The influence of H2O–EtOH and H2O–Acetone mixed solvents at various compositions on the thermodynamics of complex formation reaction between crown ether 18-crown-6
(18C6) and glycine (Gly) was studied. The standard thermodynamic parameters of the complex [Gly18C6] (log K°, ΔrH°, ΔrS°) were calculated from thermochemical data at 298.15 K obtained by titration calorimetry. The complex stability and its formation
enthalpy increase with increasing the non aqueous component concentration in both mixed solvents. The thermodynamic data were
discussed on the basis of the solvation thermodynamic approach and the solvation contributions of the reagents and of the
complex to the complex stability were analyzed.