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  • 1 Department of Pharmacy, University of Bari “A. Moro”, Via E. Orabona 4, Bari, 70125, Italy
  • 2 DICATECh, Polytechnic of Bari, Via E. Orabona 4, Bari, 70125, Italy
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Abstract

Microreactor-mediated organocatalysed Michael reactions have been developed. By using a soluble proline-derived catalyst, Michael-type reactions, leading to γ-nitroketones, have been optimized in homogeneous and continuous-flow conditions. As proof of principle, an integrated microfluidic system able to perform domino processes useful in the preparation of bicyclo[4.4.0]decanes with six contiguous stereogenic centres has been set up.

Supplementary Materials

    • Supplementary Material