Authors:
P. R. Ravi Pharmacy Department, BITS-Pilani Hyderabad Campus, Ranga Reddy (Dist.), Jawaharnagar, Andhra Pradesh, India

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N. Aditya Pharmacy Department, BITS-Pilani Hyderabad Campus, Ranga Reddy (Dist.), Jawaharnagar, Andhra Pradesh, India

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R. Vats Pharmacy Department, BITS-Pilani Hyderabad Campus, Ranga Reddy (Dist.), Jawaharnagar, Andhra Pradesh, India

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Summary

A rapid and sensitive reverse-phase liquid chromatographic method using ultraviolet detector was developed and validated for estimation of raloxifene hydrochloride in rabbit plasma. Plasma samples were extracted using simple protein precipitation-extraction method. The method was developed under isocratic conditions using a Zorbax SB-C8 analytical column with optimum mobile phase composition of 20 mM pH-4.5 ammonium acetate buffer-acetonitrile (63:37 υ/υ) at a flow rate of 1 mL min−1. The detector response was found to be linear in the concentration range of 50–1500 ng mL−1. High recoveries ranging from 97.2% to 100.2% were obtained, which precludes the use of internal standard. The developed method was found to be accurate, precise, and selective in the estimation of raloxifene hydrochloride in rabbit plasma based on the results of method validation carried out as per standard guidelines. The drug was found to be stable under various processing and storage conditions. The developed method was successfully applied in the estimation of raloxifene hydrochloride and the determination of various pharmacokinetic parameters post-intravenous bolus administration of drug in rabbits.

  • [1]. R. Keen 2007 Best Pract. Res. Clin. Rheumatol. 21 109.

  • [2]. J.A. Scott C.C. Da Camara J.E. Early 1999 Am. Fam. Physician 60 1131.

  • [3]. P.D. Delmas N.H. Bjarnason B.H. Mitlak A.C. Ravoux A.S. Shah W.J. Huster M. Draper C. Christiansen 1997 New Engl. J. Med. 337 1641.

    • Search Google Scholar
    • Export Citation
  • [4]. K.R. Snyder N. Sparano J.M. Malinowski 2000 Am. J. Health-Syst. Pharm. 57 1669.

  • [5]. D. Hochner-Celnikier 1999 Eur. J. Obstet. Gynecol. Reprod. Biol. 85 23.

  • [6]. J. Trontelj T. Vovk M. Bogataj A. Mrhar 2005 Pharmacol. Res. 52 334.

  • [7]. D.C. Pavithra L. Sivasubramanian 2006 Indian J. Pharm. Sci. 68 401.

  • [8]. B. Kanakapura A.K. Urdigere K. Tharpa 2008 Acta. Pharm. 58 347.

  • [9]. A.M. Mathrusri M.E. Bhanoji Rao B.V. Ravikumar 2007 E-J. Chem. 4 79.

  • [10]. B. Kanakapura A.K. Urdigere K. Tharpa K.B. Vinay 2008 J. Chil. Chem. Soc. 53 1635.

  • [11]. B. Kanakapura K. Tharpa A.K. Urdigere N. Rajendraprasad S.G. Hiriyanna K.B. Vinay 2009 Arch. Pharm. Res. 32 1271.

  • [12]. T. Pérez-Ruiz C. Martínez-Lozano A. Sanz E. Bravo 2004 J. Pharm. Biomed. Anal. 34 891.

  • [13]. C.Z. Huang Y.F. Li 2003 Anal. Chim. Acta. 500 105.

  • [14]. Z.Y. Yang Z.F. Zhang X.B. He G.Y. Zhao Y.Q. Zhang 2007 Chromatographia 65 197.

  • [15]. A.K. Urdigere K. Basavaiah K. Tharpa K.B. Vinay 2009 Chem. Ind. Chem. Eng. Q. 15 119.

  • [16]. M.F. Wempe V.J. Wacher K.M. Ruble M.G. Ramsey K.J. Edgar N.L. Buchanan C.M. Buchanan 2008 Int. J. Pharm. 346 25.

  • [17]. D. Bikiaris V. Karavelidis E. Karavas 2009 Molecules 14 2410.

  • [18]. S. Castañeda E. Calvo R. Largo R. González-González C. Piedra M. Díaz-Curiel G. Herrero-Beaumont 2008 J. Bone Miner. Metab. 26 53.

    • Search Google Scholar
    • Export Citation
  • [19]. K. Kaveh R. Ibrahim M.Z. AbuBakar T.A. Ibrahim 2010 Am. J. Anim. Vet. Sci. 5 139.

  • [20]. A.S. Turner 2001 Eur. Cells Mat. 1 66.

  • [21]. R.T. Turner A. Maran S. Lotinun T. Hefferan G.L. Evans M. Zhang J.D. Sibonga 2001 Rev. Endocr. Metab. Disord. 2 117.

  • [22]. Guidelines for Pre-Clinical Evaluation and Clinical Trials in Osteoporosis. World Health Organization, Geneva, 1998.

  • [23]. International Conference on Harmonization (ICH), Harmonized Tripartite Guideline on, Topic Q2B, Notes for Guidelines for Validation of Analytical Procedures: Methodology, The European Agency for the Evaluation of Medicinal Products, Human Medicines Evaluation Unit, 1996.

    • Search Google Scholar
    • Export Citation
  • [24]. Guidance for Industry: Bioanalytical Method Validation, U.S. Department of Health and Human Services, Food and Drug Administration, 2001.

    • Search Google Scholar
    • Export Citation
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Senior editors

Editor(s)-in-Chief: Kowalska, Teresa (1946-2023)

Editor(s)-in-Chief: Sajewicz, Mieczyslaw

Editors(s)

  • Danica Agbaba (University of Belgrade, Belgrade, Serbia)
  • Łukasz Komsta (Medical University of Lublin, Lublin, Poland)
  • Ivana Stanimirova-Daszykowska (University of Silesia, Katowice, Poland)
  • Monika Waksmundzka-Hajnos (Medical University of Lublin, Lublin, Poland)

Editorial Board

  • R. Bhushan (The Indian Institute of Technology, Roorkee, India)
  • J. Bojarski (Jagiellonian University, Kraków, Poland)
  • B. Chankvetadze (State University of Tbilisi, Tbilisi, Georgia)
  • M. Daszykowski (University of Silesia, Katowice, Poland)
  • T.H. Dzido (Medical University of Lublin, Lublin, Poland)
  • A. Felinger (University of Pécs, Pécs, Hungary)
  • K. Glowniak (Medical University of Lublin, Lublin, Poland)
  • B. Glód (Siedlce University of Natural Sciences and Humanities, Siedlce, Poland)
  • A. Gumieniczek (Medical University of Lublin, Lublin, Poland)
  • U. Hubicka (Jagiellonian University, Kraków, Poland)
  • K. Kaczmarski (Rzeszow University of Technology, Rzeszów, Poland)
  • H. Kalász (Semmelweis University, Budapest, Hungary)
  • K. Karljiković Rajić (University of Belgrade, Belgrade, Serbia)
  • I. Klebovich (Semmelweis University, Budapest, Hungary)
  • A. Koch (Private Pharmacy, Hamburg, Germany)
  • P. Kus (Univerity of Silesia, Katowice, Poland)
  • D. Mangelings (Free University of Brussels, Brussels, Belgium)
  • E. Mincsovics (Corvinus University of Budapest, Budapest, Hungary)
  • Á. M. Móricz (Centre for Agricultural Research, Budapest, Hungary)
  • G. Morlock (Giessen University, Giessen, Germany)
  • A. Petruczynik (Medical University of Lublin, Lublin, Poland)
  • R. Skibiński (Medical University of Lublin, Lublin, Poland)
  • B. Spangenberg (Offenburg University of Applied Sciences, Germany)
  • T. Tuzimski (Medical University of Lublin, Lublin, Poland)
  • Y. Vander Heyden (Free University of Brussels, Brussels, Belgium)
  • A. Voelkel (Poznań University of Technology, Poznań, Poland)
  • B. Walczak (University of Silesia, Katowice, Poland)
  • W. Wasiak (Adam Mickiewicz University, Poznań, Poland)
  • I.G. Zenkevich (St. Petersburg State University, St. Petersburg, Russian Federation)

 

KOWALSKA, TERESA (1946-2023)
E-mail: kowalska@us.edu.pl

SAJEWICZ, MIECZYSLAW
E-mail:msajewic@us.edu.pl

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2022  
Web of Science  
Total Cites
WoS
647
Journal Impact Factor 1.9
Rank by Impact Factor

Chemistry, Analytical (Q3)

Impact Factor
without
Journal Self Cites
1.9
5 Year
Impact Factor
1.4
Journal Citation Indicator 0.41
Rank by Journal Citation Indicator

Chemistry, Analytical (Q3)

Scimago  
Scimago
H-index
29
Scimago
Journal Rank
0.28
Scimago Quartile Score

Chemistry (miscellaneous) (Q3)

Scopus  
Scopus
Cite Score
3.1
Scopus
CIte Score Rank
General Chemistry 211/407 (48th PCTL)
Scopus
SNIP
0.549

2021  
Web of Science  
Total Cites
WoS
652
Journal Impact Factor 2,011
Rank by Impact Factor Chemistry, Analytical 66/87
Impact Factor
without
Journal Self Cites
1,789
5 Year
Impact Factor
1,350
Journal Citation Indicator 0,40
Rank by Journal Citation Indicator Chemistry, Analytical 72/99
Scimago  
Scimago
H-index
29
Scimago
Journal Rank
0,27
Scimago Quartile Score Chemistry (miscellaneous) (Q3)
Scopus  
Scopus
Cite Score
2,8
Scopus
CIte Score Rank
General Chemistry 210/409 (Q3)
Scopus
SNIP
0,586

2020
 
Total Cites
650
WoS
Journal
Impact Factor
1,639
Rank by
Chemistry, Analytical 71/83 (Q4)
Impact Factor
 
Impact Factor
1,412
without
Journal Self Cites
5 Year
1,301
Impact Factor
Journal
0,34
Citation Indicator
 
Rank by Journal
Chemistry, Analytical 75/93 (Q4)
Citation Indicator
 
Citable
45
Items
Total
43
Articles
Total
2
Reviews
Scimago
28
H-index
Scimago
0,316
Journal Rank
Scimago
Chemistry (miscellaneous) Q3
Quartile Score
 
Scopus
393/181=2,2
Scite Score
 
Scopus
General Chemistry 215/398 (Q3)
Scite Score Rank
 
Scopus
0,560
SNIP
 
Days from
58
submission
 
to acceptance
 
Days from
68
acceptance
 
to publication
 
Acceptance
51%
Rate

2019  
Total Cites
WoS
495
Impact Factor 1,418
Impact Factor
without
Journal Self Cites
1,374
5 Year
Impact Factor
0,936
Immediacy
Index
0,460
Citable
Items
50
Total
Articles
50
Total
Reviews
0
Cited
Half-Life
6,2
Citing
Half-Life
8,3
Eigenfactor
Score
0,00048
Article Influence
Score
0,164
% Articles
in
Citable Items
100,00
Normalized
Eigenfactor
0,05895
Average
IF
Percentile
20,349
Scimago
H-index
26
Scimago
Journal Rank
0,255
Scopus
Scite Score
226/167=1,4
Scopus
Scite Score Rank
Chemistry (miscellaneous) 240/398 (Q3)
Scopus
SNIP
0,494
Acceptance
Rate
41%

 

Acta Chromatographica
Publication Model Online only
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Regional discounts on country of the funding agency World Bank Lower-middle-income economies: 50%
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Acta Chromatographica
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
4
Founder Institute of Chemistry, University of Silesia
Founder's
Address
PL-40-007 Katowice, Poland, Bankowa 12
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2083-5736 (Online)

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