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  • 1 Medical University of Lublin Department of Medicinal Chemistry, Faculty of Pharmacy Jaczewskiego 4 20-090 Lublin Poland
  • 2 Medical University of Lublin Department of Medical Chemistry, Faculty of Medicine Staszica 4 20-081 Lublin Poland
  • 3 Nicolaus Copernicus University of Torun Department of Organic Chemistry, Faculty of Pharmacy Skłodowskiej-Curie 9 85-094 Bydgoszcz Poland
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The lipophilicity, log P , of 27 novel imidazo[2,1- c ][1,2,4]triazine derivatives with strong biological activity has been determined by reversed-phase thin-layer chromatography. The compounds were chromatographed on RP18 plates with methanol-water binary mobile phases containing different proportions of methanol. RM values for pure water were then extrapolated from the linear Soczewińki-Wachtmeister equation. Twelve compounds with known literature log P values acted as a reference calibration data set for computation of experimental log P values. The results obtained were compared, by principal-components analysis, with those obtained by use of nine computational methods.

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