View More View Less
  • 1 University of Debrecen Department of Medical Microbiology Debrecen Hungary
  • | 2 University of Debrecen Central Pharmacy, Faculty of Medicine Debrecen Hungary
Open access

Two Balb/C mouse models of Candida infection were used to detect serum interleukin-6 (IL-6) responses. The first model used systemic infection by Candida albicans ATCC 10231 strain infected through the lateral tail vein of mice without any specific pretreatment. The median Candida burdens of the kidneys were 1.5 × 106 CFU/ml 24 h postinoculation (p.i.) and 1.2 × 107 CFU/ml 72 h p.i., while median serum IL-6 levels were 479.3 pg/ml and 934.5 pg/ml, respectively. The Candida burden showed significant correlation with serum IL-6 24 h p.i. (R2 = 0.6358; P = 0.0082) but not 72 h p.i.The second model was a mouse vaginitis model applying intravaginal inoculation of mice pretreated with subcutaneous estradiol-valerate (10 mg/ml) 3 days before infection. Candida cell count in vaginal lavage fluid was 2.8 × 106 CFU/ml 24 h p.i. and 1.4 × 108 CFU/ml 72 h p.i. Serum IL-6 response was detected in 4 of 15 mice 24 h p.i. and 9 of 15 mice 72 h p.i. Even the responders had low IL-6 serum levels (mean values 29.9 pg/ml and 60.1 pg/ml, respectively) not correlating with Candida cell count in vaginal lavage fluid.In conclusion, serum IL-6 had strong relationship with systemic C. albicans infection while the local C. albicans infection of the vagina led to partial, prolonged and limited serum IL-6 response.

  • Mishra, N.N., Prasad, T., Sharma, N., Payasi, A., Prasad, R., Gupta, D.K., Singh, R.: Pathogenicity and drug resistance in Candida albicans and other yeast species. A review. Acta Microbiol Immunol Hung 54, 201–235 (2007).

    Singh R , 'Pathogenicity and drug resistance in Candida albicans and other yeast species. A review ' (2007 ) 54 Acta Microbiol Immunol Hung : 201 -235.

    • Search Google Scholar
  • Kim, J., Sudbery, P.: Candida albicans, a major human fungal pathogen. J Microbiol 49, 171–177 (2011).

    Sudbery P , 'Candida albicans, a major human fungal pathogen ' (2011 ) 49 J Microbiol : 171 -177.

    • Search Google Scholar
  • Pfaller, M.A., Diekema, D.J.: Epidemiology of invasive candidiasis: A persistent public health problem. Clin Microbiol Rev 20, 133–163 (2007).

    Diekema DJ , 'Epidemiology of invasive candidiasis: A persistent public health problem ' (2007 ) 20 Clin Microbiol Rev : 133 -163.

    • Search Google Scholar
  • Pfaller, M.A., Neofytos, D., Diekema, D., Azie, N., Meier-Kriesche, H.U., Quan, S.P., Horn, D.: Epidemiology and outcomes of candidemia in 3648 patients: Data from the Prospective Antifungal Therapy (PATH Alliance®) registry, 2002–2008. Diagn Microbiol Infect Dis 74, 323–331 (2012).

    Horn D , 'Epidemiology and outcomes of candidemia in 3648 patients: Data from the Prospective Antifungal Therapy (PATH Alliance®) registry, 2002–2008 ' (2012 ) 74 Diagn Microbiol Infect Dis : 323 -331.

    • Search Google Scholar
  • Majoros, L., Kardos, G., Pócsi, I., Szabó, B.: Distribution and susceptibility of Candida species isolated in the Medical University of Debrecen. Acta Microbiol Immunol Hung 49, 351–361 (2002).

    Szabó B , 'Distribution and susceptibility of Candida species isolated in the Medical University of Debrecen ' (2002 ) 49 Acta Microbiol Immunol Hung : 351 -361.

    • Search Google Scholar
  • Dóczi, I., Pető, Z., Fodor, E., Bereczki, L., Nagy, E., Hajdú, E.: Evaluation of fungaemia infections in a Hungarian university hospital between 1996 and 2009. Acta Microbiol Immunol Hung 59, 29–41 (2012).

    Hajdú E , 'Evaluation of fungaemia infections in a Hungarian university hospital between 1996 and 2009 ' (2012 ) 59 Acta Microbiol Immunol Hung : 29 -41.

    • Search Google Scholar
  • Yano, J., Noverr, M.C., Fidel, P.L., Jr.: Cytokines in the host response to Candida vaginitis: Identifying a role for non-classical immune mediators, S100 alarmins. Cytokine 58, 118–128 (2012).

    Fidel PL , 'Cytokines in the host response to Candida vaginitis: Identifying a role for non-classical immune mediators, S100 alarmins ' (2012 ) 58 Cytokine : 118 -128.

    • Search Google Scholar
  • Sobel, J.D.: Vulvovaginal candidosis. Lancet 369, 1961–1971 (2007).

    Sobel JD , 'Vulvovaginal candidosis ' (2007 ) 369 Lancet : 1961 -1971.

  • Fidel, P.L., Jr.: Immunity in vaginal candidiasis. Curr Opin Infect Dis 18, 107–111 (2005).

    Fidel PL , 'Immunity in vaginal candidiasis ' (2005 ) 18 Curr Opin Infect Dis : 107 -111.

  • Fidel, P.L., Jr., Lynch, M.E., Conaway, D.H., Tait, L., Sobel, J.D.: Mice immunized by primary vaginal Candida albicans infection develop acquired vaginal mucosal immunity. Infect Immun 63, 547–553 (1995).

    Sobel JD , 'Mice immunized by primary vaginal Candida albicans infection develop acquired vaginal mucosal immunity ' (1995 ) 63 Infect Immun : 547 -553.

    • Search Google Scholar
  • Fidel, P.L., Jr., Cutright, J., Steele, C.: Effects of reproductive hormones on experimental vaginal candidiasis. Infect Immun 68, 651–657 (2000).

    Steele C , 'Effects of reproductive hormones on experimental vaginal candidiasis ' (2000 ) 68 Infect Immun : 651 -657.

    • Search Google Scholar
  • Wozniak, K.L., Wormley, F.L., Fidel, P.L., Jr.: Candida-specific antibodies during experimental vaginal candidiasis in mice. Infect Immun 70, 5790–5799 (2002).

    Fidel PL , 'Candida-specific antibodies during experimental vaginal candidiasis in mice ' (2002 ) 70 Infect Immun : 5790 -5799.

    • Search Google Scholar
  • Fidel, P.L., Jr., Wolf, N.A., Kukuruga, M.A.: T lymphocytes in the murine vaginal mucosa are phenotypically distinct from those in the periphery. Infect Immun 64, 3793–3799 (1996).

    Kukuruga MA , 'T lymphocytes in the murine vaginal mucosa are phenotypically distinct from those in the periphery ' (1996 ) 64 Infect Immun : 3793 -3799.

    • Search Google Scholar
  • Földi, R., Kovács, R., Gesztelyi, R., Kardos, G., Berényi, R., Juhász, B., Szilágyi, J., Mózes, J., Majoros, L.: Comparison of in vitro and in vivo efficacy of caspofungin against Candida parapsilosis, C. orthopsilosis, C. metapsilosis and C. albicans. Mycopathologia 174, 311–318 (2012).

    Majoros L , 'Comparison of in vitro and in vivo efficacy of caspofungin against Candida parapsilosis, C. orthopsilosis, C. metapsilosis and C. albicans ' (2012 ) 174 Mycopathologia : 311 -318.

    • Search Google Scholar
  • Trethon, A., Prinz, G., Varga, A., Kocsis, I.: Characteristic of nosocomial bloodstream infections at a Hungarian cardiac surgery centre. Acta Microbiol Immunol Hung 59, 271–283 (2012).

    Kocsis I , 'Characteristic of nosocomial bloodstream infections at a Hungarian cardiac surgery centre ' (2012 ) 59 Acta Microbiol Immunol Hung : 271 -283.

    • Search Google Scholar
  • Romani, L., Mencacci, A., Cenci, E., Spaccapelo, R., Toniatti, C., Puccetti, P., Bistoni, F., Poli, V.: Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans. J Exp Med 183, 1345–1355 (1996).

    Poli V , 'Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans ' (1996 ) 183 J Exp Med : 1345 -1355.

    • Search Google Scholar
  • Van Enckevort, F.H.J., Netea, M.G., Hermus, A.R.M.M., Sweep, C.G.J., Meis, F.G.M., Van der Meer, J.W.M., Kullberg, B.J.: Increased susceptibility to systemic candidiasis in interleukin-6 deficient mice. Med Mycol 37, 419–426 (1999).

    Kullberg BJ , 'Increased susceptibility to systemic candidiasis in interleukin-6 deficient mice ' (1999 ) 37 Med Mycol : 419 -426.

    • Search Google Scholar
  • Steinshamn, S., Waage, A.: Tumor necrosis factor and interleukin-6 in Candida albicans infection in normal and granulocytopenic mice. Infect Immun 60, 4003–4008 (1992).

    Waage A , 'Tumor necrosis factor and interleukin-6 in Candida albicans infection in normal and granulocytopenic mice ' (1992 ) 60 Infect Immun : 4003 -4008.

    • Search Google Scholar

 

The author instruction is available in PDF.
Please, download the file from HERE

Senior editors

Editor-in-Chief: Prof. Dóra Szabó (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)

Managing Editor: Dr. Béla Kocsis (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)

Co-editor: Dr. Andrea Horváth (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)

Editorial Board

  • Prof. Éva ÁDÁM (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Sebastian AMYES (Department of Medical Microbiology, University of Edinburgh, Edinburgh, UK.)
  • Dr. Katalin BURIÁN (Institute of Clinical Microbiology University of Szeged, Szeged, Hungary; Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary.)
  • Dr. Orsolya DOBAY (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Ildikó Rita DUNAY (Institute of Inflammation and Neurodegeneration, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany; Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany)
  • Prof. Levente EMŐDY(Department of Medical Microbiology and Immunology, University of Pécs, Pécs, Hungary.)
  • Prof. Anna ERDEI (Department of Immunology, Eötvös Loránd University, Budapest, Hungary, MTA-ELTE Immunology Research Group, Eötvös Loránd University, Budapest, Hungary.)
  • Prof. Éva Mária FENYŐ (Division of Medical Microbiology, University of Lund, Lund, Sweden)
  • Prof. László FODOR (Department of Microbiology and Infectious Diseases, University of Veterinary Medicine, Budapest, Hungary)
  • Prof. József KÓNYA (Department of Medical Microbiology, University of Debrecen, Debrecen, Hungary)
  • Prof. Yvette MÁNDI (Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary)
  • Prof. Károly MÁRIALIGETI (Department of Microbiology, Eötvös Loránd University, Budapest, Hungary)
  • Prof. János MINÁROVITS (Department of Oral Biology and Experimental Dental Research, University of Szeged, Szeged, Hungary)
  • Prof. Béla NAGY (Centre for Agricultural Research, Institute for Veterinary Medical Research, Budapest, Hungary.)
  • Prof. István NÁSZ (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Kristóf NÉKÁM (Hospital of the Hospitaller Brothers in Buda, Budapest, Hungary.)
  • Dr. Eszter OSTORHÁZI (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Rozália PUSZTAI (Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary)
  • Prof. Peter L. RÁDY (Department of Dermatology, University of Texas, Houston, Texas, USA)
  • Prof. Éva RAJNAVÖLGYI (Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary)
  • Prof. Ferenc ROZGONYI (Institute of Laboratory Medicine, Semmelweis University, Budapest, Hungary)
  • Prof. Zsuzsanna SCHAFF (2nd Department of Pathology, Semmelweis University, Budapest, Hungary)
  • Prof. Joseph G. SINKOVICS (The Cancer Institute, St. Joseph’s Hospital, Tampa, Florida, USA)
  • Prof. Júlia SZEKERES (Department of Medical Biology, University of Pécs, Pécs, Hungary.)
  • Prof. Mária TAKÁCS (National Reference Laboratory for Viral Zoonoses, National Public Health Center, Budapest, Hungary.)
  • Prof. Edit URBÁN (Department of Medical Microbiology and Immunology University of Pécs, Pécs, Hungary; Institute of Translational Medicine, University of Pécs, Pécs, Hungary.)

 

Editorial Office:
Akadémiai Kiadó Zrt.
Budafoki út 187-187, A/3, H-1117 Budapest, Hungary

Editorial Correspondence:
Acta Microbiologica et Immunologica Hungarica
Institute of Medical Microbiology
Semmelweis University
P.O. Box 370
H-1445 Budapest, Hungary
Phone: + 36 1 459 1500 ext. 56101
Fax: (36 1) 210 2959
E-mail: amih@med.semmelweis-univ.hu

 Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • Global Health
  • Index Medicus
  • Index Veterinarius
  • Medline
  • Referativnyi Zhurnal
  • SCOPUS
  • Science Citation Index Expanded
2020  
Total Cites 662
WoS
Journal
Impact Factor
2,048
Rank by Immunology 145/162(Q4)
Impact Factor Microbiology 118/137 (Q4)
Impact Factor 1,904
without
Journal Self Cites
5 Year 0,671
Impact Factor
Journal  0,38
Citation Indicator  
Rank by Journal  Immunology 146/174 (Q4)
Citation Indicator  Microbiology 120/142 (Q4)
Citable 42
Items
Total 40
Articles
Total 2
Reviews
Scimago 28
H-index
Scimago 0,439
Journal Rank
Scimago Immunology and Microbiology (miscellaneous) Q4
Quartile Score Medicine (miscellaneous) Q3
Scopus 438/167=2,6
Scite Score  
Scopus General Immunology and Microbiology 31/45 (Q3)
Scite Score Rank  
Scopus 0,760
SNIP
Days from  225
sumbission
to acceptance
Days from  118
acceptance
to publication
Acceptance 19%
Rate

2019  
Total Cites
WoS
485
Impact Factor 1,086
Impact Factor
without
Journal Self Cites
0,864
5 Year
Impact Factor
1,233
Immediacy
Index
0,286
Citable
Items
42
Total
Articles
40
Total
Reviews
2
Cited
Half-Life
5,8
Citing
Half-Life
7,7
Eigenfactor
Score
0,00059
Article Influence
Score
0,246
% Articles
in
Citable Items
95,24
Normalized
Eigenfactor
0,07317
Average
IF
Percentile
7,690
Scimago
H-index
27
Scimago
Journal Rank
0,352
Scopus
Scite Score
320/161=2
Scopus
Scite Score Rank
General Immunology and Microbiology 35/45 (Q4)
Scopus
SNIP
0,492
Acceptance
Rate
16%

 

Acta Microbiologica et Immunologica Hungarica
Publication Model Online only Hybrid
Submission Fee none
Article Processing Charge 1100 EUR/article
Regional discounts on country of the funding agency World Bank Lower-middle-income economies: 50%
World Bank Low-income economies: 100%
Further Discounts Editorial Board / Advisory Board members: 50%
Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100%
Subscription fee 2021 Online subsscription: 652 EUR / 812 USD
Subscription fee 2022 Online subsscription: 662 EUR / 832 USD
Print + online subscription: 740 EUR / 930 USD
Subscription Information Online subscribers are entitled access to all back issues published by Akadémiai Kiadó for each title for the duration of the subscription, as well as Online First content for the subscribed content.
Purchase per Title Individual articles are sold on the displayed price.

Acta Microbiologica et Immunologica Hungarica
Language English
Size A4
Year of
Foundation
1954
Publication
Programme
2021 Volume 68
Volumes
per Year
1
Issues
per Year
4
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1217-8950 (Print)
ISSN 1588-2640 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Apr 2021 0 7 6
May 2021 0 21 16
Jun 2021 0 6 3
Jul 2021 0 10 9
Aug 2021 0 14 8
Sep 2021 0 6 2
Oct 2021 0 0 0