Authors:
Cosme Alvarado-Esquivel Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Mexico

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Luis Francisco Sánchez-Anguiano Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Mexico

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Alejandra Mendoza-Larios Servicios de Salud de Durango, Durango, México, Cuauhtémoc 225 norte, 34000 Durango, Mexico

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Jesús Hernández-Tinoco Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Mexico

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José Francisco Pérez-Ochoa Servicios de Salud de Durango, Durango, México, Cuauhtémoc 225 norte, 34000 Durango, Mexico

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Elizabeth Irasema Antuna-Salcido Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Mexico

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Elizabeth Rábago-Sánchez Servicios de Salud de Durango, Durango, México, Cuauhtémoc 225 norte, 34000 Durango, Mexico

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Oliver Liesenfeld Charité Medical School, Hindenburgdamm 27, D-12203 Berlin, Germany

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The presence of tissue cysts of Toxoplasma gondii has only poorly been investigated in autopsy series. We determined the presence of T. gondii cysts in a series of 51 autopsies in a public hospital using immunohistochemistry of brain and heart tissues. The association of tissue cysts with the general characteristics of the autopsy cases was also investigated.

Of the 51 cases studied, five (9.8%) were positive by immunohistochemistry for T. gondii cysts in the brain. None of the heart specimens was positive for T. gondii cysts. The presence of T. gondii cysts in brains did not vary with age, sex, birthplace, residence, education, occupation, or the presence of pathology in the brain. In contrast, multivariate analysis showed that the presence of T. gondii cysts was associated with undernourishment (OR = 33.90; 95% CI: 2.82–406.32; P = 0.005).

We demonstrated cerebral T. gondii cysts in an autopsy series in Durango City, Mexico. Results suggest that T. gondii can be more readily found in brain than in heart of infected individuals. This is the first report of an association between the presence of T. gondii in brains and undernourishment.

  • 1.

    Smith JE : A ubiquitous intracellular parasite: the cellular biology of Toxoplasma gondii. Int J Parasitol 25, 13011309 (1995)

  • 2.

    Hill DE , Chirukandoth S, Dubey JP: Biology and epidemiology of Toxoplasma gondii in man and animals. Anim Health Res Rev 6, 4161 (2005)

    • Search Google Scholar
    • Export Citation
  • 3.

    Montoya JG , Liesenfeld O: Toxoplasmosis. Lancet 363, 19651976 (2004)

  • 4.

    Jones JL , Dubey JP: Foodborne toxoplasmosis. Clin Infect Dis 55, 845851 (2012)

  • 5.

    Dubey JP (2010): Toxoplasmosis of Animals and Humans, 2nd ed. CRC Press, Boca Raton, Florida

  • 6.

    Kamerkar S , Davis PH: Toxoplasma on the brain: understanding host-pathogen interactions in chronic CNS infection. J Parasitol Res 2012, (2012)

    • Search Google Scholar
    • Export Citation
  • 7.

    Blanchard N , Dunay IR, Schlüter D: Persistence of Toxoplasma gondii in the central nervous system: a fine-tunedbalance between the parasite, the brain and the immunesystem. Parasite Immunol 37, 150158 (2015)

    • Search Google Scholar
    • Export Citation
  • 8.

    Weiss LM , Dubey JP: Toxoplasmosis: a history of clinical observations. Int J Parasitol 39, 895901 (2009)

  • 9.

    Gajewski PD , Falkenstein M, Hengstler JG, Golka K: Toxoplasma gondii impairs memory in infected seniors. BrainBehav Immun 36, 193199 (2014)

    • Search Google Scholar
    • Export Citation
  • 10.

    Flegr J : How and why Toxoplasma makes us crazy. Trends Parasitol 29, 156163 (2013)

  • 11.

    Arling TA , Yolken RH, Lapidus M, Langenberg P, Dickerson FB, Zimmerman SA, Balis T, Cabassa JA, Scrandis DA, Tonelli LH, Postolache TT: Toxoplasma gondii antibody titers and history of suicide attempts in patients with recurrent mood disorders. J Nerv Ment Dis 197, 905908 (2009)

    • Search Google Scholar
    • Export Citation
  • 12.

    Alvarado-Esquivel C , Sánchez-Anguiano LF, Arnaud-Gil CA, López-Longoria JC, Molina-Espinoza LF, Estrada-Martínez S, Liesenfeld O, Hernández-Tinoco J, SifuentesÁlvarez A, Salas-Martínez C: Toxoplasma gondii infection and suicide attempts: a case-control study in psychiatric outpatients. J Nerv Ment Dis 201, 948952 (2013)

    • Search Google Scholar
    • Export Citation
  • 13.

    Alvarado-Esquivel C , Torres-Castorena A, Liesenfeld O, Estrada-Martínez S, Urbina-Álvarez JD: High seroprevalence of Toxoplasma gondii infection in a subset of Mexican patients with work accidents and low socioeconomic status. Parasit Vectors 5, 13 (2012)

    • Search Google Scholar
    • Export Citation
  • 14.

    Dixit PG , Umap PS, Bardale RV: Toxoplasma myocarditis presenting as myocardial infarction. Indian J Med Sci 61, 218220 (2007)

  • 15.

    Strabelli TM , Siciliano RF, Vidal Campos S, Bianchi Castelli J, Bacal F, Bocchi EA, Uip DE: Toxoplasma gondii myocarditis after adult heart transplantation: successful prophylaxis with pyrimethamine. J Trop Med 2012, 853562 (2012)

    • Search Google Scholar
    • Export Citation
  • 16.

    Mroczek-Czernecka D , Rostoff P, Piwowarska W: Acute toxoplasmic perimyocarditis in a 67-year-old HIV-negative woman – a case report. Przegl Lek 63, 100103 (2006)

    • Search Google Scholar
    • Export Citation
  • 17.

    Pergola G , Cascone A, Russo M: Acute pericarditis and myocarditis by Toxoplasma gondii in an immunocompetent young man: a case report. Infez Med 18, 4852 (2010)

    • Search Google Scholar
    • Export Citation
  • 18.

    Guillot JP , Beylot J, Turner K, Lacoste D, Gabinski C, Besse P: Acute cardiac insufficiency and toxoplasmosis. Arch Mal Coeur Vaiss 82, 17671770 (1989)

    • Search Google Scholar
    • Export Citation
  • 19.

    Jautzke G , Sell M, Thalmann U, Janitschke K, Iglesias J, Schürmann B, Ruf B: Immunohistochemical demonstration of extracerebral toxoplasmosis in AIDS. Verh Dtsch Ges Pathol 75, 185188 (1991)

    • Search Google Scholar
    • Export Citation
  • 20.

    Neuen-Jacob E , Figge C, Arendt G, Wendtland B, Jacob B, Wechsler W: Neuropathological studies in the brains of AIDS patients with opportunistic diseases. Int J Legal Med 105, 339350 (1993)

    • Search Google Scholar
    • Export Citation
  • 21.

    Hofman P , Bernard E, Michiels JF, Thyss A, Le Fichoux Y, Loubière R: Extracerebral toxoplasmosis in the acquired immunodeficiency syndrome (AIDS). Pathol Res Pract 189, 894901 (1993)

    • Search Google Scholar
    • Export Citation
  • 22.

    Alvarado-Esquivel C , Estrada-Martínez S, Pizarro-Villalobos H, Arce-Quiñones M, Liesenfeld O, Dubey JP: Seroepidemiology of Toxoplasma gondii infection in general population in a northern Mexican city. J Parasitol 97, 4043 (2011)

    • Search Google Scholar
    • Export Citation
  • 23.

    Alvarado-Esquivel C , Liesenfeld O, Burciaga-López BD, Ramos-Nevárez A, Estrada-Martínez S, Cerrillo-Soto SM, Carrete-Ramírez FA, López-Centeno Mde L, Ruiz-Martínez MM: Seroepidemiology of Toxoplasma gondii infection in elderly people in a northern Mexican city. Vector Borne Zoonotic Dis 12, 568574 (2012)

    • Search Google Scholar
    • Export Citation
  • 24.

    Alvarado-Esquivel C , Cruz-Magallanes HM, Esquivel-Cruz R, Estrada-Martínez S, Rivas-González M, Liesenfeld O, Martínez-García SA, Ramírez E, Torres-Castorena A, Castañeda A, Dubey JP: Seroepidemiology of Toxoplasmagondii infection in human adults from three rural communities in Durango State, Mexico. J Parasitol 94, 811816 (2008)

    • Search Google Scholar
    • Export Citation
  • 25.

    Falangola MF , Petito CK: Choroid plexus infection in cerebral toxoplasmosis in AIDS patients. Neurology 43, 20352040 (1993)

  • 26.

    Iliakis D , Kressig RW: The relationship between malnutrition and immune. Ther Umsch 71, 5561 (2014)

  • 27.

    McConkey GA , Martin HL, Bristow GC, Webster JP: Toxo plasma gondii infection and behaviour – location, location, location? J Exp Biol 216, 113119 (2013)

    • Search Google Scholar
    • Export Citation
  • 28.

    Vyas A , Kim SK, Giacomini N, Boothroyd JC, Sapolsky RM: Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors. Proc Natl Acad Sci U S A 104, 64426447 (2007)

    • Search Google Scholar
    • Export Citation
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Senior editors

Editor(s)-in-Chief: Dunay, Ildiko Rita

Editor(s)-in-Chief: Heimesaat, Markus M.

Vice Editor(s)-in-Chief: Fuchs, Anja

Editorial Board

Chair of the Editorial Board:
Jeffrey S. Buguliskis (Thomas Jefferson University, USA)

  • Jörn Albring (University of Münster, Germany)
  • Stefan Bereswill (Charité - University Medicine Berlin, Germany)
  • Dunja Bruder (University of Megdeburg, Germany)
  • Jan Buer (University of Duisburg, Germany)
  • Jeff Buguliskis (Thomas Jefferson University, USA)
  • Edit Buzas (Semmelweis University, Hungary)
  • Charles Collyer (University of Sydney, Australia)
  • Renato Damatta (UENF, Brazil)
  • Ivelina Damjanova (Semmelweis University, Hungary)
  • Maria Deli (Biological Research Center, HAS, Hungary)
  • Olgica Djurković-Djaković (University of Belgrade, Serbia)
  • Jean-Dennis Docquier (University of Siena, Italy)
  • Anna Erdei (Eötvös Loránd University, Hungary)
  • Zsuzsanna Fabry (University of Washington, USA)
  • Beniam Ghebremedhin (Witten/Herdecke University, Germany)
  • Nancy Guillen (Institute Pasteur, France)
  • Georgina L. Hold (University of Aberdeen, United Kingdom)
  • Ralf Ignatius (Charité - University Medicine Berlin, Germany)
  • Zsuzsanna Izsvak (MDC-Berlin, Germany)
  • Achim Kaasch (University of Cologne, Germany)
  • Tamás Laskay (University of Lübeck, Germany)
  • Oliver Liesenfeld (Roche, USA)
  • Shreemanta Parida (Vaccine Grand Challenge Program, India)
  • Matyas Sandor (University of Wisconsin, USA)
  • Ulrich Steinhoff (University of Marburg, Germany)
  • Michal Toborek (University of Miami, USA)
  • Mary Jo Wick (University of Gothenburg, Sweden)
  • Susanne A. Wolf (MDC-Berlin, Germany)

 

Dr. Dunay, Ildiko Rita
Magdeburg, Germany
E-mail: ildikodunay@gmail.com

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2022  
Web of Science  
Total Cites
WoS
717
Journal Impact Factor 2.2
Rank by Impact Factor

n/a

Impact Factor
without
Journal Self Cites
2.2
5 Year
Impact Factor
2.8
Journal Citation Indicator 0.66
Rank by Journal Citation Indicator

Microbiology (Q2)

Scimago  
Scimago
H-index
11
Scimago
Journal Rank
0.614
Scimago Quartile Score Microbiology (Q3)
Microbiology (medical) (Q3)
Immunology and Allergy (Q3)
Immunology (Q3)
Scopus  
Scopus
Cite Score
8.3
Scopus
CIte Score Rank
Microbiology 33/163 (80th PCTL)
Microbiology (medical) 28/124 (77th PCTL)
Immunology and Allergy 63/211 (70th PCTL)
Immunology 69/217 (68th PCTL)
Scopus
SNIP
1.221

 

2021  
Web of Science  
Total Cites
WoS
790
Journal Impact Factor not applicable
Rank by Impact Factor not applicable
Impact Factor
without
Journal Self Cites
not applicable
5 Year
Impact Factor
not applicable
Journal Citation Indicator 0,64
Rank by Journal Citation Indicator Microbiology 81/157
Scimago  
Scimago
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not indexed
Scimago Quartile Score not indexed
Scopus  
Scopus
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Scopus
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Scopus
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not indexed

2020  
CrossRef Documents 23
WoS Cites 708
Wos H-index 27
Days from submission to acceptance 219
Days from acceptance to publication 176
Acceptance Rate 70%

2019  
WoS
Cites
558
CrossRef
Documents
24
Acceptance
Rate
92%

 

European Journal of Microbiology and Immunology
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European Journal of Microbiology and Immunology
Language English
Size A4
Year of
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2011
Volumes
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1
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4
Founder Akadémiai Kiadó
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ISSN 2062-509X (Print)
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