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  • 1 Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary
  • 2 2nd Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
  • 3 Department of Transplantation and Surgery, Semmelweis University, Baross u. 23–25, H-1082, Budapest, Hungary
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Recurrence of primary sclerosing cholangitis (rPSC) after liver transplantation (OLT) significantly affects longterm graft survival. We aimed to evaluate the incidence of rPSC and clinical data of these patients in Hungary.

Patients and Methods

We retrospectively analyzed data of 511 whole liver transplantations from 1995 to 2011. During the study period, 49 OLTs were performed in 43 adult patients with end-stage PSC (10%).


Out of 49 OLT, 24 cases were excluded, rPSC was diagnosed in six patients (12%). Patients with rPSC had significantly higher mortality (p = 0.009) and graft loss (p = 0.009) in comparison to patients without recurrent disease. Younger recipient age, higher donor BMI was observed in the rPSC group. One patient was diagnosed with de novo IBD, the remaining five patients had worsening IBD activity in the posttransplant period. PreOLT colectomy was performed in 21% of the control and none of the rPSC group. PostOLT colectomy was performed in two rPSC patients due to severe therapy resistant colitis.


Recurrent PSC significantly affects long-term mortality and graft loss. Younger age at OLT, higher donor BMI and severe active IBD may be associated with PSC recurrence. PreOLT total colectomy might have protective effect against rPSC.

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  • Medicine (miscellaneous) SJR Quartile Score (2018): Q3
  • Scimago Journal Rank (2018): 0.228
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Language: English

Founded in 2008
Publication: One volume of four issues annually
Publication Programme: 2020. Vol. 12.

Publishing Model: Open Access with no author fee

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Senior editors

Editor(s)-in-Chief: Ágoston Szél

Vice Editor(s)-in-Chief: János Gál

Vice Editor(s)-in-Chief: Kálmán Hüttl

Vice Editor(s)-in-Chief: Béla Merkely

Chair of the Editorial Board: Balázs Hauser

Editorial Board

  • Miklós Antal (University of Debrecen, Hungary)
  • Enrico Calzia (Universitätsklinikum Ulm, Germany)
  • Zoltán Csanádi (University of Debrecen, Hungary)
  • Attila Doros (Semmelweis University, Hungary)
  • Edit Dósa (Semmelweis University, Hungary)
  • Dariusz Dudek (Jagiellonian University, Poland)
  • Susumu Eguchi (Nagasaki University, Japan)
  • László Entz (Semmelweis University, Hungary)
  • Nagy A. Habib (Imperial College London, UK)
  • Balázs Hauser (Semmelweis University, Hungary)
  • Miklós D. Kertai (Duke University, USA)
  • András Komócsi (University of Pécs, Hungary)
  • Karl-Heinz Kuck (Asklepios Klinik St. Georg, Germany)
  • Pal Maurovich-Horvat (Semmelweis University, Hungary)
  • Péter Metzger (Danube Hospital/SMZ-Ost, Austria)
  • László Miskolczi (University of Miami, USA)
  • Balázs Nemes (University of Debrecen, Hungary)
  • Attila Oláh (Petz Aladár County and Teaching Hospital, Hungary)
  • Wojciech G. Polak (Erasmus Medical Center, The Netherlands)
  • Robert Reisch (Clinic Hirslanden Zurich, Switzerland)
  • Bernhard Riedel (Vanderbilt University Medical Center, USA)
  • David Royston (Harefield Hospital, UK)
  • Thomas A. Sos (New York Presbyterian Hospital, USA)
  • Wolfgang Trubel (Privatklinik Doebling, Austria)

Semmelweis University. Institute of Human Morphology and Developmental Biology
Address: Tűzoltó u. 58. H-1094 Budapest, Hungary

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