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  • 1 Semmelweis Egyetem, Városmajori Szív- és Érgyógyászati Klinika, Budapest, Magyarország; Semmelweis University, Faculty of Medicine, Heart and Vascular Centre, Budapest, Hungary
  • | 2 Semmelweis Egyetem, Egészségügyi Technológiaértékelő és Elemzési Központ, Budapest, Magyarország; Semmelweis University, Center for Health Technology Assessment, Budapest, Hungary
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Összefoglaló. A HUNgarian COronaVirus disease-19 Epidemiological Research (H-UNCOVER) vizsgálat egy országos szintű reprezentatív felmérés volt, melyet az Innovációs és Technológiai Minisztérium (ITM) támogatásával végzett el a négy orvostudományi képzést folytató magyar egyetem a Központi Statisztikai Hivatallal (KSH) együttműködve. A vizsgálat célja az volt, hogy egy reprezentatív mintán keresztül felmérje a magyar lakosság SARS-CoV-2 átfertőzöttségét, és támaszul szolgáljon a koronavírus első hulláma kapcsán meghozott restriktív intézkedések utáni lazításra. A világszinten is jelentős méretű vizsgálat alacsony átfertőzöttségi arányt mutatott, így nemcsak a restriktív intézkedések hatékonyságát mutatta meg, de egy biztos járványügyi támaszt jelentett a gazdaság újranyitásának tervezéséhez.

Summary. Close to the end of the first wave of the COVID-19 pandemic in Europe, many countries started to consider the possibility of reopening their economy, and lifting some of the containment measures introduced in the previous weeks. Such a decision is utterly complicated, as reopening might easily lead to an increase in active SARS-CoV-2 cases, but a delay puts an almost unbearable burden on the country’s economy. The objective of the HUNgarian COronaVirus disease-19 Epidemiological Research (H-UNCOVER) study was to conduct a cross-sectional survey among the Hungarian population to estimate the total number of infectious cases and the prevalence of prior SARS-CoV-2 exposure, and by using these data help to plan an exit strategy. The H-UNCOVER study was performed by the 4 medical universities in Hungary (Semmelweis University, University of Pécs, University of Debrecen and University of Szeged) with the help of the Central Statistical Office, Hungarian National Ambulance Service, Governmental offices and General Practitioners.

The study was initiated 50 days after the Hungarian restrictions and performed between 1-16 May. With the help of the Central Statistical Office, 17,787 people were selected to represent the Hungarian population of 14 years or older living in private households (n=8,283,810). SARS-CoV-2 PCR and blood tests were performed to assess the prevalence of active infection and seropositivity. These tests were accompanied by a questionnaire about symptoms, comorbidities, and COVID-19 contacts. More specifically, questions included topics about home office, going abroad after the 1st of March, or possible contacts with COVID-19 positive, or quarantined individuals, as well as symptoms which might be due to COVID-19 infection.

Altogether 67.7% of the selected individuals participated in some form in the study, which is an exceptionally high number compared to such studies. 10,502 individuals had SARS-CoV-2 PCR testing and 10,501 people had a blood test to assess SARS-CoV-2 IgG levels. Of the tested individuals, three had positive PCR and 69 had positive serological tests. Population estimates of the number of SARS-CoV-2 infections and seropositivity were 2,421 and 56,439, respectively, thus the active infection rate (2.9/10,000, 95% confidence interval: 0-6.7/10,000) and the prevalence of prior SARS-CoV-2 exposure (68/10,000, 95% confidence interval: 50-86/10,000) were low. A total of 10,474 individuals completed the questionnaire. Self-reported loss of smell or taste and body aches were significantly more frequent among those with SARS-CoV-2.

Our study suggested that the early containment measures initiated by the Government of Hungary were effective in preventing the escalation of the first wave of COVID-19 in Hungary. We also found that the highest prevalence of the disease was in Budapest, and those who attended their workplace on a regular basis, travelled abroad after the 1st of March, or contacted with a COVID-19 positive or quarantined individual had a higher tendency to become infected. In conclusion, the H-UNCOVER study supported the exit strategy after the first wave of COVID-19 in Hungary.

  • 1

    Jie, C., Li, F., & Shi, Z. L. (2019) Origin and Evolution of Pathogenic Coronaviruses. Nature Reviews Microbiology, Vol. 17. No. 3. pp. 181–192. http://www.nature.com/nrmicro [Letöltve: 2021. 06. 12.]

  • 2

    Dickson, E. Palmateer, N. E., Murray, J., Robertson, C., Waugh, C., Wallace, L. A., Mathie, L., Heatlie, K., Mavin, S., Gousias, P., Von Wissman, B., Goldberg, D. J., & McAuley, A. (2021) Enhanced Surveillance of COVID-19 in Scotland: Population-Based Seroprevalence Surveillance for SARS-CoV-2 during the First Wave of the Epidemic. Public Health, Vol. 190. pp. 132–134. https://pubmed.ncbi.nlm.nih.gov/33453689/ [Letöltve: 2021. 06. 12.]

  • 3

    Grasselli, G., Pesenti, A., & Cecconi, M. (2020) Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy. JAMA, Vol. 323. No. 16. pp. 1545–1546. .

    • Crossref
    • Export Citation
  • 4

    Gudbjartsson, D. F., Helgason, A., Jonsson, H, Magnusson, O. T., Melsted, P., Norddahl, G. L., Saemundsdottir, J., Sigurdsson, A., Sulem, P., Agustsdottir, A. B., Eiriksdottir, B., Fridriksdottir, R., Gardarsdottir, E. E., Georgsson, G., Gretarsdottir, O. S., Gudmundsson, K. R., Gunnarsdottir, T. R., Gylfason, A., Holm, H., Jensson, B. O., Jonasdottir, A., Jonsson, F., Josefsdottir, K. S., Kristjansson, T., Magnusdottir, D. N., le Roux, L., Sigmundsdottir, G., Sveinbjornsson, G., Sveinsdottir, K. E., Sveinsdottir, M., Thorarensen,E. A., Thorbjornsson, B., Löve, A., Masson, G., Jonsdottir, I., Möller, A. D., Gudnason, T., Kristinsson, K. G., Thorsteinsdottir, U., & Stefansson, K. (2020) Spread of SARS-CoV-2 in the Icelandic Population. New England Journal of Medicine, Vol. 382. No. 24. pp. 2302–2315. https://www.nejm.org/doi/full/10.1056/NEJMoa2006100

  • 5

    Hasnain, M., Pasha, M. F., & Ghani, I. (2020) Combined Measures to Control the COVID-19 Pandemic in Wuhan, Hubei, China: A Narrative Review. Journal of Biosafety and Biosecurity, Vol. 2. No. 2. pp. 51–57. .

    • Crossref
    • Export Citation
  • 6

    Herzog, S., De Bie, J., Abrams, S., Wouters, I., Ekinci, E., Patteet, L., Coppens, A., De Spiegeleer, S., Beutels, P., Van Damme, P., Hens, N., & Theeten, H. (2020) Seroprevalence of IgG Antibodies against SARS Coronavirus 2 in Belgium – a Serial Prospective Cross-Sectional Nationwide Study of Residual Samples. medRxiv, 2020. 06. 08.; 20125179. https://doi.org/10.1101/2020.06.08.20125179 [Letöltve: 2021. 06. 12.]

  • 7

    Hsieh, Y.-H., King, C.-C., Chen, C. W. S., Ho, M.-S., Hsu, Sze-Bi, Wu, Yi-Chun (2007) Impact of Quarantine on the 2003 SARS Outbreak: A Retrospective Modeling Study. Journal of Theoretical Biology, Vol. 244. No. 4. pp. 729–736. .

    • Crossref
    • Export Citation
  • 8

    Karsai, M., Koltai, J., Vásárhelyi, O., & Röst, G. (2020) Hungary in Masks/‘Maszk’ in Hungary. Corvinus Journal of Sociology and Social Policy, Vol. 11. No. 2. pp. 139–146. http://cjssp.uni-corvinus.hu/index.php/cjssp/article/view/531 [Letöltve: 2021. 06. 12.]

  • 9

    Kemenesi, G., Zeghbib, S., Somogyi, B. A., Tóth, G. E., Bányai, K., Solymosi, N., Szabo, P. M., Szabó, I., Bálint, Á., Urbán, P., Herczeg, R., Gyenesei, A., Nagy, Á., Pereszlényi, Cs. I., Babinszky, G. Cs., Dudás, G., Terhes, G., Zöldi, V., Lovas, R., Tenczer, Sz., Kornya, L., Jakab, F. (2020) Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix. https://doi.org/10.1101/2020.05.06.080119

  • 10

    Kislaya, I., Gonçalves, P., Barreto, M., de Sousa, R., Garcia, A. C., Matos, R., Guiomar, R., & Rodrigues, A. P. (2021) Seroprevalence of SARS-CoV-2 Infection in Portugal in May-July 2020: Results of the First National Serological Survey (ISNCOVID-19). Acta Medica Portuguesa, Vol. 34. No. 2. pp. 87–94. https://pubmed.ncbi.nlm.nih.gov/33641702/ [Letöltve: 2021. 06. 12.]

  • 11

    Espenhain, L., Tribler, S., Jørgensen, C. S., Hansen, C. H., Sönksen, U. W., Ethelberg, S. (2020) Title Prevalence of SARS-CoV-2 Antibodies in Denmark 2020: Results from Nationwide, Population-Based Sero-Epidemiological Surveys. medRxiv, 2021. 04. 07.; 21254703. https://doi.org/10.1101/2021.04.07.21254703 [Letöltve: 2021. 06. 12.]

  • 12

    Maver Vodičar, P., Oštrbenk Valenčak, A., Zupan, B., Županc, T. A., Kurdija, S., Korva, M., Petrovec, M., Demšar, I., Knap, N., Štrumbelj, E., Vehovar, V., & Poljak, M. (2020) Low Prevalence of Active COVID-19 in Slovenia: A Nationwide Population Study of a Probability-Based Sample. Clinical Microbiology and Infection, Vol. 26. No. 11. pp. 1514–1519. https://doi.org/10.1016/j.cmi.2020.07.013

  • 13

    Merkely, B., Szabó, A. J., Kosztin, A., Berényi, E., Sebestyén, A., Lengyel, Cs., Merkely, G., Karády, J., Várkonyi, I., Papp, Cs., Miseta, A., Betlehem, J., Burián, K., Csóka, I., Vásárhelyi, B., Ludwig, E., Prinz, Gy., Sinkó, J., Hankó, B., Varga, P., Fülöp, G. Á., Mag, K., & Vokó, Z. (2020) Novel Coronavirus Epidemic in the Hungarian Population, a Cross-Sectional Nationwide Survey to Support the Exit Policy in Hungary. GeroScience, Vol. 42. No. 4. pp. 1063–1074. Published online 2020 Jul 17. .

    • Crossref
    • Export Citation
  • 14

    Morens, D. M., & Fauci, A. S. (2012) Emerging Infectious Diseases in 2012: 20 Years after the Institute of Medicine Report. Vol. 3. No. 6. pp. e00494-12. Published online 2012 Dec 11. .

    • Crossref
    • Export Citation
  • 15

    Morens, D. M., Folkers, G. K., & Fauci, A. S. (2004) The Challenge of Emerging and Re-Emerging Infectious Diseases. Nature, Vol. 430. No. 6996. pp. 242–249. .

    • Crossref
    • Export Citation
  • 16

    Myoung-don Oh, Wan Beom Park, Sang-Won Park, Pyoeng Gyun Choe, Ji Hwan Bang, Kyoung-Ho Song, Eu Suk Kim, Hong Bin Kim, Nam Joong Kim (2018) Middle East Respiratory Syndrome: What We Learned from the 2015 Outbreak in the Republic of Korea. Korean Journal of Internal Medicine, Vol. 33. No. 2. pp. 233–246. Published online 2018 Feb 27. .

    • Crossref
    • Export Citation
  • 17

    Poljak, M., Oštrbenk Valenčak, A., Štrumbelj, E., Maver Vodičar, P., Vehovar, V., Resman Rus, K., Korva, M., Knap, N., Seme, K., Petrovec, M., Zupan, B., Demšar, J., Kurdija, S., & Avšič Županc, T. (2021) Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 in Slovenia: Results of Two Rounds of a Nationwide Population Study on a Probability-Based Sample, Challenges and Lessons Learned. Clinical Microbiology and Infection, Vol. 27. No. 7. pp. 1039.e1–1039.e7. .

    • Crossref
    • Export Citation
  • 18

    Pollán, M., Pérez-Gómez, B., Pastor-Barriuso, R., Oteo, J., Hernán, M. A., Pérez-Olmeda, M., Sanmartín, J. L., Fernández-García, A., Cruz, I., de Larrea, N. F., Molina, M., Rodríguez-Cabrera, F., Martín, M., Merino-Amador, P., Paniagua, J. L., Muñoz-Montalvo, J. F., Blanco, F., Yotti, R., & ENE-COVID Study Group (2020) Prevalence of SARS-CoV-2 in Spain (ENE-COVID): A Nationwide, Population-Based Seroepidemiological Study. The Lancet, Vol. 396. No. 10250. pp. 535–544. https://doi.org/10.1016/

  • 19

    Röst, G., Bartha, F. A., Bogya, N., Boldog, P., Dénes, A., Ferenci, T., Horváth, K. J., Juhász, A., Nagy, Cs., Tekeli, T., Vizi, Zs., & Oroszi, B. (2020). Early Phase of the COVID-19 Outbreak in Hungary and Post-Lockdown Scenarios. Viruses, Vol. 12. No. 7. p. 708. www.mdpi.com/journal/viruses;

  • 20

    Stefanelli, P., Bella, A., Fedele, G., Pancheri, S., Leone,P., Vacca, P., Neri, A., Carannante, A., Fazio, C., Benedetti, E., Fiore, S., Fabiani, C., Simmaco, M., Santino, I., Zuccali, M. G., Bizzarri, G., Magnoni, R., Benetollo, P. P., Merler, S., Brusaferro, S., Rezza, G., & Ferro, A. (2021) Prevalence of SARS-CoV-2 IgG Antibodies in an Area of Northeastern Italy with a High Incidence of COVID-19 Cases: A Population-Based Study. Clinical Microbiology and Infection, Vol. 27. No. 4. pp. 633.e1–633.e7. /pmc/articles/PMC7695553/

  • 21

    Szocska, M., Pollner, P., Schiszler, I., Joo, T., Palicz, T., McKee, M., Asztalos, A., Bencze, L., Kapronczay, M., Petrecz, P., Toth, B., Szabo, A., Weninger, A., Ader, K., Bacskai, P., Karaszi, P., Terplan, Gy., Tuboly, G., Sohonyai, A., Szoke, J., Toth, A., & Gaal, P. (2021) Countrywide Population Movement Monitoring Using Mobile Devices Generated (Big) Data during the COVID-19 Crisis. Scientific Reports, Vol. 11. No. 1. p. 5943. https://doi.org/10.1038/s41598-021-81873-6

  • 22

    Udugama, B., Kadhiresan, P., Kozlowski, H. N., Malekjahani, A., Osborne, M., Li, V. Y. C., Chen, H., Mubareka, S., Gubbay, J. B., & Chan, W. C. W. (2020) Diagnosing COVID-19: The Disease and Tools for Detection. ACS nano, Vol. 14. No. 4. pp. 3822–3835. .

    • Crossref
    • Export Citation
  • 23

    Vos, E. R. A., den Hartog, G., Schepp, R. M., Kaaijk, P., van Vliet, J., Helm, K., Smits, G., Wijmenga-Monsuur, A., Verberk, J. D. M., van Boven, M., van Binnendijk, R. S., de Melker, H. E., Mollema, L., van der Klis, F. R. M (2021) Nationwide Seroprevalence of SARS-CoV-2 and Identification of Risk Factors in the General Population of the Netherlands during the First Epidemic Wave. Journal of Epidemiology and Community Health, Vol. 75. No. 6. 489–495. http://jech.bmj.com/

  • 24

    Le Vu, S., Jones, G., Anna, F., Rose, T., Richard, J.-B., Bernard-Stoecklin, S., Goyard, S., Demeret, C., Helynck, O., Robin, C., Monnet, V., de Facci, L. P., Ungeheuer, M.-N., Léon, L., Guillois, Y., Filleul, L., Charneau, P., Lévy-Bruhl, D., van der Werf, S., & Noel, H. (2021) Prevalence of SARS-CoV-2 Antibodies in France: Results from Nationwide Serological Surveillance. Nature Communications, Vol. 12. No. 1. pp. 3025. http://www.nature.com/articles/s41467-021-23233-6

  • 25

    Wang, Ligui, Hui Chen, Shaofu Qiu, & Hongbin Song (2020) Evaluation of Control Measures for COVID-19 in Wuhan, China. Journal of Infection, Vol. 81. No. 2. pp. 318–356. Published online 2020 Apr 10. .

    • Crossref
    • Export Citation
  • 26

    Webster, R. G. (1997) Predictions for Future Human Influenza Pandemics. Journal of Infectious Diseases, Vol. 176 Suppl. 1. pp. S14–9. .

    • Crossref
    • Export Citation
  • 27

    Willeit, P., Krause, R., Lamprecht, B., Berghold, A., Hanson, B., Stelzl, E., Stoiber, H., Zuber, J., Heinen, R., Köhler, A., Bernhard, D., Borena, W., Doppler, C., von Laer, D., Schmidt, H., Pröll, J., Steinmetz, I., & Wagner, M. (2021) Prevalence of RT-QPCR-Detected SARS-CoV-2 Infection at Schools: First Results from the Austrian School-SARS-CoV-2 Prospective Cohort Study. The Lancet Regional Health - Europe 5: 100086. http://creativecommons.org/licenses/by/4.0/

  • 28

    World Health Organization (2020) Country & Technical Guidance - Coronavirus Disease (COVID-19). Environmental Protection, Vol 1. pp. 1–8.

  • 29

    Yang, Y., Peng, F., Wang, R., Guan, K., Jiang, T., Xu, G., Sun, J., & Chang C. (2020) The Deadly Coronaviruses: The 2003 SARS Pandemic and the 2020 Novel Coronavirus Epidemic in China. Journal of Autoimmunity, Vol. 109. 102434. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126544/

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Ministry of Interior
Science Strategy and Coordination Department
Address: H-2090 Remeteszőlős, Nagykovácsi út 3.
Phone: (+36 26) 795 906
E-mail: scietsec@bm.gov.hu

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Scientia et Securitas
Language Hungarian
English
Size A4
Year of
Foundation
2020
Publication
Programme
2020 Volume 1
Volumes
per Year
1
Issues
per Year
4
Founder Academic Council of Home Affairs and
Association of Hungarian PhD and DLA Candidates
Founder's
Address
H-2090 Remeteszőlős, Hungary, Nagykovácsi út 3.
H-1055 Budapest, Hungary Falk Miksa utca 1.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN ISSN 2732-2688

Editor-in-Chief:

  • Tamás NÉMETH 
    (Institute for Soil Sciences and Agricultural Chemistry, Centre for Agricultural Research
    Budapest, Hungary)

Managing Editor:

  • István SABJANICS (Ministry of Interior, Budapest, Hungary)

Editorial Board:

  • Melinda KOVÁCS (Szent István University Kaposvár Campus)Á
  • Miklós MARÓTH (Eötvös Loránd Research Network)
  • Charaf HASSAN (Budapest University of Technology and Economics)
  • Zoltán GYŐRI (Hungaricum Committee)
  • József HALLER (University of Public Service)
  • Attila ASZÓDI (Budapest University of Technology and Economics)
  • Zoltán BIRKNER (National Research, Development and Innovation Office)
  • Tamás DEZSŐ (Migration Research Institute)
  • Imre DOBÁK (University of Public Service)
  • András KOLTAY (University of Public Service)
  • Gábor KOVÁCS (University of Public Service)
  • József PALLO (University of Public Service)
  • Marcell Gyula GÁSPÁR (University of Miskolc)
  • Judit MÓGOR (Ministry of Interior National Directorate General for Disaster Management)
  • István SABJANICS (Ministry of Interior)
  • Péter SZABÓ (Hungarian University of Agriculture and Life Sciences (MATE))
  • Miklós SZÓCSKA (Semmelweis University)
  • János JÓZSA (Budapest University of Technology and Economics)
  • Valéria CSÉPE (Research Centre for Natural Sciences, Brain Imaging Centre)