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  • 1 Sichuan University West China Fourth Hospital of West China Public Health Institute No. 18, Section 3, Renmin Nanlu Chengdu P. R. China
  • | 2 Fudan University School of Public Health Shanghai P. R. China
Open access

This study is to explore the effect of ALAD polymorphism on hematopoietic, hepatic and renal toxicity from lead in occupational exposure workers

  • Battistuzzi G, Petrucci R, Silvagni L, Urbani FR, Caiola S: δ-Aminolevulinate dehydrase: a new genetic polymorphism in man. Ann. Hum. Genet. 45, 223–229 (1981)

    Caiola S , 'δ-Aminolevulinate dehydrase: a new genetic polymorphism in man ' (1981 ) 45 Ann. Hum. Genet. : 223 -229.

    • Search Google Scholar
  • Benkmann HG, Bogdanski P, Goedde HW: Polymorphism of δ-aminolevulinic acid dehydratase in various populations. Hum. Hered. 33, 62–64 (1983)

    Goedde HW , 'Polymorphism of δ-aminolevulinic acid dehydratase in various populations ' (1983 ) 33 Hum. Hered. : 62 -64.

    • Search Google Scholar
  • Can S, Bagci C, Ozaslan M, Bozkurt A, Cengiz B, Cakmak EA: Occupational lead exposure effect on liver functions and biochemical parameters. Acta Physiol. Hung. 95, 395–403 (2008)

    Cakmak EA , 'Occupational lead exposure effect on liver functions and biochemical parameters ' (2008 ) 95 Acta Physiol. Hung. : 395 -403.

    • Search Google Scholar
  • Chia SE, Zhou HJ, Yap E, Tham MT, Dong NV, Hong Tu NT: Association of renal function and delta-aminolevulinic acid dehydratase polymorphism among Vietnamese and Singapore workers exposed to inorganic lead. Occup. Environ. Med. 63, 180–186 (2006)

    Hong T N , 'Association of renal function and delta-aminolevulinic acid dehydratase polymorphism among Vietnamese and Singapore workers exposed to inorganic lead ' (2006 ) 63 Occup. Environ. Med. : 180 -186.

    • Search Google Scholar
  • Hsieh LL, Liou SH, Chen YH, Tsai LC, Yang T, Wu TN: Association between aminolevulinate dehydrogenase genotype and blood lead levels in Taiwan. J. Occup. Environ. Med. 42, 151–155 (2000)

    Wu TN , 'Association between aminolevulinate dehydrogenase genotype and blood lead levels in Taiwan ' (2000 ) 42 J. Occup. Environ. Med. : 151 -155.

    • Search Google Scholar
  • Kelada SN, Shelton E, Kaufmann RB, Khoury MJ: Delta-aminolevulinic acid dehydratase genotype and lead toxicity: a HuGE review. Am. J. Epidemiol. 154, 1–13 (2001)

    Khoury MJ , 'Delta-aminolevulinic acid dehydratase genotype and lead toxicity: a HuGE review ' (2001 ) 154 Am. J. Epidemiol. : 1 -13.

    • Search Google Scholar
  • Kim HS, Lee SS, Lee GS, Hwangbo Y, Ahn KD, Lee BK: The protective effect of delta-aminolevulinic acid dehydratase 1-2 and 2-2 isozymes against blood lead with higher hematologic parameters. Environ. Health Perspect. 112, 538–541 (2004)

    Lee BK , 'The protective effect of delta-aminolevulinic acid dehydratase 1-2 and 2-2 isozymes against blood lead with higher hematologic parameters ' (2004 ) 112 Environ. Health Perspect. : 538 -541.

    • Search Google Scholar
  • Loghman-Adham M: Renal effects of environmental and occupational lead exposure. Environ. Health Perspect. 105, 928–938 (1997)

    Loghman-Adham M , 'Renal effects of environmental and occupational lead exposure ' (1997 ) 105 Environ. Health Perspect. : 928 -938.

    • Search Google Scholar
  • Makino S, Tsuruta H, Takata T: Relationship between blood lead level and urinary ALA level in workers exposed to very low levels of lead. Ind. Health 38, 95–98 (2000)

    Takata T , 'Relationship between blood lead level and urinary ALA level in workers exposed to very low levels of lead ' (2000 ) 38 Ind. Health : 95 -98.

    • Search Google Scholar
  • Oishi H, Nomiyama H, Nomiyama K, Tomokuni K: Fluorometric HPLC determination of delta-aminolevulinic acid (ALA) in the plasma and urine of lead workers: biological indicators of lead exposure. J. Anal. Toxicol. 20, 106–110 (1996)

    Tomokuni K , 'Fluorometric HPLC determination of delta-aminolevulinic acid (ALA) in the plasma and urine of lead workers: biological indicators of lead exposure ' (1996 ) 20 J. Anal. Toxicol. : 106 -110.

    • Search Google Scholar
  • Onalaja AO, Claudio L: Genetic susceptibility to lead poisoning. Environ. Health Perspect. 108 (Suppl 1), 23–28 (2000)

    Claudio L , 'Genetic susceptibility to lead poisoning ' (2000 ) 108 Environ. Health Perspect. : 23 -28.

    • Search Google Scholar
  • Patil AJ, Bhagwat VR, Patil JA, Dongre NN, Ambekar JG, Das KK: Biochemical aspects of lead exposure in silver jewelry workers in western Maharashtra (India). J. Basic Clin. Physiol. Pharmacol. 17, 213–229 (2006)

    Das KK , 'Biochemical aspects of lead exposure in silver jewelry workers in western Maharashtra (India) ' (2006 ) 17 J. Basic Clin. Physiol. Pharmacol. : 213 -229.

    • Search Google Scholar
  • Pillai A, Gupta S: Effect of gestational and lactational exposure to lead and/or cadmium on reproductive performance and hepatic oestradiol metabolising enzymes. Toxicol. Lett. 155, 179–186 (2005)

    Gupta S , 'Effect of gestational and lactational exposure to lead and/or cadmium on reproductive performance and hepatic oestradiol metabolising enzymes ' (2005 ) 155 Toxicol. Lett. : 179 -186.

    • Search Google Scholar
  • Rabstein S, Unfried K, Ranft U, IIIig T, Kolz M, Mambetova C: Lack of association of delta-aminolevulinate dehydratase polymorphisms with blood lead levels and hemoglobin in Romanian women from a lead-contaminated region. J. Toxicol. Environ. Health 71, 716–724 (2008)

    Mambetova C , 'Lack of association of delta-aminolevulinate dehydratase polymorphisms with blood lead levels and hemoglobin in Romanian women from a lead-contaminated region ' (2008 ) 71 J. Toxicol. Environ. Health : 716 -724.

    • Search Google Scholar
  • Schwartz BS, Lee BK, Stewart W, Ahn KD, Springer K, Kelsey K: Associations of delta-aminolevulinic acid dehydratase genotype with plant, exposure duration, and blood lead and zinc protoporphyrin levels in Korean lead workers. Am. J. Epidemiol. 142, 738–745 (1995)

    Kelsey K , 'Associations of delta-aminolevulinic acid dehydratase genotype with plant, exposure duration, and blood lead and zinc protoporphyrin levels in Korean lead workers ' (1995 ) 142 Am. J. Epidemiol. : 738 -745.

    • Search Google Scholar
  • Schwartz BS, Lee BK, Lee GS, Stewart WF, Simon D, Kelsey K, Todd AC: Associations of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with polymorphisms in the vitamin D receptor and delta-aminolevulinic acid dehydratase genes. Environ. Health Perspect. 108, 949–954 (2000)

    Todd AC , 'Associations of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with polymorphisms in the vitamin D receptor and delta-aminolevulinic acid dehydratase genes ' (2000 ) 108 Environ. Health Perspect. : 949 -954.

    • Search Google Scholar
  • Shaik AP, Jamil K: A study on the ALAD gene polymorphisms associated with lead exposure. Toxicol. Ind. Health 24, 501–506 (2008)

    Jamil K , 'A study on the ALAD gene polymorphisms associated with lead exposure ' (2008 ) 24 Toxicol. Ind. Health : 501 -506.

    • Search Google Scholar
  • Smith CM, Wang X, Hu H, Kelsey KT: A polymorphism in the δ-aminolevulinic acid dehydratase gene may modify the pharmacokinetics and toxicity of lead. Environ. Health Perspect. 103, 248–253 (1995)

    Kelsey KT , 'A polymorphism in the δ-aminolevulinic acid dehydratase gene may modify the pharmacokinetics and toxicity of lead ' (1995 ) 103 Environ. Health Perspect. : 248 -253.

    • Search Google Scholar
  • Soldin OP, Pezzullo JC, Hanak B, Miller M, Soldin SJ: Changing trends in the epidemiology of pediatric lead exposure: interrelationship of blood lead and ZPP concentrations and a comparison to the US population. Ther. Drug Monit. 25, 415–420 (2003)

    Soldin SJ , 'Changing trends in the epidemiology of pediatric lead exposure: interrelationship of blood lead and ZPP concentrations and a comparison to the US population ' (2003 ) 25 Ther. Drug Monit. : 415 -420.

    • Search Google Scholar
  • Stacchiotti A, Morandini F, Bettoni F, Schena I, Lavazza A, Grigolato PG, Apostoli P, Rezzani R, Aleo MF: Stress proteins and oxidative damage in a renal derived cell line exposed to inorganic mercury and lead. Toxicology 264, 215–224 (2009)

    Aleo MF , 'Stress proteins and oxidative damage in a renal derived cell line exposed to inorganic mercury and lead ' (2009 ) 264 Toxicology : 215 -224.

    • Search Google Scholar
  • Wetmur JG, Kaya AH, Plewinska M, Desnick RJ: Molecular characterization of the human δ-aminolevulinate dehydratase 2 (ALAD2) allele: implications for molecular screening of individuals for genetic susceptibility to lead poisoning. Am. J. Hum. Genet. 49, 757–763 (1991)

    Desnick RJ , 'Molecular characterization of the human δ-aminolevulinate dehydratase 2 (ALAD2) allele: implications for molecular screening of individuals for genetic susceptibility to lead poisoning ' (1991 ) 49 Am. J. Hum. Genet. : 757 -763.

    • Search Google Scholar
  • Wetmur JG, Lehnert G, Desnick RJ: The δ-aminolevulinate dehydratase polymorphism: higher blood lead levels in lead workers and environmentally exposed children with the 1-2 and 2-2 isozymes. Environ. Res. 56, 109–119 (1991)

    Desnick RJ , 'The δ-aminolevulinate dehydratase polymorphism: higher blood lead levels in lead workers and environmentally exposed children with the 1-2 and 2-2 isozymes ' (1991 ) 56 Environ. Res. : 109 -119.

    • Search Google Scholar
  • Weaver VM, Schwartz BS, Ahn KD, Stewart WF, Kelsey KT, Todd AC: Associations of renal function with polymorphisms in the delta-aminolevulinic acid dehydratase, vitamin D receptor, and nitric oxide synthase genes in Korean lead workers. Environ. Health Perspect. 111, 1613–1619 (2003)

    Todd AC , 'Associations of renal function with polymorphisms in the delta-aminolevulinic acid dehydratase, vitamin D receptor, and nitric oxide synthase genes in Korean lead workers ' (2003 ) 111 Environ. Health Perspect. : 1613 -1619.

    • Search Google Scholar
  • Weaver VM, Schwartz BS, Jaar BG, Ahn KD, Todd AC, Lee SS: Associations of uric acid with polymorphisms in the delta-aminolevulinic acid dehydratase, vitamin D receptor, and nitric oxide synthase genes in Korean lead workers. Environ. Health Perspect. 113, 1509–1515 (2005)

    Lee SS , 'Associations of uric acid with polymorphisms in the delta-aminolevulinic acid dehydratase, vitamin D receptor, and nitric oxide synthase genes in Korean lead workers ' (2005 ) 113 Environ. Health Perspect. : 1509 -1515.

    • Search Google Scholar
  • Weaver VM, Lee BK, Todd AC, Ahn KD, Shi W, Jaar BG: Effect modification by delta-aminolevulinic acid dehydratase, vitamin D receptor, and nitric oxide synthase gene polymorphisms on associations between patella lead and renal function in lead workers. Environ. Res. 102, 61–69 (2006)

    Jaar BG , 'Effect modification by delta-aminolevulinic acid dehydratase, vitamin D receptor, and nitric oxide synthase gene polymorphisms on associations between patella lead and renal function in lead workers ' (2006 ) 102 Environ. Res. : 61 -69.

    • Search Google Scholar
  • Yang Y, Wu J, Sun P: Effects of delta-aminolevulinic acid dehydratase polymorphisms on susceptibility to lead in Han subjects from southwestern China. Int. J. Environ. Res. Public Health 9, 2326–2338 (2012)

    Sun P , 'Effects of delta-aminolevulinic acid dehydratase polymorphisms on susceptibility to lead in Han subjects from southwestern China ' (2012 ) 9 Int. J. Environ. Res. Public Health : 2326 -2338.

    • Search Google Scholar
  • Ziemsen B, Angerer J, Lehnert G, Benkmann HG, Goedde HW: Polymorphism of δ-aminolevulinic acid dehydratase in lead-exposed workers. Int. Arch. Occup. Environ. Health 58, 245–247 (1986)

    Goedde HW , 'Polymorphism of δ-aminolevulinic acid dehydratase in lead-exposed workers ' (1986 ) 58 Int. Arch. Occup. Environ. Health : 245 -247.

    • Search Google Scholar

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Senior editors

Editor(s)-in-Chief: Rosivall, László

Honorary Editor(s)-in-Chief): Monos, Emil

Managing Editor(s): Bartha, Jenő; Berhidi, Anna

Co-editor(s): Koller, Ákos; Lénárd, László; Szénási, Gábor

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Hungarian Editorial Board

      Benedek, György (Szeged)
      Benyó, Zoltán (Budapest)
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      Hamar, János (Budapest)
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