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  • 1 Department of Environmental Studies, School of Environment and Natural Resources, Doon University, Dehradun, 248001, India
  • 2 Department of Chemistry, K.L.D.A.V. (P.G.) College, Roorkee, 247667, India
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Summary

Enantiomeric resolution of two commonly used β-blockers, namely, (±)-propranolol and (±)-atenolol, has been achieved on silica gel layers which were bulkimpregnated with β-cyclodextrin. Solvent systems DMF-ethyl acetate-butanol (3:2:5, υ/υ) and butanol-acetic acid-ethyl acetate-ammonia (5:2:2:0.5, υ/υ) successfully resolved the enantiomers of (±)-propranolol and (±)-atenolol, respectively. The spots were located with iodine vapor. The effects of concentration of the chiral selector and mobile phase variation were also studied.

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