Journal of Flow Chemistry
Volume/Issue:
Volume 5: Issue 1
Synthesis of N-Hydroxypyrazin-2(1H)-ones via Selective O-Debenzylation of 1-Benzyloxypyrazin-2(1H)-ones Using Flow Methodology
Authors:
Anh Mai Chemistry Department, University of Leuven Molecular Design and Synthesis Celestijnenlaan 200 F-box 2404, 3001 Heverlee Belgium

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Wim De Borggraeve Chemistry Department, University of Leuven Molecular Design and Synthesis Celestijnenlaan 200 F-box 2404, 3001 Heverlee Belgium

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Pages:
6–10
Online Publication Date:
12 Feb 2015
Publication Date:
25 Mar 2015
Article Category:
Research Article
DOI:
https://doi.org/10.1556/jfc-d-14-00036
Keywords:
debenzylation; flow chemistry; 1-hydroxypyrazin-2(1H)-one; hydroxamic acid; aspergillic acid
Open access

This paper describes the selective and reproducible debenzylation of benzyloxypyrazinones using flow chemistry to yield N-hydroxypyrazinones. Flow methodology enabled us to avoid overreduction of the compounds to pyrazin-2(1H)-ones.

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Cover Journal of Flow Chemistry
Journal of Flow Chemistry A Journal of the Flow Chemistry Society
Print ISSN:
2062-249X
Online ISSN:
2063-0212

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Journal of Flow Chemistry
Language English
Size A4
Year of
Foundation		 2011
Volumes
per Year		 1
Issues
per Year		 4
Founder Áramlásos Kémiai Tudományos Társaság
Founder's
Address		 H-1031 Budapest, Hungary Záhony utca 7.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 2062-249X (Print)
ISSN 2063-0212 (Online)

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