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  • 1 Skubiszewski Medical University Department of Medicinal Chemistry Jaczewskiego 4 20-090 Lublin Poland
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The normal-phase thin-layer chromatographic behavior of five statin-like drugs — atorvastatin, cerivastatin, fluvastatin, lovastatin, and simvastatin — has been investigated. Chromatograms on silica gel, diol, and CN layers were developed with binary mobile phases containing hexane and a polar modifier in different proportions. The RF values obtained with all the mobile phases were then used to calculate Snyder-Soczewinski equations, assuming linear dependence of RM on the volume fraction of the mobile phase modifier, on the mole fraction of the modifier, and on their logarithms. The correlation between regression coefficients within and between models were investigated in depth. The coincidence between regression coefficients were also investigated by calculating Spearman’s rank correlation, and the similarity between modifiers was also checked by use of dendrograms.

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