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  • 1 Chinese Academy of Sciences Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics Beijing 100049 P.R. China
  • | 2 Graduate School of Chinese Academy of Sciences Beijing 100049 P.R. China
  • | 3 Shenzhen University Institute of Nuclear Technology Shenzhen 518060 P.R. China
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Abstract  

After an acute exposure to lanthanum chloride, the pharmacokinetics of calcium uptake in rats was studied by radioactive 47Ca tracer. The accumulated doses of calcium in the left femurs during 24 hours were determined. The results showed that the area under the curves (AUC), specific activity of maximal blood 47Ca concentration (Cmax), distribution rate constant (Ka) and the accumulated dose of calcium in the left femur decreased while time to Cmax (Tpeak) increased with the rising dosage of lanthanum exposure. It indicated that lanthanum expose had a negative effect on calcium absorption.