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  • 1 Medical University of Lublin Department of Medicinal Chemistry Jaczewskiego 4 20-090 Lublin Poland
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Two new simple and accurate HPTLC methods for analysis of ziprasidone in capsules have been developed and validated. The first method was normal phase chromatography on silica gel F 254 HPTLC plates with hexane-dioxane-propylamine 1:9:0.4 ( v/v ) as mobile phase. The second method was reversed phase chromatography on RP8 F 254 HPTLC plates with tetrahydrofuran-pH 9.0 phosphate buffer 5:5 ( v/v ) as mobile phase. The silica gel plates were developed to a distance of 9 cm and the RP8 plates to a distance of 4.5 cm. Both analyses were performed in horizontal chambers and the plates were scanned by videodensitometry at 254 nm. The calibration plots were linear in the ranges 0.2–1.2 μg and 0.1–1.1 μg ziprasidone (per spot) for the NP-HPTLC and RP-HPTLC methods, respectively. The precision and accuracy of the methods were fully compared between themselves and also with the control method — classical densitometry at 243 nm. No significant differences were observed. The NP-HPTLC method was also used for study of the stability of ziprasidone in solutions. The methods can be used for routine quality-control analysis.

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