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  • 1 Medical University of Lublin Department of Physical Chemistry Staszica 6 20-081 Lublin Poland
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We have investigated the use of pressurized planar electrochromatography (PPEC) and planar chromatography (TLC) for reversed-phase separation of a mixture of acetylsalicylic acid, caffeine, and acetaminophen. The mixture was separated on C18 plates; the mobile phase was prepared from acetonitrile (ACN), buffer, and bidistilled water. The effects of operating conditions such as mobile phase composition, type of the stationary phase, and mobile phase buffer pH on migration distance, separation selectivity, and separation time in TLC and PPEC were compared. The results showed that pressurized planar electrochromatography of these drugs is characterized by faster separation, better performance, and different separation selectivity. In conclusion, PPEC is a very promising mode for future application in pharmaceutical analysis.

  • D. Nurok, J.M. Koers, A.L. Nowotny, M.A. Carmichael, J.J. Kosiba, R.E. Santini, G.L. Hawkins, R.W. Reploge, Anal. Chem. 76 (2004) 1690–1695.

    Reploge R.W. , '' (2004 ) 76 Anal. Chem. : 1690 -1695.

  • G. Chen, Y. Zhu, Y. Wang, X. Xu, T. Lu, Current Med. Chem. 13 (2006) 2467–2485.

    Lu T. , '' (2006 ) 13 Current Med. Chem. : 2467 -2485.

  • B. Chenkvetadze, J. Chromatogr. A 1168 (2007) 45–70.

    Chenkvetadze B. , '' (2007 ) A1168 J. Chromatogr. : 45 -70.

  • T.K. Natishan, J. Liq. Chromatogr. 28 (2005) 1115–1160.

    Natishan T.K. , '' (2005 ) 28 J. Liq. Chromatogr. : 1115 -1160.

  • L. Suntornsuk, J. Chromatogr. Sci. 45 (2007) 559–577.

    Suntornsuk L. , '' (2007 ) 45 J. Chromatogr. Sci. : 559 -577.

  • J. Zhang, J. Koneèny, Z. Glatz, J. Hoogmattens, A. Van Schepdael, Current Anal. Chem. 3 (2007) 197–217.

    Schepdael A. , '' (2007 ) 3 Current Anal. Chem. : 197 -217.

  • A. Van Eeckhaut, Y. Michotte, Electrophoresis 27 (2006) 2880–2895.

    Michotte Y. , '' (2006 ) 27 Electrophoresis : 2880 -2895.

  • W.F. Patton, V. Panchagnula, E. Rockney, I.S. Krull, J. Liq. Chromatogr. 29 (2006) 1177–1218.

    Krull I.S. , '' (2006 ) 29 J. Liq. Chromatogr. : 1177 -1218.

  • V. Panchagnula, A. Mikulskis, L. Song, Y. Wang, M. Wang, T. Knubovets, E. Scrivener, E. Golenko, I. S. Krull, M. Schulz, H.-E. Hauck, W.F. Patton, J. Chromatogr. A 1155 (2007) 112–123.

    Patton W.F. , '' (2007 ) 1155 J. Chromatogr. A : 112 -123.

  • B. Polak, A. Hałka, T. H. Dzido, J. Planar Chromatogr. 21 (2008) 165–169.

    Dzido T. H. , '' (2008 ) 21 J. Planar Chromatogr. : 165 -169.

  • A.G. Howard, T. Shafik, F. Moffat, I.D. Wilson, J. Chromatogr. A 844 (1999) 333–340.

    Wilson I.D. , '' (1999 ) 844 J. Chromatogr. A : 333 -340.

  • T. Halkina, J. Sherma, Acta Chromatogr. 17 (2006) 250–260.

    Sherma J. , '' (2006 ) 17 Acta Chromatogr. : 250 -260.

  • A.Z. David, E. Mincsovics, I. Antal, E. Furdyga, Z. Zsigmond, I. Klebovich, J. Planar Chromatogr. 19 (2006) 355–360.

    Klebovich I. , '' (2006 ) 19 J. Planar Chromatogr. : 355 -360.

  • J.T. Franeta, D.D. Agbaba, S.M. Eric, S.P. Pavkov, S.D. Vladimirov, J. Pharm. Biomed. Anal. 24 (2001) 1169–1173.

    Vladimirov S.D. , '' (2001 ) 24 J. Pharm. Biomed. Anal. : 1169 -1173.

  • J.T. Franeta, D. Agbaba, S. Eric, S. Pavkov, M. Aleksic, S. Vladimirov, Il Farmaco 57 (2002) 709–713.

    Vladimirov S. , '' (2002 ) 57 Il Farmaco : 709 -713.

  • A.W. Abu-Qare, M.B. Abou-Donia, J. Pharm. Biomed. Anal. 26 (2001) 939–947.

    Abou-Donia M.B. , '' (2001 ) 26 J. Pharm. Biomed. Anal. : 939 -947.

  • M.J. Martin, F. Pablos, A.G. Gonzalez, Talanta 49 (1999) 453–459.

    Gonzalez A.G. , '' (1999 ) 49 Talanta : 453 -459.

  • V. Pucci, R. Mandrioli, M.A. Raggi, S. Fanali, Electrophoresis 25 (2004) 615–621.

    Fanali S. , '' (2004 ) 25 Electrophoresis : 615 -621.

  • T.H. Dzido, P.W. Plocharz, P. Ślązak, Anal. Chem. 78 (2006) 4713–4721.

    Ślązak P. , '' (2006 ) 78 Anal. Chem. : 4713 -4721.

  • T.H. Dzido, J. Mróz, G. Jóźwiak, J. Planar Chromatogr. 17 (2004) 404–410.

    Jóźwiak G. , '' (2004 ) 17 J. Planar Chromatogr. : 404 -410.

  • J. Jiskra, H.A. Claessens, C.A. Cramers, J. Sep. Sci. 26 (2003) 1305–1330.

    Cramers C.A. , '' (2003 ) 26 J. Sep. Sci. : 1305 -1330.

  • D. Nurok, J.M. Koers, D.A. Nyman, W.-M. Liao, J. Planar Chromatogr. 14 (2001) 409–414.

    Liao W.-M. , '' (2001 ) 14 J. Planar Chromatogr. : 409 -414.

  • T.H. Dzido, P.W. Płocharz, A. Klimek-Turek, A. Torbicz, B. Buszewski, J. Planar Chromatogr. 21 (2008) 295–298.

    Buszewski B. , '' (2008 ) 21 J. Planar Chromatogr. : 295 -298.

  • K.D. Bartle, P. Myers, J. Chromatogr. A 916 (2001) 3–23.

    Myers P. , '' (2001 ) 916 J. Chromatogr. A : 3 -23.

  • D. Nurok, J.M. Koers, A. Carmichael, J. Chromatogr. A 983 (2003) 247–253.

    Carmichael A. , '' (2003 ) 983 J. Chromatogr. A : 247 -253.

  • D. Nurok, M.C. Frost, D.M. Chenoweth, J. Chromatogr. A 903 (2000) 211–217.

    Chenoweth D.M. , '' (2000 ) 903 J. Chromatogr. A : 211 -217.

  • T.H. Dzido, R. Majewski, B. Polak, W. Gołkiewicz, E. Soczewiński, J. Planar Chromatogr. 16 (2003) 176–182.

    Soczewiński E. , '' (2003 ) 16 J. Planar Chromatogr. : 176 -182.

  • P.A. Tate, J. G. Dorsey, J. Chromatogr. A 1079 (2005) 317–327.

    Dorsey J. G. , '' (2005 ) 1079 J. Chromatogr. A : 317 -327.

  • D. Nurok, J. Chromatogr. A 1044 (2004) 83–96.

    Nurok D. , '' (2004 ) 1044 J. Chromatogr. A : 83 -96.

  • A.L. Novotony, D. Nurok, R.W. Reploge, G.L. Hawkins, R.E. Santini, Anal. Chem. 78 (2006) 2823–2831.

    Santini R.E. , '' (2006 ) 78 Anal. Chem. : 2823 -2831.

  • T.H. Dzido, R. Majewski, in: Proceedings of the International Symposium on Planar Separations, Budapest, 2003, p. 129.

  • P.W. Płocharz, T.H. Dzido, P. Ślązak, G.W. Jóźwiak, A. Torbicz, J. Chromatogr. A 1170 (2007) 91–100.

    Torbicz A. , '' (2007 ) 1170 J. Chromatogr. A : 91 -100.

  • T.H. Dzido, P.W. Płocharz, P. Ślązak, A. Hałka, Anal. Bioanal. Chem. 391 (2008) 2111–2118.

    Hałka A. , '' (2008 ) 391 Anal. Bioanal. Chem. : 2111 -2118.

  • C.F. Poole, in Sz. Nyiredy (ed.), Planar Chromatography — A Retrospective View for the Third Millennium, Springer, Budapest, 2001.

    Poole C.F. , '', in Planar Chromatography — A Retrospective View for the Third Millennium , (2001 ) -.

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