Authors:
S. M. Elgizawy Analytical Chemistry Department, Faculty of Pharmacy, Assuit University, 71515, Assuit, Egypt

Search for other papers by S. M. Elgizawy in
Current site
Google Scholar
PubMed
Close
,
N. Y. Hassan Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr-El Aini Street, 11562, Cairo, Egypt

Search for other papers by N. Y. Hassan in
Current site
Google Scholar
PubMed
Close
,
H. M. Lotfy Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr-El Aini Street, 11562, Cairo, Egypt

Search for other papers by H. M. Lotfy in
Current site
Google Scholar
PubMed
Close
, and
S. S. Saleh Analytical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 11787, 6th October City, Egypt

Search for other papers by S. S. Saleh in
Current site
Google Scholar
PubMed
Close
Open access

Summary

Reversed phase high-performance liquid chromatography (RP-HPLC) and thin-layer chromatography (TLC)-spectrodensitometric methods have been developed and validated for the separation and quantitation of two binary mixtures: Ofloxacin (OFX) and dexamethasone (DXM) in eye preparation; ciprofloxacin hydrochloride (CIP) and hydrocortisone (HYD) in ear preparation. The linearity ranges of RP-HPLC methods were found to be (2.5–45 μg mL−1) for OFX, (2.5–50 μg mL−1) for DXM and (1–8 μg mL−1) for both CIP and HYD. The percentage recoveries/relative standard deviation (RSD) were found to be 100.36/1.38, 100.13/1.49, 99.98/0.61 and 100.28/1.27, respectively. The linearity ranges of TLC-spectrodensitometric methods were found to be (0.5–2 μg band−1), (0.5–3.5 μg band−1), (0.2–1.6 μg band−1), and (0.6–2 μg band−1) for OFX, DXM, CIP, and HYD, respectively. The percentage recoveries/RSD were found to be 99.98/1.06, 99.93/1.18, 99.74/1.27, and 99.94/1.54, respectively. A comparative study was conducted to show the advantages of the proposed methods which showed that the TLC-spectrodensitometric methods were simpler, more sensitive, and economic, while RP-HPLC methods were more precise and robust. The methods were validated in compliance with the ICH guidelines and were successfully applied for determination of the selected drugs in their laboratory-prepared mixtures and commercial dosage forms.

  • [1]. S.C. Sweetman 2005 Martindale: The Complete Drug Reference Pharmaceutical Press London.

  • [2]. British Pharmacopoeia , The Stationery Office on behalf of the Medicines and Healthcare products Regulatory Agency (MHRA)-© Crown Copyright, 2009.

    • Search Google Scholar
    • Export Citation
  • [3]. A.I. Drakopoulos P.C. Ioannou 1997 Anal. Chim. Acta 354 197204.

  • [4]. G.H. Ragab A.S. Amin 2004 Spectrochim. Acta, Part A 60 973978.

  • [5]. H. Hopkala D. Kowalczuk 2000 Acta Pol. Pharm. 57 313.

  • [6]. J.D. Smet K. Bousserya K. Colpaertb P. D. Suttera P. De Paepec J. Decruyenaereb J.V. Bocxlaera 2009 J. Chromatogr., B 877 961967.

    • Search Google Scholar
    • Export Citation
  • [7]. V.F. Samanidou C. Demetriou I.N. Papadoyannis 2003 Anal. Bioanal. Chem. 375 623629.

  • [8]. R. Singh M. Maithani S.K. Saraf S. Saraf R.C. Gupta 2009 Eurasian J. Anal. Chem. 4 161167.

  • [9]. Y.L. Feng C. Dong 2004 J. Chromatogr. Sci. 42 474477.

  • [10]. S. Han-wen H. Pan L. Yun-kai L. Shu-xuan 2007 J. Chromatogr., B 852 145151.

  • [11]. F.A. El-Yazbi H.H. Hammud S.A. Assi 2006 Anal. Chim. Acta 580 3946.

  • [12]. J.M. L. Gallego J. P. Arroyo 2002 Anal. Chim. Acta 460 8597.

  • [13]. Q. Chen D. Zielinski J. Chen A. Koski D. Werst S. Nowak 2008 J. Pharm. Biomed. Anal. 48 732738.

  • [14]. Y. Xiong K.P. Xiao A.M. Rustum 2009 J. Pharm. Biomed. Anal. 49 646654.

  • [15]. E. Grippa L. Santini G. Castellano M.T. Gatto M.G. Leone L. Saso 2000 J. Chromatogr., B 738 1725.

  • [16]. M. Pendela G. Kahsay I. Baekelandt A.V. Schepdael E. Adams 2011 J. Pharm. Biomed. Anal. 56 641644.

  • [17]. V. Baeyens E. Varesio J.L. Veuthey R. Gurny 1997 J. Chromatogr., B 692 222226.

  • [18]. H. Sirén T. Seppänen-Laakso M. Orešič 2008 J. Chromatogr., B 871 375382.

  • [19]. T. Ruiwei M. Mingxiu L. Genghao 1999 West China J. Pharm. Sci. 4 4546.

  • [20]. L. Wei G. Hua Z. Fantao 2005 China Pharm. 10 1.

  • [21]. K. Sireesha K. Prakash 2012 Int. J. Pharm. Pharm. Sci. 4 415418.

  • [22]. W. Chun-Lan , L. Shi-Cai, and L. Lan-Ju, Chinese J. Pharm., 1 (2004).

  • [23]. L. Li , Determination of Ciprofloxacin and Hydrocortisone in Compound Ciprofloxacin Ear Drops by HPLC. Chinese Pharmaceutical Affairs, 3 (2008).

    • Search Google Scholar
    • Export Citation
  • [24]. United States Pharmacopoeia Commission, United States Pharmacopeia-National formulary. United States Pharmacopeial Inc., 22802282. 2004.

    • Search Google Scholar
    • Export Citation
  • [25]. V.P. Ranea D.B. Shindea 2009 Eurasian J. Anal. Chem. 4 304310.

  • [26]. A.S. Amin H.A. Dessouki I.A. Agwa 2011 Arab J. Chem. 4 249257.

  • [27]. K.S. Khandagle S.V. Gandhi P.B. Deshpande N.V. Gaikwad 2011 Int. J. Pharm. Pharm. Sci. 3 1 4648.

  • [28]. N.E. Wagieh M.A. Hegazy M. Abdelkawy E.A. Abdelaleem 2010 Talanta 80 20072015.

  • [29]. Y.S. El-Saharty N.A. El-Ragehy H.M. Abdel-Monem M.I. Abdel-Kawy 2010 JAR 1 7178.

  • [30]. European Egyptian Pharmaceutical Industries (EEPI) Quality Control Department, Test Method for Determination of Ciprocort Ear Drops.

    • Search Google Scholar
    • Export Citation
  • [31]. International Conference on Harmonization (ICH), Q2B Validation of Analytical Procedures: Methodology, 62, US FDA, Federal Register, 1997.

    • Search Google Scholar
    • Export Citation
  • Collapse
  • Expand
The author instructions are available in PDF.
Please, download the file from HERE.
 
The Open Access statement together with the description of the Copyright and License Policy are available in PDF.
Please, download the file from HERE.
 

 

Senior editors

Editor(s)-in-Chief: Kowalska, Teresa (1946-2023)

Editor(s)-in-Chief: Sajewicz, Mieczyslaw

Editors(s)

  • Danica Agbaba (University of Belgrade, Belgrade, Serbia)
  • Łukasz Komsta (Medical University of Lublin, Lublin, Poland)
  • Ivana Stanimirova-Daszykowska (University of Silesia, Katowice, Poland)
  • Monika Waksmundzka-Hajnos (Medical University of Lublin, Lublin, Poland)

Editorial Board

  • R. Bhushan (The Indian Institute of Technology, Roorkee, India)
  • J. Bojarski (Jagiellonian University, Kraków, Poland)
  • B. Chankvetadze (State University of Tbilisi, Tbilisi, Georgia)
  • M. Daszykowski (University of Silesia, Katowice, Poland)
  • T.H. Dzido (Medical University of Lublin, Lublin, Poland)
  • A. Felinger (University of Pécs, Pécs, Hungary)
  • K. Glowniak (Medical University of Lublin, Lublin, Poland)
  • B. Glód (Siedlce University of Natural Sciences and Humanities, Siedlce, Poland)
  • A. Gumieniczek (Medical University of Lublin, Lublin, Poland)
  • U. Hubicka (Jagiellonian University, Kraków, Poland)
  • K. Kaczmarski (Rzeszow University of Technology, Rzeszów, Poland)
  • H. Kalász (Semmelweis University, Budapest, Hungary)
  • K. Karljiković Rajić (University of Belgrade, Belgrade, Serbia)
  • I. Klebovich (Semmelweis University, Budapest, Hungary)
  • A. Koch (Private Pharmacy, Hamburg, Germany)
  • P. Kus (Univerity of Silesia, Katowice, Poland)
  • D. Mangelings (Free University of Brussels, Brussels, Belgium)
  • E. Mincsovics (Corvinus University of Budapest, Budapest, Hungary)
  • Á. M. Móricz (Centre for Agricultural Research, Budapest, Hungary)
  • G. Morlock (Giessen University, Giessen, Germany)
  • A. Petruczynik (Medical University of Lublin, Lublin, Poland)
  • R. Skibiński (Medical University of Lublin, Lublin, Poland)
  • B. Spangenberg (Offenburg University of Applied Sciences, Germany)
  • T. Tuzimski (Medical University of Lublin, Lublin, Poland)
  • Y. Vander Heyden (Free University of Brussels, Brussels, Belgium)
  • A. Voelkel (Poznań University of Technology, Poznań, Poland)
  • B. Walczak (University of Silesia, Katowice, Poland)
  • W. Wasiak (Adam Mickiewicz University, Poznań, Poland)
  • I.G. Zenkevich (St. Petersburg State University, St. Petersburg, Russian Federation)

 

KOWALSKA, TERESA (1946-2023)
E-mail: kowalska@us.edu.pl

SAJEWICZ, MIECZYSLAW
E-mail:msajewic@us.edu.pl

Indexing and Abstracting Services:

  • Science Citation Index
  • Sci Search
  • Research Alert
  • Chemistry Citation Index and Current Content/Physical
  • Chemical and Earth Sciences
  • SCOPUS
  • GoogleScholar
  • Index Copernicus
  • CABI
  • CABELLS Journalytics

2022  
Web of Science  
Total Cites
WoS
647
Journal Impact Factor 1.9
Rank by Impact Factor

Chemistry, Analytical (Q3)

Impact Factor
without
Journal Self Cites
1.9
5 Year
Impact Factor
1.4
Journal Citation Indicator 0.41
Rank by Journal Citation Indicator

Chemistry, Analytical (Q3)

Scimago  
Scimago
H-index
29
Scimago
Journal Rank
0.28
Scimago Quartile Score

Chemistry (miscellaneous) (Q3)

Scopus  
Scopus
Cite Score
3.1
Scopus
CIte Score Rank
General Chemistry 211/407 (48th PCTL)
Scopus
SNIP
0.549

2021  
Web of Science  
Total Cites
WoS
652
Journal Impact Factor 2,011
Rank by Impact Factor Chemistry, Analytical 66/87
Impact Factor
without
Journal Self Cites
1,789
5 Year
Impact Factor
1,350
Journal Citation Indicator 0,40
Rank by Journal Citation Indicator Chemistry, Analytical 72/99
Scimago  
Scimago
H-index
29
Scimago
Journal Rank
0,27
Scimago Quartile Score Chemistry (miscellaneous) (Q3)
Scopus  
Scopus
Cite Score
2,8
Scopus
CIte Score Rank
General Chemistry 210/409 (Q3)
Scopus
SNIP
0,586

2020
 
Total Cites
650
WoS
Journal
Impact Factor
1,639
Rank by
Chemistry, Analytical 71/83 (Q4)
Impact Factor
 
Impact Factor
1,412
without
Journal Self Cites
5 Year
1,301
Impact Factor
Journal
0,34
Citation Indicator
 
Rank by Journal
Chemistry, Analytical 75/93 (Q4)
Citation Indicator
 
Citable
45
Items
Total
43
Articles
Total
2
Reviews
Scimago
28
H-index
Scimago
0,316
Journal Rank
Scimago
Chemistry (miscellaneous) Q3
Quartile Score
 
Scopus
393/181=2,2
Scite Score
 
Scopus
General Chemistry 215/398 (Q3)
Scite Score Rank
 
Scopus
0,560
SNIP
 
Days from
58
submission
 
to acceptance
 
Days from
68
acceptance
 
to publication
 
Acceptance
51%
Rate

2019  
Total Cites
WoS
495
Impact Factor 1,418
Impact Factor
without
Journal Self Cites
1,374
5 Year
Impact Factor
0,936
Immediacy
Index
0,460
Citable
Items
50
Total
Articles
50
Total
Reviews
0
Cited
Half-Life
6,2
Citing
Half-Life
8,3
Eigenfactor
Score
0,00048
Article Influence
Score
0,164
% Articles
in
Citable Items
100,00
Normalized
Eigenfactor
0,05895
Average
IF
Percentile
20,349
Scimago
H-index
26
Scimago
Journal Rank
0,255
Scopus
Scite Score
226/167=1,4
Scopus
Scite Score Rank
Chemistry (miscellaneous) 240/398 (Q3)
Scopus
SNIP
0,494
Acceptance
Rate
41%

 

Acta Chromatographica
Publication Model Online only
Gold Open Access
Submission Fee none
Article Processing Charge 400 EUR/article
Regional discounts on country of the funding agency World Bank Lower-middle-income economies: 50%
World Bank Low-income economies: 100%
Further Discounts Editorial Board / Advisory Board members: 50%
Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100%
Subscription Information Gold Open Access
Purchase per Title  

Acta Chromatographica
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
4
Founder Institute of Chemistry, University of Silesia
Founder's
Address
PL-40-007 Katowice, Poland, Bankowa 12
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2083-5736 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Jan 2024 0 26 18
Feb 2024 0 63 4
Mar 2024 0 36 14
Apr 2024 0 9 5
May 2024 0 10 7
Jun 2024 0 16 4
Jul 2024 0 0 0