Authors:
M.A. Fouad Cairo University Pharmaceutical Chemistry Department, Faculty of Pharmacy Kasr El-Aini St. Cairo 11562 Egypt

Search for other papers by M.A. Fouad in
Current site
Google Scholar
PubMed
Close
and
E.F. Elkady Cairo University Pharmaceutical Chemistry Department, Faculty of Pharmacy Kasr El-Aini St. Cairo 11562 Egypt

Search for other papers by E.F. Elkady in
Current site
Google Scholar
PubMed
Close
Open access

A simple, selective, and precise stability-indicating reversed-phase liquid chromatographic method was developed and validated for the determination of nilotinib. Nilotinib was subjected to acid and alkali hydrolysis, oxidation, thermal, and photo-degradation. The degradation products were well separated from the pure drug. The method was based on isocratic elution of nilotinib and its degradation products on reversed phase C18 column (100 mm × 4.6 mm, 3.5 μm) — Zorbax Eclipse Plus using a mobile phase consisting of 10 mM KH2PO4:acetonitrile (54.5:45.5%, v/v) at a flow rate of 1 mL min−1. Quantitation was achieved with UV detection at 265 nm. Linearity, accuracy and precision were found to be acceptable over the concentration range of 0.1–80 μg mL−1. The drug was found to be susceptible to acid and base hydrolysis but resistant to oxidation, dry heat degradation, and photodegradation. The proposed method was successfully applied to the determination of nilotinib in bulk and in its pharmaceutical preparation.

  • H. Kantarjian, F. Giles, L. Wunderle, K. Bhalla, S. O’Brien, B. Wassmann, et al., New Engl. J. Med., 354, 2542–2551 (2006)

    Wassmann B , '' (2006 ) 354 New Engl. J. Med. : 2542 -2551 .

  • D.L. Deremer, C. Ustun, and K. Natarajan, Clin. Therapeut., 30, 1956–1975 (2008)

    Natarajan K , '' (2008 ) 30 Clin. Therapeut. : 1956 -1975 .

  • R.A. Larson, B.J. Druker, F. Guilhot, S.G. O’Brien, G.J. Riviere, T. Krahnke, et al., Blood, 111, 4022–4028 (2008)

    Krahnke T , '' (2008 ) 111 Blood : 4022 -4028 .

  • S. Picard, K. Titier, G. Etienne, E. Teilhet, D. Ducint, M.A. Bernard, et al., Blood, 109, 3496–3499 (2007)

    Bernard MA , '' (2007 ) 109 Blood : 3496 -3499 .

  • M. Yuki, Y. Yamakawa, T. Uchida, T. Nambu, T. Kawaguchi, A. Hamada, et al., Biol. Pharm. Bull., 34, 1126–1128 (2011)

    Hamada A , '' (2011 ) 34 Biol. Pharm. Bull. : 1126 -1128 .

  • M. Miura, N. Takahashi, and K. Sawada, Biomed Chromatogr., 24, 789–793 (2010)

    Sawada K , '' (2010 ) 24 Biomed Chromatogr. : 789 -793 .

  • S. Pursche, O.G. Ottmann, G. Ehninger, and E. Schleyer, J. Chromatogr., B: Analytical Technol. Biomed. Life Sci., 852, 208–216 (2007)

    Schleyer E , '' (2007 ) 852 J. Chromatogr., B: Analytical Technol. Biomed. Life Sci. : 208 -216 .

  • A. Davies, A.K. Hayes, K. Knight, S.J. Watmough, M. Pirmohamed, and R.E. Clark, Leukemia Res., 34, 702–707 (2010)

    Clark RE , '' (2010 ) 34 Leukemia Res. : 702 -707 .

  • G. Guetens, H. Prenen, G. De Boeck, A. van Oosterom, P. Schoeffski, M. Highley, et al., J. Chromatogr., B: Anal. Technol. Biomed. Life Sci., 846, 341–345 (2007)

    Highley M , '' (2007 ) 846 J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. : 341 -345 .

  • R.A. Parise, M.J. Egorin, S.M. Christner, D.D. Shah, W. Zhou, and J.H. Beumer, J. Chromatogr., B: Anal. Technol. Biomed. Life Sci., 877, 1894–1900 (2009)

    Beumer JH , '' (2009 ) 877 J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. : 1894 -1900 .

  • A. D’Avolio, M. Simiele, S. De Francia, A. Ariaudo, L. Baietto, J. Cusato, et al., J. Pharmaceut. Biomed. Anal., 59, 109–116 (2012)

    Cusato J , '' (2012 ) 59 J. Pharmaceut. Biomed. Anal. : 109 -116 .

  • S. De Francia, A. D’Avolio, F. De Martino, E. Pirro, L. Baietto, M. Siccardi, et al., J. Chromatogr., B: Anal. Technol. Biomed. Life Sci., 877, 1721–1726 (2009)

    Siccardi M , '' (2009 ) 877 J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. : 1721 -1726 .

  • Q2 (R1) Validation of Analytical Procedures, Proceedings of the International Conference on Harmonisation (ICH), Commission of the European Communities, Geneva, 1996

  • The United States Pharmacopeia (USP 30), National Formulary (NF 25). Rockville, MD, 2007

  • Collapse
  • Expand

Senior editors

Editor(s)-in-Chief: Sajewicz, Mieczyslaw, University of Silesia, Katowice, Poland

Editors(s)

  • Danica Agbaba, University of Belgrade, Belgrade, Serbia (1953-2024)
  • Łukasz Komsta, Medical University of Lublin, Lublin, Poland
  • Ivana Stanimirova-Daszykowska, University of Silesia, Katowice, Poland
  • Monika Waksmundzka-Hajnos, Medical University of Lublin, Lublin, Poland

Editorial Board

  • Ravi Bhushan, The Indian Institute of Technology, Roorkee, India
  • Jacek Bojarski, Jagiellonian University, Kraków, Poland
  • Bezhan Chankvetadze, State University of Tbilisi, Tbilisi, Georgia
  • Michał Daszykowski, University of Silesia, Katowice, Poland
  • Tadeusz H. Dzido, Medical University of Lublin, Lublin, Poland
  • Attila Felinger, University of Pécs, Pécs, Hungary
  • Kazimierz Glowniak, Medical University of Lublin, Lublin, Poland
  • Bronisław Glód, Siedlce University of Natural Sciences and Humanities, Siedlce, Poland
  • Anna Gumieniczek, Medical University of Lublin, Lublin, Poland
  • Urszula Hubicka, Jagiellonian University, Kraków, Poland
  • Krzysztof Kaczmarski, Rzeszow University of Technology, Rzeszów, Poland
  • Huba Kalász, Semmelweis University, Budapest, Hungary
  • Katarina Karljiković Rajić, University of Belgrade, Belgrade, Serbia
  • Imre Klebovich, Semmelweis University, Budapest, Hungary
  • Angelika Koch, Private Pharmacy, Hamburg, Germany
  • Piotr Kus, Univerity of Silesia, Katowice, Poland
  • Debby Mangelings, Free University of Brussels, Brussels, Belgium
  • Emil Mincsovics, Corvinus University of Budapest, Budapest, Hungary
  • Ágnes M. Móricz, Centre for Agricultural Research, Budapest, Hungary
  • Gertrud Morlock, Giessen University, Giessen, Germany
  • Anna Petruczynik, Medical University of Lublin, Lublin, Poland
  • Robert Skibiński, Medical University of Lublin, Lublin, Poland
  • Bernd Spangenberg, Offenburg University of Applied Sciences, Germany
  • Tomasz Tuzimski, Medical University of Lublin, Lublin, Poland
  • Adam Voelkel, Poznań University of Technology, Poznań, Poland
  • Beata Walczak, University of Silesia, Katowice, Poland
  • Wiesław Wasiak, Adam Mickiewicz University, Poznań, Poland
  • Igor G. Zenkevich, St. Petersburg State University, St. Petersburg, Russian Federation

 

SAJEWICZ, MIECZYSLAW
E-mail:mieczyslaw.sajewicz@us.edu.pl

Indexing and Abstracting Services:

  • Science Citation Index
  • Sci Search
  • Research Alert
  • Chemistry Citation Index and Current Content/Physical
  • Chemical and Earth Sciences
  • SCOPUS
  • GoogleScholar
  • Index Copernicus
  • CABI
  • CABELLS Journalytics

2023  
Web of Science  
Journal Impact Factor 1.7
Rank by Impact Factor Q3 (Chemistry, Analytical)
Journal Citation Indicator 0.43
Scopus  
CiteScore 4.0
CiteScore rank Q2 (General Chemistry)
SNIP 0.706
Scimago  
SJR index 0.344
SJR Q rank Q3

Acta Chromatographica
Publication Model Online only
Gold Open Access
Submission Fee none
Article Processing Charge 700 EUR/article
Regional discounts on country of the funding agency World Bank Lower-middle-income economies: 50%
World Bank Low-income economies: 100%
Further Discounts Editorial Board / Advisory Board members: 50%
Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100%
Subscription Information Gold Open Access
Purchase per Title  

Acta Chromatographica
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
4
Founder Institute of Chemistry, University of Silesia
Founder's
Address
PL-40-007 Katowice, Poland, Bankowa 12
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2083-5736 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Aug 2024 0 32 22
Sep 2024 0 45 24
Oct 2024 0 84 25
Nov 2024 0 83 16
Dec 2024 0 114 23
Jan 2025 0 25 14
Feb 2025 0 23 9