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  • 1 Medical University Department of Medicinal Chemistry 6 Chodzki 20-093 Lublin Poland
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Relationships between RM values and mobile phase composition have been examined for six fibrate-type drugs — bezafibrate, ciprofibrate, clofibrate, clofibric acid, fenofibrate, and gemfibrozil. They were separated in horizontal chambers on RP18 plates by use of mobile phases containing phosphate buffer and different amounts of six modifiers — acetone, acetonitrile, dioxane, isopropanol, methanol, and tetrahydrofuran. Plates were visualized under UV irradiation at λ = 254 nm, and scanned with a densitometer in multi-wavelength scan mode. Optimum modifier concentrations were also investigated on RP8 and CN plates for comparison. The linearity of relationships between RM and modifier volume fraction, molar fraction, and the logarithm of the molar fraction was calculated. Most results fitted the Snyder-Soczewiński equation with r > 0.95; for almost half r > 0.99. Separation of all the drugs was achieved on RP18 plates with mobile phase containing 70% dioxane in pH 7.60 phosphate buffer.

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