Journal of Flow Chemistry
Volume/Issue:
Volume 4: Issue 2
Tolerance of Water in Microfluidic Radiofluorinations: A Potential Methodological Shift?
Authors:
Giancarlo Pascali Institute of Clinical Physiology, CNR, Via Moruzzi 1, 56124, Pisa, Italy
LifeSciences, Australian Nuclear Science and Technology Organisation, New Illawarra Road, Lucas Heights NSW 2234, Australia

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Mariarosaria De Simone Institute of Clinical Physiology, CNR, Via Moruzzi 1, 56124, Pisa, Italy

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Lidia Matesic LifeSciences, Australian Nuclear Science and Technology Organisation, New Illawarra Road, Lucas Heights NSW 2234, Australia

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Ivan Greguric LifeSciences, Australian Nuclear Science and Technology Organisation, New Illawarra Road, Lucas Heights NSW 2234, Australia

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Piero A. Salvadori Institute of Clinical Physiology, CNR, Via Moruzzi 1, 56124, Pisa, Italy

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Pages:
86–91
Online Publication Date:
01 Jul 2014
Publication Date:
01 Jul 2014
Article Category:
Research Article
DOI:
https://doi.org/10.1556/jfc-d-13-00034
Keywords:
microfluidics; radiochemistry; radiofluorination; PET; anhydrous; water
Open access

Nucleophilic [18F]-fluorination reactions traditionally include a drying step of the labeling agent in order to achieve a successful substitution. This passage extends the time and complexity required for the whole radiotracer production, with increased hardware and detrimental effects on the radioactive recovery of such a short-lived (t½=109 min) isotope. Because the performance of radiofluorination reactions conducted under microfluidic flow conditions have been demonstrated to be more effective in terms of reaction time and yields, we have tested the tolerance to water present in this specific reaction condition, in view of eliminating the drying step in the process. To this purpose, we tested different substrates selected from typical radiofluorination intermediates. Our results show that water could be tolerated in a microfluidic environment; in particular, we observed a slight decrease in the labeling of aromatic precursors and a significant increase for iodonium salts, whereas the radiochemical yields of the other compounds studied were virtually unchanged. These findings may open the way to the possibility of simpler and faster processes for the production of new 18F-fluorinated positron emission tomography tracers.

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Cover Journal of Flow Chemistry
Journal of Flow Chemistry A Journal of the Flow Chemistry Society
Print ISSN:
2062-249X
Online ISSN:
2063-0212

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Journal of Flow Chemistry
Language English
Size A4
Year of
Foundation		 2011
Volumes
per Year		 1
Issues
per Year		 4
Founder Áramlásos Kémiai Tudományos Társaság
Founder's
Address		 H-1031 Budapest, Hungary Záhony utca 7.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 2062-249X (Print)
ISSN 2063-0212 (Online)

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