Authors:
P. Ravi BITS-Pilani Hyderabad Campus Pharmacy Department Jawaharnagar, Ranga Reddy (Dist.) Andhra Pradesh India

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R. Vats BITS-Pilani Hyderabad Campus Pharmacy Department Jawaharnagar, Ranga Reddy (Dist.) Andhra Pradesh India

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S. Joseph BITS-Pilani Hyderabad Campus Pharmacy Department Jawaharnagar, Ranga Reddy (Dist.) Andhra Pradesh India

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N. Gadekar BITS-Pilani Hyderabad Campus Pharmacy Department Jawaharnagar, Ranga Reddy (Dist.) Andhra Pradesh India

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A simple, sensitive and rapid high-performance liquid chromatography method with ultraviolet (UV) detector was developed and validated for the analysis of Nebivolol (NBL) in rat plasma. The plasma sample, spiked with raloxifene hydrochloride as an internal standard (IS), was subjected to single step protein precipitation method prior to analysis. Chromatographic separation was achieved on the Agilent C8 (150 mm × 4.6 mm, 5 μm) column and monitored at a wavelength of 280 nm. Elution was carried out, in an isocratic mode, using a mobile phase consisting of acetonitrile and potassium di-hydrogen orthophosphate buffer (pH 3.5 ± 0.1) in the ratio of 37:63 v/v. Retention times of IS and NBL were 5.1 ± 0.10 min and 8.01 ± 0.12 min, respectively. No interference was observed from plasma components in the analysis of NBL and IS. Calibration curve was linear over the range of 125–3000 ng/mL (r2 = 0.999). NBL was found to be stable under various processing and storage conditions. The developed method was applied in the quantification of NBL in plasma samples, determining various pharmacokinetic parameters from intravenous bolus and oral administration of the drug in Wistar rats. NBL was found to follow two compartmental open models in Wistar rats.

  • A. Van de Water, W. Janssens, J. Van Neuten, R. Xhonneux, J. De Cree, H. Verhaegen, R.S. Reneman, P.A. Janssen, J. Cardiovasc. Pharmacol., 11, 552 (1988)

    Janssen P.A. , '' (1988 ) 11 J. Cardiovasc. Pharmacol. : 552 -.

  • J.R. Cockcroft, P.J. Chowienczyk, S.E. Brett, C.P. Chen, A.G. Dupont, L. Van Nueten, S.J. Wooding, J.M. Ritter, J. Pharmacol. Exp. Therapeut., 274, 1067 (1995)

    Ritter J.M. , '' (1995 ) 274 J. Pharmacol. Exp. Therapeut. : 1067 -.

  • D. Wojciechowski, V. Papademetriou, Expert Rev. Cardiovasc. Ther., 6, 471 (2008)

    Papademetriou V. , '' (2008 ) 6 Expert Rev. Cardiovasc. Ther. : 471 -.

  • L. Van Nueten, J. De Crée, Cardiovasc. Drugs Ther., 12, 339 (1998)

    Crée J. , '' (1998 ) 12 Cardiovasc. Drugs Ther. : 339 -.

  • W. McNeely, K.L. Goa, Drugs, 57, 633 (1999)

    Goa K.L. , '' (1999 ) 57 Drugs : 633 -.

  • M.A. Weber, Am. J. Hypertens., 18, 169S (2005)

    Weber M.A. , '' (2005 ) 18 Am. J. Hypertens. : 169S -.

  • T. Mizutani, Drug Metab. Rev., 35, 99 (2003)

    Mizutani T. , '' (2003 ) 35 Drug Metab. Rev. : 99 -.

  • W.E. Evans, M.V. Relling, A. Rahman, H.L. McLeod, E.P. Scott, J.S. Lin, J. Clin. Invest., 91, 2150 (1993)

    Lin J.S. , '' (1993 ) 91 J. Clin. Invest. : 2150 -.

  • R. Weiss, Vasc Health Risk Manag., 2, 303 (2006)

    Weiss R. , '' (2006 ) 2 Vasc Health Risk Manag. : 303 -.

  • B.S. Nayak, P. Ellaiah, D. Pattanayak, S. Das, Asian J. Pharmaceut., 5, 175 (2011)

    Das S. , '' (2011 ) 5 Asian J. Pharmaceut. : 175 -.

  • S.S. Bushetti, P.M. Prashant, S. Kardame, RGUHS J. Pharmaceut. Sci., 1, 157 (2011)

    Kardame S. , '' (2011 ) 1 RGUHS J. Pharmaceut. Sci. : 157 -.

  • F.M. Bertera, J.S. Del Mauro, A.H. Polizio, D. Chiappetta, C.A. Taira, C. Höcht, Naunyn-Schmiedeberg’s Arch. Pharmacol., 385, 833 (2012)

    Höcht C. , '' (2012 ) 385 Naunyn-Schmiedeberg’s Arch. Pharmacol. : 833 -.

  • L. Ma, R. Gul, J. Habibi, M. Yang, L. Pulakat, A. Whaley-Connell, C.M. Ferrario, J.R. Sowers, Am. J. Physiol. Heart Circ. Physiol., 302, H2341 (2012)

    Sowers J.R. , '' (2012 ) 302 Am. J. Physiol. Heart Circ. Physiol. : H2341 -.

  • G. Sacco, S. Evangelista, S. Manzini, M. Parlani, M. Bigioni, Fut. Cardiol., 7, 757 (2011)

    Bigioni M. , '' (2011 ) 7 Fut. Cardiol. : 757 -.

  • D.A. Shah, K.K. Bhatt, R.S. Mehta, S.L. Baldania, T.R. Gandhi, Indian J. Pharm. Sci., 70, 591 (2008)

    Gandhi T.R. , '' (2008 ) 70 Indian J. Pharm. Sci. : 591 -.

  • S.U. Kokil, M.S. Bhatia, Indian J. Pharm. Sci., 71, 111 (2009)

    Bhatia M.S. , '' (2009 ) 71 Indian J. Pharm. Sci. : 111 -.

  • S.N. Meyyanathan, A.S. Birajdar, B. Suresh, Indian J. Pharm. Edu. Res., 44, 156 (2010)

    Suresh B. , '' (2010 ) 44 Indian J. Pharm. Edu. Res. : 156 -.

  • L. Abdel-Fattah, L. Abdel-Aziz, A. El-Kosasy, M. Gaied, Drug Discov. Ther., 4, 418 (2010)

    Gaied M. , '' (2010 ) 4 Drug Discov. Ther. : 418 -.

  • N.V. Ramakrishna, K.N. Vishwottam, M. Koteshwara, S. Manoj, M. Santosh, D.P. Varma, J. Pharm. Biomed. Anal., 39, 1006 (2005)

    Varma D.P. , '' (2005 ) 39 J. Pharm. Biomed. Anal. : 1006 -.

  • J. Nandania, S.J. Rajput, P. Contractor, P. Vasava, B. Solanki, M. Vohra, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 923–924, 110–119 (2013)

    Chromatogr J. , '' (2013 ) 923–924 B Analyt. Technol. Biomed. Life Sci. : 110 -119 .

  • P.S. Selvan, K.V. Gowda, U. Mandal, W.D. Solomon, T.K. Pal, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 858, 143 (2007)

    Pal T.K. , '' (2007 ) 858 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. : 143 -.

  • International Conference on Harmonization (ICH), Harmonized tripartite guideline on Topic Q2B, Notes for Guidelines for Validation of Analytical Procedures: Methodology; Pub. By: The European Agency for the Evaluation of Medicinal Products, Human Medicines Evaluation Unit (1996)

  • Guidance for Industry: Bioanalytical method validation. U.S. Department of Health and Human Services, Food and Drug Administration (2001)

  • D.V. McCalley, J. Chromatogr. A, 708, 185 (1995)

    McCalley D.V. , '' (1995 ) 708 J. Chromatogr. A : 185 -.

  • C. Stella, S. Rudaz, M. Mottaz, P.A. Carrupt, J.L. Veuthey, J. Sep. Sci., 27, 284 (2004)

    Veuthey J.L. , '' (2004 ) 27 J. Sep. Sci. : 284 -.

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Senior editors

Editor(s)-in-Chief: Kowalska, Teresa (1946-2023)

Editor(s)-in-Chief: Sajewicz, Mieczyslaw

Editors(s)

  • Danica Agbaba (University of Belgrade, Belgrade, Serbia)
  • Łukasz Komsta (Medical University of Lublin, Lublin, Poland)
  • Ivana Stanimirova-Daszykowska (University of Silesia, Katowice, Poland)
  • Monika Waksmundzka-Hajnos (Medical University of Lublin, Lublin, Poland)

Editorial Board

  • R. Bhushan (The Indian Institute of Technology, Roorkee, India)
  • J. Bojarski (Jagiellonian University, Kraków, Poland)
  • B. Chankvetadze (State University of Tbilisi, Tbilisi, Georgia)
  • M. Daszykowski (University of Silesia, Katowice, Poland)
  • T.H. Dzido (Medical University of Lublin, Lublin, Poland)
  • A. Felinger (University of Pécs, Pécs, Hungary)
  • K. Glowniak (Medical University of Lublin, Lublin, Poland)
  • B. Glód (Siedlce University of Natural Sciences and Humanities, Siedlce, Poland)
  • A. Gumieniczek (Medical University of Lublin, Lublin, Poland)
  • U. Hubicka (Jagiellonian University, Kraków, Poland)
  • K. Kaczmarski (Rzeszow University of Technology, Rzeszów, Poland)
  • H. Kalász (Semmelweis University, Budapest, Hungary)
  • K. Karljiković Rajić (University of Belgrade, Belgrade, Serbia)
  • I. Klebovich (Semmelweis University, Budapest, Hungary)
  • A. Koch (Private Pharmacy, Hamburg, Germany)
  • P. Kus (Univerity of Silesia, Katowice, Poland)
  • D. Mangelings (Free University of Brussels, Brussels, Belgium)
  • E. Mincsovics (Corvinus University of Budapest, Budapest, Hungary)
  • Á. M. Móricz (Centre for Agricultural Research, Budapest, Hungary)
  • G. Morlock (Giessen University, Giessen, Germany)
  • A. Petruczynik (Medical University of Lublin, Lublin, Poland)
  • R. Skibiński (Medical University of Lublin, Lublin, Poland)
  • B. Spangenberg (Offenburg University of Applied Sciences, Germany)
  • T. Tuzimski (Medical University of Lublin, Lublin, Poland)
  • Y. Vander Heyden (Free University of Brussels, Brussels, Belgium)
  • A. Voelkel (Poznań University of Technology, Poznań, Poland)
  • B. Walczak (University of Silesia, Katowice, Poland)
  • W. Wasiak (Adam Mickiewicz University, Poznań, Poland)
  • I.G. Zenkevich (St. Petersburg State University, St. Petersburg, Russian Federation)

 

KOWALSKA, TERESA (1946-2023)
E-mail: kowalska@us.edu.pl

SAJEWICZ, MIECZYSLAW
E-mail:msajewic@us.edu.pl

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2022  
Web of Science  
Total Cites
WoS
647
Journal Impact Factor 1.9
Rank by Impact Factor

Chemistry, Analytical (Q3)

Impact Factor
without
Journal Self Cites
1.9
5 Year
Impact Factor
1.4
Journal Citation Indicator 0.41
Rank by Journal Citation Indicator

Chemistry, Analytical (Q3)

Scimago  
Scimago
H-index
29
Scimago
Journal Rank
0.28
Scimago Quartile Score

Chemistry (miscellaneous) (Q3)

Scopus  
Scopus
Cite Score
3.1
Scopus
CIte Score Rank
General Chemistry 211/407 (48th PCTL)
Scopus
SNIP
0.549

2021  
Web of Science  
Total Cites
WoS
652
Journal Impact Factor 2,011
Rank by Impact Factor Chemistry, Analytical 66/87
Impact Factor
without
Journal Self Cites
1,789
5 Year
Impact Factor
1,350
Journal Citation Indicator 0,40
Rank by Journal Citation Indicator Chemistry, Analytical 72/99
Scimago  
Scimago
H-index
29
Scimago
Journal Rank
0,27
Scimago Quartile Score Chemistry (miscellaneous) (Q3)
Scopus  
Scopus
Cite Score
2,8
Scopus
CIte Score Rank
General Chemistry 210/409 (Q3)
Scopus
SNIP
0,586

2020
 
Total Cites
650
WoS
Journal
Impact Factor
1,639
Rank by
Chemistry, Analytical 71/83 (Q4)
Impact Factor
 
Impact Factor
1,412
without
Journal Self Cites
5 Year
1,301
Impact Factor
Journal
0,34
Citation Indicator
 
Rank by Journal
Chemistry, Analytical 75/93 (Q4)
Citation Indicator
 
Citable
45
Items
Total
43
Articles
Total
2
Reviews
Scimago
28
H-index
Scimago
0,316
Journal Rank
Scimago
Chemistry (miscellaneous) Q3
Quartile Score
 
Scopus
393/181=2,2
Scite Score
 
Scopus
General Chemistry 215/398 (Q3)
Scite Score Rank
 
Scopus
0,560
SNIP
 
Days from
58
submission
 
to acceptance
 
Days from
68
acceptance
 
to publication
 
Acceptance
51%
Rate

2019  
Total Cites
WoS
495
Impact Factor 1,418
Impact Factor
without
Journal Self Cites
1,374
5 Year
Impact Factor
0,936
Immediacy
Index
0,460
Citable
Items
50
Total
Articles
50
Total
Reviews
0
Cited
Half-Life
6,2
Citing
Half-Life
8,3
Eigenfactor
Score
0,00048
Article Influence
Score
0,164
% Articles
in
Citable Items
100,00
Normalized
Eigenfactor
0,05895
Average
IF
Percentile
20,349
Scimago
H-index
26
Scimago
Journal Rank
0,255
Scopus
Scite Score
226/167=1,4
Scopus
Scite Score Rank
Chemistry (miscellaneous) 240/398 (Q3)
Scopus
SNIP
0,494
Acceptance
Rate
41%

 

Acta Chromatographica
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Acta Chromatographica
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
4
Founder Institute of Chemistry, University of Silesia
Founder's
Address
PL-40-007 Katowice, Poland, Bankowa 12
Publisher Akadémiai Kiadó
Publisher's
Address
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Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2083-5736 (Online)

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