Authors:
N. Popovic Lafayette College Department of Chemistry Easton PA USA

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J. Sherma Lafayette College Department of Chemistry Easton PA USA

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Transfer of two rapid thin-layer chromatography (TLC) screening methods used to detect markedly substandard and fake pharmaceutical products to quantitative high-performance TLC (HPTLC)-densitometry methods is demonstrated using a model procedure that was published earlier. These TLC methods for diazepam and amodiaquine are contained in a Compendium of methods by Kenyon and Layloff and a Minilab method manual from Global Pharma Health Fund E.V., respectively, for use in countries with limited resources. Merck HPTLC Premium Purity silica gel 60 F254 glass plates, automated standard and sample solution application with a CAMAG Linomat 4, and automated densitometry with a CAMAG Scanner 3 were used for detection, identification, and quantification. Sample peak identity and purity validation were carried out by spectral comparison checks available in the winCATS software. Accuracy was estimated by the standard addition approach with overspotting standard and sample solutions. HPTLC gives better efficiency, selectivity, and resolution than TLC, and the new methods overcome the deficiencies in technology related to manual application and visual zone comparison that do not allow the Compendium and Minilab TLC procedures to support regulatory compliance actions. These new methods can be fully validated according to the International Conference on Harmonization guidelines or by interlaboratory studies if required by their applications.

  • J. Sherma and C. O'Sullivan, Acta Chromatogr., 24, 241–252 (2012)

    O'Sullivan C , '' (2012 ) 24 Acta Chromatogr. : 241 -252 .

  • A.S. Kenyon and T.P. Layloff, T.P., http://www.pharmweb.net/pwmirror/library/tlc/tlcall.pdf

  • K. Lianza and J. Sherma, J. Liq. Chromatogr. Relat. Technol., 36, 2446–2462 (2013)

    Sherma J , '' (2013 ) 36 J. Liq. Chromatogr. Relat. Technol. : 2446 -2462 .

  • E. Reich and A. Schibli, J. Planar Chromatogr.-Mod. TLC, 17, 438–443 (2004)

    Schibli A , '' (2004 ) 17 J. Planar Chromatogr.-Mod. TLC : 438 -443 .

  • T.H. Dzido and T. Tuzimski, Chambers, Sample Application, and Chromatogram Development. In: M. Waksmundzka-Hajnos, J. Sherma, and T. Kowalska (Eds) Thin Layer Chromatography in Phytochemistry, CRC Press/Taylor & Francis Group, pp. 140–141 (2008)

    Tuzimski T , '', in Thin Layer Chromatography in Phytochemistry , (2008 ) -.

  • K. Ferenczi-Fodor, Z. Vegh, A. Nagy-Turak, B. Renger, and M. Zeller, J. AOAC Int., 84, 1265–1276 (2001)

    Zeller M , '' (2001 ) 84 J. AOAC Int. : 1265 -1276 .

  • A.A. Shirkhedkar, P.M. Bugdane, and S.J. Surana, J. Chromatogr. Sci., 48, 109–113 (2010)

    Surana SJ , '' (2010 ) 48 J. Chromatogr. Sci. : 109 -113 .

  • T. Gondova and I. Petrikova, J. AOAC Int. 93, 778–782 (2010)

    Petrikova I , '' (2010 ) 93 J. AOAC Int. : 778 -782 .

  • V.S. Rajmane, S.V. Gandhi, U.P. Patil, and M.R. Sengar, J. AOAC Int., 93, 783–786 (2010)

    Sengar MR , '' (2010 ) 93 J. AOAC Int. : 783 -786 .

  • K.S. Khandagle, S.V. Gandhi, P.B. Deshpande, A.N. Kale, and P.R. Deshmukh, J. Chem. Pharm. Res., 2, 92–96 (2010)

    Deshmukh PR , '' (2010 ) 2 J. Chem. Pharm. Res. : 92 -96 .

  • K. Ferenczi-Fodor, B. Renger, and Z. Vegh, J. Planar Chromatogr.-Mod. TLC, 23, 173–179 (2010)

    Vegh Z , '' (2010 ) 23 J. Planar Chromatogr.-Mod. TLC : 173 -179 .

  • E. Kaale, P. Risha, E. Reich, and T.P. Layloff, J. AOAC Int. 93, 1836–1843 (2010)

    Layloff TP , '' (2010 ) 93 J. AOAC Int. : 1836 -1843 .

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Senior editors

Editor(s)-in-Chief: Sajewicz, Mieczyslaw, University of Silesia, Katowice, Poland

Editors(s)

  • Danica Agbaba, University of Belgrade, Belgrade, Serbia (1953-2024)
  • Łukasz Komsta, Medical University of Lublin, Lublin, Poland
  • Ivana Stanimirova-Daszykowska, University of Silesia, Katowice, Poland
  • Monika Waksmundzka-Hajnos, Medical University of Lublin, Lublin, Poland

Editorial Board

  • Ravi Bhushan, The Indian Institute of Technology, Roorkee, India
  • Jacek Bojarski, Jagiellonian University, Kraków, Poland
  • Bezhan Chankvetadze, State University of Tbilisi, Tbilisi, Georgia
  • Michał Daszykowski, University of Silesia, Katowice, Poland
  • Tadeusz H. Dzido, Medical University of Lublin, Lublin, Poland
  • Attila Felinger, University of Pécs, Pécs, Hungary
  • Kazimierz Glowniak, Medical University of Lublin, Lublin, Poland
  • Bronisław Glód, Siedlce University of Natural Sciences and Humanities, Siedlce, Poland
  • Anna Gumieniczek, Medical University of Lublin, Lublin, Poland
  • Urszula Hubicka, Jagiellonian University, Kraków, Poland
  • Krzysztof Kaczmarski, Rzeszow University of Technology, Rzeszów, Poland
  • Huba Kalász, Semmelweis University, Budapest, Hungary
  • Katarina Karljiković Rajić, University of Belgrade, Belgrade, Serbia
  • Imre Klebovich, Semmelweis University, Budapest, Hungary
  • Angelika Koch, Private Pharmacy, Hamburg, Germany
  • Piotr Kus, Univerity of Silesia, Katowice, Poland
  • Debby Mangelings, Free University of Brussels, Brussels, Belgium
  • Emil Mincsovics, Corvinus University of Budapest, Budapest, Hungary
  • Ágnes M. Móricz, Centre for Agricultural Research, Budapest, Hungary
  • Gertrud Morlock, Giessen University, Giessen, Germany
  • Anna Petruczynik, Medical University of Lublin, Lublin, Poland
  • Robert Skibiński, Medical University of Lublin, Lublin, Poland
  • Bernd Spangenberg, Offenburg University of Applied Sciences, Germany
  • Tomasz Tuzimski, Medical University of Lublin, Lublin, Poland
  • Adam Voelkel, Poznań University of Technology, Poznań, Poland
  • Beata Walczak, University of Silesia, Katowice, Poland
  • Wiesław Wasiak, Adam Mickiewicz University, Poznań, Poland
  • Igor G. Zenkevich, St. Petersburg State University, St. Petersburg, Russian Federation

 

SAJEWICZ, MIECZYSLAW
E-mail:mieczyslaw.sajewicz@us.edu.pl

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2023  
Web of Science  
Journal Impact Factor 1.7
Rank by Impact Factor Q3 (Chemistry, Analytical)
Journal Citation Indicator 0.43
Scopus  
CiteScore 4.0
CiteScore rank Q2 (General Chemistry)
SNIP 0.706
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SJR index 0.344
SJR Q rank Q3

Acta Chromatographica
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Acta Chromatographica
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
4
Founder Institute of Chemistry, University of Silesia
Founder's
Address
PL-40-007 Katowice, Poland, Bankowa 12
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2083-5736 (Online)

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