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  • 1 Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
  • 2 Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary
  • 3 Centre of Advanced Studies, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
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Summary

The pharmacokinetics of K-203, a recently synthesized bis-pyridinium aldoxime, have been investigated by reversed-phase HPLC. The K-203 content of serum samples was monitored by HPLC with ultraviolet absorbance detection at 286 nm. The low concentration of K-203 in samples of brain, eyes, and cerebrospinal fluid was also determined by HPLC; quantitative evaluation was possible by use of an amperometric detector.

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