View More View Less
  • 1 Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary
  • 2 Department of Neurology, Semmelweis University, Budapest, Hungary
  • 3 National Center for Epidemiology, Budapest, Hungary
  • 4 Department of Transplantation and Surgery, Semmelweis University, Baross utca 23, H-1082, Budapest, Hungary
Restricted access

Abstract

The complications caused by the rarely viral infections are more frequently treated in ICU (intensive care unit). The world paid attention to the WNV (West Nile virus) infections only in 1999, when 62 meningoencephalitis were registered in New York State. Six cases of WNV occur annually in Hungary. The authors present the first transplanted Hungarian patient with WNV encephalitis. The patient was hospitalized with epigastric pain, diarrhea, continuous fever, and decreasing amount of urine. The first checkup of infectious diseases was without any result. Although using of empirical antimicrobal therapy, the multiorgan failure patient remained febrile. On the basis of clinical signs, meningitis or encephalitis was suspected despite negative results of repeated cultures. On the 8th day, WNV infection was confirmed by serological examinations. With intravenous immunoglobulin therapy used within confines of supportive treatment, the patient became afebrile. After 21 days in ICU with good graft function, the patient was moved to the ward and he left the hospital after two more weeks. Until now, no prophylactic or etiological treatment has been developed for WNV. The early treatment is done with immunoglobulin or interferon; otherwise therapy has only supportive function. The disease caused by virus is more aggressive in transplanted patients and could be caused death.

  • 1. N. Stollenwerk 2008 Bench-to-bedside review: rare and common viral infections in the intensive care unit — linking pathophysiology to clinical presentation Crit Care 12 219.

    • Search Google Scholar
    • Export Citation
  • 2. M.A. Samuel M.S. Diamond 2005 Alpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival J Virol 79 13350 13361.

    • Search Google Scholar
    • Export Citation
  • 3. S. Rehana 2008 West Nile virus encephalitis in a renal transplant recipient: the role of intravenous immunoglobulin Am J Kidney Dis 52 19 21.

    • Search Google Scholar
    • Export Citation
  • 4. L.R. Petersen 2003 West Nile virus JAMA 290 524 528.

  • 5. G.L. Campbell 2002 West Nile virus Lancet Infect Dis 2 519 529.

  • 6. K.V. Ravindra 2004 West Nile virus-associated encephalitis in recipients of renal and pancreas transplants: case series and literature review Clin Infect Dis 38 1257 1260.

    • Search Google Scholar
    • Export Citation
  • 7. P. Martin-Davila 2008 Transmission of tropical and geographically restricted infections during solid-organ transplantation Clin Microbiol Rev 21 60 96.

    • Search Google Scholar
    • Export Citation
  • 8. S.A. Koepsell 2010 Seronegative naturally acquired West Nile virus encephalitis in a renal and pancreas transplant recipient Transpl Infect Dis 12 459 464.

    • Search Google Scholar
    • Export Citation
  • 9. R.N. Rosenberg 2004 West Nile virus encephalomyelitis in transplant recipients JAMA 292 859 860.

  • 10. K.L. Tyler 2006 CSF findings in 250 patients with serologically confirmed West Nile virus meningitis and encephalitis Neurology 66 361 365.

    • Search Google Scholar
    • Export Citation
  • 11. M. Ali 2005 West Nile virus infection: MR imaging findings in the nervous system Am J Neuroradiol 26 289 297.

  • 12. D. Ben-Nathan 2003 Prophylactic and therapeutic efficacy of human intravenous immunoglobulin in treating West Nile virus infection in mice J Infect Dis 188 5 12.

    • Search Google Scholar
    • Export Citation
  • 13. D. Ben-Nathan 2009 Using high titer West Nile intravenous immunoglobulin from selected Israeli donors for treatment of West Nile virus infection BMC Infect Dis 9 18.

    • Search Google Scholar
    • Export Citation
  • 14. A. Arslanoglu 2003 Serial magnetic resonance imaging of the West Nile virus encephalitis Eur J Radiol Extra 48 53 56.

  • 15. N.P. O'Grady 2008 Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America Crit Care Med 36 1330 1349.

    • Search Google Scholar
    • Export Citation

The author instruction is available in PDF.
Please, download the file from HERE.

  • Medicine (miscellaneous) SJR Quartile Score (2018): Q3
  • Scimago Journal Rank (2018): 0.228
  • SJR Hirsch-Index (2018): 11

Language: English

Founded in 2008
Publication: One volume of four issues annually
Publication Programme: 2020. Vol. 12.

Publishing Model: Open Access with no author fee

Indexing and Abstracting Services:

  • Emerging Sources Citation Index/li>
  • PubMed Central
  • SCOPUS

Senior editors

Editor(s)-in-Chief: Ágoston Szél

Vice Editor(s)-in-Chief: János Gál

Vice Editor(s)-in-Chief: Kálmán Hüttl

Vice Editor(s)-in-Chief: Béla Merkely

Chair of the Editorial Board: Balázs Hauser

Editorial Board

  • Miklós Antal (University of Debrecen, Hungary)
  • Enrico Calzia (Universitätsklinikum Ulm, Germany)
  • Zoltán Csanádi (University of Debrecen, Hungary)
  • Attila Doros (Semmelweis University, Hungary)
  • Edit Dósa (Semmelweis University, Hungary)
  • Dariusz Dudek (Jagiellonian University, Poland)
  • Susumu Eguchi (Nagasaki University, Japan)
  • László Entz (Semmelweis University, Hungary)
  • Nagy A. Habib (Imperial College London, UK)
  • Balázs Hauser (Semmelweis University, Hungary)
  • Miklós D. Kertai (Duke University, USA)
  • András Komócsi (University of Pécs, Hungary)
  • Karl-Heinz Kuck (Asklepios Klinik St. Georg, Germany)
  • Pal Maurovich-Horvat (Semmelweis University, Hungary)
  • Péter Metzger (Danube Hospital/SMZ-Ost, Austria)
  • László Miskolczi (University of Miami, USA)
  • Balázs Nemes (University of Debrecen, Hungary)
  • Attila Oláh (Petz Aladár County and Teaching Hospital, Hungary)
  • Wojciech G. Polak (Erasmus Medical Center, The Netherlands)
  • Robert Reisch (Clinic Hirslanden Zurich, Switzerland)
  • Bernhard Riedel (Vanderbilt University Medical Center, USA)
  • David Royston (Harefield Hospital, UK)
  • Thomas A. Sos (New York Presbyterian Hospital, USA)
  • Wolfgang Trubel (Privatklinik Doebling, Austria)

Semmelweis University. Institute of Human Morphology and Developmental Biology
Address: Tűzoltó u. 58. H-1094 Budapest, Hungary
E-mail: szel@ana2.sote.hu