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  • 1 University of Pécs Department of Surgical Research and Techniques, Faculty of Medicine Pécs Hungary 7624 Kodály Z. str. 20 Pécs Hungary 7624 Kodály Z. str. 20
  • | 2 General Teaching Hospital Linz L. Boltzmann Institute for Laparoscopic Surgery, Department of Surgery II. Linz Austria 4020 Krankenhaus str. 9 Linz Austria 4020 Krankenhaus str. 9
  • | 3 University of Pécs Department of Radiology, Faculty of Medicine Pécs Hungary 7624 Szigeti str. 12 Pécs Hungary 7624 Szigeti str. 12
  • | 4 University of Pécs Institute for Forensic Medicine, Faculty of Medicine Pécs Hungary 7624 Szigeti str. 12 Pécs Hungary 7624 Szigeti str. 12
  • | 5 University of Pécs Department of Orthopedics, Faculty of Medicine Pécs Hungary 7624 Szigeti str. 12 Pécs Hungary 7624 Szigeti str. 12
  • | 6 University of Pécs Institute of Biophysics, Faculty of Medicine Pécs Hungary 7624 Szigeti str. 12 Pécs Hungary 7624 Szigeti str. 12
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Abstract  

Massive bleeding from oesophagus varices presents a life threatening complication of liver cirrhosis. No effective method of treatment is available until now, that would guarantee high grade of patient wellness during the conditioning and investigation phase until the definitive treatment could be introduced. The fact that we have not found any report in the literature about self-expandable metal stents (SEMS) application in acute variceal bleeding had encouraged us to use stents usually used for oesophageal malignancy and furthermore develop a special stent for this individual indication. The aim of this study was to evaluate the tissue response to oesophagus stent designed for stop acute variceal bleeding in animal experiment in compare with another stent used for iatrogenic treatment of different strictures of the oesophagus. Tissue oxygen saturation (StO2) measurement was performed before and after the implantation of the stents. Macroscopic and histological investigations of the stented oesophagus segments were observed after 10 days. Differential scanning calorimeter (DSC) is a well-established method for the demonstration of thermal consequences of local and global conformational changes in biological systems, but it has never been used for the investigation of the oesophagus. According to our results the thermal denaturation of intact oesophagus, its mucosa and muscle fragments revealed significant differences compared to healthy sample in favour of the new stent.

Manuscript Submission: HERE

  • Impact Factor (2019): 2.731
  • Scimago Journal Rank (2019): 0.415
  • SJR Hirsch-Index (2019): 87
  • SJR Quartile Score (2019): Q3 Condensed Matter Physics
  • SJR Quartile Score (2019): Q3 Physical and Theoretical Chemistry
  • Impact Factor (2018): 2.471
  • Scimago Journal Rank (2018): 0.634
  • SJR Hirsch-Index (2018): 78
  • SJR Quartile Score (2018): Q2 Condensed Matter Physics
  • SJR Quartile Score (2018): Q2 Physical and Theoretical Chemistry

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Journal of Thermal Analysis and Calorimetry
Language English
Size A4
Year of
Foundation
1969
Volumes
per Year
4
Issues
per Year
24
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1388-6150 (Print)
ISSN 1588-2926 (Online)

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