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  • 1 University Hospital of Wales Cardiff Transplant Unit Cardiff UK
  • 2 Cardiff University Institute of Molecular and Experimental Medicine, School of Medicine Cardiff UK
  • 3 University Hospital of Wales Dept of Transplant Surgery Cardiff CF10 5NQ UK
Open access

Since its discovery in the 19th century, the complement system has developed into a clinically significant entity. The complement system has been implicated in a variety of clinical conditions, from autoimmune diseases to ischemia-reperfusion injury in transplantation. This article charts the historical progress of our understanding of the complement system and provides a synopsis on the activation pathways and its inherent regulators.

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