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Balázs Váradi
varadi.balazs@science.unideb.hu
Balázs Váradi
Debreceni Egyetem, Természettudományi és Technológiai Kar, Kémiai Intézet, Fizikai Kémiai Tanszék, Debrecen, Magyarország
Debreceni Egyetem, Doktori Tanácsok és Iskolák, Természettudományi és Informatikai Doktori Tanács, Kémiai Tudományok Doktori Iskola, Debrecen, Magyarország
Atommagkutató Intézet, Debrecen, Magyarország
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Debreceni Egyetem, Doktori Tanácsok és Iskolák, Természettudományi és Informatikai Doktori Tanács, Kémiai Tudományok Doktori Iskola, Debrecen, Magyarország
Atommagkutató Intézet, Debrecen, Magyarország
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Gergő Zoltán Sajtos
Gergő Zoltán Sajtos
Debreceni Egyetem, Természettudományi és Technológiai Kar, Kémiai Intézet, Fizikai Kémiai Tanszék, Debrecen, Magyarország
Debreceni Egyetem, Doktori Tanácsok és Iskolák, Természettudományi és Informatikai Doktori Tanács, Kémiai Tudományok Doktori Iskola, Debrecen, Magyarország
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Debreceni Egyetem, Doktori Tanácsok és Iskolák, Természettudományi és Informatikai Doktori Tanács, Kémiai Tudományok Doktori Iskola, Debrecen, Magyarország
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Károly Brezovcsik
Károly Brezovcsik
Atommagkutató Intézet, Debrecen, Magyarország
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Zoltán Szűcs
Zoltán Szűcs
Atommagkutató Intézet, Debrecen, Magyarország
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Stefan Szedlacsek
Stefan Szedlacsek
Román Akadémia, Biokémiai Intézet, Bukarest, Románia
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Gábor Nagy
Gábor Nagy
ScanoMed Kft., Debrecen, Magyarország
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Gyula Tircsó
Gyula Tircsó
Debreceni Egyetem, Természettudományi és Technológiai Kar, Kémiai Intézet, Fizikai Kémiai Tanszék, Debrecen, Magyarország
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A célzott molekuláris képalkotás egy új, ígéretes módszer a nukleáris medicinában a diagnosztika és a terápia területén. A mangánizotópok sokszínűsége elérhető közelségbe hozta a bimodális képalkotásokat, mivel az 52Mn pozitront emittáló izotóp a funkcionális PET, míg a paramágneses 55Mn-izotóp kelátjai az MR kontrasztanyag-kutatások és a PET-diagnosztikumok kapcsolását tették lehetővé. Jelen közleményben kitérünk a Mn(II)-ion komplexálására leginkább alkalmas kelátorok, illetve az ezekből származtatható kétfunkciós és intelligens Mn(II)-komplexek, valamint a lehetséges biológiai vektormolekulák bemutatására. Ezekre az előzményekre alapozva példákat mutatunk be az in vivo kísérletek során jól teljesítő vektormolekulák és az általunk kifejlesztett kelátorok 52Mn-izotóppal jelölt konjugátumainak alkalmazására.
Early diagnosis of oncological diseases is crucial for cancer treatment and survival. Imaging of cancerous tissues rely on the availability of targeting biovector molecules capable of carrying diagnostic medical radionuclides, contrast agents (CAs) or optical probes to the diseased tissue for imaging. The production of tissue-specific contrast agents or contrast agents targeted with appropriate vector molecules was fueled by their ability to accumulate in certain tissues or organs, which allows us to reduce the required dose or to visualize specific processes at the cellular/tissue level. Recent developments in antibody engineering and PET (positron emission tomography) radiochemistry have led to new ImmunoPET imaging approaches. In contrast to the antibodies, antibody fragments such as minibodies, dia-bodies, single-chain variable region fragments (scFvs), nanobodies and affibodies are smaller in size, yet retain the specificity and affinity of antibodies in addition to more desirable pharmacokinetic profiles. For such imaging studies isotopes with long half-lives are required (64Cu or 89Zr were the ones used more frequently), which brought an attention on the positron emitter 52Mn isotope (t1/2=5.59 days). On the other hand Mn(II) complexes have been intensively studied recently as monoaquated chelates of Mn(II) are considered safer alternatives to Gd(III)-based contrast agents (GBCA’s) in magnetic resonance imaging (MRI). Therefore the use of Mn(II) complexes also offers the possibility of “marrying” these two diagnostic modalities. In MRI new, safer alternatives are needed, since Nephrogenic Systemic Fibrosis (NSF) in renal patients has been linked to the toxic effect of Gd(III) ion released during dissociation of the applied CA (Gd(III) complexes). Ten years later, it was also confirmed that injected Gd(III) can accumulate in patients with healthy kidney function, while Gd(III) chelates excreted from the body increase Gd(III) concentrations in surface water (“gadolinium anomaly”). Related to this research topic, our current paper summarizes the most suitable chelators designed for complexation of Mn(II) ions. Bifunctional ligands developed for Mn(II) complexation and intelligent/responsive Mn(II)-based probes were also reviewed, furthermore, information on the possible biological vector molecules was also summarized. Based on this information we present examples of the application of vector molecules that have performed outstandingly in in vivo experiments and their 52Mn isotopically labeled conjugates that we have developed and tested using animal models.
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| Days from submission to acceptance | 59 |
| Days from acceptance to publication | 104 |
| Acceptance Rate | 81% |
| 2022 | |
|---|---|
| CrossRef Documents | 38 |
| CrossRef Cites | 10 |
| Days from submission to acceptance | 54 |
| Days from acceptance to publication | 78 |
| Acceptance Rate | 84% |
| 2021 | |
|---|---|
| CrossRef Documents | 46 |
| CrossRef Cites | 0 |
| Days from submission to acceptance | 33 |
| Days from acceptance to publication | 85 |
| Acceptance Rate | 93% |
| 2020 | |
|---|---|
| CrossRef Documents | 13 |
| CrossRef Cites | 0 |
| Days from submission to acceptance | 30 |
| Days from acceptance to publication | 62 |
| Acceptance Rate | 93% |
| Publication Model | Gold Open Access |
| Submission Fee | none |
| Article Processing Charge | none |
| Scientia et Securitas | |
|---|---|
| Language | Hungarian English |
| Size | A4 |
| Year of Foundation |
2020 |
| Volumes per Year |
1 |
| Issues per Year |
4 |
| Founder | Academic Council of Home Affairs and Association of Hungarian PhD and DLA Candidates |
| Founder's Address |
H-2090 Remeteszőlős, Hungary, Nagykovácsi út 3. H-1055 Budapest, Hungary Falk Miksa utca 1. |
| Publisher | Akadémiai Kiadó |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| Applied Licenses |
CC-BY 4.0 CC-BY-NC 4.0 |
| ISSN | 3057-9759 (print) |
| ISSN | 2732-2688 (online) |
Monthly Content Usage
| Abstract Views | Full Text Views | PDF Downloads | |
|---|---|---|---|
| Dec 2024 | 0 | 123 | 39 |
| Jan 2025 | 0 | 221 | 24 |
| Feb 2025 | 0 | 172 | 9 |
| Mar 2025 | 0 | 223 | 21 |
| Apr 2025 | 0 | 85 | 20 |
| May 2025 | 0 | 24 | 21 |
| Jun 2025 | 0 | 0 | 0 |
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