Acta Chromatographica
Volume/Issue:
Volume 28: Issue 3
Use of a model process for transfer of minilab TLC screening methods for quinine sulfate, mefloquine, and dihydroartemisinin—piperaquine phosphate tablets to quantitative HPTLC—densitometry methods
Authors:
J. Strock Lafayette College, Easton, Pennsylvania, USA

Search for other papers by J. Strock in
Current site
Google Scholar
PubMed Close
,
M. Nguyen Lafayette College, Easton, Pennsylvania, USA

Search for other papers by M. Nguyen in
Current site
Google Scholar
PubMed Close
, and
J. Sherma Lafayette College, Easton, Pennsylvania, USA

Search for other papers by J. Sherma in
Current site
Google Scholar
PubMed Close
Pages:
363–372
Online Publication Date:
Sep 2016
Publication Date:
01 Sep 2016
Article Category:
Research Article
DOI:
https://doi.org/10.1556/1326.2016.28.3.6
Keywords:
quinine sulfate; mefloquine; dihydroartemisinin; piperaquine; lumefantrine; artemether; thin-layer chromatography; fake drugs; transfer of TLC methods to HPTLC—densitometry
Open access

Transfer of four thin-layer chromatography (TLC) Global Pharma Health Fund Minilab mobile kit protocols for detecting fake pharmaceutical products to quantitative high-performance TLC (HPTLC)—densitometry methods was carried out using a model process published earlier. The developed and validated methods were for the drugs quinine sulfate, mefloquine, dihydroartemisinin, and piperaquine phosphate. EMD Millipore Premium Purity silica gel 60 F254 glass plates, automated standard and sample solution application with a CAMAG Linomat 4, and automated densitometry with a CAMAG Scanner 3 for detection, identification, and quantification were used. Sample peak identity and purity validation were carried out by spectral comparison checks available in the winCATS software, and accuracy was estimated by the standard addition approach. HPTLC gives better efficiency, selectivity, and resolution than TLC, and the new methods overcome the deficiencies in technology related to manual application and visual zone comparison that do not allow the Minilab TLC procedures to support regulatory compliance actions. These new methods should be fully validated according to International Conference on Harmonization guidelines or by interlaboratory studies if required by their applications. In addition, a previously reported transferred simultaneous HPTLC–densitometry method for lumefantrine and artemether was used to analyze a new combination tablet to demonstrate its applicability.

  • [1]

    J. Sherma and C. O’Sullivan, Acta Chromatogr., 24, 241–252 (2012)

  • [2]

    K. Lianza and J. Sherma, J. Liq. Chromatogr. Relat. Technol., 36, 2446–2452 (2013)

  • [3]

    N. Popovic and J. Sherma, Acta Chromatogr., 26, 615–623 (2014)

  • [4]

    M. Nguyen and J. Sherma, Trends Chromatogr., 8, 131–135 (2013)

  • [5]

    M. Nguyen and J. Sherma, J. Liq. Chromatogr. Relat. Technol., 37, 2956–2970 (2014)

  • [6]

    J. Strock , M. Nguyen, and J. Sherma, J. Liq. Chromatogr. Relat. Technol., in press

  • [7]

    K. Ferenczi-Fodor, Z. Vegh, A. Nagy-Turak, B. Renger, and M. Zeller, J. AOAC Int., 84, 1265–1276

  • [8]

    A. S. Kenyon and T. P. Layloff, http://www.pharmweb.net/pwmirror/library/tlc/tlcall. pdf

  • [9]

    http://www.gphf.org

  • [10]

    E. Kaale , P. Risha, E. Reich, and T. P. Layloff, J. AOAC Int., 93, 1836–1843 (2010)

  • Collapse
  • Expand
Cover Acta Chromatographica
Acta Chromatographica
Online ISSN:
2083-5736

Senior editors

Editor(s)-in-Chief: Sajewicz, Mieczyslaw, University of Silesia, Katowice, Poland

Editors(s)

  • Danica Agbaba, University of Belgrade, Belgrade, Serbia (1953-2024)
  • Łukasz Komsta, Medical University of Lublin, Lublin, Poland
  • Ivana Stanimirova-Daszykowska, University of Silesia, Katowice, Poland
  • Monika Waksmundzka-Hajnos, Medical University of Lublin, Lublin, Poland

Editorial Board

  • Ravi Bhushan, The Indian Institute of Technology, Roorkee, India
  • Jacek Bojarski, Jagiellonian University, Kraków, Poland
  • Bezhan Chankvetadze, State University of Tbilisi, Tbilisi, Georgia
  • Michał Daszykowski, University of Silesia, Katowice, Poland
  • Tadeusz H. Dzido, Medical University of Lublin, Lublin, Poland
  • Attila Felinger, University of Pécs, Pécs, Hungary
  • Kazimierz Glowniak, Medical University of Lublin, Lublin, Poland
  • Bronisław Glód, Siedlce University of Natural Sciences and Humanities, Siedlce, Poland
  • Anna Gumieniczek, Medical University of Lublin, Lublin, Poland
  • Urszula Hubicka, Jagiellonian University, Kraków, Poland
  • Krzysztof Kaczmarski, Rzeszow University of Technology, Rzeszów, Poland
  • Huba Kalász, Semmelweis University, Budapest, Hungary
  • Katarina Karljiković Rajić, University of Belgrade, Belgrade, Serbia
  • Imre Klebovich, Semmelweis University, Budapest, Hungary
  • Angelika Koch, Private Pharmacy, Hamburg, Germany
  • Piotr Kus, Univerity of Silesia, Katowice, Poland
  • Debby Mangelings, Free University of Brussels, Brussels, Belgium
  • Emil Mincsovics, Corvinus University of Budapest, Budapest, Hungary
  • Ágnes M. Móricz, Centre for Agricultural Research, Budapest, Hungary
  • Gertrud Morlock, Giessen University, Giessen, Germany
  • Anna Petruczynik, Medical University of Lublin, Lublin, Poland
  • Robert Skibiński, Medical University of Lublin, Lublin, Poland
  • Bernd Spangenberg, Offenburg University of Applied Sciences, Germany
  • Tomasz Tuzimski, Medical University of Lublin, Lublin, Poland
  • Adam Voelkel, Poznań University of Technology, Poznań, Poland
  • Beata Walczak, University of Silesia, Katowice, Poland
  • Wiesław Wasiak, Adam Mickiewicz University, Poznań, Poland
  • Igor G. Zenkevich, St. Petersburg State University, St. Petersburg, Russian Federation

 

SAJEWICZ, MIECZYSLAW
E-mail:mieczyslaw.sajewicz@us.edu.pl

Indexing and Abstracting Services:

  • Science Citation Index
  • SCOPUS
  • DOAJ
  • Sci Search
  • Research Alert
  • Chemistry Citation Index and Current Content/Physical
  • Chemical and Earth Sciences
  • GoogleScholar
  • Index Copernicus
  • CABI
  • CABELLS Journalytics

2024  
Scopus  
CiteScore  
CiteScore rank  
SNIP  
Scimago  
SJR index 0.285
SJR Q rank Q3

2023  
Web of Science  
Journal Impact Factor 1.7
Rank by Impact Factor Q3 (Chemistry, Analytical)
Journal Citation Indicator 0.43
Scopus  
CiteScore 4.0
CiteScore rank Q2 (General Chemistry)
SNIP 0.706
Scimago  
SJR index 0.344
SJR Q rank Q3

Acta Chromatographica
Publication Model Online only
Gold Open Access
Submission Fee none
Article Processing Charge 700 EUR/article
Regional discounts on country of the funding agency World Bank Lower-middle-income economies: 50%
World Bank Low-income economies: 100%
Further Discounts Editorial Board / Advisory Board members: 50%
Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100%
Subscription Information Gold Open Access
Purchase per Title  

Acta Chromatographica
Language English
Size A4
Year of
Foundation		 1988
Volumes
per Year		 1
Issues
per Year		 4
Founder Institute of Chemistry, University of Silesia
Founder's
Address		 PL-40-007 Katowice, Poland, Bankowa 12
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 2083-5736 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Dec 2024 0 86 2
Jan 2025 0 41 4
Feb 2025 0 45 4
Mar 2025 0 50 2
Apr 2025 0 27 8
May 2025 0 5 2
Jun 2025 0 0 0