In earlier experiments single benzpyrene treatment of newborn rats caused strong alterations in the endorphin content of adult rats' immune cells. In the present experiments young (4-6 weeks old) male rats were studied for demonstrating the effect of the single neonatal or repeated (neonatally and at weanling) benzpyrene exposure on the serotonin content of immune cells (blood lymphocytes, monocytes, granulocytes; peritoneal fluid lymphocytes, mast cells, monocytes and granulocytes, thymic lymphocytes). Flow cytometric analysis showed that 50 µg benzpyrene treatment of five-week-old animals was ineffective after 5 days and this was the situation four weeks after single neonatal (20 µg) benzpyrene exposure. However, the repeated treatment of neonatally benzpyrene exposed 4 weeks old animals after 5 days resulted in elevated blood and thymic lymphocyte serotonin amount and in one index (peritoneal monocyte-granulocyte group) reduced serotonin content. This means that neonatal benzpyrene treatment does not influence directly the serotonin content (production or transport) of immune cells (unlike to the endorphin content) however, sensitizes them to a following benzpyrene exposure. The results widen the list of harmful effects (influencing steroid receptor binding, sexual behavior and immune cells' endorphin content) of perinatal benzpyrene exposure.
Csaba G, Karabélyos C: Transgenerational effect of a single neonatal benzpyrene treatment (imprinting) on the sexual behavior of adult female rats. Hum. Exp. Toxicol. 16, 553-556 (1997)
'Transgenerational effect of a single neonatal benzpyrene treatment (imprinting) on the sexual behavior of adult female rats ' () 16 Hum. Exp. Toxicol. : 553 -556.
Csaba G, Kovács P, Pállinger É: Effect of single neonatal endorphin treatment on the hormone content of adult rat white blood cells and mast cells. Cell Biol. Int. 27, 423-427 (2003)
'Effect of single neonatal endorphin treatment on the hormone content of adult rat white blood cells and mast cells ' () 27 Cell Biol. Int. : 423 -427.
Csaba G, Kovács P, Pállinger É: Endorphin content of white blood cells and peritoneal cells in neonatally benzpyrene treated adult rats. Acta Physiol. Hung. 90, 207-215 (2003)
'Endorphin content of white blood cells and peritoneal cells in neonatally benzpyrene treated adult rats ' () 90 Acta Physiol. Hung. : 207 -215.
Csaba G, Pállinger E: Prolonged impact of pubertal serotonin treatment (hormonal imprinting) on the later serotonin content of white blood cells. Life Sci. 71, 879-885 (2002)
'Prolonged impact of pubertal serotonin treatment (hormonal imprinting) on the later serotonin content of white blood cells ' () 71 Life Sci. : 879 -885.
Faraj BA, Olkowski ZL, Jackson RT: Expression of high-affinity serotonin transporter in human lymphocytes. Int. J. Immunopharmacol. 16, 561-567 (1994)
'Expression of high-affinity serotonin transporter in human lymphocytes ' () 16 Int. J. Immunopharmacol. : 561 -567.
Ferriere F, Khan NA, Meyniel JP, Deschaux P: Characterisation of serotonin transport mechanisms in rainbow trout peripheral blood lymphocytes role in PHA-induced lymphoproliferation. Dev. Comp. Immunol. 23, 37-50 (1999)
'Characterisation of serotonin transport mechanisms in rainbow trout peripheral blood lymphocytes role in PHA-induced lymphoproliferation ' () 23 Dev. Comp. Immunol. : 37 -50.
Bern HA, Jones LA, Mori T, Young PN: Exposure of neonatal mice to steroids: long-term effects on the mammary gland and other reproductive structures. J. Steroid Biochem. 6, 673-676 (1975)
'Exposure of neonatal mice to steroids: long-term effects on the mammary gland and other reproductive structures ' () 6 J. Steroid Biochem. : 673 -676.
Gibson DFC, Roberts SA, Evans GS: Changes in the hormone dependency of epithelial cell proliferation in the genital tract of mice following neonatal oestrogen treatment. Eur. J. Cancer 27, 1295-1301 (1991)
'Changes in the hormone dependency of epithelial cell proliferation in the genital tract of mice following neonatal oestrogen treatment ' () 27 Eur. J. Cancer : 1295 -1301.
Gordon J, Barnes NM: Lymphocytes transport serotonin and dopamine agony or ecstasy? Trends Immunol. 24, 438-443 (2003)
'Lymphocytes transport serotonin and dopamine agony or ecstasy ' () 24 Trends Immunol. : 438 -443.
Mirzahosseini S, Karabélyos Cs, Dobozy O, Csaba G: Changes in sexual behavior of adult male and female rats neonatally treated with vitamin D3. Hum. Exp. Toxicol. 15, 573-576 (1996)
'Changes in sexual behavior of adult male and female rats neonatally treated with vitamin D3 ' () 15 Hum. Exp. Toxicol. : 573 -576.
Mossner R, Lesch KP: Role of serotonin in the immune system and in neuroimmune interactions. Brain Behav. Immun. 12, 249-271 (1998)
'Role of serotonin in the immune system and in neuroimmune interactions ' () 12 Brain Behav. Immun. : 249 -271.
Nelson KG, Sakai Y, Eitzman B, Steel T, McLachlan JA: Exposure to diethylstilbestrol during a critical developmental period of the mouse reproductive tract leads to persistent induction of two estrogen-regulated genes. Cell Growth Differ. 5, 595-606 (1994)
'Exposure to diethylstilbestrol during a critical developmental period of the mouse reproductive tract leads to persistent induction of two estrogen-regulated genes ' () 5 Cell Growth Differ. : 595 -606.
Serafeim A, Gordon J: The immune system gets nervous. Curr. Opin. Pharmacol. 1, 398-403 (2001)
'The immune system gets nervous ' () 1 Curr. Opin. Pharmacol. : 398 -403.
Stefulj J, Jernej B, Cucin-Sain L, Rinner I, Schauenstein K mRNA expression of serotonin receptors in cells of the immune tissues of the rat. Brain. Behav. Immun. 14, 219-224 (2000)
'mRNA expression of serotonin receptors in cells of the immune tissues of the rat ' () 14 Brain. Behav. Immun. : 219 -224.
Tchernitchin A, Tchernitchin N: Imprinting of path of heterodifferentiation by prenatal or neonatal exposition to hormones Pharmaceuticals, pollutants and other agents and conditions. Med. Sci. Res. 20, 391-397 (1992)
'Imprinting of path of heterodifferentiation by prenatal or neonatal exposition to hormones Pharmaceuticals, pollutants and other agents and conditions ' () 20 Med. Sci. Res. : 391 -397.
Urbina M, Pineda S, Pinango L, Carreira L Lima L: 3H Paroxetine binding to human peripheral lymphocyte membranes of patients in major depression before and after treatment with fluoxetine. Int. J. Immunopharmacol. 21, 631-646 (1999)
'3H Paroxetine binding to human peripheral lymphocyte membranes of patients in major depression before and after treatment with fluoxetine ' () 21 Int. J. Immunopharmacol. : 631 -646.
Weihe E, Eiden LE: Chemical neuroanatomy of the vesicular amine transporters. FASEB J. 14, 2435-2449 (2000)
'Chemical neuroanatomy of the vesicular amine transporters ' () 14 FASEB J. : 2435 -2449.
Csaba G: Phylogeny and ontogeny of chemical signaling: origin and development of hormone receptors. Int. Rev. Cytol. 155, 1-48 (1994)
'Phylogeny and ontogeny of chemical signaling: origin and development of hormone receptors ' () 155 Int. Rev. Cytol. : 1 -48.
Csaba G, Inczefi-Gonda A: Uterus estrogen receptors' binding capacity is reduced in rat if exposed by benzpyrene neonatally. J. Dev. Physiol. 19, 217-219 (1993)
'Uterus estrogen receptors' binding capacity is reduced in rat if exposed by benzpyrene neonatally ' () 19 J. Dev. Physiol. : 217 -219.
Csaba G, Inczefi-Gonda A: Transgenerational effect of a single neonatal benzpyrene treatment on the glucocorticoid receptor of the rat thymus. Hum. Exp. Toxicol. 17, 88-92 (1998)
'Transgenerational effect of a single neonatal benzpyrene treatment on the glucocorticoid receptor of the rat thymus ' () 17 Hum. Exp. Toxicol. : 88 -92.
Csaba G: Hormonal imprinting: its role during the evolution and development of hormones and receptors. Cell Biol. Int. 24, 407-414 (2000)
'Hormonal imprinting: its role during the evolution and development of hormones and receptors ' () 24 Cell Biol. Int. : 407 -414.
Csaba G: Phytogeny and ontogeny of hormone receptors: the selection theory of receptor formation and hormonal imprinting. Biol. Rev. 55, 47-63 (1980)
'Phytogeny and ontogeny of hormone receptors: the selection theory of receptor formation and hormonal imprinting ' () 55 Biol. Rev. : 47 -63.
Jahnova E: The role of serotonin in the regulation of the human immune response. Bratisl. Lek. Listy 95, 181-184(1994)
'The role of serotonin in the regulation of the human immune response ' () 95 Bratisl. Lek. Listy : 181 -184.