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  • 1 Semmelweis University Department of Genetics, Cell and Immunobiology Budapest Hungary
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The unicellular ciliate, Tetrahymena has receptors for hormones of the higher ranked animals, these hormones (e.g. insulin, triiodothyronine, ACTH, histamine, etc.) are also produced by it and it has signal pathways and second messengers for signal transmission. These components are chemically and functionally very similar to that of mammalian ones. The exogenously given hormones regulate different functions, as movement, phagocytosis, chemotaxis, cell growth, secretion, excretion and the cells’ own hormone production. The receptors are extremely sensitive, certain hormones are sensed (and response is provoked) at 10−21 M concentration, which makes likely that the function could work by the effect of hormones produced by the Tetrahymena itself. The signal reception is selective, it can differentiate between closely related hormones. The review is listing the hormones produced by the Tetrahymena, the receptors which can receive signals and the signal pathways and second messengers as well, as the known effects of mammalian hormones to the life functions of Tetrahymena. The possible and justified role of hormonal system in the Tetrahymena as a single cell and inside the Tetrahymena population, as a community is discussed. The unicellular hormonal system and mammalian endocrine system are compared and evolutionary conclusions are drawn.

  • Csaba, G.: Phylogeny and ontogeny of hormone receptors: the selection theory of receptor formation and hormonal imprinting. Biol. Rev. 55, 47–63 (1980).

    Csaba G. , 'Phylogeny and ontogeny of hormone receptors: the selection theory of receptor formation and hormonal imprinting ' (1980 ) 55 Biol. Rev. : 47 -63.

    • Search Google Scholar
  • Csaba, G.: Ontogeny and Phylogeny of Hormone Receptors. Karger, Basel, 1981.

    Csaba G. , '', in Ontogeny and Phylogeny of Hormone Receptors , (1981 ) -.

  • Csaba, G.: The unicellular Tetrahymena as a model cell for receptor research. Int. Rev. Cytol. 95, 327–377 (1985).

    Csaba G. , 'The unicellular Tetrahymena as a model cell for receptor research ' (1985 ) 95 Int. Rev. Cytol. : 327 -377.

    • Search Google Scholar
  • Csaba, G.: Phylogeny and ontogeny of hormone receptors: Origin and development of hormone receptors. Int. Rev. Cytol. 155, 1–48 (1994).

    Csaba G. , 'Phylogeny and ontogeny of hormone receptors: Origin and development of hormone receptors ' (1994 ) 155 Int. Rev. Cytol. : 1 -48.

    • Search Google Scholar
  • Csaba, G.: Hormonal imprinting: Phylogeny, ontogeny, diseases and possible role in present day human evolution. Cell Biochem. Funct. 26, 1–10 (2008).

    Csaba G. , 'Hormonal imprinting: Phylogeny, ontogeny, diseases and possible role in present day human evolution ' (2008 ) 26 Cell Biochem. Funct. : 1 -10.

    • Search Google Scholar
  • Janakidevi, K., Dewey, W. C., Kidder, G. W.: Serotonin in protozoa. Arch. Biochem. Biophys. 113, 758–759 (1966).

    Kidder G. W. , 'Serotonin in protozoa ' (1966 ) 113 Arch. Biochem. Biophys. : 758 -759.

  • Essman, E. J.: The serotonergic system in Tetrahymena pyriformis. Res. Clin. Lab. 17, 77–82 (1987).

    Essman E. J. , 'The serotonergic system in Tetrahymena pyriformis ' (1987 ) 17 Res. Clin. Lab. : 77 -82.

    • Search Google Scholar
  • Csaba, G., Kovács, P., Pállinger, É.: EDAC fixation increases the demonstrability of biogenic amines in the unicellular Tetrahymena: A flow cytometric and confocal microscopic comparative analysis. Cell Biol. Int. 30, 345–348 (2006).

    Pállinger , 'EDAC fixation increases the demonstrability of biogenic amines in the unicellular Tetrahymena: A flow cytometric and confocal microscopic comparative analysis ' (2006 ) 30 Cell Biol. Int. : 345 -348.

    • Search Google Scholar
  • Csaba, G.: Presence in and effects of pineal indoleamines at very low level of phylogeny. Experientia 49, 627–634 (1993).

    Csaba G. , 'Presence in and effects of pineal indoleamines at very low level of phylogeny ' (1993 ) 49 Experientia : 627 -634.

    • Search Google Scholar
  • Csaba, G., Kovács, P., Pállinger, É.: Increased hormone levels in Tetrahymena after long-lasting starvation. Cell Biol. Int. 31, 924–928 (2007).

    Pállinger , 'Increased hormone levels in Tetrahymena after long-lasting starvation ' (2007 ) 31 Cell Biol. Int. : 924 -928.

    • Search Google Scholar
  • Csaba, G., Lajkó, E., Pállinger, É.: Serotonin in Tetrahymena. How does it work? Acta Protozool. 49, 133–138 (2010).

    Pállinger , 'Serotonin in Tetrahymena. How does it work? ' (2010 ) 49 Acta Protozool. : 133 -138.

    • Search Google Scholar
  • Feldman, J. M., Roche, J. M., Blum, J. J.: Monoamine oxidase and catechol-O-methyl transferase activity in Tetrahymena. J. Protozool. 24, 459–462 (1977).

    Blum J. J. , 'Monoamine oxidase and catechol-O-methyl transferase activity in Tetrahymena ' (1977 ) 24 J. Protozool. : 459 -462.

    • Search Google Scholar
  • Kőhidai, L., Vakkuri, O., Keresztesi, M., Lappaluoto, J., Csaba, G.: Melatonin in the unicellular Tetrahymena pyriformis: Effects of different lighting conditions. Cell Biochem. Funct. 20, 269–272 (2002).

    Csaba G. , 'Melatonin in the unicellular Tetrahymena pyriformis: Effects of different lighting conditions ' (2002 ) 20 Cell Biochem. Funct. : 269 -272.

    • Search Google Scholar
  • Hardeland, R., Poeggeler, B.: Non-verebrate melatonin. J. Pineal Res. 34, 233–241 (2002).

    Poeggeler B. , 'Non-verebrate melatonin ' (2002 ) 34 J. Pineal Res. : 233 -241.

  • Kőhidai, L., Vakkuri, O., Keresztesi, M., Lappalauto, J., Csaba, G.: Induction of melatonin synthesis in Tetrahymena pyriformis by hormonal imprinting — a unicellular “factory” of the indoleamine. Cell. Mol. Biol. 49, 521–524 (2003).

    Csaba G. , 'Induction of melatonin synthesis in Tetrahymena pyriformis by hormonal imprinting — a unicellular “factory” of the indoleamine ' (2003 ) 49 Cell. Mol. Biol. : 521 -524.

    • Search Google Scholar
  • Hegyesi, H., Kovács, P., Falus, A., Csaba, G.: Presence and localization of histidine decarboxylase enzyme (HDC) and histamine in Tetrahymena pyriformis. Cell Biol. Int. 22, 493–497 (1998).

    Csaba G. , 'Presence and localization of histidine decarboxylase enzyme (HDC) and histamine in Tetrahymena pyriformis ' (1998 ) 22 Cell Biol. Int. : 493 -497.

    • Search Google Scholar
  • Hegyesi, H., Szalai, C., Falus, A., Csaba, G.: The histidine decarboxylase (HDC) gene of Tetrahymena pyriformis is similar to the mammalian one. A study of HDC expression. Biosci. Rep.19, 73–79 (1999

    Csaba G. , 'The histidine decarboxylase (HDC) gene of Tetrahymena pyriformis is similar to the mammalian one. A study of HDC expression ' (1999 ) 19 Biosci. Rep. : 73 -79.

    • Search Google Scholar
  • Csaba, G., Sudár, F.: Localization of 3H-histamine in the nucleus of Tetrahymena. Acta Morphol. Hung. 27, 89–94 (1979).

    Sudár F. , 'Localization of 3H-histamine in the nucleus of Tetrahymena ' (1979 ) 27 Acta Morphol. Hung. : 89 -94.

    • Search Google Scholar
  • Csaba, G., Sudár, F., Ubornyák, L.: Comparative study of the internalization and nuclear localization of amino acid type hormones in Tetrahymena and rat lymphocytes. Exp. Clin. Endocrinol. 82, 61–67 (1983).

    Ubornyák L. , 'Comparative study of the internalization and nuclear localization of amino acid type hormones in Tetrahymena and rat lymphocytes ' (1983 ) 82 Exp. Clin. Endocrinol. : 61 -67.

    • Search Google Scholar
  • Csaba, G., Nagy, S. U.: Presence (hPL, prostaglandin) and absence (triiodothyronine, thyroxine) of hormones in Tetrahymena: Experimental facts and open questions. Acta Physiol. Hung. 70, 105–110 (1987).

    Nagy S. U. , 'Presence (hPL, prostaglandin) and absence (triiodothyronine, thyroxine) of hormones in Tetrahymena: Experimental facts and open questions ' (1987 ) 70 Acta Physiol. Hung. : 105 -110.

    • Search Google Scholar
  • Csaba, G., Pállinger, É.: Thyrotropin (TSH) regulates triiodothyronine (T3) production in the unicellular Tetrahymena. Acta Biol. Hung. 62, 228–234 (2011).

    Pállinger , 'Thyrotropin (TSH) regulates triiodothyronine (T3) production in the unicellular Tetrahymena ' (2011 ) 62 Acta Biol. Hung. : 228 -234.

    • Search Google Scholar
  • Blum, J. J.: An adrenergic control system in Tetrahymena. Proc. Natl. Acad. Sci. U.S.A 58, 81–88 (1967).

    Blum J. J. , 'An adrenergic control system in Tetrahymena ' (1967 ) 58 Proc. Natl. Acad. Sci. U.S.A : 81 -88.

    • Search Google Scholar
  • Nomura, T., Tazawa, M., Ohtsuki, M., Sumi-Ichinose, C., Hagino, Y., Ota, A., Nakashima, A., Mori, K., Sugimoto, T., Ueno, M. O., Nozawa, Y., Ichinose, H., Nagatsu, T.: Enzymes related to catecholamine biosynthesis in Tetrahymena pyriformis. Presence of GTP cyclohydrolase I. Comp. Biochem. Physiol. B. 120, 753–760 (1998).

    Nagatsu T. , 'Enzymes related to catecholamine biosynthesis in Tetrahymena pyriformis ' (1998 ) 120 Presence of GTP cyclohydrolase I. Comp. Biochem. Physiol. B. : 753 -760.

    • Search Google Scholar
  • Gundersen, R. E., Thompson, G. A., Jr.: Further studies of dopamine metabolism and funtion in Tetrahymena. J. Protozool. 32, 25–31 (1985).

    Thompson G. A. , 'Further studies of dopamine metabolism and funtion in Tetrahymena ' (1985 ) 32 J. Protozool. : 25 -31.

    • Search Google Scholar
  • Takeda, N., Sugiyama, K.: Metabolism of biogenic monoamines in the ciliated protozoan, Tetrahymena pyriformis. Comp. Biochem. Physiol. C. 106, 63–70 (1993).

    Sugiyama K. , 'Metabolism of biogenic monoamines in the ciliated protozoan, Tetrahymena pyriformis ' (1993 ) 106 Comp. Biochem. Physiol. C. : 63 -70.

    • Search Google Scholar
  • Ud-Daula, A., Pfister, G., Schramm, K. W.: Growth inhibition and biodegradation of catecholamines in the ciliated protozoan Tetrahymena pyriformis. J. Environ. Sci. Health A. 4, 1610–1617 (2008).

    Schramm K. W. , 'Growth inhibition and biodegradation of catecholamines in the ciliated protozoan Tetrahymena pyriformis ' (2008 ) 4 J. Environ. Sci. Health A. : 1610 -1617.

    • Search Google Scholar
  • Ud-Daula, A., Pfister, G., Schramm, K. W.: ISTA 13-catecholamine toxicity and metabolism in the ciliated protozoan Tetrahymena pyriformis. Environ. Toxicol. 24, 549–554 (2009).

    Schramm K. W. , 'ISTA 13-catecholamine toxicity and metabolism in the ciliated protozoan Tetrahymena pyriformis ' (2009 ) 24 Environ. Toxicol. : 549 -554.

    • Search Google Scholar
  • LeRoith, D., Shiloach, J., Roth, J., Lesniak, M. A.: Evolutionary origins of vertebrate hormones: Substances similar to mammalian insulins are native to unicellular eukaryotes. Proc. Natl. Acad. Sci. U.S.A. 77, 184–188 (1980).

    Lesniak M. A. , 'Evolutionary origins of vertebrate hormones: Substances similar to mammalian insulins are native to unicellular eukaryotes ' (1980 ) 77 Proc. Natl. Acad. Sci. U.S.A. : 184 -188.

    • Search Google Scholar
  • Deftos, L. J., LeRoith, D., Shiloach, J., Roth, J.: Salmon calcitonin-like immunoactivity in extracts of Tetrahymena pyriformis. Horm. Metab. Res. 17, 82–85 (1985).

    Roth J. , 'Salmon calcitonin-like immunoactivity in extracts of Tetrahymena pyriformis ' (1985 ) 17 Horm. Metab. Res. : 82 -85.

    • Search Google Scholar
  • Souza, A. M. F. de., Lopez, J. A.: Insulin or insulin-like studies on unicellular organisms: A review. Brazil. Arch. Biol. Techn. 47, 973–981 (2004).

    Lopez J. A. , 'Insulin or insulin-like studies on unicellular organisms: A review ' (2004 ) 47 Brazil. Arch. Biol. Techn. : 973 -981.

    • Search Google Scholar
  • LeRoith, D., Shiloach, J., Heffron, R., Rubinovitz, C., Tanenbaum, R., Roth, J.: Insulin-related material in microbes: Similarities and differences from mammalian insulins. Can. J. Biochem. Cell Biol. 63, 839–849 (1985).

    Roth J. , 'Insulin-related material in microbes: Similarities and differences from mammalian insulins ' (1985 ) 63 Can. J. Biochem. Cell Biol. : 839 -849.

    • Search Google Scholar
  • Fülöp, A. K., Csaba, G.: Turnover and intranuclear localization of 125I-insulin in Tetrahymena. An autoradiographic study. Acta Morphol. Hung. 39, 71–77 (1991).

    Csaba G. , 'Turnover and intranuclear localization of 125I-insulin in Tetrahymena. An autoradiographic study ' (1991 ) 39 Acta Morphol. Hung. : 71 -77.

    • Search Google Scholar
  • LeRoith, D., Liotta, A. S., Roth, J., Shiloach, J., Lewis, M. E., Pert, C. B., Krieger, D. T.: Corticotropin and beta-endorphin-like materials are native to unicellular organisms. Proc. Natl. Acad. Sci. U.S.A. 79, 2088–2090 (1982).

    Krieger D. T. , 'Corticotropin and beta-endorphin-like materials are native to unicellular organisms ' (1982 ) 79 Proc. Natl. Acad. Sci. U.S.A. : 2088 -2090.

    • Search Google Scholar
  • Rodriguez, E., Lazaro, M. I., Renaud, F. L., Marino, M.: Opioid activity of beta-endorphin-like proteins from Tetrahymena. J. Eukaryot. Microbiol. 51, 60–65 (2004).

    Marino M. , 'Opioid activity of beta-endorphin-like proteins from Tetrahymena ' (2004 ) 51 J. Eukaryot. Microbiol. : 60 -65.

    • Search Google Scholar
  • Csaba, G., Kovács, P., Pállinger, É.: Comparison of the amount and demonstrability of endogeneous hormones and bound insulin after paraformaldehyde and EDAC fixation in Tetrahymena. Acta Protozool. 45, 455–459 (2006).

    Pállinger , 'Comparison of the amount and demonstrability of endogeneous hormones and bound insulin after paraformaldehyde and EDAC fixation in Tetrahymena ' (2006 ) 45 Acta Protozool. : 455 -459.

    • Search Google Scholar
  • Csaba, G., Pállinger, É.: Effect of stress and stress hormones on the hormone (insulin) binding of Tetrahymena. Cell Biochem. Funct. 27, 448–451 (2009).

    Pállinger , 'Effect of stress and stress hormones on the hormone (insulin) binding of Tetrahymena ' (2009 ) 27 Cell Biochem. Funct. : 448 -451.

    • Search Google Scholar
  • Csaba, G., Kovács, P.: Localization of beta-endorphin in Tetrahymena by confocal microscopy. Induction of the prolonged production of the hormone by hormonal imprinting. Cell Biol. Int. 23, 695–702 (1999).

    Kovács P. , 'Localization of beta-endorphin in Tetrahymena by confocal microscopy. Induction of the prolonged production of the hormone by hormonal imprinting ' (1999 ) 23 Cell Biol. Int. : 695 -702.

    • Search Google Scholar
  • Csaba, G., Kovács, P.: Human chorionic gonadotropin (HCG) like hormones (FSH, LH, TSH) in Tetrahymena. A confocal microscopic analysis. Acta Protozool. 39, 191–198 (2000).

    Kovács P. , 'Human chorionic gonadotropin (HCG) like hormones (FSH, LH, TSH) in Tetrahymena. A confocal microscopic analysis ' (2000 ) 39 Acta Protozool. : 191 -198.

    • Search Google Scholar
  • Schwabe, C., LeRoith, D., Thompson, R. P., Shiloach, J., Roth, J.: Relaxin extracted from protozoa (Tetrahymena pyriformis). Molecular and immunologic properties. J. Biol. Chem. 258, 2778–2781 (1983).

    Roth J. , 'Relaxin extracted from protozoa (Tetrahymena pyriformis). Molecular and immunologic properties ' (1983 ) 258 J. Biol. Chem. : 2778 -2781.

    • Search Google Scholar
  • Berelowitz, M., LeRoith, D., von Schenk, H., Newgard, C., Szabo, M., Frohman, L. A., Shiloach, J., Roth, J.: Somatostatin-like immunoactivity and biological activity is present in Tetrahymena pyriformis, a ciliated protozoan. Endocrinology 110, 1939–1944 (1982).

    Roth J. , 'Somatostatin-like immunoactivity and biological activity is present in Tetrahymena pyriformis, a ciliated protozoan ' (1982 ) 110 Endocrinology : 1939 -1944.

    • Search Google Scholar
  • Kőhidai, L., Csaba, G.: Effects of mammalian vasoconstrictor peptide, endothelin-1, on Tetrahymena pyriformis GL, and the immunocytological detection of endogeneous endothelin-like activity. Comp. Biochem. Physiol. C. 111, 311–316 (1995).

    Csaba G. , 'Effects of mammalian vasoconstrictor peptide, endothelin-1, on Tetrahymena pyriformis GL, and the immunocytological detection of endogeneous endothelin-like activity ' (1995 ) 111 Comp. Biochem. Physiol. C. : 311 -316.

    • Search Google Scholar
  • Csaba, G., Kovács, P., Pállinger, É.: Presence and localization of epidermal growth factor (EGF)- and EGF-receptor-like immunoreactivity in Tetrahymena. Cell Biol. Int. 28, 491–496 (2004).

    Pállinger , 'Presence and localization of epidermal growth factor (EGF)- and EGF-receptor-like immunoreactivity in Tetrahymena ' (2004 ) 28 Cell Biol. Int. : 491 -496.

    • Search Google Scholar
  • Kőhidai, L., Kovács, P., Lázár-Molnár, E., Csaba, G.: Presence, uptake and localization of an immunoreactively interleukin 6 (IL-6)-like molecule in Tetrahymena pyriformis. Cell Biol. Int. 24, 749–755 (2000).

    Csaba G. , 'Presence, uptake and localization of an immunoreactively interleukin 6 (IL-6)-like molecule in Tetrahymena pyriformis ' (2000 ) 24 Cell Biol. Int. : 749 -755.

    • Search Google Scholar
  • Csaba, G., Inczefi-Gonda, Á., Fehér, T.: Induction of steroid binding sites (receptors) and presence of steroid hormones in the unicellular Tetrahymena pyriformis. Comp. Biochem. Physiol. A. 82, 567–570 (1985).

    Fehér T. , 'Induction of steroid binding sites (receptors) and presence of steroid hormones in the unicellular Tetrahymena pyriformis ' (1985 ) 82 Comp. Biochem. Physiol. A. : 567 -570.

    • Search Google Scholar
  • Csaba, G., Poteczin, E., Fehér, T., Kovács, P.: Steroid hormones (hydrocortisone, oestradiol and testosterone) uptake, storage or induced synthesis in Tetrahymena. Cell Biol. Int. 22, 875–878 (1998).

    Kovács P. , 'Steroid hormones (hydrocortisone, oestradiol and testosterone) uptake, storage or induced synthesis in Tetrahymena ' (1998 ) 22 Cell Biol. Int. : 875 -878.

    • Search Google Scholar
  • Inazu, A., Sato, K., Nakayama, T., Deyashiki, Y., Hara, A., Nozawa, Y.: Purification and characterization of a novel dimeric 20-alpha-hydroxysteroid dehydrogenase from Tetrahymena pyriformis. Biochem. J. 297, 195–200 (1994).

    Nozawa Y. , 'Purification and characterization of a novel dimeric 20-alpha-hydroxysteroid dehydrogenase from Tetrahymena pyriformis ' (1994 ) 297 Biochem. J. : 195 -200.

    • Search Google Scholar
  • Lamontagne, N. S., Johnson, D. F., Homlund, C. E.: The transformation of testosterone by Tetrahymena pyriformis. J. Steroid Biochem. 7, 177–183 (1976).

    Homlund C. E. , 'The transformation of testosterone by Tetrahymena pyriformis ' (1976 ) 7 J. Steroid Biochem. : 177 -183.

    • Search Google Scholar
  • Lamontagne, N. S., Will, A. R., Johnson, D. F., Holmlund, C. E. The conversion of pregnenolone to progesterone in Tetrahymena pyriformis. J. Steroid Biochem. 8, 329–334 (1977).

    Holmlund C. E. , 'The conversion of pregnenolone to progesterone in Tetrahymena pyriformis ' (1977 ) 8 J. Steroid Biochem. : 329 -334.

    • Search Google Scholar
  • Hokama, Y., Yokochi, L., Abad, M. A., Shigemura, L., Kimura, L. H., Okamo, C., Chou, S. C.: Presence of prostaglandins (PGs) in Tetrahymena pyriformis, GL and the effect of aspirin. Res. Commun. Chem. Pathol. Pharmacol. 38, 169–172 (1982).

    Chou S. C. , 'Presence of prostaglandins (PGs) in Tetrahymena pyriformis, GL and the effect of aspirin ' (1982 ) 38 Res. Commun. Chem. Pathol. Pharmacol. : 169 -172.

    • Search Google Scholar
  • McPartland, J. M., Matias, I., DiMarzo, V., Glass, M.: Evolutionary origins of the endocannabinoid system. Gene 370, 64–67 (2006).

    Glass M. , 'Evolutionary origins of the endocannabinoid system ' (2006 ) 370 Gene : 64 -67.

  • Anagnostopoulos, D., Rakiec, C., Wood, J., Pandarinathan, L., Zvonok, N., Makríyannis, A., Siafaka-Kapadai, A.: Identification of endocannabinoid and related N-acylethanolamines in Tetrahymena. A new class of compounds for Tetrahymena. Protist 161, 452–465 (2010).

    Siafaka-Kapadai A. , 'Identification of endocannabinoid and related N-acylethanolamines in Tetrahymena. A new class of compounds for Tetrahymena ' (2010 ) 161 Protist : 452 -465.

    • Search Google Scholar
  • Csaba, G., Lantos, T.: Effect of insulin on glucose uptake of Protozoa. Experientia 31, 1097–1098 (1975).

    Lantos T. , 'Effect of insulin on glucose uptake of Protozoa ' (1975 ) 31 Experientia : 1097 -1098.

    • Search Google Scholar
  • Csaba, G., Sudár, F., Nagy, S. U., Dobozy, O.: Localization of hormone receptors in Tetrahymena. Protoplasma 91, 179–189 (1977).

    Dobozy O. , 'Localization of hormone receptors in Tetrahymena ' (1977 ) 91 Protoplasma : 179 -189.

    • Search Google Scholar
  • Christopher, G. K., Sundermann, C. A.: Conventional and confocal microscopic studies of insulin receptor induction in Tetrahymena pyriformis. Exp. Cell Res. 20, 477–484 (1992).

    Sundermann C. A. , 'Conventional and confocal microscopic studies of insulin receptor induction in Tetrahymena pyriformis ' (1992 ) 20 Exp. Cell Res. : 477 -484.

    • Search Google Scholar
  • Christopher, G. K., Sundermann, C. A.: Isolation and partial characterization of the insulin binding sites of Tetrahymena pyriformis. Biochem. Biophys. Res. Commun. 212, 515–523 (1995).

    Sundermann C. A. , 'Isolation and partial characterization of the insulin binding sites of Tetrahymena pyriformis ' (1995 ) 212 Biochem. Biophys. Res. Commun. : 515 -523.

    • Search Google Scholar
  • Christensen, S. T., Guerra, C. F., Awan, A., Wheatley, D. N., Satir, P.: Insulin-receptor-like proteins in Tetrahymena thermophila ciliary membranes. Curr. Biol. 13, R50–52 (2003).

    Satir P. , 'Insulin-receptor-like proteins in Tetrahymena thermophila ciliary membranes ' (2003 ) 13 Curr. Biol. : R50 -52.

    • Search Google Scholar
  • Leick, V., Bog-Hansen, T. C. Juhl, H. A.: Insulin-FGF-binding ciliary membrane glycoprotein from Tetrahymena. J. Membr. Biol. 181, 47–53 (2001)

    Juhl H. A. , 'Insulin-FGF-binding ciliary membrane glycoprotein from Tetrahymena ' (2001 ) 181 J. Membr. Biol. : 47 -53.

    • Search Google Scholar
  • Christopher, G. K., Sundermann, C. A.: Intracellular insulin binding in Tetrahymena pyriformis. Tissue Cell 28, 427–437 (1996).

    Sundermann C. A. , 'Intracellular insulin binding in Tetrahymena pyriformis ' (1996 ) 28 Tissue Cell : 427 -437.

    • Search Google Scholar
  • Hegyesi, H., Csaba, G.: Specific insulin binding by, and imprintability of, the nuclear membrane of Tetrahymena. Cytobios 72, 153–157 (1992).

    Csaba G. , 'Specific insulin binding by, and imprintability of, the nuclear membrane of Tetrahymena ' (1992 ) 72 Cytobios : 153 -157.

    • Search Google Scholar
  • Csaba, G., Hegyesi, H.: Specificity of insulin binding by plasma and nuclear membrane receptors in Tetrahymena: Similarities and dissimilitaries at the two levels. Cytobios 70, 153–158 (1992).

    Hegyesi H. , 'Specificity of insulin binding by plasma and nuclear membrane receptors in Tetrahymena: Similarities and dissimilitaries at the two levels ' (1992 ) 70 Cytobios : 153 -158.

    • Search Google Scholar
  • Hegyesi, H., Csaba, G.: Effect of permanent starvation on the insulin receptors of the nuclear envelope of Tetrahymena. Acta Microbiol. Immunol. Hung. 41, 241–245 (1994).

    Csaba G. , 'Effect of permanent starvation on the insulin receptors of the nuclear envelope of Tetrahymena ' (1994 ) 41 Acta Microbiol. Immunol. Hung. : 241 -245.

    • Search Google Scholar
  • Kovács, P., Csaba, G.: Evidence of the receptor nature of the binding sites induced in Tetrahymena by insulin treatment. A quantitative cytofluorimetric technique for the study of binding kinetics. Cell Biochem. Funct. 8, 49–56 (1990).

    Csaba G. , 'Evidence of the receptor nature of the binding sites induced in Tetrahymena by insulin treatment. A quantitative cytofluorimetric technique for the study of binding kinetics ' (1990 ) 8 Cell Biochem. Funct. : 49 -56.

    • Search Google Scholar
  • Csaba, G., Kovács, P., Inczefi-Gonda, Á.: Insulin binding sites induced in the Tetrahymena by rat liver receptor antibody. Z. Naturforsch. 39, 183–185 (1984).

    Inczefi-Gonda , 'Insulin binding sites induced in the Tetrahymena by rat liver receptor antibody ' (1984 ) 39 Z. Naturforsch. : 183 -185.

    • Search Google Scholar
  • Csaba, G., Hegyesi, H.: Immunocytochemical verification of the insulin receptor’s specificity in the nuclear envelope of Tetrahymena. Comparison with receptors of the plasma membrane. Biosci. Rep. 14, 25–31 (1994).

    Hegyesi H. , 'Immunocytochemical verification of the insulin receptor’s specificity in the nuclear envelope of Tetrahymena. Comparison with receptors of the plasma membrane ' (1994 ) 14 Biosci. Rep. : 25 -31.

    • Search Google Scholar
  • Csaba, G., Kovács, P., Kőhidai, L.: Tetrahymena cells distinguish insulin preparations according to either their amorphous and crystalline form or their bovine and porcine origin: Aspects of hormone binding and chemotaxis in relation to imprinting. Microbios 80, 215–221 (1994).

    Kőhidai L. , 'Tetrahymena cells distinguish insulin preparations according to either their amorphous and crystalline form or their bovine and porcine origin: Aspects of hormone binding and chemotaxis in relation to imprinting ' (1994 ) 80 Microbios : 215 -221.

    • Search Google Scholar
  • Csaba, G., Kovács, P., Tóthfalusi, L., Pállinger, É.: Effects of extremely low concentrations of hormones on the insulin binding of Tetrahymena. Cell Biol. Int. 30, 957–962 (2006).

    Pállinger , 'Effects of extremely low concentrations of hormones on the insulin binding of Tetrahymena ' (2006 ) 30 Cell Biol. Int. : 957 -962.

    • Search Google Scholar
  • Csaba, G., Kovács, P., Pállinger, É.: Effect of femtomolar concentrations of hormones on insulin binding by Tetrahymena, as a function of time. Cell Biochem. Funct. 28, 205–209 (2008).

    Pállinger , 'Effect of femtomolar concentrations of hormones on insulin binding by Tetrahymena, as a function of time ' (2008 ) 28 Cell Biochem. Funct. : 205 -209.

    • Search Google Scholar
  • Kovács, P., Csaba, G.: Effect of bacitracin on Tetrahymena. Acta Protozool. 31, 241–246 (1992).

    Csaba G. , 'Effect of bacitracin on Tetrahymena ' (1992 ) 31 Acta Protozool. : 241 -246.

  • Csaba, G., Kovács, P., Pállinger, É.: Comparison of the insulin binding, uptake and endogenous insulin content in long- and short-term starvation in Tetrahymena. Cell Biochem. Funct. 26, 64–69 (2008).

    Pállinger , 'Comparison of the insulin binding, uptake and endogenous insulin content in long- and short-term starvation in Tetrahymena ' (2008 ) 26 Cell Biochem. Funct. : 64 -69.

    • Search Google Scholar
  • Csaba, G., Kőhidai, L.: Interrelationship of hormone concentration, hormonal imprinting and receptor down-regulation in Tetrahymena. Acta Protozool. 28, 183–186 (1989).

    Kőhidai L. , 'Interrelationship of hormone concentration, hormonal imprinting and receptor down-regulation in Tetrahymena ' (1989 ) 28 Acta Protozool. : 183 -186.

    • Search Google Scholar
  • Csaba, G., Kovács, P., László, V.: Impact of simultaneous and successive imprinting of different peptide molecules on receptor “memory” in Tetrahymena. Acta Protozool. 28, 175–182 (1989).

    László V. , 'Impact of simultaneous and successive imprinting of different peptide molecules on receptor “memory” in Tetrahymena ' (1989 ) 28 Acta Protozool. : 175 -182.

    • Search Google Scholar
  • Csaba, G., Lantos, T.: Effect of hormones on protozoa. Studies on the phagocytotic effect of histamine, 5-hydroxytryptamine and indoleacetic acid in Tetrahymena pyriformis. Cytobiologie 7, 361–365 (1973).

    Lantos T. , 'Effect of hormones on protozoa. Studies on the phagocytotic effect of histamine, 5-hydroxytryptamine and indoleacetic acid in Tetrahymena pyriformis ' (1973 ) 7 Cytobiologie : 361 -365.

    • Search Google Scholar
  • Kovács, P., Csaba, G.: Detection of histamine binding sites (receptors) in Tetrahymena by fluorescence technique. Acta Biol. Med. Ger. 39, 237–241 (1980).

    Csaba G. , 'Detection of histamine binding sites (receptors) in Tetrahymena by fluorescence technique ' (1980 ) 39 Acta Biol. Med. Ger. : 237 -241.

    • Search Google Scholar
  • Csaba, G., Ubornyák, L.: Quantitative observations on triiodothyronine and histamine binding in Tetrahymena. Acta Protozool. 18, 491–496 (1979).

    Ubornyák L. , 'Quantitative observations on triiodothyronine and histamine binding in Tetrahymena ' (1979 ) 18 Acta Protozool. : 491 -496.

    • Search Google Scholar
  • Kovács, P., Darvas, Z., Csaba, G.: Investigation of histamine-antihistamine differentiation ability of Tetrahymena receptors, by means of lectins and antihistamine antibodies. Acta Biol. Hung. 32, 111–117 (1981).

    Csaba G. , 'Investigation of histamine-antihistamine differentiation ability of Tetrahymena receptors, by means of lectins and antihistamine antibodies ' (1981 ) 32 Acta Biol. Hung. : 111 -117.

    • Search Google Scholar
  • Csaba, G., Darvas, Z., László, V.: A functional study of concanavalin A-histamine binding site overlap in Tetrahymena phagocytosis test. Comp. Biochem. Physiol. A. 75, 457–460 (1983).

    László V. , 'A functional study of concanavalin A-histamine binding site overlap in Tetrahymena phagocytosis test ' (1983 ) 75 Comp. Biochem. Physiol. A. : 457 -460.

    • Search Google Scholar
  • Csaba, G., Sudár, F.: Demonstration of triiodothyronine binding sites of Tetrahymena by a new scanning autoradiography method. Acta Biol. Med. Ger. 37, 1381–1386 (1978).

    Sudár F. , 'Demonstration of triiodothyronine binding sites of Tetrahymena by a new scanning autoradiography method ' (1978 ) 37 Acta Biol. Med. Ger. : 1381 -1386.

    • Search Google Scholar
  • Csaba, G., Inczefi-Gonda, Á.: Specificity of the dexamethasone-induced steroid receptor in Tetrahymena. Experientia 45, 174–175 (1989).

    Inczefi-Gonda , 'Specificity of the dexamethasone-induced steroid receptor in Tetrahymena ' (1989 ) 45 Experientia : 174 -175.

    • Search Google Scholar
  • Chiesa, R., Silva, W. I., Renaud, F. L.: Pharmacological characterization of an opioid receptor in the ciliate Tetrahymena. J. Eukaryot. Microbiol. 40, 800–804 (1993).

    Renaud F. L. , 'Pharmacological characterization of an opioid receptor in the ciliate Tetrahymena ' (1993 ) 40 J. Eukaryot. Microbiol. : 800 -804.

    • Search Google Scholar
  • O’Neill, J. B., Pert, C. B., Ruff, M. R., Smith, C. C., Higgins, W. J., Zipser, B.: Identification and characterization of the opiate receptor in the ciliated protozoan, Tetrahymena. Brain Res. 450, 303–315 (1988).

    Zipser B. , 'Identification and characterization of the opiate receptor in the ciliated protozoan, Tetrahymena ' (1988 ) 450 Brain Res. : 303 -315.

    • Search Google Scholar
  • Zipser, B., Ruff, M. R., O’Neill, J. B., Smith, C. C., Higgins, W. J., Pert, C. B.: The opiate receptor: A single 110 kDa recognition molecule appears to be conserved in Tetrahymena, leech and rat. Brain Res. 463, 296–304 (1988).

    Pert C. B. , 'The opiate receptor: A single 110 kDa recognition molecule appears to be conserved in Tetrahymena, leech and rat ' (1988 ) 463 Brain Res. : 296 -304.

    • Search Google Scholar
  • Csaba, G., Fülöp, A. K., Inczefi-Gonda, Á.: Presence of benzodiazepine binding sites (receptors) and amplification thereof by imprinting in Tetrahymena. Experientia 45, 96–98 (1989).

    Inczefi-Gonda , 'Presence of benzodiazepine binding sites (receptors) and amplification thereof by imprinting in Tetrahymena ' (1989 ) 45 Experientia : 96 -98.

    • Search Google Scholar
  • Kovács, P., Csaba, G.: Studies on the lectin binding capacity of the Tetrahymena. Acta Protozool. 21, 69–75 (1982).

    Csaba G. , 'Studies on the lectin binding capacity of the Tetrahymena ' (1982 ) 21 Acta Protozool. : 69 -75.

    • Search Google Scholar
  • Kudo, S., Muto, Y., Nozawa, Y.: Regulation by calcium of hormone-insensitive adenylate cyclase and calmodulin-dependent guanylate cyclase in Tetrahymena plasma membrane. Comp. Biochem. Physiol. B. 80, 813–816 (1985).

    Nozawa Y. , 'Regulation by calcium of hormone-insensitive adenylate cyclase and calmodulin-dependent guanylate cyclase in Tetrahymena plasma membrane ' (1985 ) 80 Comp. Biochem. Physiol. B. : 813 -816.

    • Search Google Scholar
  • Schultz, J. E., Klumpp, S.: Calcium-regulated guanylyl cyclases from Paramecium and Tetrahymena. Methods Enzymol. 195, 466–474 (1991).

    Klumpp S. , 'Calcium-regulated guanylyl cyclases from Paramecium and Tetrahymena ' (1991 ) 195 Methods Enzymol. : 466 -474.

    • Search Google Scholar
  • Kőhidai, L., Barsony, J., Roth, J., Marx, S. J.: Rapid effects of insulin on cyclic GMP location in an intact protozoan. Experientia 48, 478–481 (1992).

    Marx S. J. , 'Rapid effects of insulin on cyclic GMP location in an intact protozoan ' (1992 ) 48 Experientia : 478 -481.

    • Search Google Scholar
  • Umeki, S., Nozawa, Y.: Adenylate and guanylate cyclases in Tetrahymena. Proc. Mol. Subcell. Biol. 17, 40–60 (1996).

    Nozawa Y. , 'Adenylate and guanylate cyclases in Tetrahymena ' (1996 ) 17 Proc. Mol. Subcell. Biol. : 40 -60.

    • Search Google Scholar
  • Weber, J. H., Vishnyakov, A., Hambach, K., Schultz, A., Schultz, J. E., Linder, J. U.: Adenylyl cyclases from Plasmodium, Paramecium and Tetrahymena are novel ion channel/enzyme fusion proteins. Cell Signal. 16, 115–125 (2004).

    Linder J. U. , 'Adenylyl cyclases from Plasmodium, Paramecium and Tetrahymena are novel ion channel/enzyme fusion proteins ' (2004 ) 16 Cell Signal. : 115 -125.

    • Search Google Scholar
  • Schultz, J. E., Schönborn, C.: Cyclic AMP formation in Tetrahymena pyriformis is controlled by a K(+)-coductance. FEBS Lett. 356, 322–326 (1994).

    Schönborn C. , 'Cyclic AMP formation in Tetrahymena pyriformis is controlled by a K(+)-coductance ' (1994 ) 356 FEBS Lett. : 322 -326.

    • Search Google Scholar
  • Derkach, K. V., Shpakov, A. O., Uspenskaia, Z. I., Iudin, A. L.: Functional characteristics of calcium-sensitive adenylyl cyclase of ciliate Tetrahymena pyriformis. Tsitologia 52, 967–972 (2010).

    Iudin A. L. , 'Functional characteristics of calcium-sensitive adenylyl cyclase of ciliate Tetrahymena pyriformis ' (2010 ) 52 Tsitologia : 967 -972.

    • Search Google Scholar
  • Shpakov, A. O., Derkach, K. V., Uspenskaia, Z. I., Kuznetsova, L. A., Plesneva, S. A., Pertseva, M. N.: Regulation of activity of adenylate cyclase and protein kinase Aof the infusorians Dileptus anser and Tetrahymena pyriformis by biogenic amines and peptide hormones. Dokl. Biochem. Biophys. 388, 32–34 (2003).

    Pertseva M. N. , 'Regulation of activity of adenylate cyclase and protein kinase Aof the infusorians Dileptus anser and Tetrahymena pyriformis by biogenic amines and peptide hormones ' (2003 ) 388 Dokl. Biochem. Biophys. : 32 -34.

    • Search Google Scholar
  • Shpakov, A. O., Derkach, K. V., Uspenskaia, Z. T.: Effect of natural amino acids and sugars on cyclase activities in infusoria Tetrahymena pyriformis and Dileptus anser. Zh. Evol. Biokhim. Fiziol. 47, 128–135 (2011).

    Uspenskaia Z. T. , 'Effect of natural amino acids and sugars on cyclase activities in infusoria Tetrahymena pyriformis and Dileptus anser ' (2011 ) 47 Zh. Evol. Biokhim. Fiziol. : 128 -135.

    • Search Google Scholar
  • Shemarova, I. V., Selivanova, G. V., Vlasova, T. D.: The influence of the EGF on proliferative signal transduction in ciliate Tetrahymena pyriformis. Tsitologia 49, 156–160 (2007).

    Vlasova T. D. , 'The influence of the EGF on proliferative signal transduction in ciliate Tetrahymena pyriformis ' (2007 ) 49 Tsitologia : 156 -160.

    • Search Google Scholar
  • Csaba, G., Nagy, S. U.: Effect of vertebrate hormones on the cyclic AMP level in Tetrahymena. Acta Biol. Med. Ger. 35, 1399–1401 (1976).

    Nagy S. U. , 'Effect of vertebrate hormones on the cyclic AMP level in Tetrahymena ' (1976 ) 35 Acta Biol. Med. Ger. : 1399 -1401.

    • Search Google Scholar
  • Csaba, G., Lantos, T.: Effect of cyclic AMP and theophylline on phagocytotic activity of Tetrahymena pyriformis. Experientia 32, 321–322 (1976).

    Lantos T. , 'Effect of cyclic AMP and theophylline on phagocytotic activity of Tetrahymena pyriformis ' (1976 ) 32 Experientia : 321 -322.

    • Search Google Scholar
  • Derkach, K. V., Shpakov, A. O., Kuznetsova, L. A., Irlina, I. S., Plesneva, S. A., Pertseva, M. N.: Regulation of adenylate cyclase system of Tetrahymena pyriformis by hormone and non-hormone agents and its dependency on adenylate cyclase basal activity. Zh. Evol. Biochim. Fiziol. 39, 332–338 (2003).

    Pertseva M. N. , 'Regulation of adenylate cyclase system of Tetrahymena pyriformis by hormone and non-hormone agents and its dependency on adenylate cyclase basal activity ' (2003 ) 39 Zh. Evol. Biochim. Fiziol. : 332 -338.

    • Search Google Scholar
  • Csaba, G., Nagy, S. U., Lantos, T.: Cyclic AMP and its functional relationship in Tetrahymena: A comparison between phagocytosis and glucose uptake. Acta Biol. Med. Ger. 37, 505–507 (1978).

    Lantos T. , 'Cyclic AMP and its functional relationship in Tetrahymena: A comparison between phagocytosis and glucose uptake ' (1978 ) 37 Acta Biol. Med. Ger. : 505 -507.

    • Search Google Scholar
  • Csaba, G., Sudár, F.: Electron microscopic localization and hormonal (diiodotyrosine) induction of adenylate cyclase in the Tetrahymena. Acta Histochem. 77, 7–9 (1985).

    Sudár F. , 'Electron microscopic localization and hormonal (diiodotyrosine) induction of adenylate cyclase in the Tetrahymena ' (1985 ) 77 Acta Histochem. : 7 -9.

    • Search Google Scholar
  • Linder, J. U., Schultz, J. E.: Guanyl cyclases in unicellular organisms. Mol. Cell. Biochem. 230, 149–158 (2002).

    Schultz J. E. , 'Guanyl cyclases in unicellular organisms ' (2002 ) 230 Mol. Cell. Biochem. : 149 -158.

    • Search Google Scholar
  • Hegyesi, H., Csaba, G.: A calcium-dependent protein kinase is present in Tetrahymena. Cell Biochem. Funct. 12, 221–226 (1994).

    Csaba G. , 'A calcium-dependent protein kinase is present in Tetrahymena ' (1994 ) 12 Cell Biochem. Funct. : 221 -226.

    • Search Google Scholar
  • Staarup, E. M., Schousbue, P., Hansen, H. Q., Kristiansen, K., Hoffmann, E. K., Rasmussen, L., Christensen, S. T.: Effects of protein kinase C activators and staurosporine on protein kinase activity, cell survival and proliferation in Tetrahymena thermophila. Microbios 91, 368–369 (1997).

    Christensen S. T. , 'Effects of protein kinase C activators and staurosporine on protein kinase activity, cell survival and proliferation in Tetrahymena thermophila ' (1997 ) 91 Microbios : 368 -369.

    • Search Google Scholar
  • Nagao, S., Nozawa, Y.: Calmodulin-binding proteins of Tetrahymena microsomal membranes. Comp. Biochem. Physiol. B. 82, 689–693 (1985).

    Nozawa Y. , 'Calmodulin-binding proteins of Tetrahymena microsomal membranes ' (1985 ) 82 Comp. Biochem. Physiol. B. : 689 -693.

    • Search Google Scholar
  • Schultz, J. E., Klumpp, S.: Calcium/calmodulin-regulated guanylate cyclases in the ciliary membranes from Paramecium and Tetrahymena. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 17, 275–283 (1984).

    Klumpp S. , 'Calcium/calmodulin-regulated guanylate cyclases in the ciliary membranes from Paramecium and Tetrahymena ' (1984 ) 17 Adv. Cyclic Nucleotide Protein Phosphorylation Res. : 275 -283.

    • Search Google Scholar
  • Kovács, P., Csaba, G.: Effect of phorbol 12-myristate 13-acetate (PMA) on the phosphoinositol (PI) system in Tetrahymena. Study of the 32P incorporation and breakdown of phospholipids. Cell Biochem. Funct. 13, 85–89 (1995).

    Csaba G. , 'Effect of phorbol 12-myristate 13-acetate (PMA) on the phosphoinositol (PI) system in Tetrahymena. Study of the 32P incorporation and breakdown of phospholipids ' (1995 ) 13 Cell Biochem. Funct. : 85 -89.

    • Search Google Scholar
  • Kovács, P., Csaba, G.: PLA2 activity in Tetrahymena pyriformis. Effects of inhibitors and stimulators. J. Lipid Mediat. Cell Signal. 15, 233–247 (1997).

    Csaba G. , 'PLA2 activity in Tetrahymena pyriformis. Effects of inhibitors and stimulators ' (1997 ) 15 J. Lipid Mediat. Cell Signal. : 233 -247.

    • Search Google Scholar
  • Leondaritis, G., Galanopoulou, D.: Characterization of inositol phospholipids and identification of a mastoparan-induced polyphosphoinositide response in Tetrahymena pyriformis. Lipids 35, 525–532 (2000).

    Galanopoulou D. , 'Characterization of inositol phospholipids and identification of a mastoparan-induced polyphosphoinositide response in Tetrahymena pyriformis ' (2000 ) 35 Lipids : 525 -532.

    • Search Google Scholar
  • Ryals, P. I.: Inositols and phosphoinositides in Tetrahymena. Acta Protozool. 48, 191–202 (2009).

    Ryals P. I. , 'Inositols and phosphoinositides in Tetrahymena ' (2009 ) 48 Acta Protozool. : 191 -202.

    • Search Google Scholar
  • Leondaritis, G., Sarri, T., Dafnis, I., Efstathiou, A., Galanopoulou, D.: Biochemical and genetic evidence for the presence of multiple phosphatidylinositol- and phosphatidylinositol-4,5-bisphosphate-specific phospholipase C in Tetrahymena. Eukaryot. Cell 10, 412–422 (2011).

    Galanopoulou D. , 'Biochemical and genetic evidence for the presence of multiple phosphatidylinositol- and phosphatidylinositol-4,5-bisphosphate-specific phospholipase C in Tetrahymena ' (2011 ) 10 Eukaryot. Cell : 412 -422.

    • Search Google Scholar
  • Láng, J., Rákász, V., Magyar, A., Pállinger, É., Kőhidai, L.: Chemotactic effects of odorants and tastants on the ciliate Tetrahymena pyriformis. J. Rec. Sign. Transd. 31, 423–433 (2011).

    Kőhidai L. , 'Chemotactic effects of odorants and tastants on the ciliate Tetrahymena pyriformis ' (2011 ) 31 J. Rec. Sign. Transd. : 423 -433.

    • Search Google Scholar
  • Kovács, P., Csaba, G., Nakashima, S., Nozawa, Y.: Phospholipase D activity in the Tetrahymena pyriformis GL. Cell Biochem. Funct. 15, 53–60 (1997).

    Nozawa Y. , 'Phospholipase D activity in the Tetrahymena pyriformis GL ' (1997 ) 15 Cell Biochem. Funct. : 53 -60.

    • Search Google Scholar
  • Kovács, P., Kőhidai, L., Csaba, G.: Effect of 3-amino-1-propanol on the phosphatidylinositol (PI) and glycosyl phosphatidylinositol (GPI) systems of Tetrahymena. Comp. Biochem. Physiol. C. 118, 63–87 (1997).

    Csaba G. , 'Effect of 3-amino-1-propanol on the phosphatidylinositol (PI) and glycosyl phosphatidylinositol (GPI) systems of Tetrahymena ' (1997 ) 118 Comp. Biochem. Physiol. C. : 63 -87.

    • Search Google Scholar
  • Rasmussen, M., Rasmussen, L.: Are cells rescued from “low density death” by co-operation between phospholipases C and D? Cell Biol. Int. 24, 121–123 (2000).

    Rasmussen L. , 'Are cells rescued from “low density death” by co-operation between phospholipases C and D? ' (2000 ) 24 Cell Biol. Int. : 121 -123.

    • Search Google Scholar
  • Kovács, P., Csaba, G.: Effect of insulin on the incorporation of 3H-inositol phospholipids (PI, PIP, PIP2) and glycosyl-phosphatidylinositols (GPIs) of Tetrahymena pyriformis. Biosci. Rep. 14, 215–219 (1994).

    Csaba G. , 'Effect of insulin on the incorporation of 3H-inositol phospholipids (PI, PIP, PIP2) and glycosyl-phosphatidylinositols (GPIs) of Tetrahymena pyriformis ' (1994 ) 14 Biosci. Rep. : 215 -219.

    • Search Google Scholar
  • László, V., Csaba, G.: The effect of vasopressin on the phosphoinositides of Tetrahymena pyriformis. Relationship with glycogen content. Acta Microbiol. Immunol. Hung. 42, 209–213 (1995).

    Csaba G. , 'The effect of vasopressin on the phosphoinositides of Tetrahymena pyriformis ' (1995 ) 42 Relationship with glycogen content. Acta Microbiol. Immunol. Hung. : 209 -213.

    • Search Google Scholar
  • Kovács, P., Csaba, G., Ito, Y., Nozawa, Y.: Effect of insulin on the phospholipase-D activity of untreated and insulin-pretreated (hormonally imprinted) Tetrahymena. Biochem. Biophys. Res. Commun. 15, 359–361 (1996).

    Nozawa Y. , 'Effect of insulin on the phospholipase-D activity of untreated and insulin-pretreated (hormonally imprinted) Tetrahymena ' (1996 ) 15 Biochem. Biophys. Res. Commun. : 359 -361.

    • Search Google Scholar
  • Kovács, P., Hegyesi, H., Kőhidai, L., Nemes, P., Csaba, G.: Effect of C2 ceramide on the inositol phospholipid metabolism (uptake of 32P, 3H-serine and 3H-palmitic acid) and apoptosis-related morphological changes in Tetrahymena. Comp. Biochem. Physiol. C. 122, 215–224 (1999).

    Csaba G. , 'Effect of C2 ceramide on the inositol phospholipid metabolism (uptake of 32P, 3H-serine and 3H-palmitic acid) and apoptosis-related morphological changes in Tetrahymena ' (1999 ) 122 Comp. Biochem. Physiol. C. : 215 -224.

    • Search Google Scholar
  • Kovács, P., Csaba, G.: Involvement of the phosphoinositol (PI) system in the mechanism of hormonal imprinting. Biochem. Biophys. Res. Commun. 170, 119–126 (1990).

    Csaba G. , 'Involvement of the phosphoinositol (PI) system in the mechanism of hormonal imprinting ' (1990 ) 170 Biochem. Biophys. Res. Commun. : 119 -126.

    • Search Google Scholar
  • Christopher, G. K., Sundermann, C. A.: Effect of long-term insulin exposure on insulin binding in Tetrahymena pyriformis. Tissue Cell 27, 585–589 (1995).

    Sundermann C. A. , 'Effect of long-term insulin exposure on insulin binding in Tetrahymena pyriformis ' (1995 ) 27 Tissue Cell : 585 -589.

    • Search Google Scholar
  • Kőhidai, L., Csaba, G.: Effects of insulin and histamine in themselves and in combination on the glucose metabolism of Tetrahymena. Acta Biol. Hung. 36, 281–285 (1985).

    Csaba G. , 'Effects of insulin and histamine in themselves and in combination on the glucose metabolism of Tetrahymena ' (1985 ) 36 Acta Biol. Hung. : 281 -285.

    • Search Google Scholar
  • Hegyesi, H., Csaba, G.: Time and concentration dependence of growth-promoting activity of insulin and histamine in Tetrahymena. Application of the MTT-method for the determination of cell proliferation in Tetrahymena. Cell Biol. Int. 21, 289–293 (1997).

    Csaba G. , 'Time and concentration dependence of growth-promoting activity of insulin and histamine in Tetrahymena. Application of the MTT-method for the determination of cell proliferation in Tetrahymena ' (1997 ) 21 Cell Biol. Int. : 289 -293.

    • Search Google Scholar
  • Shemarova, I. V., Selivanova, G. V., Vlasova, T. D.: The influence of epidermal growth factor and insulin on proliferation and DNA synthesis in ciliates Tetrahymena pyriformis. Tsitologiia 44, 1097–1103 (2002).

    Vlasova T. D. , 'The influence of epidermal growth factor and insulin on proliferation and DNA synthesis in ciliates Tetrahymena pyriformis ' (2002 ) 44 Tsitologiia : 1097 -1103.

    • Search Google Scholar
  • Darvas, Z., Árva, G., Csaba, G., Vargha, P.: Enhancement of cilia regeneration by hormone treatment of Tetrahymena. Acta Microbiol. Hung. 35, 45–48 (1988).

    Vargha P. , 'Enhancement of cilia regeneration by hormone treatment of Tetrahymena ' (1988 ) 35 Acta Microbiol. Hung. : 45 -48.

    • Search Google Scholar
  • Kőhidai, L., Lovas, B., Csaba, G.: Effect of adrenocorticotrophic hormone (ACTH) and insulin on the phagocytic capacity of Tetrahymena. Zoolog. Sci. 12, 277–281 (1995).

    Csaba G. , 'Effect of adrenocorticotrophic hormone (ACTH) and insulin on the phagocytic capacity of Tetrahymena ' (1995 ) 12 Zoolog. Sci. : 277 -281.

    • Search Google Scholar
  • Mugnani, D., Ricci, N., Banchetti, R., Kovács, P.: Insulin treatment affects the behavior of Tetrahymena pyriformis and T. malaccensis. Cytobios 81, 87–95 (1995).

    Kovács P. , 'Insulin treatment affects the behavior of Tetrahymena pyriformis and T. malaccensis ' (1995 ) 81 Cytobios : 87 -95.

    • Search Google Scholar
  • Csaba, G., Kovács, P., Pállinger, É.: How does the unicellular Tetrahymena utilise the hormones that it produces? Paying a visit to the realm of atto- and zeptomolar concentrations. Cell Tissue Res. 327, 199–203 (2007).

    Pállinger , 'How does the unicellular Tetrahymena utilise the hormones that it produces? Paying a visit to the realm of atto- and zeptomolar concentrations ' (2007 ) 327 Cell Tissue Res. : 199 -203.

    • Search Google Scholar
  • Kőhidai, L., Csaba, G. Mitochondrial dehydrogenases in different taxa of Tetrahymena: Effect of insulin. Biosci. Rep. 17, 529–535 (1997).

    Csaba G. , 'Mitochondrial dehydrogenases in different taxa of Tetrahymena: Effect of insulin ' (1997 ) 17 Biosci. Rep. : 529 -535.

    • Search Google Scholar
  • Kovács, P., Müller, W. E., Csaba, G.: Alectin-like molecule is discharged from mucocysts of Tetrahymena pyriformis in the presence of insulin. J. Eukaryot. Microbiol. 44, 487–491 (1997).

    Csaba G. , 'Alectin-like molecule is discharged from mucocysts of Tetrahymena pyriformis in the presence of insulin ' (1997 ) 44 J. Eukaryot. Microbiol. : 487 -491.

    • Search Google Scholar
  • Kovács, P., Lovas, G., Csaba, G.: Influence of insulin on the movement of Tetrahymena pyriformis. Hormonal imprinting alters the velocity. Comp. Biochem. Physiol. 107, 375–379 (1994).

    Csaba G. , 'Influence of insulin on the movement of Tetrahymena pyriformis ' (1994 ) 107 Hormonal imprinting alters the velocity. Comp. Biochem. Physiol. : 375 -379.

    • Search Google Scholar
  • Kőhidai, L., Karsa, J., Csaba, G.: Effects of hormones on chemotaxis in Tetrahymena: Investigations on receptor memory. Microbios 77, 75–85 (1994).

    Csaba G. , 'Effects of hormones on chemotaxis in Tetrahymena: Investigations on receptor memory ' (1994 ) 77 Microbios : 75 -85.

    • Search Google Scholar
  • Kovács, P., Csaba, G.: Effect of insulin on Blepharisma undulans (Stein) at primary exposure and reexposure. Acta Protozool. 29, 131–139 (1990).

    Csaba G. , 'Effect of insulin on Blepharisma undulans (Stein) at primary exposure and reexposure ' (1990 ) 29 Acta Protozool. : 131 -139.

    • Search Google Scholar
  • Csaba, G., Lajkó, E., Pállinger, É.: Comparison of the effect of hormones on the hormone synthesis of Tetrahymena in medium and salt solution. Cell Biol. Int. 34, 1095–1098 (2010).

    Pállinger , 'Comparison of the effect of hormones on the hormone synthesis of Tetrahymena in medium and salt solution ' (2010 ) 34 Cell Biol. Int. : 1095 -1098.

    • Search Google Scholar
  • Csaba, G., Ubornyák, L.: Effect of polypeptide hormones (insulin, thyrotropin, gonadotropin, adrenocorticotropin) on RNA synthesis in Tetrahymena, as assessed from incorporation of 3H-uridine. Acta Biol. Hung. 33, 381–384 (1982).

    Ubornyák L. , 'Effect of polypeptide hormones (insulin, thyrotropin, gonadotropin, adrenocorticotropin) on RNA synthesis in Tetrahymena, as assessed from incorporation of 3H-uridine ' (1982 ) 33 Acta Biol. Hung. : 381 -384.

    • Search Google Scholar
  • Fülöp, A. K., Csaba, G.: Effect of insulin, prednisolone and diiodothyronine on 3H-uridine intake and localization in Tetrahymena. Acta Morphol. Hung. 38, 7–16 (1990).

    Csaba G. , 'Effect of insulin, prednisolone and diiodothyronine on 3H-uridine intake and localization in Tetrahymena ' (1990 ) 38 Acta Morphol. Hung. : 7 -16.

    • Search Google Scholar
  • Christensen, S. T.: Insulin rescues the unicellular eukaryote Tetrahymena from dying in a complete synthetic nutrient medium. Cell Biol. Int. 17, 833–837 (1993).

    Christensen S. T. , 'Insulin rescues the unicellular eukaryote Tetrahymena from dying in a complete synthetic nutrient medium ' (1993 ) 17 Cell Biol. Int. : 833 -837.

    • Search Google Scholar
  • Christensen, S. T.: Signaling in unicellular eukaryotes. Int. Rev. Cytol. 177, 181–253 (1998).

    Christensen S. T. , 'Signaling in unicellular eukaryotes ' (1998 ) 177 Int. Rev. Cytol. : 181 -253.

    • Search Google Scholar
  • Christensen, S. T., Sorensen, H., Beyer, N. H., Kristiansen, K., Rasmussen, L., Rasmussen, M. I.: Cell death in Tetrahymena thermophyla: New observations on culture conditions. Cell Biol. Int. 25, 509–519 (2001).

    Rasmussen M. I. , 'Cell death in Tetrahymena thermophyla: New observations on culture conditions ' (2001 ) 25 Cell Biol. Int. : 509 -519.

    • Search Google Scholar
  • Christensen, S. T., Wheatley, D. N., Rasmussen, M. I., Rasmussen, L.: Mechanism controlling death, survival and proliferation in a model unicellular eukaryote Tetrahymena thermophila. Cell Death Differ. 2, 301–308 (1995).

    Rasmussen L. , 'Mechanism controlling death, survival and proliferation in a model unicellular eukaryote Tetrahymena thermophila ' (1995 ) 2 Cell Death Differ. : 301 -308.

    • Search Google Scholar
  • Wheatley, D. N., Christensen, S. T.: Origins of signalling and memory: matters of life versus death. Acta Biol. Hung. 50, 441–461 (1999).

    Christensen S. T. , 'Origins of signalling and memory: matters of life versus death ' (1999 ) 50 Acta Biol. Hung. : 441 -461.

    • Search Google Scholar
  • Rasmussen, L., Christensen, S. T., Schousbue, P., Wheatley, D. N.: Cell survival and multiplication. FEMS Microbiol. Lett. 137, 123–128 (1996).

    Wheatley D. N. , 'Cell survival and multiplication ' (1996 ) 137 FEMS Microbiol. Lett. : 123 -128.

    • Search Google Scholar
  • Christensen, S. T., Kemp, K., Quie, H., Rasmussen, L.: Cell death, survival and proliferation in Tetrahymena thermophila. Effects of insulin, sodium nitroprusside, 8-Bromo cyclic GMP, NG-methyl-L-arginine and methylene blue. Cell Biol. Int. 20, 653–656 (1996).

    Rasmussen L. , 'Cell death, survival and proliferation in Tetrahymena thermophila. Effects of insulin, sodium nitroprusside, 8-Bromo cyclic GMP, NG-methyl-L-arginine and methylene blue ' (1996 ) 20 Cell Biol. Int. : 653 -656.

    • Search Google Scholar
  • Christensen, S. T.: Insulin produces a biphasic response in Tetrahymena thermophila by stimulating cell survival and activating proliferation in two separate concentration intervals. Cell Biol. Int. 20, 437–444 (1996).

    Christensen S. T. , 'Insulin produces a biphasic response in Tetrahymena thermophila by stimulating cell survival and activating proliferation in two separate concentration intervals ' (1996 ) 20 Cell Biol. Int. : 437 -444.

    • Search Google Scholar
  • Csaba, G., Németh, G., Kovács, P., Vargha, P., Vas, Á.: Chemical reception mechanism at a low level of phylogeny. Influence of polypeptide hormones and non-hormone polypeptides on the growth of Tetrahymena. Biosystems 17, 227–231 (1985).

    Vas , 'Chemical reception mechanism at a low level of phylogeny ' (1985 ) 17 Influence of polypeptide hormones and non-hormone polypeptides on the growth of Tetrahymena. Biosystems : 227 -231.

    • Search Google Scholar
  • Lajkó, E., Pállinger, É., Csaba, G.: Investigations on the triiodothyronine (T3)-specificity of thyrotropic (TSH) and gonadotropic (HCG) hormone in the unicellular Tetrahymena. Acta Microbiol. Immunol. Hung. 58, 85–91 (2011).

    Csaba G. , 'Investigations on the triiodothyronine (T3)-specificity of thyrotropic (TSH) and gonadotropic (HCG) hormone in the unicellular Tetrahymena ' (2011 ) 58 Acta Microbiol. Immunol. Hung. : 85 -91.

    • Search Google Scholar
  • Kőhidai, L., Keresztesi, M., Csaba, G.: Effect of epidermal growth factor (EGF) on Tetrahymena pyriformis. Acta Protozool. 40, 221–224 (2001.

    Csaba G. , 'Effect of epidermal growth factor (EGF) on Tetrahymena pyriformis ' (2001 ) 40 Acta Protozool. : 221 -224.

    • Search Google Scholar
  • Shemarova, I. V., Selivanova, G. V., Vlasova, T. D.: A cytophotometric study of the influence exerted by epidermal growth factor on RNA and protein synthesis in the ciliate Tetrahymena pyriformis. Tsitologia 46, 993–995 (2004).

    Vlasova T. D. , 'A cytophotometric study of the influence exerted by epidermal growth factor on RNA and protein synthesis in the ciliate Tetrahymena pyriformis ' (2004 ) 46 Tsitologia : 993 -995.

    • Search Google Scholar
  • Salaman, A., Roman, M., Renaud, F. L., Silva, W. I.: Effect of chronic opioid treatment on phagocytosis in Tetrahymena. Neuropeptides 16, 115–120 (1990).

    Silva W. I. , 'Effect of chronic opioid treatment on phagocytosis in Tetrahymena ' (1990 ) 16 Neuropeptides : 115 -120.

    • Search Google Scholar
  • De Jesus, S., Renaud, F. L.: Phagocytosis in Tetrahymena thermophila: Naloxone reversible inhibition by opiates. Comp. Biochem. Physiol. C. 92, 139–142 (1989).

    Renaud F. L. , 'Phagocytosis in Tetrahymena thermophila: Naloxone reversible inhibition by opiates ' (1989 ) 92 Comp. Biochem. Physiol. C. : 139 -142.

    • Search Google Scholar
  • Csaba, G., Kovács, P.: Oxytocin and vasopressin change the activity of the contractile vacuole in Tetrahymena: Newer contributions to the phylogeny of hormones and hormone receptors. Comp. Biochem. Physiol. 102, 353–355 (1992).

    Kovács P. , 'Oxytocin and vasopressin change the activity of the contractile vacuole in Tetrahymena: Newer contributions to the phylogeny of hormones and hormone receptors ' (1992 ) 102 Comp. Biochem. Physiol. : 353 -355.

    • Search Google Scholar
  • Jahn, I., Csaba, G.: The influence of arginine vasopressin (APV) on phagocytosis in the unicellular Tetrahymena. Acta Protozool. 26, 39–44 (1987).

    Csaba G. , 'The influence of arginine vasopressin (APV) on phagocytosis in the unicellular Tetrahymena ' (1987 ) 26 Acta Protozool. : 39 -44.

    • Search Google Scholar
  • Kovács, K., Kőhidai, L., Pállinger, É., Csaba, G.: Effect of oxytocin and its analogues on the phagocytosis of Tetrahymena: Outstanding impact of isotocin. Acta Protozool. 41, 191–197 (2002).

    Csaba G. , 'Effect of oxytocin and its analogues on the phagocytosis of Tetrahymena: Outstanding impact of isotocin ' (2002 ) 41 Acta Protozool. : 191 -197.

    • Search Google Scholar
  • Kőhidai, L., Csaba, G.: Different and selective chemotactic responses of Tetrahymena pyriformis to two families of signal molecules: Lectins and peptide hormones. Acta Microbiol. Immunol. Hung. 43, 83–91 (1996).

    Csaba G. , 'Different and selective chemotactic responses of Tetrahymena pyriformis to two families of signal molecules: Lectins and peptide hormones ' (1996 ) 43 Acta Microbiol. Immunol. Hung. : 83 -91.

    • Search Google Scholar
  • Hamana, K., Iwai, K.: Effects of steroid hormones on the growth of Tetrahymena. J. Biochem. 69, 463–469 (1971).

    Iwai K. , 'Effects of steroid hormones on the growth of Tetrahymena ' (1971 ) 69 J. Biochem. : 463 -469.

    • Search Google Scholar
  • Holmlund, C. E.: On the mechanism of growth inhibition of Tetrahymena pyriformis by steroids. Biochem. Biophys. Acta 248, 363–378 (1971).

    Holmlund C. E. , 'On the mechanism of growth inhibition of Tetrahymena pyriformis by steroids ' (1971 ) 248 Biochem. Biophys. Acta : 363 -378.

    • Search Google Scholar
  • Csaba, G., Lantos, T., Nagy, S. U., Arányi, P., Náray, A.: Effects of steroids on Tetrahymena. Acta Biol. Med. Ger. 37, 1377–1380 (1978).

    Náray A. , 'Effects of steroids on Tetrahymena ' (1978 ) 37 Acta Biol. Med. Ger. : 1377 -1380.

    • Search Google Scholar
  • Kőhidai, L., Katona, J., Csaba, G.: Effects of steroid hormones on five functional parameters of Tetrahymena: Evolutionary conclusions. Cell Biochem. Funct. 21, 19–26 (2003).

    Csaba G. , 'Effects of steroid hormones on five functional parameters of Tetrahymena: Evolutionary conclusions ' (2003 ) 21 Cell Biochem. Funct. : 19 -26.

    • Search Google Scholar
  • Umeki, S., Nozawa, Y.: Repression by dexamethasone of epinephrine induced modulation of the fatty-acyl-CoA desaturase system in Tetrahymena microsomes. Eur. J. Biochem. 142, 356–359 (1984).

    Nozawa Y. , 'Repression by dexamethasone of epinephrine induced modulation of the fatty-acyl-CoA desaturase system in Tetrahymena microsomes ' (1984 ) 142 Eur. J. Biochem. : 356 -359.

    • Search Google Scholar
  • Umeki, S., Nozawa, Y.: Suppression by dexamethasone of isoproterenol-mediated changes in fatty-acyl-CoA desaturase activity of Tetrahymena microsomes. Lipids 20, 850–853 (1985).

    Nozawa Y. , 'Suppression by dexamethasone of isoproterenol-mediated changes in fatty-acyl-CoA desaturase activity of Tetrahymena microsomes ' (1985 ) 20 Lipids : 850 -853.

    • Search Google Scholar
  • Quinones-Maldonado, V., Renaud, F. L.: Effect of biogenic amines on phagocytosis in Tetrahymena thermophila. J. Protozool. 34, 435–438 (1987).

    Renaud F. L. , 'Effect of biogenic amines on phagocytosis in Tetrahymena thermophila ' (1987 ) 34 J. Protozool. : 435 -438.

    • Search Google Scholar
  • Csaba, G., Németh, G., Prohászka, J.: Effect of hormones and related compounds on the multiplication of Tetrahymena. Exp. Cell Biol. 47, 307–311 (1979).

    Prohászka J. , 'Effect of hormones and related compounds on the multiplication of Tetrahymena ' (1979 ) 47 Exp. Cell Biol. : 307 -311.

    • Search Google Scholar
  • Rodriguez, E., Renaud, F. L.: On the possible role of serotonin int he regulation of regeneration of cilia. J. Cell Biol. 85, 242–247 (1980).

    Renaud F. L. , 'On the possible role of serotonin int he regulation of regeneration of cilia ' (1980 ) 85 J. Cell Biol. : 242 -247.

    • Search Google Scholar
  • Castrodad, F. A., Renaud, F. L., Ortiz, J., Philips, D. M.: Biogenic amines stimulate regeneration of cilia in Tetrahymena thermophila. J. Protozool. 35, 260–264 (1988).

    Philips D. M. , 'Biogenic amines stimulate regeneration of cilia in Tetrahymena thermophila ' (1988 ) 35 J. Protozool. : 260 -264.

    • Search Google Scholar
  • Csaba, G., László, V., Darvas, Z.: Effects of H1 and H2 receptor antagonists on Tetrahymena. Acta Biol. Med. Ger. 37, 161–163 (1978).

    Darvas Z. , 'Effects of H1 and H2 receptor antagonists on Tetrahymena ' (1978 ) 37 Acta Biol. Med. Ger. : 161 -163.

    • Search Google Scholar
  • Csaba, G., Darvas, Z.: Receptor-level interrelationships of amino acids and the adequate amino acid type hormones in Tetrahymena: A receptor evolution model. Biosystems 19, 55–59 (1986).

    Darvas Z. , 'Receptor-level interrelationships of amino acids and the adequate amino acid type hormones in Tetrahymena: A receptor evolution model ' (1986 ) 19 Biosystems : 55 -59.

    • Search Google Scholar
  • Csaba, G., Kovács, P., Pállinger, É.: Hormonal interactions in Tetrahymena: Effect of hormones on levels of epidermal growth factor (EGF). Cell Biol. Int. 29, 301–305 (2005).

    Pállinger , 'Hormonal interactions in Tetrahymena: Effect of hormones on levels of epidermal growth factor (EGF) ' (2005 ) 29 Cell Biol. Int. : 301 -305.

    • Search Google Scholar
  • Csaba, G., Kovács, P., Pállinger, É.: Effect of hormones on the concentration of a digoxin-like material in Tetrahymena. Acta Protozool. 44, 81–84 (2005).

    Pállinger , 'Effect of hormones on the concentration of a digoxin-like material in Tetrahymena ' (2005 ) 44 Acta Protozool. : 81 -84.

    • Search Google Scholar
  • Csaba, G., Lantos, T.: Effect of epinephrine on glucose metabolism in Tetrahymena. Endokrinologie 66, 239–240 (1976).

    Lantos T. , 'Effect of epinephrine on glucose metabolism in Tetrahymena ' (1976 ) 66 Endokrinologie : 239 -240.

    • Search Google Scholar
  • Csaba, G., Lantos, T.: Effect of amino acid and polypeptide hormones on the phagocytosis of Tetrahymena pyriformis. Acta Protozool. 13, 409–413 (1975).

    Lantos T. , 'Effect of amino acid and polypeptide hormones on the phagocytosis of Tetrahymena pyriformis ' (1975 ) 13 Acta Protozool. : 409 -413.

    • Search Google Scholar
  • Kőhidai, L., Csaba, G., Karsa, J.: Effects of atrial natriuretic peptide on the unicellular Tetrahymena pyriformis model. Microbios 82, 27–40 (1995).

    Karsa J. , 'Effects of atrial natriuretic peptide on the unicellular Tetrahymena pyriformis model ' (1995 ) 82 Microbios : 27 -40.

    • Search Google Scholar
  • Csaba, G., Kovács, P., Falus, A.: Human cytokines interleukin (IL)-3 and IL-6 affect the growth and insulin binding of the unicellular organism Tetrahymena. Cytokine 7, 771–774 (1995).

    Falus A. , 'Human cytokines interleukin (IL)-3 and IL-6 affect the growth and insulin binding of the unicellular organism Tetrahymena ' (1995 ) 7 Cytokine : 771 -774.

    • Search Google Scholar
  • Kőhidai, L., Kovács, K., Csaba, G.: Direct chemotactic effect of bradykinin and related peptides — significance of amino- and carboxyterminal character of oligopeptides in chemotaxis of Tetrahymena pyriformis. Cell Biol. Int. 26, 55–62 (2002).

    Csaba G. , 'Direct chemotactic effect of bradykinin and related peptides — significance of amino- and carboxyterminal character of oligopeptides in chemotaxis of Tetrahymena pyriformis ' (2002 ) 26 Cell Biol. Int. : 55 -62.

    • Search Google Scholar
  • Kőhidai, L., Csaba, G.: Chemotaxis and chemotactic selection induced with cytokines (IL-8, RANTES and TNF-alpha) in the unicellular Tetrahymena pyriformis. Cytokine 10, 481–486 (1998).

    Csaba G. , 'Chemotaxis and chemotactic selection induced with cytokines (IL-8, RANTES and TNF-alpha) in the unicellular Tetrahymena pyriformis ' (1998 ) 10 Cytokine : 481 -486.

    • Search Google Scholar
  • Kovács, P., Kőhidai, L., Csaba, G.: Effects of tumor necrosis factor alpha (TNF alpha) on the phospholipid metabolism of Tetrahymena pyriformis. Cell Biochem. Funct. 16, 87–97 (1998).

    Csaba G. , 'Effects of tumor necrosis factor alpha (TNF alpha) on the phospholipid metabolism of Tetrahymena pyriformis ' (1998 ) 16 Cell Biochem. Funct. : 87 -97.

    • Search Google Scholar
  • Kőhidai, L., Vakkuri, O., Keresztesi, M., Pállinger, É., Leppaluoto, J., Csaba, G.: Impact of melatonin on cell division, phagocytosis and chemotaxis of Tetrahymena pyriformis. Acta Protozool. 41, 85–89 (2002).

    Csaba G. , 'Impact of melatonin on cell division, phagocytosis and chemotaxis of Tetrahymena pyriformis ' (2002 ) 41 Acta Protozool. : 85 -89.

    • Search Google Scholar
  • Csaba, G., Németh, G.: Effect of hormones and their precursors on Protozoa — the selective responsiveness of Tetrahymena. Comp. Biochem. Physiol. B. 65, 387–390 (1980).

    Németh G. , 'Effect of hormones and their precursors on Protozoa — the selective responsiveness of Tetrahymena ' (1980 ) 65 Comp. Biochem. Physiol. B. : 387 -390.

    • Search Google Scholar
  • Csaba, G., Madarász, B.: Localization of concanavalin-A binding sites in Tetrahymena by scanning electron microscopy. Experientia 35, 1161–1162 (1979).

    Madarász B. , 'Localization of concanavalin-A binding sites in Tetrahymena by scanning electron microscopy ' (1979 ) 35 Experientia : 1161 -1162.

    • Search Google Scholar
  • Kőhidai, L., Bánky, C., Csaba, G.: Comparison of the lectin-induced chemotaxtic selection and chemical imprinting on Tetrahymena pyriformis. Acta Protozool. 42, 91–97 (2003).

    Csaba G. , 'Comparison of the lectin-induced chemotaxtic selection and chemical imprinting on Tetrahymena pyriformis ' (2003 ) 42 Acta Protozool. : 91 -97.

    • Search Google Scholar
  • Mitsuma, T., Nogimori, T., Chaya, M.: Tuftsin stimulates thyrotropin secretion in rats. Experientia 41, 113–114 (1985).

    Chaya M. , 'Tuftsin stimulates thyrotropin secretion in rats ' (1985 ) 41 Experientia : 113 -114.

    • Search Google Scholar
  • Najjar, V. A.: Tufstin a natural activator of phagocyte cells: An overview. Ann. N.Y. Acad. Sci. 419, 1–11 (1983).

    Najjar V. A. , 'Tufstin a natural activator of phagocyte cells: An overview ' (1983 ) 419 Ann. N.Y. Acad. Sci. : 1 -11.

    • Search Google Scholar
  • Csaba, G., László, V., Kovács, P.: Effect of tuftsin on the phagocytotic activity of the unicellular Tetrahymena. Does primary interaction develop imprinting? Z. Naturforsch. 41, 805–806 (1986).

    Kovács P. , 'Effect of tuftsin on the phagocytotic activity of the unicellular Tetrahymena. Does primary interaction develop imprinting? ' (1986 ) 41 Z. Naturforsch. : 805 -806.

    • Search Google Scholar
  • Láng, O., Mezõ, G., Hudecz, F., Kőhidai, L.: Effect of tuftsin and oligotuftsuns on the chemotaxis and chemotactic selection of Tetrahymena pyriformis. Cell Biol. Int. 30, 603–609 (2006).

    Kőhidai L. , 'Effect of tuftsin and oligotuftsuns on the chemotaxis and chemotactic selection of Tetrahymena pyriformis ' (2006 ) 30 Cell Biol. Int. : 603 -609.

    • Search Google Scholar
  • Mezõ, G., Láng, O., Jakab, A., Bai, K. B., Szabo, I., Schlossr, G., Láng, J., Kőhidai, L.: Synthesis of oligotuftsin-based branched oligopeptide conjugates for chemotactic drug targeting. J. Pept. Sci. 12, 328–336 (2006).

    Kőhidai L. , 'Synthesis of oligotuftsin-based branched oligopeptide conjugates for chemotactic drug targeting ' (2006 ) 12 J. Pept. Sci. : 328 -336.

    • Search Google Scholar
  • Selye, H.: A syndrome produced by diverse nocuous agents. Nature 138, 32 (1936).

    Selye H. , 'A syndrome produced by diverse nocuous agents ' (1936 ) 138 Nature : 32 -.

  • Nozawa, Y.: Adaptive regulation of membrane lipids and fluidity during thermal acclimation in Tetrahymena. Proc. Jpn. Acad. B. 87, 450–462 (2011).

    Nozawa Y. , 'Adaptive regulation of membrane lipids and fluidity during thermal acclimation in Tetrahymena ' (2011 ) 87 Proc. Jpn. Acad. B. : 450 -462.

    • Search Google Scholar
  • Glover, C. V., Vavra, K. J., Guttman, S. D., Gorovsky, M. A.: Heat shock and deciliation induce phosphorylation of histone H1 in T. pyriformis. Cell 23, 73–77 (1981).

    Gorovsky M. A. , 'Heat shock and deciliation induce phosphorylation of histone H1 in T. pyriformis ' (1981 ) 23 Cell : 73 -77.

    • Search Google Scholar
  • Galego, L., Barahona, I., Rodrigues-Posuada, C.: Response of Tetrahymena pyriformis to stress induced by starvation. Eur. J. Biochem. 139, 163–171 (1984).

    Rodrigues-Posuada C. , 'Response of Tetrahymena pyriformis to stress induced by starvation ' (1984 ) 139 Eur. J. Biochem. : 163 -171.

    • Search Google Scholar
  • Galego, L., Rodrigues-Pousada, C.: Regulation of gene expression in Tetrahymena pyriformis under heat-shock and during recovery. Eur. J. Biochem. 149, 571–578 (1985).

    Rodrigues-Pousada C. , 'Regulation of gene expression in Tetrahymena pyriformis under heat-shock and during recovery ' (1985 ) 149 Eur. J. Biochem. : 571 -578.

    • Search Google Scholar
  • Csaba, G., Pállinger, É.: A general response to stressors by the unicellular Tetrahymena: Effect of stress on the hormone levels. Cell Biochem. Funct. 26, 797–800 (2008).

    Pállinger , 'A general response to stressors by the unicellular Tetrahymena: Effect of stress on the hormone levels ' (2008 ) 26 Cell Biochem. Funct. : 797 -800.

    • Search Google Scholar
  • Luporini, V., Vallesi, A., Miceli, C., Bradshaw, R. A.: Chemical signaling in ciliates. J. Eukaryot. Microbiol. 42, 208–212 (1995).

    Bradshaw R. A. , 'Chemical signaling in ciliates ' (1995 ) 42 J. Eukaryot. Microbiol. : 208 -212.

    • Search Google Scholar
  • Banchetti, R., Erra, F.: The behavior of the unicellular eukaryotes. Riv. Biol. 95, 473–489 (2002).

    Erra F. , 'The behavior of the unicellular eukaryotes ' (2002 ) 95 Riv. Biol. : 473 -489.

  • Banchetti, R., Erra, F.: The ethology of Protozoa and the “adaptive space” hypothesis: A heuristic approach to the biology of these eukaryotic unicellular organisms. Protistology 3, 58–68 (2003).

    Erra F. , 'The ethology of Protozoa and the “adaptive space” hypothesis: A heuristic approach to the biology of these eukaryotic unicellular organisms ' (2003 ) 3 Protistology : 58 -68.

    • Search Google Scholar
  • Kőhidai, L., Gál, G., Banchetti, R.: Interspecific effect of Er-1 and Er-2 Euplotes pheromones in Tetrahymena. Curr. Zool. 52, 1125–1132 (2006).

    Banchetti R. , 'Interspecific effect of Er-1 and Er-2 Euplotes pheromones in Tetrahymena ' (2006 ) 52 Curr. Zool. : 1125 -1132.

    • Search Google Scholar
  • Csaba, G., Pállinger, É.: How applicable is the general adaptation syndrome to the unicellular Tetrahymena? Cell Biochem. Funct. 27, 12–15 (2009).

    Pállinger , 'How applicable is the general adaptation syndrome to the unicellular Tetrahymena? ' (2009 ) 27 Cell Biochem. Funct. : 12 -15.

    • Search Google Scholar
  • Stevenson, R. W.: Further evidence for non-pancreatic insulin immunoreactivity in guinea pig brain. Horm. Metab. Res. 15, 526–529 (1983).

    Stevenson R. W. , 'Further evidence for non-pancreatic insulin immunoreactivity in guinea pig brain ' (1983 ) 15 Horm. Metab. Res. : 526 -529.

    • Search Google Scholar
  • Csaba, G.: The immune-endocrine system: hormones, receptors and endocrine function of immune cells. The packed-transport theory. Adv. Neuroimm. Biol. 1, 71–85 (2011).

    Csaba G. , 'The immune-endocrine system: hormones, receptors and endocrine function of immune cells. The packed-transport theory ' (2011 ) 1 Adv. Neuroimm. Biol. : 71 -85.

    • Search Google Scholar
  • Roth, J., LeRoith, D., Collier, E. S., Weaver, N. R., Watkinson, A., Cleland, C. F., Glick, S. M.: Evolutionary origins of neuropeptides, hormones and receptors: Possible applications to immunology. J. Immunol. 155 (Suppl. 2) 816s-819s (1985).

  • Csaba, G.: The biological basis and clinical significance of hormonal imprinting, an epigenetic process. Clin. Epigenet. 2, 187–196 (2011).

    Csaba G. , 'The biological basis and clinical significance of hormonal imprinting, an epigenetic process ' (2011 ) 2 Clin. Epigenet. : 187 -196.

    • Search Google Scholar
  • Csaba, G., Pállinger, É.: Is there a hormonal network in Tetrahymena? A sytematic investigation of hormonal effects on the hormone content. Cell Biochem. Funct. 26, 303–308 (2008).

    Pállinger , 'Is there a hormonal network in Tetrahymena? A sytematic investigation of hormonal effects on the hormone content ' (2008 ) 26 Cell Biochem. Funct. : 303 -308.

    • Search Google Scholar
  • Csaba, G., Dobozy, O., Deák, B. M.: HCG-TSH overlap and induction of Galli-Mainini reaction with TSH in adult male frogs. Horm. Metab. Res. 14, 617–618 (1982).

    Deák B. M. , 'HCG-TSH overlap and induction of Galli-Mainini reaction with TSH in adult male frogs ' (1982 ) 14 Horm. Metab. Res. : 617 -618.

    • Search Google Scholar
  • Renaud, F. L., Colon, I., Lebron, J., Ortiz, N., Rodriguez, F., Cadilla, C.: A novel opioid mechanism seems to modulate phagocytosis in Tetrahymena. J. Eukaryot. Microbiol. 42, 205–207 (1995).

    Cadilla C. , 'A novel opioid mechanism seems to modulate phagocytosis in Tetrahymena ' (1995 ) 42 J. Eukaryot. Microbiol. : 205 -207.

    • Search Google Scholar
  • Koch, A. S., Fehér, J., Lukovits, I.: A simple model of dynamic receptor pattern generation. Biol. Cybernet. 32, 125–138 (1979).

    Lukovits I. , 'A simple model of dynamic receptor pattern generation ' (1979 ) 32 Biol. Cybernet. : 125 -138.

    • Search Google Scholar
  • Csaba, G., Kovács, P.: Impact of 5-azacytidine on insulin binding and insulin-induced receptor formation in Tetrahymena. Biochem. Biophys. Res. Commun. 168, 709–713 (1990).

    Kovács P. , 'Impact of 5-azacytidine on insulin binding and insulin-induced receptor formation in Tetrahymena ' (1990 ) 168 Biochem. Biophys. Res. Commun. : 709 -713.

    • Search Google Scholar
  • Gutierrez, J. C., Callejas, S., Bomiquel, S., Martin-Gonzalez, A.: DNAmethylation in ciliates: implications in differentiation processes. Int. Microbiol. 3, 130–146 (2000).

    Martin-Gonzalez A. , 'DNAmethylation in ciliates: implications in differentiation processes ' (2000 ) 3 Int. Microbiol. : 130 -146.

    • Search Google Scholar
  • Kőhidai, L., Bõsze, Sz., Soós, P., Illyés, E., Láng, O., Mák, M., Sebestyén, F., Hudecz, F.: Chemotactic activity of oligopeptides containing EWS motif on Tetrahymena pyriformis. The effect of amidation of the C-terminal residue. Cell Biochem. Funct. 21, 113–120 (2003).

    Hudecz F. , 'Chemotactic activity of oligopeptides containing EWS motif on Tetrahymena pyriformis. The effect of amidation of the C-terminal residue ' (2003 ) 21 Cell Biochem. Funct. : 113 -120.

    • Search Google Scholar
  • Kőhidai, L., Soós, P., Csaba, G.: Effects of dipeptides containing the amino acid, proline on the chemotaxis of Tetrahymena pyriformis. Evolutionary conclusions on the formation of hormone receptors and hormones. Cell Biol. Int. 21, 341–345 (1997).

    Csaba G. , 'Effects of dipeptides containing the amino acid, proline on the chemotaxis of Tetrahymena pyriformis ' (1997 ) 21 Evolutionary conclusions on the formation of hormone receptors and hormones. Cell Biol. Int. : 341 -345.

    • Search Google Scholar
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