View More View Less
  • 1 Royal London Hospital, Pathology and Pharmacy Building Immunology Department 80 Newark Street, Whitechapel London E1 2ES UK
  • 2 King’s College Hospital Department of Immunological Medicine London UK
  • 3 Barts Health NHS Trust Immunology Department London UK
Open access

Pseudomonas aeruginosa (PA) is commonly isolated from the respiratory secretions of antibody deficiency patients, but the significance of this has not been well studied. We have reviewed our adult antibody deficiency cohort of 179 patients and assessed the prevalence and characteristics of PA infection and the effects of early antibiotic eradication treatments. Of the 34 patients with PA, 55.9% (19) underwent successful eradication and were infection-free, 38.2% (13) had intermittent infection, and 5.9% (2) had chronic PA. PA infection was significantly associated with bronchiectasis (p < 0.0001), with 36.1% (22 out of 61) of patients with bronchiectasis developing a PA infection. Infection status was also significantly associated with chronic sinusitis (p < 0.0001). Most treated PA exacerbations were symptomatic and with colony counts of ≥1000 cfu/ml. Current eradication protocols used at our center involve early treatment at first positive isolate with ciprofloxacin for 3 weeks and nebulized colomycin for 3 months, and if eradication fails, intravenous ceftazidime and gentamycin or colomycin is administered for 2 weeks. Continued sputum surveillance and early eradication treatments upon positive PA culture may help to limit chronic PA infection in antibody deficiency patients.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • Cysticfibrosis.org: UK Cystic Fibrosis registry 2012 Annual Data Report. Bromley, Kent (2012)

    '', in UK Cystic Fibrosis registry 2012 Annual Data Report. Bromley, Kent , (2012 ) -.

  • Foundation CF: Cystic Fibrosis Foundation patient registry 2012 Annual Data Report. Bethesda, Maryland (2012)

    Foundation CF , '', in Cystic Fibrosis Foundation patient registry 2012 Annual Data Report. Bethesda, Maryland , (2012 ) -.

    • Search Google Scholar
  • Li Z, Kosorok MR, Farrell PM, Laxova A, West SE, et al.: Longitudinal development of mucoid Pseudomonas aeruginosa infection and lung disease progression in children with cystic fibrosis. JAMA 293, 581–588 (2005)

    West SE , 'Longitudinal development of mucoid Pseudomonas aeruginosa infection and lung disease progression in children with cystic fibrosis ' (2005 ) 293 JAMA : 581 -588.

    • Search Google Scholar
  • Martinez-Garcia MA, Soler-Cataluna JJ, Perpina-Tordera M, Roman-Sanchez P, Soriano J: Factors associated with lung function decline in adult patients with stable noncystic fibrosis bronchiectasis. Chest 132, 1565–1572 (2007)

    Soriano J , 'Factors associated with lung function decline in adult patients with stable noncystic fibrosis bronchiectasis ' (2007 ) 132 Chest : 1565 -1572.

    • Search Google Scholar
  • Wilson CB, Jones PW, O’Leary CJ, Hansell DM, Cole PJ, et al.: Effect of sputum bacteriology on the quality of life of patients with bronchiectasis. Eur Respir J 10, 1754–1760 (1997)

    Cole PJ , 'Effect of sputum bacteriology on the quality of life of patients with bronchiectasis ' (1997 ) 10 Eur Respir J : 1754 -1760.

    • Search Google Scholar
  • Pettit SJ, Bourne H, Spickett GP: Survey of infection in patients receiving antibody replacement treatment for immune deficiency. J Clin Pathol 55, 577–580 (2002)

    Spickett GP , 'Survey of infection in patients receiving antibody replacement treatment for immune deficiency ' (2002 ) 55 J Clin Pathol : 577 -580.

    • Search Google Scholar
  • Winkelstein JA, Marino MC, Lederman HM, Jones SM, Sullivan K, et al.: X-linked agammaglobulinemia: report on a United States registry of 201 patients. Medicine (Baltimore) 85, 193–202 (2006)

    Sullivan K , 'X-linked agammaglobulinemia: report on a United States registry of 201 patients ' (2006 ) 85 Medicine (Baltimore) : 193 -202.

    • Search Google Scholar
  • Frederiksen B, Koch C, Hoiby N: Antibiotic treatment of initial colonization with Pseudomonas aeruginosa postpones chronic infection and prevents deterioration of pulmonary function in cystic fibrosis. Pediatr Pulmonol 23, 330–335 (1997)

    Hoiby N , 'Antibiotic treatment of initial colonization with Pseudomonas aeruginosa postpones chronic infection and prevents deterioration of pulmonary function in cystic fibrosis ' (1997 ) 23 Pediatr Pulmonol : 330 -335.

    • Search Google Scholar
  • Hansen CR, Pressler T, Hoiby N: Early aggressive eradication therapy for intermittent Pseudomonas aeruginosa airway colonization in cystic fibrosis patients: 15 years experience. J Cyst Fibros 7, 523–530 (2008)

    Hoiby N , 'Early aggressive eradication therapy for intermittent Pseudomonas aeruginosa airway colonization in cystic fibrosis patients: 15 years experience ' (2008 ) 7 J Cyst Fibros : 523 -530.

    • Search Google Scholar
  • Lee TW, Brownlee KG, Denton M, Littlewood JM, Conway SP: Reduction in prevalence of chronic Pseudomonas aeruginosa infection at a regional pediatric cystic fibrosis center. Pediatr Pulmonol 37, 104–110 (2004)

    Conway SP , 'Reduction in prevalence of chronic Pseudomonas aeruginosa infection at a regional pediatric cystic fibrosis center ' (2004 ) 37 Pediatr Pulmonol : 104 -110.

    • Search Google Scholar
  • Pressler T, Bohmova C, Conway S, Dumcius S, Hjelte L, et al.: Chronic Pseudomonas aeruginosa infection definition: EuroCareCF Working Group report. J Cyst Fibros 10(Suppl. 2), S75–78 (2011)

    Hjelte L , 'Chronic Pseudomonas aeruginosa infection definition: EuroCareCF Working Group report ' (2011 ) 10 J Cyst Fibros : 75 -78.

    • Search Google Scholar
  • Ratjen F, Walter H, Haug M, Meisner C, Grasemann H, et al.: Diagnostic value of serum antibodies in early Pseudomonas aeruginosa infection in cystic fibrosis patients. Pediatr Pulmonol 42, 249–255 (2007)

    Grasemann H , 'Diagnostic value of serum antibodies in early Pseudomonas aeruginosa infection in cystic fibrosis patients ' (2007 ) 42 Pediatr Pulmonol : 249 -255.

    • Search Google Scholar
  • Lee TW, Brownlee KG, Conway SP, Denton M, Littlewood JM: Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients. J Cyst Fibros 2, 29–34 (2003)

    Littlewood JM , 'Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients ' (2003 ) 2 J Cyst Fibros : 29 -34.

    • Search Google Scholar
  • Proesmans M, Balinska-Miskiewicz W, Dupont L, Bossuyt X, Verhaegen J, et al.: Evaluating the “Leeds criteria” for Pseudomonas aeruginosa infection in a cystic fibrosis centre. Eur Respir J 27, 937–943 (2006)

    Verhaegen J , 'Evaluating the “Leeds criteria” for Pseudomonas aeruginosa infection in a cystic fibrosis centre ' (2006 ) 27 Eur Respir J : 937 -943.

    • Search Google Scholar
  • Pressler T, Karpati F, Granstrom M, Knudsen PK, Lindblad A, et al.: Diagnostic significance of measurements of specific IgG antibodies to Pseudomonas aeruginosa by three different serological methods. J Cyst Fibros 8, 37–42 (2009)

    Lindblad A , 'Diagnostic significance of measurements of specific IgG antibodies to Pseudomonas aeruginosa by three different serological methods ' (2009 ) 8 J Cyst Fibros : 37 -42.

    • Search Google Scholar
  • Ballmann M, Rabsch P, von der Hardt H: Long-term follow up of changes in FEV1 and treatment intensity during Pseudomonas aeruginosa colonisation in patients with cystic fibrosis. Thorax 53, 732–737 (1998)

    Hardt H , 'Long-term follow up of changes in FEV1 and treatment intensity during Pseudomonas aeruginosa colonisation in patients with cystic fibrosis ' (1998 ) 53 Thorax : 732 -737.

    • Search Google Scholar
  • Doring G, Conway SP, Heijerman HG, Hodson ME, Hoiby N, et al.: Antibiotic therapy against Pseudomonas aeruginosa in cystic fibrosis: a European consensus. Eur Respir J 16, 749–767 (2000)

    Hoiby N , 'Antibiotic therapy against Pseudomonas aeruginosa in cystic fibrosis: a European consensus ' (2000 ) 16 Eur Respir J : 749 -767.

    • Search Google Scholar
  • Gathmann B, Grimbacher B, Beaute J, Dudoit Y, Mahlaoui N, et al.: The European internet-based patient and research database for primary immunodeficiencies: results 2006–2008. Clin Exp Immunol 157(Suppl. 1), 3–11 (2009)

    Mahlaoui N , 'The European internet-based patient and research database for primary immunodeficiencies: results 2006–2008 ' (2009 ) 157 Clin Exp Immunol : 3 -11.

    • Search Google Scholar

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Jun 2020 0 4 1
Jul 2020 0 2 0
Aug 2020 0 1 0
Sep 2020 0 2 1
Oct 2020 0 4 1
Nov 2020 0 13 5
Dec 2020 0 0 0