Ultra high-performance liquid chromatography (UHPLC) coupled with high-resolution quadrupole time-of-flight (Q-TOF) mass spectrometry was used for the preliminary photodegradation study of nine new generation psychotropic drugs. Based on the above method, two ionization sample modes — electrospray and atmospheric pressure chemical ionization were used for the registration of photodegradation profiles of the selected drugs. Multivariate chemometric analysis showed that electrospray ionization (ESI) method is more specific than atmospheric pressure chemical ionization (APCI) in high-resolution mass spectrometry (HR-MS) analysis of the analyzed psychotropic drugs. It was noticed that, with the use of ESI method, more potential photodegradation products can be identified and lower limits of its detection can be obtained.
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R.Ekman, J.Sillbering, A.M.Westman-Brinkmalm, and A.Kraj, Mass Spectrometry Instrumentation, Interpretation, and Applications, John Wiley & Sons, 2009
R.Ekman, J.Sillbering, A.M.Westman-Brinkmalm, and A.Kraj, Mass Spectrometry Instrumentation, Interpretation, and Applications, John Wiley & Sons, 2009)| false