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  • 1 Medical University of Lublin Department of Medicinal Chemistry 4 Jaczewskiego Str. 20-090 Lublin Poland
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Chromatographic behavior in normal-phase thin-layer chromatography has been investigated for six atypical antipsychotic drugs (amisulpride, clozapine, olanzapine, quetiapine, risperidone, and ziprasidone). The drugs were separated on silica gel, alumina, NH 2 , CN, diol, and polyamide plates with mixtures of n -hexane and six polar modifiers (acetone, dioxane, diethylamine, ethanol, isopropanol, and tetrahydrofuran) as mobile phases. The linearity of relationships between RM and volume fraction of modifier, the logarithm of the volume fraction, the molar fraction, and the logarithm of the molar fraction was tested. The results usually fitted the Snyder-Soczewiński equation, with r > 0.9. The best separation was achieved on silica gel plates with ethanol- n -hexane, 1 + 1 ( v/v ), containing 1.5% aqueous ammonia, as mobile phase.

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