View More View Less
  • 1 Institute of Chemistry, Silesian University, 9 Szkolna Street, 40-006, Katowice, Poland
Full access

Summary

Enantiomer separations have been one of the most important and, simultaneously, one of the most difficult to accomplish analytical (and technological) tasks, present at the top of separation scientists' agenda since the early sixties of the last century. Awareness of their importance has been awakened by an infamous case of the racemic drug thalidomide, a widely advertised sedative drug which had unexpected teratogenic activity in pregnant women that resulted in thousands of ‘flipper babies’ born in the late fifties and the early sixties in many countries around the world. Since that time, separation scientists have developed numerous methods for enantiomer separation, basically by use of gas chromatography (GC), high-performance liquid chromatography (HPLC), and capillary electrophoresis (CE). In this respect, planar chromatography has remained to a large extent an undervalued enantiomer separation technique, despite separation performance sufficient to separate a pair of enantiomers. The large number of GC, HPLC, and CE enantiomer separation strategies and methods developed are evidence that — once confronted with this particular and no doubt very important challenge — instrumental chromatographic techniques have lost if not face, then, to a large extent, their reputation as robust, universal, and efficient separation tools. In these circumstances, planar chromatography on silica gel seems a very promising and tempting alternative, basically because of the advantageous properties of microcrystalline silica gel and the 2D effective diffusion available only in planar chromatographic mode. Enhancement of the enantiomer separating power of the silica gel by simple mechanical impregnation with a properly chosen chiral selector, and additional coupling of this with efficient instrumental detection (e.g. densitometric, DAD, or mass spectrometric) can yield in a simple, robust, and universal tool for separation of enantiomers comparable with the long-established chromatographic enantiomer-separation techniques. In this mini review, favourable preconditions for silica-gel-based planar chromatographic separation of enantiomers which can elevate planar chromatography to the status of leading tool for separation of enantiomers are discussed. Further improvements which can enhance the enantiomer separation performance of chiral planar chromatography are also indicated.

  • [1]. E. Gil-Av , B. Feibush, and R. Charles-Sigler, Tetrahedron Lett., 1009 (1966).

  • [2]. B. Feibush 1967 Separation of Optical Antipodes by the Method of Gas Chromatography The Weizmann Institute of Science Rehovot.

  • [3]. E. Gil-Av D. Nurok 1974 G.C. Giddings R.A. Heller Advances in Chromatography Dekker New York 99172.

  • [4]. E. Gil-Av 1975 J. Mol. Evol. 6 131.

  • [5]. W.H. Pirkle M.H. Hyun 1984 J. Org. Chem. 49 3043.

  • [6]. W.H. Pirkle M.H. Hyun B. Bank 1984 J. Chromatogr. 316 585.

  • [7]. W.H. Pirkle M.H. Hyun 1985 J. Chromatogr. 322 287.

  • [8]. W.H. Pirkle M.H. Hyun 1985 J. Chromatogr. 322 295.

  • [9]. W.H. Pirkle C.J. Welch 1992 J. Liq. Chromatogr. 15 1947.

  • [10]. W.H. Pirkle C.J. Welch 1994 Tetrahedron Asym. 5 777.

  • [11]. C. Wolf 2008 Dynamic Stereochemistry of Chiral Compounds. Principles and Applications RSC Publishing Cambridge.

  • [12]. T. Kowalska J. Sherma 2007 Thin Layer Chromatography in Chiral Separations and Analysis Chromatographic Science Series 98 CRC Press Boca Raton.

    • Search Google Scholar
    • Export Citation
  • [13]. M. Sajewicz H.-E. Hauck G. Drabik E. Namysło B. Głód T. Kowalska 2006 J. Planar Chromatogr. 19 278.

  • [14]. R. Bhushan V. Parshad 1996 J. Chromatogr. A 721 369.

  • [15]. M. Sajewicz G. Grygierczyk M. Gontarska T. Kowalska 2007 J. Liq. Chromatogr. Relat. Technol. 30 2185.

  • [16]. M. Sajewicz M. Gontarska A. Dąbrowsa T. Kowalska 2007 J. Liq. Chromatogr. Relat. Technol. 30 2369.

  • [17]. M. Sajewicz R. Piętka G. Drabik E. Namysło T. Kowalska 2006 J. Planar Chromatogr. 19 273.

  • [18]. W. Gołkiewicz B. Polak 2007 T. Kowalska J. Sherma Thin Layer Chromatography in Chiral Separations and Analysis Chromatographic Science Series 98 CRC Press Boca Raton 305322.

    • Search Google Scholar
    • Export Citation
  • [19]. M. Sajewicz D. Kronenbach D. Staszek M. Wróbel G. Grygierczyk T. Kowalska 2008 J. Liq. Chromatogr. Relat. Technol. 31 2006.

  • [20]. L. Cecchi P. Malaspina 1991 Anal. Biochem. 192 219.

  • [21]. M. Sajewicz M. Gontarska D. Kronenbach T. Kowalska 2008 Acta Chromatogr. 20 209.

  • [22]. M. Sajewicz D. Kronenbach M. Gontarska T. Kowalska 2010 J. Liq. Chromatogr. Relat. Technol. 33 10471057.

The author instruction is available in PDF.
Please, download the file from HERE.
 
The Open Access statement together with the description of the Copyright and License Policy are available in PDF.
Please, download the file from HERE.
 

 

Senior editors

Editor(s)-in-Chief: Kowalska, Teresa

Editor(s)-in-Chief: Sajewicz, Mieczyslaw

Editors(s) Danica Agbaba (University of Belgrade, Belgrade, Serbia);
Ivana Stanimirova-Daszykowska (University of Silesia, Katowice, Poland),
Monika Waksmundzka-Hajnos (Medical University of Lublin, Lublin, Poland)

Editorial Board

R. Bhushan (The Indian Institute of Technology, Roorkee, India)
J. Bojarski (Jagiellonian University, Kraków, Poland)
B. Chankvetadze (State University of Tbilisi, Tbilisi, Georgia)
M. Daszykowski (University of Silesia, Katowice, Poland)
T.H. Dzido (Medical University of Lublin, Lublin, Poland)
A. Felinger (University of Pécs, Pécs, Hungary)
K. Glowniak (Medical University of Lublin, Lublin, Poland)
B. Glód (Siedlce University of Natural Sciences and Humanities, Siedlce, Poland)
K. Kaczmarski (Rzeszow University of Technology, Rzeszów, Poland)
H. Kalász (Semmelweis University, Budapest, Hungary)
I. Klebovich (Semmelweis University, Budapest, Hungary)
A. Koch (Private Pharmacy, Hamburg, Germany)
Ł. Komsta (Medical University of Lublin, Lublin, Poland)
P. Kus (Univerity of Silesia, Katowice, Poland)
D. Mangelings (Free University of Brussels, Brussels, Belgium)
E. Mincsovics (Corvinus University of Budapest, Budapest, Hungary)
G. Morlock (Giessen University, Giessen, Germany)
J. Sherma (Lafayette College, Easton, PA, USA)
R. Skibiński (Medical University of Lublin, Lublin, Poland)
B. Spangenberg (Offenburg University of Applied Sciences, Germany)
T. Tuzimski (Medical University of Lublin, Lublin, Poland)
Y. Vander Heyden (Free University of Brussels, Brussels, Belgium)
A. Voelkel (Poznań University of Technology, Poznań, Poland)
B. Walczak (University of Silesia, Katowice, Poland)
W. Wasiak (Adam Mickiewicz University, Poznań, Poland)

KOWALSKA, TERESA
E-mail: kowalska@us.edu.pl

SAJEWICZ, MIECZYSLAW
E-mail:msajewic@us.edu.pl

Indexing and Abstracting Services:

  • Science Citation Index
  • Sci Search
  • Research Alert
  • Chemistry Citation Index and Current Content/Physical
  • Chemical and Earth Sciences
  • SCOPUS
  • GoogleScholar
  • Index Copernicus
  • CABI
2020
 
Total Cites
650
WoS
Journal
Impact Factor
1,639
Rank by
Chemistry, Analytical 71/83 (Q4)
Impact Factor
 
Impact Factor
1,412
without
Journal Self Cites
5 Year
1,301
Impact Factor
Journal
0,34
Citation Indicator
 
Rank by Journal
Chemistry, Analytical 75/93 (Q4)
Citation Indicator
 
Citable
45
Items
Total
43
Articles
Total
2
Reviews
Scimago
28
H-index
Scimago
0,316
Journal Rank
Scimago
Chemistry (miscellaneous) Q3
Quartile Score
 
Scopus
393/181=2,2
Scite Score
 
Scopus
General Chemistry 215/398 (Q3)
Scite Score Rank
 
Scopus
0,560
SNIP
 
Days from
58
sumbission
 
to acceptance
 
Days from
68
acceptance
 
to publication
 
Acceptance
51%
Rate

2019  
Total Cites
WoS
495
Impact Factor 1,418
Impact Factor
without
Journal Self Cites
1,374
5 Year
Impact Factor
0,936
Immediacy
Index
0,460
Citable
Items
50
Total
Articles
50
Total
Reviews
0
Cited
Half-Life
6,2
Citing
Half-Life
8,3
Eigenfactor
Score
0,00048
Article Influence
Score
0,164
% Articles
in
Citable Items
100,00
Normalized
Eigenfactor
0,05895
Average
IF
Percentile
20,349
Scimago
H-index
26
Scimago
Journal Rank
0,255
Scopus
Scite Score
226/167=1,4
Scopus
Scite Score Rank
Chemistry (miscellaneous) 240/398 (Q3)
Scopus
SNIP
0,494
Acceptance
Rate
41%

 

Acta Chromatographica
Publication Model Online only
Gold Open Access
Submission Fee none
Article Processing Charge 400 EUR/article
Regional discounts on country of the funding agency World Bank Lower-middle-income economies: 50%
World Bank Low-income economies: 100%
Further Discounts Editorial Board / Advisory Board members: 50%
Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100%
Subscription Information Gold Open Access
Purchase per Title  

Acta Chromatographica
Language English
Size A4
Year of
Foundation
1992
Publication
Programme
2021 Volume 33
Volumes
per Year
1
Issues
per Year
4
Founder Institute of Chemistry, University of Silesia
Founder's
Address
PL-40-007 Katowice, Poland, Bankowa 12
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-6290 (Print)
ISSN 2083-5736 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Apr 2021 6 0 0
May 2021 5 0 0
Jun 2021 8 0 0
Jul 2021 0 1 0
Aug 2021 0 4 0
Sep 2021 0 3 2
Oct 2021 0 0 0