In this study, we examined the relationship between levels of lactoferrin (LF) and IL-17 in human serum and breast milk and the development of allergy in children. LF and IL-17 levels were determined by ELISA in healthy (n=19) and allergic mothers (n=21) on the 5th day after delivery. Two years later, information on breastfeeding and allergic outcomes was collected by questionnaires from parents of both groups and district child care nurses. Significantly higher concentrations of LF were found in the breast milk of allergic mothers compared to the healthy controls. At 2 years of age, only those three infants became allergic from the atopic group in whose starting breast milk samples a very high LF level (306 μg mg–1 protein) or simultaneously elevated concentrations of LF and IL-17 were measured. These findings indicate that the very early measurement of LF and IL-17 levels in the breast milk of allergic mothers may help to predict the allergy development in their infants.
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-
Bottcher, M.F. & Jenmalm, M.C. (2002): Breastfeeding and the development of atopic disease during childhood. Clin. Exp. Allergy, 32, 59–161.
-
Bournazou, I., Mackenzie, K.J., Duffin, R., Rossi, A.G. & Gregory, C.D. (2010): Inhibition of eosinophil migration by lactoferrin. Immunol. Cell. Biol., 88, 220–223.
-
Choi, G.S., Shin, S.Y., Kim, J.H., Lee, H.Y., Palikhe, N.S., Ye, Y.M., Kim, S.H. & Park, H.S. (2010): Serum lactoferrin level as a serologic biomarker for allergic rhinitis. Clin. Exp. Allergy, 40, 403–410.
-
Ciprandi, G., Fenoglio, D., De Amici, M., Quaglini, S., Negrini, S. & Filaci, G. (2008): Serum IL-17 levels in patients with allergic rhinitis. J. Allergy Clin. Immun., 122, 650–652.
-
De La Rosa, G., Yang, D., Tewary, P., Varadhachary, A. & Oppenheim, J.J. (2008): Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses. J. Immunol. 180, 6868–6876.
-
Elrod, K.C., Moore, W.R., Abraham, W.M. & Tanaka, R.D. (1997): Lactoferrin, a potent tryptase inhibitor, abolishes late-phase airway responses in allergic sheep. Am. J. Resp. Crit. Care, 156, 375–381.
-
He, S., Mceuen, A.R., Blewett, S.A., Li, P., Buckley, M.G., Leufkens, P. & Walls, A.F. (2003): The inhibition of mast cell activation by neutrophil lactoferrin: uptake by mast cells and interaction with tryptase, chymase and cathepsin G. Biochem Pharmacol., 65, 1007–1015.
-
Jarvinen, K.M. & Suomalainen, H. (2001): Development of cow’s milk allergy in breast-fed infants. Clin. Exp. Allergy, 31, 978–987.
-
Kallenbach, J., Baynes, R., Fine, B., Dajee, D. & Bezwoda, W. (1992): Persistent neutrophil activation in mild asthma. J. Allergy Clin. Immun., 90, 272–274.
-
Kurukulaaratchy, R.J., Matthews, S. & Arshad, S.H. (2006): Relationship between childhood atopy and wheeze: what mediates wheezing in atopic phenotypes? Ann. Allerg. Asthma Im., 97, 84–91.
-
Lim, R.H., Kobzik, L. & Dahl, M. (2010): Risk for asthma in offspring of asthmatic mothers versus fathers: a metaanalysis. PLoS One , 5, 10134.
-
Litonjua, A.A., Carey, V.J., Burge, H.A., Weiss, S.T. & Gold, D.R. (1998): Parental history and the risk for childhood asthma. Does mother confer more risk than father? Am. J. Resp. Crit. Care, 158, 176–181.
-
Raby, B.A., Klanderman, B., Murphy, A., Mazza, S., Camargo, C.A., Jr.., Silverman, E.K. & Weiss, S.T. (2007): A common mitochondrial haplogroup is associated with elevated total serum IgE levels. J. Allergy Clin. Immun., 120, 351–358.
-
Rudloff, S., Niehues, T., Rutsch, M., Kunz, C. & Schroten, H. (1999): Inflammation markers and cytokines in breast milk of atopic and nonatopic women. Allergy, 54, 206–211.
-
SzabÓ, Z., Szilasi, M., Brugos, L., Szanto, S., Kovacs, I., Szeles, M., Lakos, G., Antal-Szalmas, P., Edes, I. & Sipka, S. (2000): Differences in the changes of allergen-specific IgE serum levels and the chemiluminescence of peripheral blood phagocytes in patients with allergic rhinoconjunctivitis during the ragweed season. Immunol. Lett., 74, 201–205.
-
Wills-Karp, M., Brandt, D. & Morrow, A.L. (2004): Understanding the origin of asthma and its relationship to breastfeeding. Adv. Exp. Med. Biol., 554, 171–191.
-
Zifa, E., Daniil, Z., Skoumi, E., Stavrou, M., Papadimitriou, K., Terzenidou, M., Kostikas, K., Bagiatis, V., Gourgoulianis, K.I. & Mamuris, Z. (2012): Mitochondrial genetic background plays a role in increasing risk to asthma. Mol. Biol. Rep., 39, 4697–4708.
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Oxidation in foods and beverages and antioxidant applications. Vols 1 & 2
E.A. Decker, R.J. Elias and D.J. McClements (Eds) Woodhead Publishing Ltd., Oxford, Cambridge, Philadelphia, New Delhi 2010, ISBN 978-1-84569-648-1; ISBN 978-84569-983-3, 408 and 528 pages.
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