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A. Maciejowska
A. Maciejowska
Institute of Chemistry, University of Silesia, 9 Szkolna Street, 40-006, Katowice, Poland
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A. Godziek
A. Godziek
Institute of Chemistry, University of Silesia, 9 Szkolna Street, 40-006, Katowice, Poland
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M. Sajewicz
M. Sajewicz
Institute of Chemistry, University of Silesia, 9 Szkolna Street, 40-006, Katowice, Poland
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T. Kowalska
T. Kowalska
Institute of Chemistry, University of Silesia, 9 Szkolna Street, 40-006, Katowice, Poland
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Abstract
This study is devoted to the thin-layer chromatographic demonstration of spontaneous chiral conversion of l-hydroxyproline (l-Hyp) to d-hydroxyproline (d-Hyp), and to its spontaneous peptidization, when dissolved in 70% aqueous methanol and stored at room temperature in a stoppered glass vessel. The adopted enantioseparation conditions were the same ones, as employed earlier for a successful enantioseparation of l- and d-proline. To this effect, we used microcrystalline cellulose as stationary phase and a quaternary mixture composed of 2-butanol:pyridine:glacial acetic acid:water (30:20:4:24, v/v) as mobile phase. Structural difference between proline and hydroxyproline consists in the presence of one hydroxyl group per molecule of the latter amino acid, which makes the respective enantioseparation a more difficult task. Consequently, the obtained separation effect was not a complete (i.e., a baseline) resolution of the two Hyp antimers yet a sufficient enough proof of the appearance of d-Hyp, apparently due to spontaneous chiral conversion taking place in the course of the l-Hyp solution storage and ageing period. The condensation products were discovered both in the fresh and the aged l-Hyp solution, yet in the aged sample, the condensation product yields were considerably higher than in the freshly prepared one (as convincingly demonstrated by mass spectrometry). Demonstration of the condensation products was performed with the aid of thin-layer chromatography (TLC), liquid chromatography-mass spectrometry (LC-MS), and thin-layer chromatography-mass spectrometry (TLC-MS).
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Senior editors
Editor(s)-in-Chief: Sajewicz, Mieczyslaw, University of Silesia, Katowice, Poland
Editors(s)
- Danica Agbaba, University of Belgrade, Belgrade, Serbia (1953-2024)
- Łukasz Komsta, Medical University of Lublin, Lublin, Poland
- Ivana Stanimirova-Daszykowska, University of Silesia, Katowice, Poland
- Monika Waksmundzka-Hajnos, Medical University of Lublin, Lublin, Poland
Editorial Board
- Ravi Bhushan, The Indian Institute of Technology, Roorkee, India
- Jacek Bojarski, Jagiellonian University, Kraków, Poland
- Bezhan Chankvetadze, State University of Tbilisi, Tbilisi, Georgia
- Michał Daszykowski, University of Silesia, Katowice, Poland
- Tadeusz H. Dzido, Medical University of Lublin, Lublin, Poland
- Attila Felinger, University of Pécs, Pécs, Hungary
- Kazimierz Glowniak, Medical University of Lublin, Lublin, Poland
- Bronisław Glód, Siedlce University of Natural Sciences and Humanities, Siedlce, Poland
- Anna Gumieniczek, Medical University of Lublin, Lublin, Poland
- Urszula Hubicka, Jagiellonian University, Kraków, Poland
- Krzysztof Kaczmarski, Rzeszow University of Technology, Rzeszów, Poland
- Huba Kalász, Semmelweis University, Budapest, Hungary
- Katarina Karljiković Rajić, University of Belgrade, Belgrade, Serbia
- Imre Klebovich, Semmelweis University, Budapest, Hungary
- Angelika Koch, Private Pharmacy, Hamburg, Germany
- Piotr Kus, Univerity of Silesia, Katowice, Poland
- Debby Mangelings, Free University of Brussels, Brussels, Belgium
- Emil Mincsovics, Corvinus University of Budapest, Budapest, Hungary
- Ágnes M. Móricz, Centre for Agricultural Research, Budapest, Hungary
- Gertrud Morlock, Giessen University, Giessen, Germany
- Anna Petruczynik, Medical University of Lublin, Lublin, Poland
- Robert Skibiński, Medical University of Lublin, Lublin, Poland
- Bernd Spangenberg, Offenburg University of Applied Sciences, Germany
- Tomasz Tuzimski, Medical University of Lublin, Lublin, Poland
- Adam Voelkel, Poznań University of Technology, Poznań, Poland
- Beata Walczak, University of Silesia, Katowice, Poland
- Wiesław Wasiak, Adam Mickiewicz University, Poznań, Poland
- Igor G. Zenkevich, St. Petersburg State University, St. Petersburg, Russian Federation
SAJEWICZ, MIECZYSLAW
E-mail:mieczyslaw.sajewicz@us.edu.pl
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| 2024 | |
|---|---|
| Scopus | |
| CiteScore | |
| CiteScore rank | |
| SNIP | |
| Scimago | |
| SJR index | 0.285 |
| SJR Q rank | Q3 |
| 2023 | |
|---|---|
| Web of Science | |
| Journal Impact Factor | 1.7 |
| Rank by Impact Factor | Q3 (Chemistry, Analytical) |
| Journal Citation Indicator | 0.43 |
| Scopus | |
| CiteScore | 4.0 |
| CiteScore rank | Q2 (General Chemistry) |
| SNIP | 0.706 |
| Scimago | |
| SJR index | 0.344 |
| SJR Q rank | Q3 |
| Acta Chromatographica | |
|---|---|
| Publication Model | Online only Gold Open Access |
| Submission Fee | none |
| Article Processing Charge |
700 EUR/article For MS submitted before 1 Feb 2025: 400 EUR/article |
| Regional discounts on country of the funding agency | World Bank Lower-middle-income economies: 50% World Bank Low-income economies: 100% |
| Further Discounts | Editorial Board / Advisory Board members: 50% Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100% |
| Subscription Information | Gold Open Access |
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| Acta Chromatographica | |
|---|---|
| Language | English |
| Size | A4 |
| Year of Foundation |
1988 |
| Volumes per Year |
1 |
| Issues per Year |
4 |
| Founder | Institute of Chemistry, University of Silesia |
| Founder's Address |
PL-40-007 Katowice, Poland, Bankowa 12 |
| Publisher | Akadémiai Kiadó |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 2083-5736 (Online) |
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| May 2025 | 0 | 12 | 4 |
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