Authors:
I. BorosUniversity Medical School of Debrecen PET Centre Nagyerdei krt 98 H-4012 Debrecen Hungary

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G. HorváthUniversity Medical School of Debrecen PET Centre Nagyerdei krt 98 H-4012 Debrecen Hungary

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S. LehelUniversity Medical School of Debrecen PET Centre Nagyerdei krt 98 H-4012 Debrecen Hungary

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T. MáriánUniversity Medical School of Debrecen PET Centre Nagyerdei krt 98 H-4012 Debrecen Hungary

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Z. KovácsUniversity Medical School of Debrecen Department of Pharmacology Nagyerdei krt 98 H-4012 Debrecen Hungary

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J. SzentmiklósiInstitute of Nuclear Research of the Hungarian Academy of Science Bem tér 18/C H-4026 Debrecen Hungary

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G. TóthInstitute of Isotopes Co. Ltd. P.O. Box 851 H-1525 Budapest Hungary

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L. TrónUniversity Medical School of Debrecen PET Centre Nagyerdei krt 98 H-4012 Debrecen Hungary

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Abstract  

[11C]-labeled form of ten A2a adenosine receptor specific 8-styryl-7-methyl-xanthine derivatives ([11C]-caffeines) were synthesised by N-methylation of the corresponding 8-styryl-xanthine derivatives using [11C]-methyl iodide in optimized reaction conditions. The results show that the [11C]-methylations take place with excellent radiochemical yields (35–93%), and can be utilised easily in online preparations. These labeled ligands may facilitate the positron emission tomographic (PET) investigation of adenosine A2a receptors.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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