The lipophilicity, log
, of 27 novel imidazo[2,1-
][1,2,4]triazine derivatives with strong biological activity has been determined by reversed-phase thin-layer chromatography. The compounds were chromatographed on RP18 plates with methanol-water binary mobile phases containing different proportions of methanol.
values for pure water were then extrapolated from the linear
equation. Twelve compounds with known literature log
values acted as a reference calibration data set for computation of experimental log
values. The results obtained were compared, by principal-components analysis, with those obtained by use of nine computational methods.
K. Sztanke, T. Tkaczyński
, Acta Pol. Pharm. — Drug Res.