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  • 1 Medical University of Lublin Department of Medicinal Chemistry Jaczewskiego 4 20-090 Lublin Poland
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Two new simple and accurate methods for determination of quetiapine in tablets-normal phase (NP) and reversed-phase (RP) high performance thin layer chromatography (HPTLC), each with densitometric and videodensitometric detection, were developed and validated. NP-HPTLC was developed with HPTLC silica F 254 plates and hexane-dioxane-propylamine 1:9:0.4 ( v/v ) as mobile phase. RPHPTLC was carried out using HPTLC RP8 F 254 plates with tetrahydrofuran-phosphate buffer, pH 9.0, 5:5 ( v/v ) as mobile phase. The silica gel plates were developed to a distance of 9 cm and RP8 plates to a distance of 4.5 cm. Both analyses were performed in horizontal chambers and scanned with a densitometer at 243 nm and a video-densitometer at 254 nm. Calibration plots were linear in the range 0.2–1.2 μg quetiapine per spot for NP-HPTLC and in the range 0.1–1.1 μg for RP-HPTLC. The precision and accuracy of the four methods were fully compared and no significant differences were observed. The methods can be used in routine pharmaceutical analysis.

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