View More View Less
  • 1 Department of Inorganic and Analytical Chemistry, Jagiellonian University, Collegium Medicum, 9 Medyczna Street, 30-688, Cracow, Poland
Restricted access

Summary

The chromatographic-densitometric method was developed for the simultaneous determination of various pharmaceutical agents, such as haloperidol, fluxetine, promazine, doxepin, clonazepam, alprazolam, and risperidone in biological material. Two mobile phases, A (acetone-diethylamine-cyclohexane (2.5:2.5:20, υ/υ/υ)) and B (trichloromethane-acetone-25% NH3 (25:25:0.5, υ/υ/υ)), were used for the separation of the above-mentioned compounds. Silica gel-covered F254 TLC plates were used as stationary phases. Densitometric recording was carried out at 254 nm wavelength. Well-developed peaks, easy to quantify, and quality analysis were obtained after achieving the separation of compounds in the developed conditions. It was demonstrated that the presence of a matrix (plasma or urine) did not affect the shape of the peaks and their localization on the chromatograms.

  • [1]. Y. Higashi M. Kitahara M. Furii 2006 Biomed. Chromatogr. 20 166172.

  • [2]. M.R. Rouini Y.H. Ardakani K.A. Moghaddam F. Splatani 2008 Talanta 75 671676.

  • [3]. X.J. Kang , L.Q. Chen, Y. Wang, Y.Y. Zhang, and Z.Z. Gu, Design of Packed-Fiber Solid-Phase Extraction Device for Analysis of the Drug and Its Metabolite in Plasma, Biomed Microdevices, Springer Science + Business Media, 2009.

    • Search Google Scholar
    • Export Citation
  • [4]. I.F. Bares F. Pehourcq Ch. Jarry 2004 J. Pharm. Biomed. Anal. 36 865869.

  • [5]. A. Lerena P. Dorado R. Berecz A. Gonzalez M.J. Norberto A. de la Rubia M. Caceres 2003 J. Chromatogr. B 783 2531.

  • [6]. L.P. Melo A.M. Nogueira F.M. Lancas M.E.C. Queiroz 2009 Anal. Chim. Acta 663 5764.

  • [7]. B.J.G. Silva F.M. Lancas M.E.C. Queiroz 2008 J. Chromatogr. B 862 181188.

  • [8]. B.J.G. Silva R.H.C. Queiroz M.E.C. Queiroz 2007 J. Anal. Toxicol. 31 313320.

  • [9]. M.D. Cantu D.R. Toso C.A. Lacerda F.M. Lancas E. Carrilho M.E.C. Queiroz 2006 Anal. Bioanal. Chem. 386 256263.

  • [10]. G. Zhang A.V. Terry Jr. M.G. Bartlett 2007 J. Chromatogr. B 856 2028.

  • [11]. L. M. M. Grillo C. Bartoletti G. Boncompagni M.A. Raggi 2007 Anal. Bioanal. Chem. 388 235243.

  • [12]. V.F. Samanidou M.K. Nika I.N. Papadoyannis 2007 J. Sep. Sci. 30 23912400.

  • [13]. K.B. Borges E.F. Freire I. Martins M.E.P.B. de Siqueira 2009 Talanta 78 233241.

  • [14]. V.F. Samanidou A.P. Pechlivanidou I.N. Papadoyannis 2007 J. Sep. Sci. 30 679687.

  • [15]. W.M. Mullett J. Pawliszyn 2001 J. Pharm. Biomed. Anal. 26 899908.

  • [16]. R. Mandrioli S. Fanali A. Ferranti M.A. Raggi 2002 J. Pharm. Biomed. Anal. 30 969977.

  • [17]. W.R. Malfara C. Bertucci M.E.C. Queiroz S.D. Carvalho M.L.P. Bianchi E.J. Cesarino J.A. Crippa R.H.C. Queiroz 2007 J. Pharm. Biomed. Anal. 44 955962.

    • Search Google Scholar
    • Export Citation
  • [18]. Ch. Frahnert M.L. Rao K. Grasmader 2003 J. Chromatogr. B 794 3547.

  • [19]. L. Vlase S. Imre S. Leucuta 2005 Talanta 66 659663.

  • [20]. N. Unceta S. Barrondo I.R. de Azua A.G. Caballero M.A. Goicolea J. Salles R.J. Barrio 2007 J. Chromatogr. B 852 519528.

  • [21]. I. Kovacevic M. Pokrajac B. Miljkovic D. Jovanovic M. Prostran 2006 J. Chromatogr. B 830 372376.

  • [22]. N. Kishikawa Ch. Hamachi Y. Imamura Y. Ohba K. Nakashima Y. Tagawa N. Kuroda 2006 Anal. Bioanal. Chem. 386 719724.

  • [23]. T. Arinobu H. Hattori M. Iwai A. Ishiib T. Kumazawa O. Suzuki H. Seno 2002 J. Chromatogr. B 776 107113.

  • [24]. N. Castaing K. Titier M. Receveur-Daurel M. Le-Deodic D. Le-Bars N. Moore M. Molimard 2007 J. Anal. Toxicol. 31 334341.

  • [25]. F.C.W. Sutherland D. Badenhorst A.D. de Jager T. Scanes H.K.L. Hundt K.J. Swart A.F. Hundt 2001 J. Chromatogr. A 914 4551.

  • [26]. S. Souverain M. Mottaz S. Cherkaoui J.L. Veuthey 2003 Anal. Bioanal. Chem. 377 880885.

  • [27]. A.L. Saber 2009 Talanta 78 295299.

  • [28]. H. Juan Z. Zhiling L. Huande 2005 J. Chromatogr. B 820 3339.

  • [29]. A.J. Santos-Neto J. Bergquist F.M. Lancas P.J.R. Sjoberg 2008 J. Chromatogr. A 1189 514522.

  • [30]. Ch. Abbara I. Bardot A. Cailleux G. Lallement A. Le Bouil A. Turcant P. Clair B. Diquet 2008 J. Chromatogr. B 874 4250.

  • [31]. L.E. Cavedal F.D. Mendes C.C. Domingues A.K. Patni T. Monif S. Reyar A.S. Pereira G.D. Mendes G. De Nucci 2007 J. Mass Spectrom. 42 8188.

    • Search Google Scholar
    • Export Citation
  • [32]. S.J. Marin R. Coles M. Merrell G.A. McMillin 2008 J. Anal. Toxicol. 32 491498.

  • [33]. G. Zhang A.V. Terry Jr. M.G. Bartlett 2007 J. Chromatogr. B 858 276281.

  • [34]. C. Kratzsch F.T. Peters T. Kraemer A.A. Weber H.H. Maurer 2003 J. Mass Spectrom. 38 283295.

  • [35]. A. de Castro M. Concheiro O. Quintela A. Cruz M. Lopez-Rivadulla 2008 J. Pharm. Biomed. Anal. 48 183193.

  • [36]. T. Shinozuka M. Terada E. Tanaka 2006 Forensic Sci. Int. 162 108112.

  • [37]. C. Kratzsch O. Tenberken F.T. Peters A.A. Weber T. Kraemer H.H. Maurer 2004 J. Mass Spectrom. 39 856872.

  • [38]. H. Kirchherr W.N. Kühn-Velten 2006 J. Chromatogr. B 843 100113.

  • [39]. M.A. Saracino M. Amore E. Baioni C. Petio M.A. Raggi 2008 Anal. Chim. Acta 624 308316.

  • [40]. S.M.R. Wille P. Van Hee H.M. Neels C.H. Van Peteghem W.E. Lambert 2007 J. Chromatogr. A 1176 236245.

  • [41]. S.M.R. Wille K.E. Maudens C.H. Van Peteghem W.E.E. Lambert 2005 J. Chromatogr. A 1098 1929.

  • [42]. C. Fernandes E. Van Hoeck P. Sandra F.M. Lancas 2008 Anal. Chim. Acta 614 201207.

  • [43]. X.P. Lee Ch. Hasegawa T. Kumazawa N. Shinmen Y. Shoji H. Seno K. Sato 2008 J. Sep. Sci. 31 22652271.

  • [44]. M.A. Martínez C. Sanchez de la Torre E. Almarza 2003 J. Anal. Toxicol. 27 353358.

  • [45]. S.M. Wu W.K. Ko H.L. Wu S.H. Chen 1999 J. Chromatogr. A 846 239243.

  • [46]. C.C. Lu Y.J. Jong W.K. Ko S.M. Wu 2007 Electrophoresis 28 32903295.

  • [47]. F.J. Lara A.M. García-Campana L. Gamiz-Gracia J.M. Bosque-Sendra F. Ales-Barrero 2006 Electrophoresis 27 23482359.

  • [48]. M.D. Cantu S. Hillebrand M.E.C. Queiroz F.M. Lancas E. Carrilho 2004 J. Chromatogr. B 799 127132.

  • [49]. K. Madej J. Kochana M. Wozniakiewicz 2007 J. Liq. Chromatogr. Relat. Technol. 30 185198.

  • [50]. J. Li F. Zhao H. Ju 2006 Anal. Chim. Acta 575 5761.

  • [51]. T. Galeano-Díaz M.I. Acedo-Valenzuela N. Mora-Díez A. Silva-Rodríguez 2006 Electrophoresis 26 35183527.

  • [52]. S.C. Lin C.W. Whang 2008 J. Sep. Sci. 31 39213929.

  • [53]. M. Shamsipur L. Shafiee-Dastgerdi Z. Talebpour S. Haghgoo 2007 J. Pharm. Biomed. Anal. 43 11161121.

  • [54]. N. Dhavale S. Gandhi S. Sabnis K. Bothara 2008 Chromatographia 67 487490.

  • [55]. C. Shah B. Suhagia N. Shah D. Patel N. Patel 2008 Indian J. Pharm. Sci. 70 251255.

  • [56]. T. Gondova D. Halamova K. Spacayova 2008 J. Liq. Chromatogr. Relat. Technol. 31 24292441.

  • [57]. A. Pelander D. Backstrom I. Ojanpera 2007 J. Chromatogr. B 857 337340.

  • [58]. C.R. Shah N.J. Shah B.N. Suhagia N.M. Patel 2007 J. AOAC Int. 90 15731578.

  • [59]. R.B. Patel M.R. Patel M.B. Shankar K.K. Bhatt 2009 J. AOAC Int. 92 10821088.

  • [60]. S.K. Patel N.J. Patel 2009 Chromatographia 69 393396.

  • [61]. A. Maślanka J. Krzek 2005 J. AOAC Int. 88 7079.

  • [62]. A. Maślanka J. Krzek 2007 J. Planar Chromatogr. 20 463475.

  • [63]. ICH Guideline Q2B, Validation of Analytical Procedures: Methodology (CPMP CH/281/95), Geneva, Switzerland, 1996.

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Nov 2020 2 0 0
Dec 2020 1 0 0
Jan 2021 0 0 0
Feb 2021 0 0 0
Mar 2021 0 0 0
Apr 2021 0 0 0
May 2021 0 0 0