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  • 1 Cardiff University, Park Place, Main Building, Cardiff CF10 3AT, UK
  • 2 Willowbrook Technical Units, Llandogo Road, St. Mellons, Cardiff CF3 0EF, UK
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Rapid alkylations of thiols are performed in a packed-bed flow reactor where potassium carbonate acts as a heterogeneous base in anhydrous solvents at ambient temperature. The reaction also has a high efficiency as the removal of the solvent is the only work up required to isolate the product. The products can be used in a subsequent oxidation which was performed sequentially in semibatch mode. The alkylations of phenol and benzyl amine have been demonstrated on an array of bases, but higher temperatures and longer reaction times are required than with thiols.

Supplementary Materials

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