Authors:
M. Alutis Charité — University Medicine Berlin CC5, Department of Microbiology and Hygiene, Campus Benjamin Franklin Hindenburgdamm 27 D-12203 Berlin Germany

Search for other papers by M. Alutis in
Current site
Google Scholar
PubMed
Close
,
U. Grundmann Charité — University Medicine Berlin CC5, Department of Microbiology and Hygiene, Campus Benjamin Franklin Hindenburgdamm 27 D-12203 Berlin Germany

Search for other papers by U. Grundmann in
Current site
Google Scholar
PubMed
Close
,
A. Fischer Charité — University Medicine Berlin CC5, Department of Microbiology and Hygiene, Campus Benjamin Franklin Hindenburgdamm 27 D-12203 Berlin Germany

Search for other papers by A. Fischer in
Current site
Google Scholar
PubMed
Close
,
A. Kühl Charité — University Medicine Berlin Department of Internal Medicine, Rheumatology and Clinical Immunology/Research Center ImmunoSciences (RCIS) Berlin Germany

Search for other papers by A. Kühl in
Current site
Google Scholar
PubMed
Close
,
S. Bereswill Charité — University Medicine Berlin CC5, Department of Microbiology and Hygiene, Campus Benjamin Franklin Hindenburgdamm 27 D-12203 Berlin Germany

Search for other papers by S. Bereswill in
Current site
Google Scholar
PubMed
Close
, and
M. Heimesaat Charité — University Medicine Berlin CC5, Department of Microbiology and Hygiene, Campus Benjamin Franklin Hindenburgdamm 27 D-12203 Berlin Germany

Search for other papers by M. Heimesaat in
Current site
Google Scholar
PubMed
Close
Open access

Increased levels of the matrix metalloproteinases-2 and -9 (also referred to gelatinase-A and -B, respectively) can be detected in intestinal inflammation. We have recently shown that selective gelatinase blockage by the synthetic compound RO28-2653 ameliorates acute murine ileitis and colitis. We here investigated whether RO28-2653 exerts anti-inflammatory effects in acute Campylobacter jejuni-induced enterocolitis of gnotobiotic IL-10−/− mice generated following antibiotic treatment. Mice were perorally infected with C. jejuni (day 0) and either treated with RO28-2653 (75 mg/kg body weight/day) or placebo from day 1 until day 6 post infection (p.i.) by gavage. Irrespective of the treatment, infected mice displayed comparable pathogen loads within the gastrointestinal tract. Following RO28-2653 administration, however, infected mice exhibited less severe symptoms such as bloody diarrhea as compared to placebo controls. Furthermore, less distinct apoptosis but higher numbers of proliferating cells could be detected in the colon of RO28-2653-treated as compared to placebo-treated mice at day 7 p.i. Remarkably, gelatinase blockage resulted in lower numbers of T- and B-lymphocytes as well as macrophages and monocytes in the colonic mucosa of C. jejuni-infected gnotobiotic IL-10−/− mice. Taken together, synthetic gelatinase inhibition exerts anti-inflammatory effects in experimental campylobacteriosis.

  • Hermans D, Pasmans F, Messens W, Martel A, Van Immerseel F, et al.: Poultry as a host for the zoonotic pathogen Campylobacter jejuni. Vector Borne Zoonotic Dis 12, 89–98 (2012)

    Immerseel F , 'Poultry as a host for the zoonotic pathogen Campylobacter jejuni ' (2012 ) 12 Vector Borne Zoonotic Dis : 89 -98 .

    • Search Google Scholar
  • Man SM: The clinical importance of emerging Campylobacter species. Nat Rev Gastroenterol Hepatol 8, 669–685 (2011)

    Man SM , 'The clinical importance of emerging Campylobacter species ' (2011 ) 8 Nat Rev Gastroenterol Hepatol : 669 -685 .

    • Search Google Scholar
  • Lane JA, Mehra RK, Carrington SD, Hickey RM: The food glycome: a source of protection against pathogen colonization in the gastrointestinal tract. Int J Food Microbiol 142, 1–13 (2010)

    Hickey RM , 'The food glycome: a source of protection against pathogen colonization in the gastrointestinal tract ' (2010 ) 142 Int J Food Microbiol : 1 -13 .

    • Search Google Scholar
  • Guerry P, Szymanski CM: Campylobacter sugars sticking out. Trends Microbiol 16, 428–435 (2008)

    Szymanski CM , 'Campylobacter sugars sticking out ' (2008 ) 16 Trends Microbiol : 428 -435 .

    • Search Google Scholar
  • Kist M, Bereswill S: Campylobacter jejuni. Contrib Microbiol 8, 150–165 (2001)

    Bereswill S , 'Campylobacter jejuni ' (2001 ) 8 Contrib Microbiol : 150 -165 .

  • Havelaar AH, van Pelt W, Ang CW, Wagenaar JA, van Putten JP, et al.: Immunity to Campylobacter: its role in risk assessment and epidemiology. Crit Rev Microbiol 35, 1–22 (2009)

    Putten JP , 'Immunity to Campylobacter: its role in risk assessment and epidemiology ' (2009 ) 35 Crit Rev Microbiol : 1 -22 .

    • Search Google Scholar
  • Janssen R, Krogfelt KA, Cawthraw SA, van Pelt W, Wagenaar JA, et al.: Host-pathogen interactions in Campylobacter infections: the host perspective. Clin Microbiol Rev 21, 505–518 (2008)

    Wagenaar JA , 'Host-pathogen interactions in Campylobacter infections: the host perspective ' (2008 ) 21 Clin Microbiol Rev : 505 -518 .

    • Search Google Scholar
  • van Spreeuwel JP, Duursma GC, Meijer CJ, Bax R, Rosekrans PC, et al.: Campylobacter colitis: histological immunohistochemical and ultrastructural findings. Gut 26, 945–951 (1985)

    Rosekrans PC , 'Campylobacter colitis: histological immunohistochemical and ultrastructural findings ' (1985 ) 26 Gut : 945 -951 .

    • Search Google Scholar
  • Walker RI, Caldwell MB, Lee EC, Guerry P, Trust TJ, et al.: Pathophysiology of Campylobacter enteritis. Microbiol Rev 50, 81–94 (1986)

    Trust TJ , 'Pathophysiology of Campylobacter enteritis ' (1986 ) 50 Microbiol Rev : 81 -94 .

    • Search Google Scholar
  • Haag LM, Fischer A, Otto B, Plickert R, Kuhl AA, et al.: Campylobacter jejuni induces acute enterocolitis in gnotobiotic IL-10−/− mice via Toll-like-receptor-2 and-4 signaling. PLoS One 7, e40761 (2012)

    Kuhl AA , 'Campylobacter jejuni induces acute enterocolitis in gnotobiotic IL-10−/− mice via Toll-like-receptor-2 and-4 signaling ' (2012 ) 7 PLoS One : 40761 -.

    • Search Google Scholar
  • Heimesaat MM, Lugert R, Fischer A, Alutis M, Kuhl AA, et al.: Impact of Campylobacter jejuni cj0268c knockout mutation on intestinal colonization, translocation, and induction of immunopathology in gnotobiotic IL-10 deficient mice. PLoS One 9, e90148 (2014)

    Kuhl AA , 'Impact of Campylobacter jejuni cj0268c knockout mutation on intestinal colonization, translocation, and induction of immunopathology in gnotobiotic IL-10 deficient mice ' (2014 ) 9 PLoS One : 90148 -.

    • Search Google Scholar
  • Heimesaat MM, Alutis M, Grundmann U, Fischer A, Tegtmeyer N, et al.: The role of serine protease HtrA in acute ulcerative enterocolitis and extra-intestinal immune responses during Campylobacter jejuni infection of gnotobiotic IL-10 deficient mice. Front Cell Infect Microbiol 4, 77 (2014)

    Tegtmeyer N , 'The role of serine protease HtrA in acute ulcerative enterocolitis and extra-intestinal immune responses during Campylobacter jejuni infection of gnotobiotic IL-10 deficient mice ' (2014 ) 4 Front Cell Infect Microbiol : 77 -.

    • Search Google Scholar
  • Warren HS, Fitting C, Hoff E, Adib-Conquy M, Beasley-Topliffe L, et al.: Resilience to bacterial infection: difference between species could be due to proteins in serum. J Infect Dis 201, 223–232 (2010)

    Beasley-Topliffe L , 'Resilience to bacterial infection: difference between species could be due to proteins in serum ' (2010 ) 201 J Infect Dis : 223 -232 .

    • Search Google Scholar
  • Masanta WO, Heimesaat MM, Bereswill S, Tareen AM, Lugert R, et al.: Modification of intestinal microbiota and its consequences for innate immune response in the pathogenesis of Campylobacteriosis. Clin Dev Immunol, 526860 (2013)

    Lugert R , '', in Clin Dev Immunol , (2013 ) -.

  • Birkedal-Hansen H, Moore WG, Bodden MK, Windsor LJ, Birkedal-Hansen B, et al.: Matrix metalloproteinases: a review. Crit Rev Oral Biol Med 4, 197–250 (1993)

    Birkedal-Hansen B , 'Matrix metalloproteinases: a review ' (1993 ) 4 Crit Rev Oral Biol Med : 197 -250 .

    • Search Google Scholar
  • Brinckerhoff CE, Matrisian LM: Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol 3, 207–214 (2002)

    Matrisian LM , 'Matrix metalloproteinases: a tail of a frog that became a prince ' (2002 ) 3 Nat Rev Mol Cell Biol : 207 -214 .

    • Search Google Scholar
  • Nelson AR, Fingleton B, Rothenberg ML, Matrisian LM: Matrix metalloproteinases: biologic activity and clinical implications. J Clin Oncol 18, 1135–1149 (2000)

    Matrisian LM , 'Matrix metalloproteinases: biologic activity and clinical implications ' (2000 ) 18 J Clin Oncol : 1135 -1149 .

    • Search Google Scholar
  • Goetzl EJ, Banda MJ, Leppert D: Matrix metalloproteinases in immunity. J Immunol 156, 1–4 (1996)

    Leppert D , 'Matrix metalloproteinases in immunity ' (1996 ) 156 J Immunol : 1 -4 .

  • Crawford HC, Matrisian LM: Mechanisms controlling the transcription of matrix metalloproteinase genes in normal and neoplastic cells. Enzyme Protein 49, 20–37 (1996)

    Matrisian LM , 'Mechanisms controlling the transcription of matrix metalloproteinase genes in normal and neoplastic cells ' (1996 ) 49 Enzyme Protein : 20 -37 .

    • Search Google Scholar
  • Saren P, Welgus HG, Kovanen PT: TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages. J Immunol 157, 4159–4165 (1996)

    Kovanen PT , 'TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages ' (1996 ) 157 J Immunol : 4159 -4165 .

    • Search Google Scholar
  • Salmela MT, MacDonald TT, Black D, Irvine B, Zhuma T, et al.: Upregulation of matrix metalloproteinases in a model of T cell mediated tissue injury in the gut: analysis by gene array and in situ hybridisation. Gut 51, 540–547 (2002)

    Zhuma T , 'Upregulation of matrix metalloproteinases in a model of T cell mediated tissue injury in the gut: analysis by gene array and in situ hybridisation ' (2002 ) 51 Gut : 540 -547 .

    • Search Google Scholar
  • Munoz M, Heimesaat MM, Danker K, Struck D, Lohmann U, et al.: Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetallo-proteinase-2 and IL-22 but independent of IL-17. J Exp Med 206, 3047–3059 (2009)

    Lohmann U , 'Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetallo-proteinase-2 and IL-22 but independent of IL-17 ' (2009 ) 206 J Exp Med : 3047 -3059 .

    • Search Google Scholar
  • Heimesaat MM, Dunay IR, Fuchs D, Trautmann D, Fischer A, et al.: Selective gelatinase blockage ameliorates acute DSS colitis. Eur J Microbiol Immunol (Bp) 1, 228–236 (2011)

    Fischer A , 'Selective gelatinase blockage ameliorates acute DSS colitis ' (2011 ) 1 Eur J Microbiol Immunol (Bp) : 228 -236 .

    • Search Google Scholar
  • von Lampe B, Barthel B, Coupland SE, Riecken EO, Rosewicz S: Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease. Gut 47, 63–73 (2000)

    Rosewicz S , 'Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease ' (2000 ) 47 Gut : 63 -73 .

    • Search Google Scholar
  • Bailey CJ, Hembry RM, Alexander A, Irving MH, Grant ME, et al.: Distribution of the matrix metalloproteinases stromelysin, gelatinases A and B, and collagenase in Crohn’s disease and normal intestine. J Clin Pathol 47, 113–116 (1994)

    Grant ME , 'Distribution of the matrix metalloproteinases stromelysin, gelatinases A and B, and collagenase in Crohn’s disease and normal intestine ' (1994 ) 47 J Clin Pathol : 113 -116 .

    • Search Google Scholar
  • Baugh MD, Perry MJ, Hollander AP, Davies DR, Cross SS, et al.: Matrix metalloproteinase levels are elevated in inflammatory bowel disease. Gastroenterology 117, 814–822 (1999)

    Cross SS , 'Matrix metalloproteinase levels are elevated in inflammatory bowel disease ' (1999 ) 117 Gastroenterology : 814 -822 .

    • Search Google Scholar
  • Lein M, Jung K, Ortel B, Stephan C, Rothaug W, et al.: The new synthetic matrix metalloproteinase inhibitor (Roche 28-2653) reduces tumor growth and prolongs survival in a prostate cancer standard rat model. Oncogene 21, 2089–2096 (2002)

    Rothaug W , 'The new synthetic matrix metalloproteinase inhibitor (Roche 28-2653) reduces tumor growth and prolongs survival in a prostate cancer standard rat model ' (2002 ) 21 Oncogene : 2089 -2096 .

    • Search Google Scholar
  • Bernardo MM, Brown S, Li ZH, Fridman R, Mobashery S: Design, synthesis, and characterization of potent, slowbinding inhibitors that are selective for gelatinases. J Biol Chem 277, 11201–11207 (2002)

    Mobashery S , 'Design, synthesis, and characterization of potent, slowbinding inhibitors that are selective for gelatinases ' (2002 ) 277 J Biol Chem : 11201 -11207 .

    • Search Google Scholar
  • Heimesaat MM, Bereswill S, Fischer A, Fuchs D, Struck D, et al.: Gram-negative bacteria aggravate murine small in testinal Th1-type immunopathology following oral infection with Toxoplasma gondii. J Immunol 177, 8785–8795 (2006)

    Struck D , 'Gram-negative bacteria aggravate murine small in testinal Th1-type immunopathology following oral infection with Toxoplasma gondii ' (2006 ) 177 J Immunol : 8785 -8795 .

    • Search Google Scholar
  • Bereswill S, Munoz M, Fischer A, Plickert R, Haag LM, et al.: Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation. PLoS One 5, e15099 (2010)

    Haag LM , 'Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation ' (2010 ) 5 PLoS One : 15099 -.

    • Search Google Scholar
  • Haag LM, Fischer A, Otto B, Plickert R, Kuhl AA, et al.: Intestinal microbiota shifts towards elevated commensal Escherichia coli loads abrogate colonization resistance against Campylobacter jejuni in mice. PLoS One 7, e35988 (2012)

    Kuhl AA , 'Intestinal microbiota shifts towards elevated commensal Escherichia coli loads abrogate colonization resistance against Campylobacter jejuni in mice ' (2012 ) 7 PLoS One : 35988 -.

    • Search Google Scholar
  • Heimesaat MM, Nogai A, Bereswill S, Plickert R, Fischer A, et al.: MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease. Gut 59, 1079–1087 (2010)

    Fischer A , 'MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease ' (2010 ) 59 Gut : 1079 -1087 .

    • Search Google Scholar
  • Bereswill S, Fischer A, Plickert R, Haag LM, Otto B, et al.: Novel murine infection models provide deep insights into the “Menage a Trois” of Campylobacter jejuni, Microbiota and host innate immunity. PLoS One 6, e20953 (2011)

    Otto B , 'Novel murine infection models provide deep insights into the “Menage a Trois” of Campylobacter jejuni, Microbiota and host innate immunity ' (2011 ) 6 PLoS One : 20953 -.

    • Search Google Scholar
  • Heimesaat MM, Haag LM, Fischer A, Otto B, Kuhl AA, et al.: Survey of extra-intestinal immune responses in asymptomatic long-term Campylobacter jejuni-infected mice. Eur J Microbiol Immunol (Bp) 3, 174–182 (2013)

    Kuhl AA , 'Survey of extra-intestinal immune responses in asymptomatic long-term Campylobacter jejuni-infected mice ' (2013 ) 3 Eur J Microbiol Immunol (Bp) : 174 -182 .

    • Search Google Scholar
  • Haag LM, Fischer A, Otto B, Grundmann U, Kuhl AA, et al.: Campylobacter jejuni infection of infant mice: acute enterocolitis is followed by asymptomatic intestinal and extra-intestinal immune responses. Eur J Microbiol Immunol (Bp) 2, 2–11 (2012)

    Kuhl AA , 'Campylobacter jejuni infection of infant mice: acute enterocolitis is followed by asymptomatic intestinal and extra-intestinal immune responses ' (2012 ) 2 Eur J Microbiol Immunol (Bp) : 2 -11 .

    • Search Google Scholar
  • Naito Y, Takagi T, Kuroda M, Katada K, Ichikawa H, et al.: An orally active matrix metalloproteinase inhibitor, ONO-4817, reduces dextran sulfate sodium-induced colitis in mice. Inflamm Res 53, 462–468 (2004)

    Ichikawa H , 'An orally active matrix metalloproteinase inhibitor, ONO-4817, reduces dextran sulfate sodium-induced colitis in mice ' (2004 ) 53 Inflamm Res : 462 -468 .

    • Search Google Scholar
  • Parks WC, Lopez-Boado YS, Wilson CL: Matrilysin in epithelial repair and defense. Chest 120, 36S–41S (2001)

    Wilson CL , 'Matrilysin in epithelial repair and defense ' (2001 ) 120 Chest : 36S -41S .

    • Search Google Scholar
  • Wang M, Qin X, Mudgett JS, Ferguson TA, Senior RM, et al.: Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response. Proc Natl Acad Sci U S A 96, 6885–6889 (1999)

    Senior RM , 'Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response ' (1999 ) 96 Proc Natl Acad Sci U S A : 6885 -6889 .

    • Search Google Scholar
  • Collapse
  • Expand

Senior editors

Editor(s)-in-Chief: Dunay, Ildiko Rita, Prof. Dr. Pharm, Dr. rer. nat., University of Magdeburg, Germany

Editor(s)-in-Chief: Heimesaat, Markus M., Prof. Dr. med., Charité - University Medicine Berlin, Germany

Editorial Board

  • Berit Bangoura, Dr. DVM. PhD,  University of Wyoming, USA
  • Stefan Bereswill, Prof. Dr. rer. nat., Charité - University Medicine Berlin, Germany
  • Dunja Bruder, Prof. Dr. rer. nat., University of Magdeburg, Germany
  • Jan Buer, Prof. Dr. med., University of Duisburg, Germany
  • Edit Buzas, Prof. Dr. med., Semmelweis University, Hungary
  • Renato Damatta, Prof. PhD, UENF, Brazil
  • Maria Deli, MD, PhD, DSc, Biological Research Center, HAS, Hungary
  • Olgica Djurković-Djaković, Prof. Phd, University of Belgrade, Serbia
  • Jean-Dennis Docquier, Prof. Dr. med., University of Siena, Italy
  • Zsuzsanna Fabry, Prof. Phd, University of Washington, USA
  • Ralf Ignatius, Prof. Dr. med., Charité - University Medicine Berlin, Germany
  • Achim Kaasch, Prof. Dr. med., Otto von Guericke University Magdeburg, Germany
  • Oliver Liesenfeld, Prof. Dr. med., Inflammatix, USA
  • Matyas Sandor, Prof. PhD, University of Wisconsin, USA
  • Ulrich Steinhoff, Prof. PhD, University of Marburg, Germany
  • Michal Toborek, Prof. PhD, University of Miami, USA
  • Susanne A. Wolf, PhD, MDC-Berlin, Germany

 

Dr. Dunay, Ildiko Rita
Magdeburg, Germany
E-mail: ildiko.dunay@med.ovgu.de

Indexing and Abstracting Services:

  • PubMed Central
  • Scopus
  • ESCI
  • CABI
  • CABELLS Journalytics

 

2024  
Scopus  
CiteScore  
CiteScore rank  
SNIP  
Scimago  
SJR index 0.569
SJR Q rank Q3

2023  
Web of Science  
Total Cites
WoS
674
Journal Impact Factor 3.3
Rank by Impact Factor

Q2

Impact Factor
without
Journal Self Cites
3.1
5 Year
Impact Factor
3.2
Scimago  
Scimago
H-index
15
Scimago
Journal Rank
0.601
Scimago Quartile Score Microbiology (medical) (Q2)
Microbiology (Q3)
Immunology and Allergy (Q3)
Immunology (Q3)
Scopus  
Scopus
Cite Score
5.0
Scopus
CIte Score Rank
Microbiology (medical) Q2
Scopus
SNIP
0.832

 

European Journal of Microbiology and Immunology
Publication Model Gold Open Access
Online only
Submission Fee none
Article Processing Charge 900 EUR/article
Regional discounts on country of the funding agency World Bank Lower-middle-income economies: 50%
World Bank Low-income economies: 100%
Further Discounts Editorial Board / Advisory Board members: 50%
Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100%
Subscription Information Gold Open Access
Purchase per Title  

European Journal of Microbiology and Immunology
Language English
Size A4
Year of
Foundation
2011
Volumes
per Year
1
Issues
per Year
4
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2062-509X (Print)
ISSN 2062-8633 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Dec 2024 0 28 1
Jan 2025 0 52 2
Feb 2025 0 71 1
Mar 2025 0 95 3
Apr 2025 0 36 2
May 2025 0 10 3
Jun 2025 0 0 0