Acta Chromatographica
Volume/Issue:
Volume 22: Issue 4
Simultaneous RP-HPLC quantification of vasicine and vasicinone in Adhatoda vasica and its formulation
Authors:
A. Suthar Herbal Department, Piramal Life Sciences Ltd, 1 Nirlon Complex, Off Western Express Highway, Goregaon (East), Mumbai, 400 063, Maharashtra, India

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P. Hamarapurkar Pharmaceutical Analysis, Principal K.M. Kundnani College of Pharmacy, Jote Joy Building, Rambhau Salgaoankar Marg, Cuffe Parade, Mumbai, 400 005, Maharashtra, India

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P. Patil Pharmaceutical Analysis, Principal K.M. Kundnani College of Pharmacy, Jote Joy Building, Rambhau Salgaoankar Marg, Cuffe Parade, Mumbai, 400 005, Maharashtra, India

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M. Phale Pharmaceutical Analysis, Principal K.M. Kundnani College of Pharmacy, Jote Joy Building, Rambhau Salgaoankar Marg, Cuffe Parade, Mumbai, 400 005, Maharashtra, India

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K. Katkar Herbal Department, Piramal Life Sciences Ltd, 1 Nirlon Complex, Off Western Express Highway, Goregaon (East), Mumbai, 400 063, Maharashtra, India

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G. Mundada Herbal Department, Piramal Life Sciences Ltd, 1 Nirlon Complex, Off Western Express Highway, Goregaon (East), Mumbai, 400 063, Maharashtra, India

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V. S. Chauhan Herbal Department, Piramal Life Sciences Ltd, 1 Nirlon Complex, Off Western Express Highway, Goregaon (East), Mumbai, 400 063, Maharashtra, India

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Pages:
599–608
Online Publication Date:
01 Dec 2010
Publication Date:
01 Dec 2010
Article Category:
Research Article
DOI:
https://doi.org/10.1556/achrom.22.2010.4.9
Keywords:
vasicine; vasicinone; RP-HPLC
Open access

Summary

A simple, specific, and precise RP-HPLC method with photodiode-array detection has been developed for simultaneous analysis of the quinazoline alkaloids vasicine and vasicinone, pharmacologically important constituents of Adhatoda vasica. The compounds were separated by use of 0.1% trifluoroacetic acid in water:acetonitrile 90:10 as isocratic mobile phase at a flow rate of 1.0 mL min−1. Under these conditions, plots of integrated peak area against concentration were linear over the ranges 0.05–10.0 μg mL−1 and 0.5–100.0 μg mL−1 (r2 = 0.999 and 0.998) for vasicine and vasicinone, respectively. Mean recovery was 99.06% for vasicine and 98.69% for vasicinone. The method is therefore suitable for routine analysis of vasicine and vasicinone in Adhatoda vasica plants of different varieties and in herbal medicinal products prepared from the plants.

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Cover Acta Chromatographica
Acta Chromatographica
Online ISSN:
2083-5736

Senior editors

Editor(s)-in-Chief: Sajewicz, Mieczyslaw, University of Silesia, Katowice, Poland

Editors(s)

  • Danica Agbaba, University of Belgrade, Belgrade, Serbia
  • Łukasz Komsta, Medical University of Lublin, Lublin, Poland
  • Ivana Stanimirova-Daszykowska, University of Silesia, Katowice, Poland
  • Monika Waksmundzka-Hajnos, Medical University of Lublin, Lublin, Poland

Editorial Board

  • Ravi Bhushan, The Indian Institute of Technology, Roorkee, India
  • Jacek Bojarski, Jagiellonian University, Kraków, Poland
  • Bezhan Chankvetadze, State University of Tbilisi, Tbilisi, Georgia
  • Michał Daszykowski, University of Silesia, Katowice, Poland
  • Tadeusz H. Dzido, Medical University of Lublin, Lublin, Poland
  • Attila Felinger, University of Pécs, Pécs, Hungary
  • Kazimierz Glowniak, Medical University of Lublin, Lublin, Poland
  • Bronisław Glód, Siedlce University of Natural Sciences and Humanities, Siedlce, Poland
  • Anna Gumieniczek, Medical University of Lublin, Lublin, Poland
  • Urszula Hubicka, Jagiellonian University, Kraków, Poland
  • Krzysztof Kaczmarski, Rzeszow University of Technology, Rzeszów, Poland
  • Huba Kalász, Semmelweis University, Budapest, Hungary
  • Katarina Karljiković Rajić, University of Belgrade, Belgrade, Serbia
  • Imre Klebovich, Semmelweis University, Budapest, Hungary
  • Angelika Koch, Private Pharmacy, Hamburg, Germany
  • Piotr Kus, Univerity of Silesia, Katowice, Poland
  • Debby Mangelings, Free University of Brussels, Brussels, Belgium
  • Emil Mincsovics, Corvinus University of Budapest, Budapest, Hungary
  • Ágnes M. Móricz, Centre for Agricultural Research, Budapest, Hungary
  • Gertrud Morlock, Giessen University, Giessen, Germany
  • Anna Petruczynik, Medical University of Lublin, Lublin, Poland
  • Robert Skibiński, Medical University of Lublin, Lublin, Poland
  • Bernd Spangenberg, Offenburg University of Applied Sciences, Germany
  • Tomasz Tuzimski, Medical University of Lublin, Lublin, Poland
  • Adam Voelkel, Poznań University of Technology, Poznań, Poland
  • Beata Walczak, University of Silesia, Katowice, Poland
  • Wiesław Wasiak, Adam Mickiewicz University, Poznań, Poland
  • Igor G. Zenkevich, St. Petersburg State University, St. Petersburg, Russian Federation

 

SAJEWICZ, MIECZYSLAW
E-mail:mieczyslaw.sajewicz@us.edu.pl

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2023  
Web of Science  
Journal Impact Factor 1.7
Rank by Impact Factor Q3 (Chemistry, Analytical)
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CiteScore 4.0
CiteScore rank Q2 (General Chemistry)
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SJR Q rank Q3

Acta Chromatographica
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Acta Chromatographica
Language English
Size A4
Year of
Foundation		 1988
Volumes
per Year		 1
Issues
per Year		 4
Founder Institute of Chemistry, University of Silesia
Founder's
Address		 PL-40-007 Katowice, Poland, Bankowa 12
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 2083-5736 (Online)

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