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  • 1 Universitat de Barcelona, Av. Joan XXIII s/n, 08028-Barcelona, Spain
  • 2 FutureChemistry Holding BV, Toernooiveld 100, 6525 EC Nijmegen, The Netherlands
  • 3 Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
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An Amberlite IR 120 H-promoted one-pot Fischer indolization from a cis-decahydroquinoline using a range of phenylhydrazines led to compounds with the pyrido[2,3-a]carbazole scaffold. The process may be conducted either in batch mode or in a continuous manner in a flow reactor. The stereochemical course of the Fischer indole reaction changed in going from using free phenylhydrazine to the corresponding hydrochloride in batch conditions, whereas, with the short reaction times in continuous flow, no changes due to isomerization processes were observed.

Supplementary Materials

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