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A. Malenovic Department of Drug Analysis, Faculty of Pharmacy, Vojvode Stepe 450, Belgrade, Serbia

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B. Jancic-Stojanovic Department of Drug Analysis, Faculty of Pharmacy, Vojvode Stepe 450, Belgrade, Serbia

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M. Medenica Department of Physical Chemistry, Faculty of Pharmacy, Vojvode Stepe 450, Belgrade, Serbia

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D. Ivanovic Department of Drug Analysis, Faculty of Pharmacy, Vojvode Stepe 450, Belgrade, Serbia

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Summary

This paper reports development and validation of a new microemulsion liquid chromatographic (MELC) method for rapid screening of simvastatin and simvastatin acid in human plasma. Plasma samples were injected directly into the HPLC system after appropriate sample dilution with mobile phase. Separations were performed on a 4.6 mm × 150 mm, 5-μm particle, C18 column, with UV detection at 238 nm. The mobile phase was 0.5% (w/υ) diisopropyl ether, 1.0% (w/υ) sodium dodecylsulphate (SDS), 4.0% (w/v) n-butanol, and 94.5% (w/w) aqueous 25 mM disodium hydrogen phosphate, pH 7.0, at a flow rate of 1 mL min−1. The method was evaluated according to criteria stated in FDA bioanalytical method validation guidance. The unique approach applied in this paper enables direct analysis of simvastatin and simvastatin acid, so the method can be used to obtain reliable results in a rapid and simple way.

  • [1]. C. Dollery 1999 Therapeutic Drugs Churchill Livingstone Edinburgh.

  • [2]. J. De Graaf P.N. Demacker A.F. Stalenhoef 1993 Neth. J. Med. 43 254.

  • [3]. G. Carlucci P. Mazzeo L. Biordi M. Bologna 1992 J. Pharm. Biomed. Anal. 10 693.

  • [4]. H. Ochiai N. Uchiyama K. Imagaki S. Hata T. Kamei 1997 J. Chromatogr. B 694 211.

  • [5]. J.D. Gilbert T.V. Olah M.J. Morris M.S. Schwartz D.A. McLoughlin 1994 E. Reid H.M. Hill I.D. Wilson Methodological Surveys in Bioanalysis of Drugs, Vol. 23 Royal Society of Chemistry Cambridge.

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    • Export Citation
  • [6]. J. Shentu X. Zhang Z. Chen L. Wu M. Shi 2002 Yaowu Fenxi Zazhi Chinese J. Pharm. Anal. 22 18.

  • [7]. L. Tan L. Yang X. Zhang Y. Yuan S. Ling 2000 Sepu Chinese J. Chromatogr. 18 232.

  • [8]. B. Barret J. Huclova V. Borek-Dohalsky B. Nemec I. Jelinek 2006 J. Pharm. Biomed. Anal. 41 517.

  • [9]. H. Yang Y. Feng Y. Luan 2003 J. Chromatogr. B 785 369.

  • [10]. X.S. Miao C.D. Metcalfe 2003 J. Chromatogr. A 998 133.

  • [11]. M.J. Morris J.D. Gilbert J.Y.K. Hsieh B.K. Matuszewski H.G. Ramjit W.F. Bayne 1993 Biol. Mass Spectrom. 22 1.

  • [12]. D.T.M. El-Sherbiny S.M. El-Ashry M.A. Mustafa A. Abd-El-Rahman El-Emam S.H. Hansen 2003 J. Sep. Sci. 26 503.

  • [13]. B. Jančić D. Ivanović M. Medenica A. Malenović N. Dimković 2005 J. Chromatogr. A 1088 187.

  • [14]. Guidance for Industry: Bioanalytical Method Validation, US Department of Health and Human Service, Food and Drug Administration, CDER, Rockville, USA, May 2001.

    • Search Google Scholar
    • Export Citation
  • [15]. P.J. Pentikainen M. Saraheimo J.I. Schwartz R.D. Amin M.S. Schwartz F.D. Brunner-Ferber J.D. Rogers 1992 J. Clin. Pharmacol. 32 136.

    • Search Google Scholar
    • Export Citation
  • [16]. P.H. Hubert P. Chiep J. Crommen B. Boulanger E. Chapizet N. Mercier S. Bervoas-Martin P. Chevalier D. Grandjean P. Lagorce M. Lallier M.C. Laparra M. Laurentie J.C. Nivet 1999 Anal. Chim Acta 391 135.

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Senior editors

Editor(s)-in-Chief: Kowalska, Teresa (1946-2023)

Editor(s)-in-Chief: Sajewicz, Mieczyslaw, University of Silesia, Katowice, Poland

Editors(s)

  • Danica Agbaba, University of Belgrade, Belgrade, Serbia
  • Łukasz Komsta, Medical University of Lublin, Lublin, Poland
  • Ivana Stanimirova-Daszykowska, University of Silesia, Katowice, Poland
  • Monika Waksmundzka-Hajnos, Medical University of Lublin, Lublin, Poland

Editorial Board

  • Ravi Bhushan, The Indian Institute of Technology, Roorkee, India
  • Jacek Bojarski, Jagiellonian University, Kraków, Poland
  • Bezhan Chankvetadze, State University of Tbilisi, Tbilisi, Georgia
  • Michał Daszykowski, University of Silesia, Katowice, Poland
  • Tadeusz H. Dzido, Medical University of Lublin, Lublin, Poland
  • Attila Felinger, University of Pécs, Pécs, Hungary
  • Kazimierz Glowniak, Medical University of Lublin, Lublin, Poland
  • Bronisław Glód, Siedlce University of Natural Sciences and Humanities, Siedlce, Poland
  • Anna Gumieniczek, Medical University of Lublin, Lublin, Poland
  • Urszula Hubicka, Jagiellonian University, Kraków, Poland
  • Krzysztof Kaczmarski, Rzeszow University of Technology, Rzeszów, Poland
  • Huba Kalász, Semmelweis University, Budapest, Hungary
  • Katarina Karljiković Rajić, University of Belgrade, Belgrade, Serbia
  • Imre Klebovich, Semmelweis University, Budapest, Hungary
  • Angelika Koch, Private Pharmacy, Hamburg, Germany
  • Piotr Kus, Univerity of Silesia, Katowice, Poland
  • Debby Mangelings, Free University of Brussels, Brussels, Belgium
  • Emil Mincsovics, Corvinus University of Budapest, Budapest, Hungary
  • Ágnes M. Móricz, Centre for Agricultural Research, Budapest, Hungary
  • Gertrud Morlock, Giessen University, Giessen, Germany
  • Anna Petruczynik, Medical University of Lublin, Lublin, Poland
  • Robert Skibiński, Medical University of Lublin, Lublin, Poland
  • Bernd Spangenberg, Offenburg University of Applied Sciences, Germany
  • Tomasz Tuzimski, Medical University of Lublin, Lublin, Poland
  • Yvan Vander Heyden, Free University of Brussels, Brussels, Belgium
  • Adam Voelkel, Poznań University of Technology, Poznań, Poland
  • Brata Walczak, University of Silesia, Katowice, Poland
  • Wiesław Wasiak, Adam Mickiewicz University, Poznań, Poland
  • Igor G. Zenkevich, St. Petersburg State University, St. Petersburg, Russian Federation

 

KOWALSKA, TERESA (1946-2023)
E-mail: kowalska@us.edu.pl

SAJEWICZ, MIECZYSLAW
E-mail:msajewic@us.edu.pl

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2023  
Web of Science  
Journal Impact Factor 1.7
Rank by Impact Factor Q3 (Chemistry, Analytical)
Journal Citation Indicator 0.43
Scopus  
CiteScore 4.0
CiteScore rank Q2 (General Chemistry)
SNIP 0.706
Scimago  
SJR index 0.344
SJR Q rank Q3

Acta Chromatographica
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Acta Chromatographica
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
4
Founder Institute of Chemistry, University of Silesia
Founder's
Address
PL-40-007 Katowice, Poland, Bankowa 12
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2083-5736 (Online)

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