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  • 1 Ege University Institute of Nuclear Sciences, Department of Nuclear Applications Institute of Nuclear Sciences, Department of Nuclear Applications 35100 Bornova, Izmir Turkey
  • | 2 Afyon Kocatepe University Banaz Meslek Yuksekokulu Cay Meslek Yuksekokulu Cay, Afyon Turkey
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Abstract  

An estrogen derivative 1-(3, 17-α-estradiolyl propin-1-yl-3-(1,4,8,11-tetraazacyclotetradecyl)-propanate (ESTACPA) was synthesized. The product was purified by HPLC and characterized by NMR and IR spectroscopy. The synthesized compound was labeled with 99mTc. The biodistribution studies were performed on female Albino Wistar rats. The rats were sacrificed and their organs were removed. The radioactivities of the organs were counted using a gamma-counter. The activity per gram tissue was calculated and time versus activity curves were generated. The 99mTc-ESTACPA uptake by the uterus and ovary such as ER-rich tissues, were observed. The pancreas and stomach also showed a significant uptake.