Journal of Thermal Analysis and Calorimetry
Volume/Issue:
Volume 102: Issue 1
Amorphization of a crystalline active pharmaceutical ingredient and thermoanalytical measurements on this glassy form
Authors:
Orsolya Jójárt-Laczkovich Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6, 6720 Szeged, Hungary

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Piroska Szabó-Révész Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6, 6720 Szeged, Hungary

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Pages:
243–247
Online Publication Date:
04 Nov 2009
Publication Date:
01 Oct 2010
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10973-009-0530-5
Keywords:
Amorphization; Clopidogrel hydrogen sulfate; DSC; FT-IR spectroscopy; Solvent method; T g ; X-ray powder diffraction
Open access

Abstract  

Amorphization is nowadays a method that is frequently applied in the pharmaceutical industry. The primary aim of this study is to achieve the amorphization of clopidogrel hydrogen sulphate as an active pharmaceutical ingredient (API) with various solvents and to choose the most suitable one. A secondary aim was to determine the glass-transition temperature (Tg) of this API and to classify it as a good or poor glass former. To investigate the amorphous form, differential scanning calorimetry, X-ray powder diffraction, and FT-IR analysis were applied. The melting point (Tm) was 177.4 °C (450.6 K), and Tg was determined to be 88.9 °C (362.1 K). The quotient Tg/Tm was 0.80, and this API was therefore classified as a good glass former.

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Cover Journal of Thermal Analysis and Calorimetry
Journal of Thermal Analysis and Calorimetry
Print ISSN:
1388-6150
Online ISSN:
1572-8943

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation		 1969
Volumes
per Year		 1
Issues
per Year		 24
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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