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Yaprak Engin-Ustun
Yaprak Engin-Ustun
Bozok University Faculty of Medicine, Yozgat, Turkey
Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara, Turkey
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Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara, Turkey
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Emel Kiyak Caglayan
Emel Kiyak Caglayan
Bozok University Faculty of Medicine, Yozgat, Turkey
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Mustafa Kara
Mustafa Kara
Bozok University Faculty of Medicine, Yozgat, Turkey
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Ayse Yesim Gocmen
Ayse Yesim Gocmen
Bozok University Faculty of Medicine, Yozgat, Turkey
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M. Fevzi Polat
M. Fevzi Polat
Bozok University Faculty of Medicine, Yozgat, Turkey
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Ayla Aktulay
Ayla Aktulay
Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara, Turkey
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Objective
Our aim was to determine how Ramadan fasting effects serum Human NAD-dependent deacetylase sirtuin 1 (SIRT1/SIR2L1) and visfatin levels during pregnancy.
Materials and methods
Thirty-six patients were included in this case-control study. The patient group consisted of 18 pregnant women who were Ramadan fasting. Another healthy 18 pregnant women with matching pregnancy weeks and ages formed the control group. Blood samples were obtained from the patients for biochemical analyses and serum adipokine level measurements.
Results
The mean sirtuin and visfatin levels in fasting pregnant women were 2.87 ± 0.95 and 60.18 ± 19.49 ng/mL, respectively, while the mean serum sirtuin and visfatin levels in the control group was determined to be 4.28 ± 1.45 and 23.26 ± 6.18 ng/mL, respectively. A statistically significant difference was determined between the groups (p = 0.002, p = 0.0001). A correlation analysis provided a negative correlation between number of fasting days and sirtuin levels (r = 0.45, p = 0.005) and a positive correlation with visfatin levels (r = 0.73, p = 0.0001).
Conclusion
As a result, while the serum sirtuin 1 level of pregnant women decreased due to fasting in Ramadan, we determined that their visfatin levels increased and this increase was in correlation with the days of fasting.
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| 2019 | |
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11 |
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0,220 |
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Medicine (miscellaneous) Q3 |
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155/133=1,2 |
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General Medicine 199/529 (Q2) |
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0,343 |
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206 |
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23 |
| Interventional Medicine and Applied Science | |
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