incidence and risk factors ' (2002 ) 30 Am J Infect Control : 26 -31.
-
Nambiar, S., Singh, N.: Change in epidemiology of health care-associated infections in a neonatal intensive care unit. Pediatr Infect Dis J 21 , 839–842 (2002).
Singh N. , 'Change in epidemiology of health care-associated infections in a neonatal intensive care unit ' (2002 ) 21 Pediatr Infect Dis J : 839 -842.
-
Ng, P. C., Lam, H. S.: Diagnostic markers for neonatal sepsis. Curr Opin Pediatr 18 , 125–131 (2006).
Lam H. S. , 'Diagnostic markers for neonatal sepsis ' (2006 ) 18 Curr Opin Pediatr : 125 -131.
-
Park, C. H., Seo, J. H., Lim, J. Y. et al.: Changing trend of neonatal infection: Experience at a newly established regional medical center in Korea. Pediatrics International 49 , 24–30 (2007).
Lim J. Y. , 'Changing trend of neonatal infection: Experience at a newly established regional medical center in Korea ' (2007 ) 49 Pediatrics International : 24 -30.
-
Patrick, C. C., Kaplan, S. L., Baker, C. J. et al.: Persistent bacteremia due to coagulase-negative staphylococci in low birth weight neonates. Pediatrics 84 , 977–985 (1989).
Baker C. J. , 'Persistent bacteremia due to coagulase-negative staphylococci in low birth weight neonates ' (1989 ) 84 Pediatrics : 977 -985.
-
Persson, E., Trollfors, B., Brandberg, L. L., Tessin, I.: Septicaemia and meningitis in neonates and during early infancy in the Göteborg area of Sweden. Acta Paediatr 91 , 1087–1092 (2002).
Tessin I. , 'Septicaemia and meningitis in neonates and during early infancy in the Göteborg area of Sweden ' (2002 ) 91 Acta Paediatr : 1087 -1092.
-
Pessoa-Silva, C. L., Moreira, B. M., Almeida, V. C. et al.: Extended-spectrum B-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit: risk factors for infection and colonization. J Hosp Infect 53 , 198–206 (2003).
Almeida V. C. , 'Extended-spectrum B-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit: risk factors for infection and colonization ' (2003 ) 53 J Hosp Infect : 198 -206.
-
Phares, C. R., Lynfield, R., Farley, M. M. et al.: Epidemiology of invasive group B streptococcal disease in the United States, 1999–2005. JAMA 299 , 2056–2065 (2008).
Farley M. M. , 'Epidemiology of invasive group B streptococcal disease in the United States, 1999–2005 ' (2008 ) 299 JAMA : 2056 -2065.
-
Prevention of perinatal group B streptococcal disease: revised guideline from CDC. MMWR Recomm Rep 51 (RR-11), 1–22 (2002).
-
Quinn, J. P., Rodvold, K. A.: Antibiotic policies in neonatal intensive-care units. Lancet 355 , 946–947 (2000).
Rodvold K. A. , 'Antibiotic policies in neonatal intensive-care units ' (2000 ) 355 Lancet : 946 -947.
-
Rallu, F., Barriga, P., Scrivo, C. et al.: Sensitivities of antigen detection and PCR assays greatly increased compared to that of the standard culture method for screening for group B Streptococcus carriage in pregnant woman. J Clin Microbiol 44 , 725–728 (2006).
Scrivo C. , 'Sensitivities of antigen detection and PCR assays greatly increased compared to that of the standard culture method for screening for group B Streptococcus carriage in pregnant woman ' (2006 ) 44 J Clin Microbiol : 725 -728.
-
Raymond, J., Aujard, Y., The European Study Group: Nosocomial infections in paediatric patients: a European, multicenter prospective study. Infect Control Hosp Epidemiol 21 , 260–263 (2000).
Aujard Y. , 'The European Study Group: Nosocomial infections in paediatric patients: a European, multicenter prospective study ' (2000 ) 21 Infect Control Hosp Epidemiol : 260 -263.
-
Rubin, L. G., Sanchez, P. J., Siegel, J. et al.: Evaluation and treatment of neonates with suspected late-onset sepsis: a survey of neonatologists’ practices. Pediatrics 110 , e42 (2002).
Siegel J. , 'Evaluation and treatment of neonates with suspected late-onset sepsis: a survey of neonatologists’ practices ' (2002 ) 110 Pediatrics : e42 -.
-
Sabui, T., Tudehope, D., Tilse, M.: Clinical significance of quantitative blood cultures in newborn infants. J Pediatr Child Health 35 , 578–581 (1999).
Tilse M. , 'Clinical significance of quantitative blood cultures in newborn infants ' (1999 ) 35 J Pediatr Child Health : 578 -581.
-
Saiman, L., Ludington, E., Pfaller, M. et al.: Risk factors for candidemia in neonatal intensive care unit patients. Pediatr Infect Dis J 20 , 134–140 (2001).
Pfaller M. , 'Risk factors for candidemia in neonatal intensive care unit patients ' (2001 ) 20 Pediatr Infect Dis J : 134 -140.
-
Saiman, L.: Strategies for prevention of nosocomial sepsis in the neonatal intensive care unit. Curr Opin Pediatr 18 , 101–106 (2006).
Saiman L. , 'Strategies for prevention of nosocomial sepsis in the neonatal intensive care unit ' (2006 ) 18 Curr Opin Pediatr : 101 -106.
-
Saiman, L.: Risk factors for hospital-acquired infections in the neonatal intensive care unit. Seminars in Perinatology 26 , 315–321 (2002).
Saiman L. , 'Risk factors for hospital-acquired infections in the neonatal intensive care unit ' (2002 ) 26 Seminars in Perinatology : 315 -321.
-
Schrag, S. J., Zell, E. R., Lynfield, R. et al.: A population-based comparison of strategies to prevent early-onset group B streptococcal disease in neonates. N Eng J Med 347 , 233–239 (2002).
Lynfield R. , 'A population-based comparison of strategies to prevent early-onset group B streptococcal disease in neonates ' (2002 ) 347 N Eng J Med : 233 -239.
-
Schrag, S. J., Zywicki, S., Farley, M. M. et al.: Group B streptococcal disease in the era of intrapartum antibiotic prophylaxis. N Eng J Med 342 , 15–20 (2000).
Farley M. M. , 'Group B streptococcal disease in the era of intrapartum antibiotic prophylaxis ' (2000 ) 342 N Eng J Med : 15 -20.
-
Schuchat, A., Zywicki, S. S., Dinsmoor, M. J. et al.: Risk factors and opportunities for prevention of early-onset neonatal sepsis: a multicenter case-control study. Pediatrics 105 , 21–26 (2000).
Dinsmoor M. J. , 'Risk factors and opportunities for prevention of early-onset neonatal sepsis: a multicenter case-control study ' (2000 ) 105 Pediatrics : 21 -26.
-
Shah, S., Ehrenkranz, R. A., Gallagher, P. G.: Increasing incidence of Gram-negative rod bacteremia in a newborn intensive care unit. Pediatr Infect Dis J 18 , 591–595 (1999).
Gallagher P. G. , 'Increasing incidence of Gram-negative rod bacteremia in a newborn intensive care unit ' (1999 ) 18 Pediatr Infect Dis J : 591 -595.
-
Silva, G. D. I., Kantzanou, M., Justice, A. et al.: The ica operon and biofilm production in coagulase-negative staphylococci associated with carriage and disease in a neonatal intensive care unit. J Clin Microbiol 40 , 382–388 (2002).
Justice A. , 'The ica operon and biofilm production in coagulase-negative staphylococci associated with carriage and disease in a neonatal intensive care unit ' (2002 ) 40 J Clin Microbiol : 382 -388.
-
Singh-Naz, N., Rakowsky, A., Cantwell, E. et al.: Nosocomial enterococcal infections in children. J Infect 40 , 145–149 (2000).
Cantwell E. , 'Nosocomial enterococcal infections in children ' (2000 ) 40 J Infect : 145 -149.
-
Slagle, T. A., Bifano, E. M., Wolf, J. W., Gross, S. J.: Routine endotracheal cultures for the prediction of sepsis in ventilated babies. Archives of Disease in Childhood 64 , 34–38 (1989).
Gross S. J. , 'Routine endotracheal cultures for the prediction of sepsis in ventilated babies ' (1989 ) 64 Archives of Disease in Childhood : 34 -38.
-
Sohn, A. H., Garrett, D. O., Sinkowitz-Cochran, R. L. et al.: Prevalence of nosocomial infections in neonatal intensive care units patients: results from the first national point-prevalence survey. J Pediatr 139 , 821–827 (2001).
Sinkowitz-Cochran R. L. , 'Prevalence of nosocomial infections in neonatal intensive care units patients: results from the first national point-prevalence survey ' (2001 ) 139 J Pediatr : 821 -827.
-
Stoll, B. J., Gordon, T., Korones, S. B. et al.: Late-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr 129 , 63–71 (1996).
Korones S. B. , 'Late-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network ' (1996 ) 129 J Pediatr : 63 -71.
-
Stoll, B. J., Hansen, N., Fanaroff, A. A. et al.: Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants. N Eng J Med 347 , 240–247 (2002).
Fanaroff A. A. , 'Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants ' (2002 ) 347 N Eng J Med : 240 -247.
-
Stoll, B. J., Hansen, N., Fanaroff, A. A. et al.: Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 110 , 285–291 (2002).
Fanaroff A. A. , 'Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network ' (2002 ) 110 Pediatrics : 285 -291.
-
Stover, B. H., Shulman, S. T., Bratcher, D. F. et al.: Nosocomial infection rates in US children’s hospitals’ neonatal and pediatric intensive care units. Am J Infect Control 29 , 152–157 (2001).
Bratcher D. F. , 'Nosocomial infection rates in US children’s hospitals’ neonatal and pediatric intensive care units ' (2001 ) 29 Am J Infect Control : 152 -157.
-
Szabo, D., Filetoth, Z., Szentandrassy, J. et al.: Molecular epidemiology of a cluster of cases due to Klebsiella pneumoniae producing SHV-5 extended-spectrum B-lactamase in the premature intensive care unit of a Hungarian hospital. J Clin Microbiol 37 , 4167–4169 (1999).
Szentandrassy J. , 'Molecular epidemiology of a cluster of cases due to Klebsiella pneumoniae producing SHV-5 extended-spectrum B-lactamase in the premature intensive care unit of a Hungarian hospital ' (1999 ) 37 J Clin Microbiol : 4167 -4169.
-
Szabo, D., Silveira, F., Fujitani, S., Paterson, D. L.: Mechanisms of resistance of bacteria causing ventilator-associated pneumonia. Clin Chest Med 26 , 75–79 (2005).
Paterson D. L. , 'Mechanisms of resistance of bacteria causing ventilator-associated pneumonia ' (2005 ) 26 Clin Chest Med : 75 -79.
-
The International Neonatal Network: The CRIB (clinical risk index for babies) score: a tool for assessing initial neonatal risk and comparing performance of neonatal intensive care units. Lancet 342 , 193–198 (1993).
'The CRIB (clinical risk index for babies) score: a tool for assessing initial neonatal risk and comparing performance of neonatal intensive care units ' (1993 ) 342 Lancet : 193 -198.
-
Tseng, Y. C., Chiu, Y. C., Wang, J. H. et al.: Nosocomial bloodstream infection in a neonatal intensive care unit of a medical center: a three-year review. J Microbiol Immunol Infect 35 , 168–172 (2002).
Wang J. H. , 'Nosocomial bloodstream infection in a neonatal intensive care unit of a medical center: a three-year review ' (2002 ) 35 J Microbiol Immunol Infect : 168 -172.
-
Tullu, M. S., Deshmukh, C. T., Baveja, S. M.: Bacterial nosocomial pneumonia in paediatric intensive care unit. J Postgrad Med 46 , 18–22 (2000).
Baveja S. M. , 'Bacterial nosocomial pneumonia in paediatric intensive care unit ' (2000 ) 46 J Postgrad Med : 18 -22.
-
Usukara, Y., Igarashi, T.: Examination of severe, hospital acquired infcetions affecting extremely low birthweight (ELBW) infants. Pediatrics International 45 , 230–232 (2003).
Igarashi T. , 'Examination of severe, hospital acquired infcetions affecting extremely low birthweight (ELBW) infants ' (2003 ) 45 Pediatrics International : 230 -232.
-
van der Zwet, W. C., Kaiser, A. M., van Elburg, R. M. et al.: Nosocomial infections in a Dutch neonatal intensive care unit: surveillance study with definitions for infection specifically adapted for neonates. J Hosp Infect 61 , 300–311 (2005).
Elburg R. M. , 'Nosocomial infections in a Dutch neonatal intensive care unit: surveillance study with definitions for infection specifically adapted for neonates ' (2005 ) 61 J Hosp Infect : 300 -311.
-
Vesikari, T., Janas, M., Gröngroos, P. et al.: Neonatal septicemia. Arch Dis Child 60 , 542–546 (1985).
Gröngroos P. , 'Neonatal septicemia ' (1985 ) 60 Arch Dis Child : 542 -546.
-
Vidyasagar, D.: A new score to detect neonatal nosocomial infection: ‘a rule of 14’. Crit Care Med 28 , 2166–2167 (2000).
Vidyasagar D. , 'A new score to detect neonatal nosocomial infection: ‘a rule of 14’ ' (2000 ) 28 Crit Care Med : 2166 -2167.
-
Villari, P., Sarnatoro, C., Lacuzio, L.: Molecular epidemiology of a Staphylococcus epidermidis in a neonatal intensive care unit over a three year period. J Clin Microbiol 38 , 1740–1746 (2000).
Lacuzio L. , 'Molecular epidemiology of a Staphylococcus epidermidis in a neonatal intensive care unit over a three year period ' (2000 ) 38 J Clin Microbiol : 1740 -1746.
-
von Baum, H., Lin, D., Wendt, C.: Prevalence of colonisation with third-generation cephalosporin-resistant Enterobacteriacae in ICU patients of Heidelberg University Hospitals. Clin Microbiol Infect 10 , 436–440 (2004).
Wendt C. , 'Prevalence of colonisation with third-generation cephalosporin-resistant Enterobacteriacae in ICU patients of Heidelberg University Hospitals ' (2004 ) 10 Clin Microbiol Infect : 436 -440.
-
Von Dolinger de Brito, D., de Almeida Silva, H., Jose Oliveira, E. et al.: Effect of neonatal intensive care unit environment on the incidence of hospital-acquired infection in neonates. J Hosp Infect 65 , 314–318 (2007).
Jose Oliveira E. , 'Effect of neonatal intensive care unit environment on the incidence of hospital-acquired infection in neonates ' (2007 ) 65 J Hosp Infect : 314 -318.
-
Wei, S. H., Chiu, H. H., Hung, K. C. et al.: Epidemiologic trends in nosocomial bacteremia in a neonatal intensive care unit. J Microbiol Immunol Infect 38 , 283–288 (200).
-
Weinstein, R. A.: Laboratory role in the management of hospital acquired infections. Review Emerg Infect Dis 7 , 188–192 (2001).
Weinstein R. A. , 'Laboratory role in the management of hospital acquired infections ' (2001 ) 7 Review Emerg Infect Dis : 188 -192.
-
Wilson, M. P., Spencer, R. C.: Predominance of Gram-negative bacilli and increasing antimicrobial resistance in nosocomial bloodstream infections at a university hospital in southern Taiwan, 1996–2003. J Hosp Infect 42 , 1–6 (1999).
Spencer R. C. , 'Predominance of Gram-negative bacilli and increasing antimicrobial resistance in nosocomial bloodstream infections at a university hospital in southern Taiwan, 1996–2003 ' (1999 ) 42 J Hosp Infect : 1 -6.
-
Wu, C. J., Lee, H. C., Lee, N. Y. et al.: Controlling antimicrobial resistance in hospitals: infection control and use of antibiotics. J Microbiol Immunol Infect 39 , 135–143 (2006).
Lee N. Y. , 'Controlling antimicrobial resistance in hospitals: infection control and use of antibiotics ' (2006 ) 39 J Microbiol Immunol Infect : 135 -143.
-
Yu, W., Cheng, H., Lin, H. et al.: Outbreak investigation of nosocomial Enterobacter cloaceae bacteremia in a neonatal intensive care unit. Scand J Infect Dis 32 , 293–298 (2000).
Lin H. , 'Outbreak investigation of nosocomial Enterobacter cloaceae bacteremia in a neonatal intensive care unit ' (2000 ) 32 Scand J Infect Dis : 293 -298.
-
Zaidi, A. K., Huskins, W. C., Thaver, D. et al.: Hospital-aquired neonatal infections in developing countries. Lancet 365 , 1175–1188 (2005).
Thaver D. , 'Hospital-aquired neonatal infections in developing countries ' (2005 ) 365 Lancet : 1175 -1188.
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Editorial Office:
Akadémiai Kiadó Zrt.
Budafoki út 187-187, A/3, H-1117 Budapest, Hungary
Editorial Correspondence:
Acta Microbiologica et Immunologica Hungarica
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- Science Citation Index Expanded
| 2020 | |
| Total Cites | 662 |
| WoS | |
| Journal Impact Factor |
2,048 |
| Rank by | Immunology 145/162(Q4) |
| Impact Factor | Microbiology 118/137 (Q4) |
| Impact Factor | 1,904 |
| without | |
| Journal Self Cites | |
| 5 Year | 0,671 |
| Impact Factor | |
| Journal | 0,38 |
| Citation Indicator | |
| Rank by Journal | Immunology 146/174 (Q4) |
| Citation Indicator | Microbiology 120/142 (Q4) |
| Citable | 42 |
| Items | |
| Total | 40 |
| Articles | |
| Total | 2 |
| Reviews | |
| Scimago | 28 |
| H-index | |
| Scimago | 0,439 |
| Journal Rank | |
| Scimago | Immunology and Microbiology (miscellaneous) Q4 |
| Quartile Score | Medicine (miscellaneous) Q3 |
| Scopus | 438/167=2,6 |
| Scite Score | |
| Scopus | General Immunology and Microbiology 31/45 (Q3) |
| Scite Score Rank | |
| Scopus | 0,760 |
| SNIP | |
| Days from | 225 |
| submission | |
| to acceptance | |
| Days from | 118 |
| acceptance | |
| to publication | |
| Acceptance | 19% |
| Rate |
| 2019 | |
|---|---|
| Total Cites WoS |
485 |
| Impact Factor | 1,086 |
| Impact Factor without Journal Self Cites |
0,864 |
| 5 Year Impact Factor |
1,233 |
| Immediacy Index |
0,286 |
| Citable Items |
42 |
| Total Articles |
40 |
| Total Reviews |
2 |
| Cited Half-Life |
5,8 |
| Citing Half-Life |
7,7 |
| Eigenfactor Score |
0,00059 |
| Article Influence Score |
0,246 |
| % Articles in Citable Items |
95,24 |
| Normalized Eigenfactor |
0,07317 |
| Average IF Percentile |
7,690 |
| Scimago H-index |
27 |
| Scimago Journal Rank |
0,352 |
| Scopus Scite Score |
320/161=2 |
| Scopus Scite Score Rank |
General Immunology and Microbiology 35/45 (Q4) |
| Scopus SNIP |
0,492 |
| Acceptance Rate |
16% |
| Acta Microbiologica et Immunologica Hungarica | |
|---|---|
| Publication Model | Online only Hybrid |
| Submission Fee | none |
| Article Processing Charge | 1100 EUR/article |
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| Subscription fee 2022 | Online subsscription: 662 EUR / 832 USD Print + online subscription: 740 EUR / 930 USD |
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| Purchase per Title | Individual articles are sold on the displayed price. |
| Acta Microbiologica et Immunologica Hungarica | |
|---|---|
| Language | English |
| Size | A4 |
| Year of Foundation |
1954 |
| Volumes per Year |
1 |
| Issues per Year |
4 |
| Founder | Magyar Tudományos Akadémia |
| Founder's Address |
H-1051 Budapest, Hungary, Széchenyi István tér 9. |
| Publisher | Akadémiai Kiadó |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 1217-8950 (Print) |
| ISSN | 1588-2640 (Online) |
Monthly Content Usage
| Abstract Views | Full Text Views | PDF Downloads | |
|---|---|---|---|
| Sep 2021 | 29 | 0 | 0 |
| Oct 2021 | 26 | 0 | 0 |
| Nov 2021 | 53 | 0 | 0 |
| Dec 2021 | 37 | 2 | 0 |
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| Feb 2022 | 33 | 0 | 0 |
| Mar 2022 | 0 | 0 | 0 |
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