View More View Less
  • 1 University of Medicine and Pharmacy 2nd Internal Medicine, Clinic “Iuliu Hatieganu” Cluj-Napoca Romania
  • 2 Clinica Medicală II 2-4 Clinicilor street 400006 Cluj-Napoca Romania
  • 3 144/4 Observatorului str 3400 Cluj Napoca Romania
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $752.00

The role of vitamin K in the synthesis of some coagulation factors is well known. The implication of vitamin K in vascular health was demonstrated in many surveys and studies conducted over the past years on the vitamin K-dependent proteins non-involved in coagulation processes. The vitamin K-dependent matrix Gla protein is a potent inhibitor of the arterial calcification, and may become a non-invasive biochemical marker for vascular calcification. Vitamin K 2 is considered to be more important for vascular system, if compared to vitamin K 1 . This paper is reviewing the data from recent literature on the involvement of vitamin K and vitamin K-dependent proteins in cardiovascular health.

  • Abedin M, Tintut Y, Demer LL: Vascular calcification. Mechanisms and clinical ramifications. Arterioscler. Thromb. Biol. 24, 1161–1170 (2004)

    Demer L.L. , 'Vascular calcification. Mechanisms and clinical ramifications ' (2004 ) 24 Arterioscler. Thromb. Biol. : 1161 -1170.

    • Search Google Scholar
  • Berkner KL, Runge KW: The physiology of vitamin K nutriture and vitamin K-dependent protein function in atherosclerosis. J. Tromb. Haemost. 2, 2118–2132 (2004)

    Runge K.W. , 'The physiology of vitamin K nutriture and vitamin K-dependent protein function in atherosclerosis ' (2004 ) 2 J. Tromb. Haemost. : 2118 -2132.

    • Search Google Scholar
  • Boon A, Cheriex E, Lodder J, Kessels F: Cardiac valve calcification: characteristics of patients with calcification of the mitral annulus or aortic valve. Heart 78, 472–474 (1997)

    Kessels F. , 'Cardiac valve calcification: characteristics of patients with calcification of the mitral annulus or aortic valve ' (1997 ) 78 Heart : 472 -474.

    • Search Google Scholar
  • Booth SL, Lichtenstein AH, Dallal G: Phylloquinone absorption from phylloquinone-fortified oil is greater than from a vegetable in younger and older men and women. J. Nutr. 132, 2609–2612 (2002)

    Dallal G. , 'Phylloquinone absorption from phylloquinone-fortified oil is greater than from a vegetable in younger and older men and women ' (2002 ) 132 J. Nutr. : 2609 -2612.

    • Search Google Scholar
  • Boström K, Tsao D, Shen S, Wang Y, Demer LL: Matrix Gla protein modulates differentiation induced by bone morphogeneic protein-2 (BMP-2) in C3H10T1/2 cells. J. Biol. Chem. 276, 14044–14052 (2001)

    Demer L.L. , 'Matrix Gla protein modulates differentiation induced by bone morphogeneic protein-2 (BMP-2) in C3H10T1/2 cells ' (2001 ) 276 J. Biol. Chem. : 14044 -14052.

    • Search Google Scholar
  • Cranenburg EC, Schurgers LJ, Vermeer C: Vitamin K: the coagulation vitamin that became omnipotent. Thromb. Haemost. 98, 120–125 (2007)

    Vermeer C. , 'Vitamin K: the coagulation vitamin that became omnipotent ' (2007 ) 98 Thromb. Haemost. : 120 -125.

    • Search Google Scholar
  • Cranenburg EC, Vermeer C, Koos R, Boumans ML, Hackeng TM, Bouwman FG, Kwaijtaal M, Brandenburg VM, Ketteler M, Schurgers LJ: The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcification. J. Vasc. Res. 45, 427–436 (2008)

    Schurgers L.J. , 'The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcification ' (2008 ) 45 J. Vasc. Res. : 427 -436.

    • Search Google Scholar
  • Danilevicius CF, Lopes JB, Pereira RMR: Bone metabolism and vascular calcification. Braz. J. Med. Biol. Res. 40, 435–442 (2007)

    Pereira R.M.R. , 'Bone metabolism and vascular calcification ' (2007 ) 40 Braz. J. Med. Biol. Res. : 435 -442.

    • Search Google Scholar
  • Davidson RT, Foley AL, Engelke JA, Suttie JW: Conversion of dietary phylloquinone to tissue menaquinones-4 in rats is not dependent on gut bacteria. J. Nutr. 128, 220–223 (1998)

    Suttie J.W. , 'Conversion of dietary phylloquinone to tissue menaquinones-4 in rats is not dependent on gut bacteria ' (1998 ) 128 J. Nutr. : 220 -223.

    • Search Google Scholar
  • Dobrin B: Mechanical factors associated with the development of intimal and medial thickening in vein grafts subjected to arterial pressure: a model of arteries exposed to hypertension. Hypertension 26, 3–43 (1995)

    Dobrin B. , 'Mechanical factors associated with the development of intimal and medial thickening in vein grafts subjected to arterial pressure: a model of arteries exposed to hypertension ' (1995 ) 26 Hypertension : 3 -43.

    • Search Google Scholar
  • Doherty TM, Fitzpatrick LA, Inoue D, Qiao JH, Fishbein MC, Detrano RC, Shah PK, Rajavashisth TB: Molecular, endocrine, and genetic mechanisms of arterial calcification. Endocrin. Rev. 25, 629–672 (2004)

    Rajavashisth T.B. , 'Molecular, endocrine, and genetic mechanisms of arterial calcification ' (2004 ) 25 Endocrin. Rev. : 629 -672.

    • Search Google Scholar
  • Engelse MA, Neele JM, Bronckers AL, Pannekoek H, de Vries CJ: Vascular calcification: expression patterns of the osteoblast-specific gene core binding factor alpha-1 and the protective factor matrix Gla protein in human atherogenesis. Cardiovasc. Res. 52, 281–289 (2001)

    Vries C.J. , 'Vascular calcification: expression patterns of the osteoblast-specific gene core binding factor alpha-1 and the protective factor matrix Gla protein in human atherogenesis ' (2001 ) 52 Cardiovasc. Res. : 281 -289.

    • Search Google Scholar
  • Food and Nutrition Board Institute of Medicine (2001). Dietary reference intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. National Academy Press, Washington, DC, USA

    '', in Dietary reference intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc , (2001 ) -.

    • Search Google Scholar
  • Gast GC, de Roos NM, Sluijs I, Bots ML, Beulens JW, Geleijnse JM, Witteman JC, Grobbee DE, Peeters PH, van der Schouw YT: High menaquinone intake reduces the incidence of coronary heart disease. Nutr. Metab. Cardivasc. Dis. 19, 504–510 (2009)

    Schouw Y.T. , 'High menaquinone intake reduces the incidence of coronary heart disease ' (2009 ) 19 Nutr. Metab. Cardivasc. Dis. : 504 -510.

    • Search Google Scholar
  • Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JC: Dietary intake of menaquinones is associated with a reduced risk of coronary heart disease: the Rotterdam study. J. Nutr. 134, 3100–3105 (2004)

    Witteman J.C. , 'Dietary intake of menaquinones is associated with a reduced risk of coronary heart disease: the Rotterdam study ' (2004 ) 134 J. Nutr. : 3100 -3105.

    • Search Google Scholar
  • Goodman WG: Vascular calcification in chronic renal failure. Lancet 358, 1115–1116 (2001)

    Goodman W.G. , 'Vascular calcification in chronic renal failure ' (2001 ) 358 Lancet : 1115 -1116.

    • Search Google Scholar
  • Hall JG, Pauli RM, Wilson KM: Maternal and fetal sequelae of anticoagulation during pregnancy. Am. J. Med. 68, 122–140 (1980)

    Wilson K.M. , 'Maternal and fetal sequelae of anticoagulation during pregnancy ' (1980 ) 68 Am. J. Med. : 122 -140.

    • Search Google Scholar
  • Hofbauer LC, Brueck CC, Shanahan CM, Schoppet M, Dobnig H: Vascular calcification and osteoporosis — from clinical observation towards molecular understanding. Osteoporosis 18, 251–259 (2007)

    Dobnig H. , 'Vascular calcification and osteoporosis — from clinical observation towards molecular understanding ' (2007 ) 18 Osteoporosis : 251 -259.

    • Search Google Scholar
  • Hruska KA, Mathew S, Saab G: Bone morphogenetic proteins in vascular calcification. Circ. Res. 97, 105–114 (2005)

    Saab G. , 'Bone morphogenetic proteins in vascular calcification ' (2005 ) 97 Circ. Res. : 105 -114.

    • Search Google Scholar
  • Jie KS, Bots ML, Vermeer C, Witteman JC, Grobbee DE: Vitamin K intake and osteocalcin levels in women with and without aortic atherosclerosis: a population-based study. Atherosclerosis 116, 117–123 (1995)

    Grobbee D.E. , 'Vitamin K intake and osteocalcin levels in women with and without aortic atherosclerosis: a population-based study ' (1995 ) 116 Atherosclerosis : 117 -123.

    • Search Google Scholar
  • Kapustin A, Shanahan CM: Targeting vascular calcification: softening-up a hard target. Current Opinion in Pharmacology 9, 84–89 (2009)

    Shanahan C.M. , 'Targeting vascular calcification: softening-up a hard target ' (2009 ) 9 Current Opinion in Pharmacology : 84 -89.

    • Search Google Scholar
  • Koos R, Mahnken AH, Mühlenbruch G, Brandenburg V, Pflueger B, Wildberger JE, Kühl HP: Relation of oral anticoagulation to cardiac valvular and coronary calcium assessed by multislice spiral computed tomography. Am. J. Cardiol. 96, 747–749 (2005)

    Kühl H.P. , 'Relation of oral anticoagulation to cardiac valvular and coronary calcium assessed by multislice spiral computed tomography ' (2005 ) 96 Am. J. Cardiol. : 747 -749.

    • Search Google Scholar
  • Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G: Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386, 78–81 (1997)

    Karsenty G. , 'Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein ' (1997 ) 386 Nature : 78 -81.

    • Search Google Scholar
  • McFarlane SI, Muniyappa R, Shin JJ, Bahtiyar G, Sowers JR: Osteoporosis and cardiovascular disease: brittle bones and boned arteries — is there a link? Endocrine 23, 1–10 (2004)

    Sowers J.R. , 'Osteoporosis and cardiovascular disease: brittle bones and boned arteries — is there a link? ' (2004 ) 23 Endocrine : 1 -10.

    • Search Google Scholar
  • Murshed M, Schinke T, McKee MD, Karsenty G: Extracellular matrix mineralization is regulated locally; different roles of two Gla-containing proteins. J. Cell Biol. 165, 625–630 (2004)

    Karsenty G. , 'Extracellular matrix mineralization is regulated locally; different roles of two Gla-containing proteins ' (2004 ) 165 J. Cell Biol. : 625 -630.

    • Search Google Scholar
  • Nimptsch K, Nieters A, Hailer S, Wolfram G, Linseisen J: The association between dietary vitamin K intake and serum undecarboxylated osteocalcin is modulated by vitamin K epoxide reductase genotype. Br. J. Nutr. 25, 1–9 (2008)

    Linseisen J. , 'The association between dietary vitamin K intake and serum undecarboxylated osteocalcin is modulated by vitamin K epoxide reductase genotype ' (2008 ) 25 Br. J. Nutr. : 1 -9.

    • Search Google Scholar
  • Okano T, Shimomura Y, Yamane M, Suhara Y, Kamao M, Sugiura M, Nakagawa K: Conversion of phylloquinone (Vitamin K1) into menaquinones-4 (Vitamin K2) in mice: two possible routes for menaquinones-4 accumulation in cerebra of mice. J. Biol. Chem. 283, 11270–11279 (2008)

    Nakagawa K. , 'Conversion of phylloquinone (Vitamin K1) into menaquinones-4 (Vitamin K2) in mice: two possible routes for menaquinones-4 accumulation in cerebra of mice ' (2008 ) 283 J. Biol. Chem. : 11270 -11279.

    • Search Google Scholar
  • Parker BD, Ix JH, Cranenburg EC, Vermeer C, Whooley MA, Schurgers LJ: Association of kidney function and uncarboxylated matrix Gla protein: data from the Heart and Soul Study. Nephrol. Dial. Transplant. 24, 2095–2101 (2009)

    Schurgers L.J. , 'Association of kidney function and uncarboxylated matrix Gla protein: data from the Heart and Soul Study ' (2009 ) 24 Nephrol. Dial. Transplant. : 2095 -2101.

    • Search Google Scholar
  • Pauli RM, Lian JB, Mosher DF, Suttie JW: Association of congenital deficiency multiple vitamin K-dependent coagulation factors and the phenotype of the warfarin embriopathy: clue to the mechanism of teratogenicity of coumarin derivatives. Am. J. Hum. Gen. 41, 566–583 (1987)

    Suttie J.W. , 'Association of congenital deficiency multiple vitamin K-dependent coagulation factors and the phenotype of the warfarin embriopathy: clue to the mechanism of teratogenicity of coumarin derivatives ' (1987 ) 41 Am. J. Hum. Gen. : 566 -583.

    • Search Google Scholar
  • Presnell SR, Stafford DW: The vitamin K-dependent carboxylase. Thromb. Haemost. 87, 937–947 (2002)

    Stafford D.W. , 'The vitamin K-dependent carboxylase ' (2002 ) 87 Thromb. Haemost. : 937 -947.

    • Search Google Scholar
  • Price PA, Faus SA, Wiliamson MK: Warfarin-induced artery calcification is accelerated by growth and vitamin D. Arteriscler. Thromb. Vasc. Biol. 20, 317–327 (2000)

    Wiliamson M.K. , 'Warfarin-induced artery calcification is accelerated by growth and vitamin D ' (2000 ) 20 Arteriscler. Thromb. Vasc. Biol. : 317 -327.

    • Search Google Scholar
  • Rieder MJ, Reiner AP, Gage BF, Nickerson DA, Eby CS, McLeod HL, Blough DK, Thummel KE, Veenstra DL, Rettie AE: Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. N. Engl. J. Med. 352, 2285–2293 (2005)

    Rettie A.E. , 'Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose ' (2005 ) 352 N. Engl. J. Med. : 2285 -2293.

    • Search Google Scholar
  • Rogers NM, Teubner DJ, Coates PT: Calcific uremic arteriolopathy: advances in pathogenesis and treatment. Semin. Dial. 20, 150–157 (2007)

    Coates P.T. , 'Calcific uremic arteriolopathy: advances in pathogenesis and treatment ' (2007 ) 20 Semin. Dial. : 150 -157.

    • Search Google Scholar
  • Ross R: Atherosclerosis — an inflammatory disease. N. Engl. J. Med. 340, 115–126 (1999)

    Ross R. , 'Atherosclerosis — an inflammatory disease ' (1999 ) 340 N. Engl. J. Med. : 115 -126.

    • Search Google Scholar
  • Schurgers LJ, Aebert H, Vermeer C, Bültmann B, Janzen J: Oral anticoagulant treatment: friend or foe in cardiovascular diseases? Blood 104, 3231–3232 (2004)

    Janzen J. , 'Oral anticoagulant treatment: friend or foe in cardiovascular diseases? ' (2004 ) 104 Blood : 3231 -3232.

    • Search Google Scholar
  • Schurgers LJ, Cranenburg ECM, Vermeer C: Matrix Gla-protein: The calcification inhibitor in need of vitamin K. Thromb. Haemost. 100, 593–603 (2008)

    Vermeer C. , 'Matrix Gla-protein: The calcification inhibitor in need of vitamin K ' (2008 ) 100 Thromb. Haemost. : 593 -603.

    • Search Google Scholar
  • Schurgers LJ, Geleijnse JM, Grobbee DE, Pols HAP, Hofman A, Witteman JCM, Vermeer C: Nutritional intake of vitamin K1 (phylloquinone) and K2 (menaquinone) in the Netherlands. J. Nutr. Environ. Med. 9, 115–122 (1999)

    Vermeer C. , 'Nutritional intake of vitamin K1 (phylloquinone) and K2 (menaquinone) in the Netherlands ' (1999 ) 9 J. Nutr. Environ. Med. : 115 -122.

    • Search Google Scholar
  • Schrugers LJ, Spronk HM, Soute BA, Schiffers PM, DeMey JG, Vermeer C: Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats. Blood 109, 2823–2831 (2007)

    Vermeer C. , 'Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats ' (2007 ) 109 Blood : 2823 -2831.

    • Search Google Scholar
  • Schurgers LJ, Teunissen KJ, Knapen MH, Kwaijtaal M, van Diest R, Appels A, Reutelingsperger CP, Cleutjens JP, Vermeer C: Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification. Arteriscler. Thromb. Vasc. Biol. 25, 1629–1633 (2005)

    Vermeer C. , 'Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification ' (2005 ) 25 Arteriscler. Thromb. Vasc. Biol. : 1629 -1633.

    • Search Google Scholar
  • Schurgers LJ, Vermeer C: Differential lipoprotein transport pathways of K-vitamins in healthy subjects. Biochim. Biophys. Acta. 1570, 27–32 (2002)

    Vermeer C. , 'Differential lipoprotein transport pathways of K-vitamins in healthy subjects ' (2002 ) 1570 Biochim. Biophys. Acta. : 27 -32.

    • Search Google Scholar
  • Shanahan CM: Mechanisms of vascular calcification in renal disease. Clin. Nephrol. 63, 146–157 (2005)

    Shanahan C.M. , 'Mechanisms of vascular calcification in renal disease ' (2005 ) 63 Clin. Nephrol. : 146 -157.

    • Search Google Scholar
  • Spronk HMH: Vitamin K epoxide reductase complex and vascular calcification. Is this the important link between vitamin K and arterial vessel wall? Circulation 113, 1550–1552 (2006)

    Spronk H.M.H. , 'Vitamin K epoxide reductase complex and vascular calcification. Is this the important link between vitamin K and arterial vessel wall? ' (2006 ) 113 Circulation : 1550 -1552.

    • Search Google Scholar
  • Spronk HM, Soute BA, Schrugers LJ, Cleutjens JP, Thijssen HH, De Mey JG, Vermeer C: Matrix Gla protein accumulates at the border of regions of calcification and normal tissue in the media of arterial vessel wall. Biochem. Biophys. Res. Commun. 289, 485–490 (2001)

    Vermeer C. , 'Matrix Gla protein accumulates at the border of regions of calcification and normal tissue in the media of arterial vessel wall ' (2001 ) 289 Biochem. Biophys. Res. Commun. : 485 -490.

    • Search Google Scholar
  • Spronk MH, Soute SA, Schrugers LJ, Thijssen HH, De Mey JG, Vermeer C: Tissue-specific utilization of menaquinones-4 results in the prevention of arterial calcification in warfarin-treated rats. J. Vasc. Res. 40, 531–537 (2003)

    Vermeer C. , 'Tissue-specific utilization of menaquinones-4 results in the prevention of arterial calcification in warfarin-treated rats ' (2003 ) 40 J. Vasc. Res. : 531 -537.

    • Search Google Scholar
  • Stafford DW: The vitamin K cycle. J. Thromb. Haemost. 3, 1873–1878 (2005)

    Stafford D.W. , 'The vitamin K cycle ' (2005 ) 3 J. Thromb. Haemost. : 1873 -1878.

  • Steitz SA, Speer MY, Curinga G, Yang HY, Haynes P, Aebersold R, Schinke T, Karsenty G, Giachelli CM: Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers. Circ. Res. 89, 1147–1154 (2001)

    Giachelli C.M. , 'Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers ' (2001 ) 89 Circ. Res. : 1147 -1154.

    • Search Google Scholar
  • Suhara Y, Wada A, Okano T: Elucidation of the mechanism producing menaquinones-4 in osteoblastic cells. Bioorg. Med. Chem. Lett. 2009, doi:10.1016/j.bmcl.2009.01.021.

  • Sweatt A, Sane DC, Hutson SM, Wallin R: Matrix Gla protein (MGP) and bone morphogenetic protein-2 in aortic calcified lesions of aging rats. J. Thromb. Haemost. 1, 178–185 (2003)

    Wallin R. , 'Matrix Gla protein (MGP) and bone morphogenetic protein-2 in aortic calcified lesions of aging rats ' (2003 ) 1 J. Thromb. Haemost. : 178 -185.

    • Search Google Scholar
  • Thijssen HH, Drittij-Reijnders MJ: Vitamin K status in human tissues: tissue-specific accumulation of phylloquinone and menaquinones-4. Br. J. Nutr. 75, 121–127 (1996)

    Drittij-Reijnders M.J. , 'Vitamin K status in human tissues: tissue-specific accumulation of phylloquinone and menaquinones-4 ' (1996 ) 75 Br. J. Nutr. : 121 -127.

    • Search Google Scholar
  • Van Winckel M, De Bruyne R, Van De Velde S, Van Biervlit S: Vitamin K, an update for the paediatrician. Eur. J. Pediatr. 168, 127–134 (2009)

    Biervlit S. , 'Vitamin K, an update for the paediatrician ' (2009 ) 168 Eur. J. Pediatr. : 127 -134.

    • Search Google Scholar
  • Vattikuti R, Towler DA: Osteogenetic regulation of vascular calcification: an early perspective. Am. J. Psyhiol. Endocrinol. Metabol. 286, E686–E696 (2004)

    Towler D.A. , 'Osteogenetic regulation of vascular calcification: an early perspective ' (2004 ) 286 Am. J. Psyhiol. Endocrinol. Metabol. : E686 -E696.

    • Search Google Scholar
  • Vermeer C, Shearer MJ, Zittermann A, Bolton-Smith C, Szulc P, Hodges S, Walter P, Rambeck W, Stöcklin E, Weber P: Beyond deficiency: Potential benefits of increased intakes of vitamin K for bone and vascular health. Eur. J. Nutr. 43, 325–335 (2004)

    Weber P. , 'Beyond deficiency: Potential benefits of increased intakes of vitamin K for bone and vascular health ' (2004 ) 43 Eur. J. Nutr. : 325 -335.

    • Search Google Scholar
  • Wallin R, Schurgers L, Wajin N: Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification. Thromb. Res. 122, 411–417 (2008)

    Wajin N. , 'Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification ' (2008 ) 122 Thromb. Res. : 411 -417.

    • Search Google Scholar
  • Wang Y, Zhang W, Zhang Y, Yang Y, Sun L, Hu S, Chen J, Zhang C, Zheng Y, Zhen Y, Sun K, Fu C, Yang T, Wang J, Sun J, Wu H, Glasgow WC, Hui R: VKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection). Circulation 113, 1612–1625 (2006)

    Hui R. , 'VKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection) ' (2006 ) 113 Circulation : 1612 -1625.

    • Search Google Scholar
  • Yagami K, Suh JY, Enomoto-Iwamoto M, Koyama E, Abrams WR, Shapiro IM, Pacifici M, Iwamoto M: Matrix Gla protein is a developmental regulator of chondrocyte mineralization and, when constitutively expressed, blocks endochondral and intramembranous ossification in the limb. J. Cell. Biol. 147, 1097–1108 (1999)

    Iwamoto M. , 'Matrix Gla protein is a developmental regulator of chondrocyte mineralization and, when constitutively expressed, blocks endochondral and intramembranous ossification in the limb ' (1999 ) 147 J. Cell. Biol. : 1097 -1108.

    • Search Google Scholar
  • Yuan HY, Chen JJ, Lee MT, Wung JC, Chen YF, Charng MJ, Lu MJ, Hung CR, Wei CY, Chen CH, Wu JY, Chen YT: A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity. Hum. Mol. Genet. 14, 1745–1751 (2005)

    Chen Y.T. , 'A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity ' (2005 ) 14 Hum. Mol. Genet. : 1745 -1751.

    • Search Google Scholar

The author instruction is available in PDF.

Please, download the file from HERE

  • Impact Factor (2016): 0.571
  • 5-year Impact Factor (2016): 0.675
  • Physiology (Medical) Quartile score (2016): Q4
  • SJR Indicator (2016): 0.276
  • H-Index (2016): H-Index (2016): 23

Language: English

Founded in 1950
Publication: One volume of four issues annually
Publication Programme: 2016: Vol. 103
Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • EMBASE/Excerpta Medica
  • Global Health
  • Index Copernicus
  • Index Medicus
  • Medline
  • Referativnyi Zhurnal
  • Science Citation Index Expanded
  • SCOPUS

 

Subscribers can access the electronic version of every printed article.

Senior editors

Editor(s)-in-Chief: Rosivall, László

Honorary Editor(s)-in-Chief): Monos, Emil

Managing Editor(s): Bartha, Jenő; Berhidi, Anna

Co-editor(s): Koller, Ákos; Lénárd, László; Szénási, Gábor

Assistant Editor(s): G. Dörnyei (Budapest), Zs. Miklós (Budapest), Gy. Nádasy (Budapest)

Hungarian Editorial Board

      Benedek, György (Szeged)
      Benyó, Zoltán (Budapest)
      Boros, Mihály (Szeged)
      Chernoch, László (Debrecen)
      Détári, László (Budapest)
      Hamar, János (Budapest)
      Hantos, Zoltán (Szeged)
      Hunyady, László (Budapest)
      Imre, Sándor (Debrecen)
      Jancsó, Gábor (Szeged)
      Karádi, Zoltán (Pécs)
      Kovács, László (Debrecen)
      Palkovits, Miklós (Budapest)
      Papp, Gyula (Szeged)
      Pavlik, Gábor (Budapest)
      Spät, András (Budapest)
      Szabó, Gyula (Szeged)
      Szelényi, Zoltán (Pécs)
      Szolcsányi, János (Pécs)
      Szollár, Lajos (Budapest)
      Szücs, Géza (Debrecen)
      Telegdy, Gyula (Szeged)
      Toldi, József (Szeged)
      Tósaki, Árpád (Debrecen)

International Editorial Board

      R. Bauer (Jena)
      W. Benjelloun (Rabat)
      A. W. Cowley Jr. (Milwaukee)
      D. Djuric (Belgrade)
      C. Fry (London)
      S. Greenwald (London)
      O. Hänninen (Kuopio)
      H. G. Hinghofer-Szalkay (Graz)
      Th. Kenner (Graz)
      Gy. Kunos (Richmond)
      M. Mahmoudian (Tehran)
      T. Mano (Seki, Gifu)
      G. Navar (New Orleans)
      H. Nishino (Nagoya)
      O. Petersen (Liverpool)
      U. Pohl (Münich)
      R. S. Reneman (Maastricht)
      A. Romanovsky (Phoenix)
      G. M. Rubanyi (Richmond)
      T. Sakata (Oita)
      A. Siddiqui (Karachi)
      Cs. Szabo (Beverly)
      E. Vicaut (Paris)
      N. Westerhof (Amsterdam)
      L. F. Zhang (Xi'an)

Editorial Office:
Akadémiai Kiadó Zrt.
Prielle Kornélia u. 21–35, H-1117 Budapest, Hungary

Editorial Correspondence:
Acta Physiologica Hungarica
Semmelweis University, Faculty of Medicine Institute of Pathophysiology
Nagyvárad tér 4, H-1089 Budapest, Hungary
Phone/Fax: +36-1-2100-100
E-mail: aph@semmelweis-univ.hu