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  • 1 Research Group: Neuroimmunophysiology & Chrononutrition Department of Physiology Science Faculty Badajoz Spain
  • 2 University of Extremadura Health Education Lab., Experimental Science Education Area Badajoz Spain
  • 3 University of Extremadura Experimental Science Education Area Av/de Elvas, sn CP: 06071 Badajoz Spain
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The hop (Humulus lupulus), a component of beer, is a sedative plant whose pharmacological activity is due principally to its bitter resins, especially to the α-acid component 2-methyl-3-buten-2-ol. The mechanism of action of the resin of hop consists of increasing the activity of the neurotransmitter γ-aminobutyric (GABA), inhibiting the central nervous system (CNS). Objectives: To analyze in an experimental model of diurnal animal the sedative effect of hop, a component of beer, on the activity/rest rhythm. Methods: Experiments were performed with common quail (Coturnix coturnix) similar to humans in the sleep-wake rhythm, isolated in 25 × 25 × 25 cm methacrylate cages, with food and water ad libitum, in a room with artificial ventilation (22 ± 1 °C) and a lighting cycle of 12L/12D (n = 5). The doses administered, close to the content of non-alcoholic beer, were 1, 2 and 11 mg extract of hop as one capsule per day, at 18:00 h for one week. A control group received capsules only with a methylcellulose excipient and a basal group received no treatment. The chronobiological analysis of the animals’ activity captured and logged by the software DAS24 was performed using the Ritme computer program (cosinor methods). Results: With the dose of 2 mg, there was a statistically significant (p < 0.05) reduction of the arithmetic mean nocturnal activity (23 ± 3.0) with respect to the basal (38.56 ± 2.79), control (38.1 ± 2.8) and other doses groups 1 mg (52.04 ± 3.65) and 11 mg (47.47 ± 5.88). This dose of 2 mg, similar to the concentration in beer, was more effective in reducing nocturnal activity than the other doses of 1 and 11 mg, as well as preserving the circadian activity/rest rhythm. Conclusion: The concentration of 2 mg of hop extract effectively decreased nocturnal activity in the circadian activity rhythm. On the basis of this investigation, administration of non-alcoholic beer would be recommended due to its hop content and consequent sedative action, which would be an aid to nocturnal sleep.

  • Abourashed EA, Koetter U, Brattstrom A: In vitro binding experiments with a valerian, hops and the fixed combination extract (Ze91019) to selected central nervous system receptor. Phytomedicine 11, 633–638 (2004)

    Brattstrom A. , 'In vitro binding experiments with a valerian, hops and the fixed combination extract (Ze91019) to selected central nervous system receptor ' (2004 ) 11 Phytomedicine : 633 -638.

    • Search Google Scholar
  • Aoshima H, Takeda K, Okita Y, Sheikh Julfikar H, Koda H, Yoshinobu K: Effects of beer and hop on ionotropic γ-aminobutyric acid receptors. J. Agric. Food Chem. 54, 2514–1519 (2006)

    Yoshinobu K. , 'Effects of beer and hop on ionotropic γ-aminobutyric acid receptors ' (2006 ) 54 J. Agric. Food Chem. : 2514 -1519.

    • Search Google Scholar
  • Bravo L, Cabo J, Fraile A, Jimenez J, Villar A: Estudio farmacodinámico del lúpulo (Humulus lupulus L.). Acción tranquilizante. Boll. Chim. Farm. 113, 310–315 (1974)

    Villar A. , 'Estudio farmacodinámico del lúpulo (Humulus lupulus L.). Acción tranquilizante ' (1974 ) 113 Boll. Chim. Farm. : 310 -315.

    • Search Google Scholar
  • Bravo R, Franco LF, Sánchez C, Rodríguez AB, Barriga C, Cubero J (2011): The sedative effects of hop (Humulus lupulus), a component of beer, in the rhythm of activity / rest. Proceeding of the 11th European Nutrition Conference FENS, Oct 26–29, 2011, Madrid, Spain

  • Brattstrom A: Scientific evidence for fixed extract combination (Ze 91019) from valerian and hops traditionally used as sleep-inducing aid. Wien. Med. Wochenschr. 21, 847–851 (2007)

    Brattstrom A. , 'Scientific evidence for fixed extract combination (Ze 91019) from valerian and hops traditionally used as sleep-inducing aid ' (2007 ) 21 Wien. Med. Wochenschr. : 847 -851.

    • Search Google Scholar
  • De la Iglesia HO, Cambras T, Schwatz WJ, Diez-Noguera A: Forced desynchronization of dual circadian oscillators within the rat suprachiasmatic nucleus. Curr. Biol. 14, 796–800 (2004)

    Diez-Noguera A. , 'Forced desynchronization of dual circadian oscillators within the rat suprachiasmatic nucleus ' (2004 ) 14 Curr. Biol. : 796 -800.

    • Search Google Scholar
  • Deeb D, Gao X, Jiang H, Arbab AS, Dulchavsky SA, Gautam SC: Grow inhibitory and apoptosis-inducing effects of xanthohumol, a prenylated chalcone present in hops, in human prostate cancer cells. Anticancer Res. 30, 3333–3339 (2010)

    Gautam S.C. , 'Grow inhibitory and apoptosis-inducing effects of xanthohumol, a prenylated chalcone present in hops, in human prostate cancer cells ' (2010 ) 30 Anticancer Res. : 3333 -3339.

    • Search Google Scholar
  • Dimpfel W, Suter A: Sleep improving effects of a single dose administration of valerians/hops fluid extract a double blind, randomized, placebo-controlled sleep-EEG study in parallel design using electrohypnograms. Eur. J. Med. Res. 26, 200–204 (2008)

    Suter A. , 'Sleep improving effects of a single dose administration of valerians/hops fluid extract a double blind, randomized, placebo-controlled sleep-EEG study in parallel design using electrohypnograms ' (2008 ) 26 Eur. J. Med. Res. : 200 -204.

    • Search Google Scholar
  • Hänsel R, Wohlfart R, Coper H: Sedative-hypnotic compounds in the exhalation of hops II. Z. Naturforsch. C. 35, 1096–1097 (1980)

    Coper H. , 'Sedative-hypnotic compounds in the exhalation of hops II ' (1980 ) 35 Z. Naturforsch. C. : 1096 -1097.

    • Search Google Scholar
  • Hernández H (1999): Tratado de Nutrición. Edt. Diaz de Santos, Spain

    Hernández H. , '', in Tratado de Nutrición , (1999 ) -.

  • Koether U, Schrader E, Kaufeler R, Brattstrom A: A randomized double blind, placebo-controlled, prospective clinical efficacy of fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder. Phytother. Res. 21, 847–851 (2007)

    Brattstrom A. , 'A randomized double blind, placebo-controlled, prospective clinical efficacy of fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder ' (2007 ) 21 Phytother. Res. : 847 -851.

    • Search Google Scholar
  • Kotronoulas G, Stamatakis A, Stylianopoulou F: Hormones, hormonal agents and neuropeptides involved in the neuroendocrine regulation of sleep in humans. Hormone 8, 232–248 (2010)

    Stylianopoulou F. , 'Hormones, hormonal agents and neuropeptides involved in the neuroendocrine regulation of sleep in humans ' (2010 ) 8 Hormone : 232 -248.

    • Search Google Scholar
  • Lee KM, Jung KS, Song DK, Krauter M, Kim HY: Effects of Humulus lupulus extract on the central nervous system in mice. Planta Med. 59(Suppl): A691 (1993)

    Kim H.Y. , 'Effects of Humulus lupulus extract on the central nervous system in mice ' (1993 ) 59 Planta Med. : A691 -.

    • Search Google Scholar
  • Magalhanes PJ, Carvalho DO, Cruz JM, Guido LF, Barros Fundamentals and health benefits of xanthohumol, a natural product derived from hops and beer. Nat. Prod. Commun. 4, 591–610 (2009)

    Barros A.A. , 'Fundamentals and health benefits of xanthohumol, a natural product derived from hops and beer ' (2009 ) 4 Nat. Prod. Commun. : 591 -610.

    • Search Google Scholar
  • Maldonado M, Moreno H, Calvo JR: Melatonin present in beer contributes to increase the levels of melatonin and antioxidant capacity of the human serum. Clin. Nutr. 28, 188–191 (2009)

    Calvo J.R. , 'Melatonin present in beer contributes to increase the levels of melatonin and antioxidant capacity of the human serum ' (2009 ) 28 Clin. Nutr. : 188 -191.

    • Search Google Scholar
  • Malheiros RD, Morales VM, Bruno DG, Malheiros EB, Furlan RL, Macari M: Environmental temperature and cloacal and surface temperature in broiled chicks in first week post hatch. J. Appl. Poultry Res. 9, 112–117 (2000)

    Macari M. , 'Environmental temperature and cloacal and surface temperature in broiled chicks in first week post hatch ' (2000 ) 9 J. Appl. Poultry Res. : 112 -117.

    • Search Google Scholar
  • Meissner O, Haberlein H: Influence of xanthohumol on the binding behaviour of GABA A receptors and their lateral mobility at hippocampal neurons. Plant. Med. 72, 656–658 (2006)

    Haberlein H. , 'Influence of xanthohumol on the binding behaviour of GABA A receptors and their lateral mobility at hippocampal neurons ' (2006 ) 72 Plant. Med. : 656 -658.

    • Search Google Scholar
  • Morin CM, Koetter U, Bastien C, Ware JC, Wooten V: Valerian-hops combination and diphenhydramine for treating insomnia; a randomized placebo-controlled clinical trial. Sleep 28, 1465–1471 (2005)

    Wooten V. , 'Valerian-hops combination and diphenhydramine for treating insomnia; a randomized placebo-controlled clinical trial ' (2005 ) 28 Sleep : 1465 -1471.

    • Search Google Scholar
  • Negrão R, Costa R, Duarte D, Taveira Gomes T, Mendanha M, Moura L, Vasques L, Azevedo I, Soares R: Angiogenesis and inflammation signaling are targets of beer polyphenols on vascular cells. J. Cell Biochem. 11, 1270–1279 (2010)

    Soares R. , 'Angiogenesis and inflammation signaling are targets of beer polyphenols on vascular cells ' (2010 ) 11 J. Cell Biochem. : 1270 -1279.

    • Search Google Scholar
  • Romeo J, Warnberg J, Nova E, Ligia E, González-Gros, Marcos A: Changes in the immune system after moderate beer consumption. Ann. Nutr. Metab. 51, 359–366 (2007)

    Marcos A. , 'Changes in the immune system after moderate beer consumption ' (2007 ) 51 Ann. Nutr. Metab. : 359 -366.

    • Search Google Scholar
  • Ross SM: Sleep disorders: a single dose administration of valerians/hops fluids extract (dormeasan) is found to be effective in improving sleep. Holist. Nurs. Pract. 23, 253–356 (2009)

    Ross S.M. , 'Sleep disorders: a single dose administration of valerians/hops fluids extract (dormeasan) is found to be effective in improving sleep ' (2009 ) 23 Holist. Nurs. Pract. : 253 -356.

    • Search Google Scholar
  • Salter S, Brownie S: Treating primary insomnia the efficacy of valerian and hops. Aust. Fam. Physician. 39, 433–437 (2010)

    Brownie S. , 'Treating primary insomnia the efficacy of valerian and hops ' (2010 ) 39 Aust. Fam. Physician. : 433 -437.

    • Search Google Scholar
  • Sanchez C, Barriga C, RodrÍguez A, Franco L, Rivero M, Cubero J: Effects of oral administration of L-methionine on activity/rest rhythm. Acta Physiol. Hung. 97, 224–233 (2010).

    Cubero J. , 'Effects of oral administration of L-methionine on activity/rest rhythm ' (2010 ) 97 Acta Physiol. Hung. : 224 -233.

    • Search Google Scholar
  • Sanchez C, Bravo L, Rubio C, RodrÍguez A, Barriga C, Cubero J: Cerveza y salud, beneficios sobre el sueño. Rev. Esp. Nutr. Comunitaria 16, 168–171 (2010).

    Cubero J. , 'Cerveza y salud, beneficios sobre el sueño ' (2010 ) 16 Rev. Esp. Nutr. Comunitaria : 168 -171.

    • Search Google Scholar
  • Schellenberg R, Sauer S, Abourashed E, Koetter U, Brattstrom A: The fixed combination of valerian and hops (Ze91019) acts via a central adenosine mechanism. Planta Med. 70, 594–597 (2004)

    Brattstrom A. , 'The fixed combination of valerian and hops (Ze91019) acts via a central adenosine mechanism ' (2004 ) 70 Planta Med. : 594 -597.

    • Search Google Scholar
  • Schmitz M, Jackel M: Comparative study for assessing quality of life of patients with exogenous sleep disorders (temporary sleep onset and sleep interruption disorders) treated with hops-valerian preparation and benzodiazepine drug. Wien Med. Wochenschr. 148, 291–298 (1998)

    Jackel M. , 'Comparative study for assessing quality of life of patients with exogenous sleep disorders (temporary sleep onset and sleep interruption disorders) treated with hops-valerian preparation and benzodiazepine drug ' (1998 ) 148 Wien Med. Wochenschr. : 291 -298.

    • Search Google Scholar
  • Schiller H, Foster A, Vonhoff C, Hegger M, Biller A, Winterhoff H: Sedating effects of Humulus lupulus L. extract. Phytomedicine 13, 535–541 (2006)

    Winterhoff H. , 'Sedating effects of Humulus lupulus L. extract ' (2006 ) 13 Phytomedicine : 535 -541.

    • Search Google Scholar
  • Vonderheid-Guth B, Todorova A, Brattstrom A, Dimpfel W: Pharmacodynamic effects of valerian and hops extract combination (Ze 91019) on the quantitative-topographical EEG in the healthy volunteers. Eur. J. Med. Res. 5, 139–144 (2000)

    Dimpfel W. , 'Pharmacodynamic effects of valerian and hops extract combination (Ze 91019) on the quantitative-topographical EEG in the healthy volunteers ' (2000 ) 5 Eur. J. Med. Res. : 139 -144.

    • Search Google Scholar
  • Wohlfart R, Hansel R, Schmidt H: The sedative-hypnotic principle of hops. 4. Pharmacology of the hop substance 2-methyl-3-buten-ol. Planta Med. 48, 120–123 (1983)

    Schmidt H. , 'The sedative-hypnotic principle of hops. 4. Pharmacology of the hop substance 2-methyl-3-buten-ol ' (1983 ) 48 Planta Med. : 120 -123.

    • Search Google Scholar
  • Zanoli P, Zavatti M: Pharmacognostic and pharmacological profile of Humulus lupulus L. J. Ethnopharmacol. 116, 383–396 (2008)

    Zavatti M. , 'Pharmacognostic and pharmacological profile of Humulus lupulus L ' (2008 ) 116 J. Ethnopharmacol. : 383 -396.

    • Search Google Scholar
  • Zanoli P, Zavatti M, Rivasi M, Brusiani F, Losi G, Puia R, Avallone R, Baraldi M: Evidence the β-acids fraction of hops reduces central GABAergic neurotransmission. J. Ethnopharmacol. 109, 87–92 (2007)

    Baraldi M. , 'Evidence the β-acids fraction of hops reduces central GABAergic neurotransmission ' (2007 ) 109 J. Ethnopharmacol. : 87 -92.

    • Search Google Scholar
  • Zanoli P, Rivasi M, Zavatti M, Brusiani F, Baraldi M: New insight in the neuropharmacological activity of Humulus lupulus L. J. Ethnopharmacol. 102, 102–106 (2005)

    Baraldi M. , 'New insight in the neuropharmacological activity of Humulus lupulus L ' (2005 ) 102 J. Ethnopharmacol. : 102 -106.

    • Search Google Scholar

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