Authors:
S. Joshi Department of Chemistry, K.L.D.A.V. (P.G.) College, Roorkee, Uttarakhand, India, 247667

Search for other papers by S. Joshi in
Current site
Google Scholar
PubMed
Close
,
C. Bhatia Department of Chemistry, K.L.D.A.V. (P.G.) College, Roorkee, Uttarakhand, India, 247667

Search for other papers by C. Bhatia in
Current site
Google Scholar
PubMed
Close
,
C. S. Bal Talwar Pharma, Jhabrera Road, Manglore, Roorkee, Uttarakhand, India, 247656

Search for other papers by C. S. Bal in
Current site
Google Scholar
PubMed
Close
, and
M. S. M. Rawat Department of Chemistry, H.N.B. Garhwal University, Srinagar, Uttarakhand, India

Search for other papers by M. S. M. Rawat in
Current site
Google Scholar
PubMed
Close
Open access

Summary

A simple, reversed-phase HPLC method has been developed for rapid, simultaneous quantification of phenylephrine hydrochloride, guaiphenesin, ambroxol hydrochloride, and salbutamol (as salbutamol sulphate) in a commercial cough-cold liquid formulation. The compounds were separated on a 250 mm × 4.6 mm C8 column with a gradient prepared from pH 3.0 phosphate buffer and 1:1 methanol-acetonitrile as mobile phase at a flow rate of 1.0 mL min−1. Elution of the analytes was achieved in less than 15 min. Detection was by UV absorbance at 273 nm for phenylephrine hydrochloride and guaiphenesin and 225 nm for ambroxol hydrochloride and salbutamol. Percentage recovery and RSD were, respectively, 100.09% and 0.22% for phenylephrine hydrochloride, 100.43% and 0.50% for guaiphenesin, 100.91% and 0.70% for ambroxol hydrochloride, and 100.54% and 0.55% for salbutamol. The components of the syrup formulation were quantified on the basis of the peak areas obtained from freshly prepared standard solutions. The method was validated in accordance with ICH guidelines.

  • [1]. R. Bhushan S. Joshi M. Arora M. Gupta 2005 J. Planar Chromatogr. 18 164.

  • [2]. S. Joshi A. Sharma C.S. Bal M.S.M. Rawat 2009 Asian J. Pharm. 3 274277.

  • [3]. W.E. Serafin 1996 Drugs used in the treatment of asthma P.B. Molinof R.W. Ruddon The Goodman & Gilman's pharmacological basis of therapeutics 9th edn McGraw-Hill New York.

    • Search Google Scholar
    • Export Citation
  • [4]. B. Olmo A. Garcia A. Marin C. Barbas 2005 J. Chromatogr. B 817 159.

  • [5]. A.E. Gindy S. Emara A. Mostafa 2006 J. Pharm. Biomed. Anal. 41 421.

  • [6]. A.E. Gindy S. Emara H. Shaaban 2007 J. Pharm. Biomed. Anal. 43 973.

  • [7]. M.S. Ali M. Ghori S. Rafiuddin A.R. Khatri 2007 J. Pharm. Biomed. Anal. 43 158.

  • [8]. G.M. Hadad A.E. Gindy W.M.M. Mahmoud 2008 Spectrochim. Acta 70 655.

  • [9]. S.M. Amer S.S. Abbas M.A. Shehata N.M. Ali 2008 J. AOAC Int. 91 27.

  • [10]. M. Palabıyık F. Onur 2007 Chromatographia 66 93.

  • [11]. M.R. Louhaichi S. Jebali M.H. Loueslati N. Adhoum L. Monser 2009 Talanta 78 991.

  • [12]. X. Xu X. Lui J.T. Stewart 2000 J. Liq. Chromatogr. Relat. Technol. 23 1.

  • [13]. Y. Dong X. Chen Y. Chen Z. Hu 2005 J. Pharm. Biomed. Anal. 39 285.

  • [14]. E. Mario L.G. Meehan 2006 J. Pharm. Sci. 59 538.

  • [15]. H.N. Dave R.C. Mashru A.R. Thakkar 2007 Anal. Chim. Acta 597 113.

  • [16]. International Conference on Harmonization on Technical Requirements for Registration of Pharmaceuticals for Human Use, Validation of Analytical Procedures: Text and Methodology Q2 (R1), Geneva, 2005.

    • Search Google Scholar
    • Export Citation
  • [17]. P.D. Sethi , High Performance Liquid Chromatography, CBS Publishers and Distributors, New Delhi, 2001, pp. 105109.

  • [18]. L.R. Snyder J.L. Glajch J. Kirkland 1988 Practical HPLC Method Development Wiley-Interscience Publication New York 126127.

  • Collapse
  • Expand
The author instructions are available in PDF.
Please, download the file from HERE.

 

 

Senior editors

Editor(s)-in-Chief: Kowalska, Teresa (1946-2023)

Editor(s)-in-Chief: Sajewicz, Mieczyslaw, University of Silesia, Katowice, Poland

Editors(s)

  • Danica Agbaba, University of Belgrade, Belgrade, Serbia
  • Łukasz Komsta, Medical University of Lublin, Lublin, Poland
  • Ivana Stanimirova-Daszykowska, University of Silesia, Katowice, Poland
  • Monika Waksmundzka-Hajnos, Medical University of Lublin, Lublin, Poland

Editorial Board

  • Ravi Bhushan, The Indian Institute of Technology, Roorkee, India
  • Jacek Bojarski, Jagiellonian University, Kraków, Poland
  • Bezhan Chankvetadze, State University of Tbilisi, Tbilisi, Georgia
  • Michał Daszykowski, University of Silesia, Katowice, Poland
  • Tadeusz H. Dzido, Medical University of Lublin, Lublin, Poland
  • Attila Felinger, University of Pécs, Pécs, Hungary
  • Kazimierz Glowniak, Medical University of Lublin, Lublin, Poland
  • Bronisław Glód, Siedlce University of Natural Sciences and Humanities, Siedlce, Poland
  • Anna Gumieniczek, Medical University of Lublin, Lublin, Poland
  • Urszula Hubicka, Jagiellonian University, Kraków, Poland
  • Krzysztof Kaczmarski, Rzeszow University of Technology, Rzeszów, Poland
  • Huba Kalász, Semmelweis University, Budapest, Hungary
  • Katarina Karljiković Rajić, University of Belgrade, Belgrade, Serbia
  • Imre Klebovich, Semmelweis University, Budapest, Hungary
  • Angelika Koch, Private Pharmacy, Hamburg, Germany
  • Piotr Kus, Univerity of Silesia, Katowice, Poland
  • Debby Mangelings, Free University of Brussels, Brussels, Belgium
  • Emil Mincsovics, Corvinus University of Budapest, Budapest, Hungary
  • Ágnes M. Móricz, Centre for Agricultural Research, Budapest, Hungary
  • Gertrud Morlock, Giessen University, Giessen, Germany
  • Anna Petruczynik, Medical University of Lublin, Lublin, Poland
  • Robert Skibiński, Medical University of Lublin, Lublin, Poland
  • Bernd Spangenberg, Offenburg University of Applied Sciences, Germany
  • Tomasz Tuzimski, Medical University of Lublin, Lublin, Poland
  • Yvan Vander Heyden, Free University of Brussels, Brussels, Belgium
  • Adam Voelkel, Poznań University of Technology, Poznań, Poland
  • Brata Walczak, University of Silesia, Katowice, Poland
  • Wiesław Wasiak, Adam Mickiewicz University, Poznań, Poland
  • Igor G. Zenkevich, St. Petersburg State University, St. Petersburg, Russian Federation

 

KOWALSKA, TERESA (1946-2023)
E-mail: kowalska@us.edu.pl

SAJEWICZ, MIECZYSLAW
E-mail:msajewic@us.edu.pl

Indexing and Abstracting Services:

  • Science Citation Index
  • Sci Search
  • Research Alert
  • Chemistry Citation Index and Current Content/Physical
  • Chemical and Earth Sciences
  • SCOPUS
  • GoogleScholar
  • Index Copernicus
  • CABI
  • CABELLS Journalytics

2023  
Web of Science  
Journal Impact Factor 1.7
Rank by Impact Factor Q3 (Chemistry, Analytical)
Journal Citation Indicator 0.43
Scopus  
CiteScore 4.0
CiteScore rank Q2 (General Chemistry)
SNIP 0.706
Scimago  
SJR index 0.344
SJR Q rank Q3

Acta Chromatographica
Publication Model Online only
Gold Open Access
Submission Fee none
Article Processing Charge 400 EUR/article
Regional discounts on country of the funding agency World Bank Lower-middle-income economies: 50%
World Bank Low-income economies: 100%
Further Discounts Editorial Board / Advisory Board members: 50%
Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100%
Subscription Information Gold Open Access
Purchase per Title  

Acta Chromatographica
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
4
Founder Institute of Chemistry, University of Silesia
Founder's
Address
PL-40-007 Katowice, Poland, Bankowa 12
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2083-5736 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Feb 2024 0 49 7
Mar 2024 0 33 10
Apr 2024 0 7 9
May 2024 0 10 8
Jun 2024 0 17 9
Jul 2024 0 3 0
Aug 2024 0 0 0